Sym-bis（benzimidazole）-2,2＇-ethylene cations act as a new axle template for threading cucurbit[6]uril derivatives on,forming[2]pseudorotaxane and[3]pseudorotaxane.These new complexes have been studied using 1 H NMR...Sym-bis（benzimidazole）-2,2＇-ethylene cations act as a new axle template for threading cucurbit[6]uril derivatives on,forming[2]pseudorotaxane and[3]pseudorotaxane.These new complexes have been studied using 1 H NMR,UV-vis absorption spectroscopy and X-ray analysis.Changes in the 1 H NMR spectra indicate that the two types of pseudorotaxane can be formed by varying the host concentration. UV-vis absorption titration experiments at different pH values demonstrate that interesting pK_a shifts of the bis-benzimidazole derivatives can be induced by the host-guest complexation.The associated constants were calculated to be 2.81×10^4 L/mol and 9.06×10^6 L/mol for the[2]pseudorotaxanes and ｜3]pseudorotaxanes,respectively.Furthermore,X-ray diffraction studies of the solid state structures provide unequivocal proof of the host concentration dependent pseudorotaxane,which is strongly in line with the evidences in solution.展开更多
A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound ...A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95μmol/L （mononuclear tumor cell line （U937）） and 5.58 μmol/L （cervical cancer cell （HeLa））. Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA.展开更多
Two zinc（II） complexes, namely, [Zn（L1）Cl2]2 （1） and {[Zn（L2）（tbta）]·3H2O}n （2） （L1 = 1,3-bis（2-methylbenzimidazol-1-ylmethyl）benzene, H2tbta = tetrabromoterephthalic acid, L2 = 1,3-bis（2-methylbe...Two zinc（II） complexes, namely, [Zn（L1）Cl2]2 （1） and {[Zn（L2）（tbta）]·3H2O}n （2） （L1 = 1,3-bis（2-methylbenzimidazol-1-ylmethyl）benzene, H2tbta = tetrabromoterephthalic acid, L2 = 1,3-bis（2-methylbenzimidazol-1-yl）-2-propanol） have been successfully obtained under hydrothermal conditions. Complex 1 displays binuclear structure which is further extended into a 1D supramolecular chain through π–π stacking. Complex 2 features 2D （4,4） network based on L2/tbta2– double linker. The thermal stability, fluorescence properties and catalytic activities of two complexes for degradation of Methyl orange in a Fenton-like process were discussed.展开更多
Two new three-dimensional coordination polymers, namely [Mn（L）（bpdc）]n（1）, [Mn（L）0.5（ndc）]n（2）（L = 1,4-bis（2-methylbenzimidazole）butane, H2 bpdc = 4,4＇-biphenyldicarboxylic acid, H2 ndc = 2,6-naphthale...Two new three-dimensional coordination polymers, namely [Mn（L）（bpdc）]n（1）, [Mn（L）0.5（ndc）]n（2）（L = 1,4-bis（2-methylbenzimidazole）butane, H2 bpdc = 4,4＇-biphenyldicarboxylic acid, H2 ndc = 2,6-naphthalenedicarboxylic acid） have been successfully synthesized under hydrothermal conditions. Two complexes were characterized by physico-chemical, spectroscopic methods and single-crystal X-ray diffraction. Complex 1 shows a 3D → 3D 5-fold interpenetrated network with a 4-connected uninodal dia topology. Complex 2 possesses a 3D → 3D 3-fold interpenetrating architecture with a binodal（4,5）-connected xah topology. The fluorescence and thermal properties of the title complexes were discussed.展开更多
A new Ni(II) coordination polymer [Ni(L)2(SCN)2]n(L = 1,4-bis(benzimidazol-1-yl)butane) was synthesized hydrothermally and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The...A new Ni(II) coordination polymer [Ni(L)2(SCN)2]n(L = 1,4-bis(benzimidazol-1-yl)butane) was synthesized hydrothermally and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group C2/c with a = 9.4760(3), b = 24.0408(8), c = 16.5871(5) A, β = 99.832(3)°, V = 3723.2(2) A3, Z = 4, Dc = 1.348 g/cm3, F(000) = 1576, the final R = 0.0486 and w R = 0.0936 for 2938 observed reflections with I 】 2σ(I) for the complex. Structural analysis shows that the coordination polymer possesses a 2D(4,4) layer structure which is composed of Ni(II) centers bridged by L ligand with two kinds of conformations and further assembled into a 3D supramolecular network via π-π stacking interactions. In addition, the fluorescence and catalytic properties, for the degradation of Congo red, of the complex were investigated.展开更多
The title compound,[Zn2（H2C4BIm）（ox）2]·2H2O（1,H2C4BIm = 2,2＇-（1,4-bu-tanediyl）bis（1H-benzimidazole）,has been synthesized by the hydrothermal reaction of Zn（NO3）2·6H2O with H2C4BIm and Na2C2O4 in ...The title compound,[Zn2（H2C4BIm）（ox）2]·2H2O（1,H2C4BIm = 2,2＇-（1,4-bu-tanediyl）bis（1H-benzimidazole）,has been synthesized by the hydrothermal reaction of Zn（NO3）2·6H2O with H2C4BIm and Na2C2O4 in water solution.It crystallizes in the triclinic system,space group P1 with a = 9.445（9）,b = 9.598（9）,c = 14.962（14） ,α = 72.160（10）,β = 79.905（12）,γ = 83.680（11）°,Mr = 633.18,V = 1269（2） 3,Z = 2,Dc = 1.657 g/cm3,F（000） = 644,μ = 1.953 mm-1,the final R = 0.0671 and wR = 0.1689.X-ray crystal structure analysis revealed that 1 is a 3D network with（203）2（20）3 topology in which the ZnII atom can be considered as a 3-connected node and both ox2-and H2C4BIm serve as the linear linkers.展开更多
One new benzimidazole derivative copper（II） complex 1（C10H6Cu N2, Mr = 217.71） has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbc...One new benzimidazole derivative copper（II） complex 1（C10H6Cu N2, Mr = 217.71） has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a = 17.417（2）, b = 8.9963（8）, c = 11.3432（9） ？, V = 1777.3（3） ？3, Z = 8, μ（Mo Kα） = 2.403, F（000） = 872, Dc = 1.627 g/cm3. The final R = 0.0598 for 1153 observed reflections with I 〉 2σ（I） and w R = 0.17 for all data. The in vitro anti-cancer activities of 1, Cu Cl2 and the benzimidazole ligand L were investigated using human cervical（Hela） and hepatocellular carcinoma（Hep-G2） cancer cell lines. The copper（II） complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper（II） salt.展开更多
Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is rep...Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is reported and a novel method for the preparation of various kinds of cycloalkanedione is provided.展开更多
Two new coordination polymers [Cu_2(bbim)(dpa)_2(C_2H_5OH)_2](1), [Co(dpa)_2(bbbm)](2)(H_2dpa = diphenic acid, bbim = 1,1?-(1,6-hexanediyl)bis-1H-benzimidazole, bbbm = 1,1?-(1,4-butanediyl)bis-1 H-benzimidazole) const...Two new coordination polymers [Cu_2(bbim)(dpa)_2(C_2H_5OH)_2](1), [Co(dpa)_2(bbbm)](2)(H_2dpa = diphenic acid, bbim = 1,1?-(1,6-hexanediyl)bis-1H-benzimidazole, bbbm = 1,1?-(1,4-butanediyl)bis-1 H-benzimidazole) constructed from bis(benzimidazole)-based ligands with different lengths and diphenic acid co-ligand have been synthesized under solvothermal conditions.Complex 1 possesses Cu-dpa helical chains. The adjacent chains are connected by the bbim ligands into two-dimensional(2D) 3-connected(63) topology. Differently, the layer structure of 2 was consisted by one-dimensional chains containing alternated 8-and 18-membered rings. Furthermore,the thermal stability and fluorescence property for all crystalline materials have been investigated.展开更多
Mn(bzimpy) 2 (1) [bzimpy=2,6 bis(benzimidazol 2 yl)pyridine], a mononuclear manganese(II) complex, was synthesized by the reaction of Mn(OOCMe) 2 with bzimpy in absolute ethanol. The complex was structura...Mn(bzimpy) 2 (1) [bzimpy=2,6 bis(benzimidazol 2 yl)pyridine], a mononuclear manganese(II) complex, was synthesized by the reaction of Mn(OOCMe) 2 with bzimpy in absolute ethanol. The complex was structurally characterized by elemental analysis, cyclic voltammetry, and X ray crystallography. In the complex, the manganese nitrogen distances were different, and the geometry and the metal ion environment showed the distortion. The cyclic voltammetric measurements have been performed to assess its redox characteristics. The presence of oxidation wave at +0.62 V and +0.81 V vs. SCE or +0.8 V and +1.0 V vs. NHE suggested that this complex could catalyze the oxidation of water, therefore, simulate the water oxidizing complex (WOC) of photosystem II (PS II). The measurements of photoreduction of 2,6 dichlorophenolindophenol (DCPIP), and oxygen evolution in the manganese depleted and the complex 1 reconstituted PS II preparations just support our conjecture.展开更多
基金supported by the National Natural Science Foundation of China(No,21272045)the Natural Science Foundation of Guizhou Province and Guizhou Universitythe "Chun-Hui" Funds of the Chinese Ministry of Education are gratefully acknowledged
文摘Sym-bis（benzimidazole）-2,2＇-ethylene cations act as a new axle template for threading cucurbit[6]uril derivatives on,forming[2]pseudorotaxane and[3]pseudorotaxane.These new complexes have been studied using 1 H NMR,UV-vis absorption spectroscopy and X-ray analysis.Changes in the 1 H NMR spectra indicate that the two types of pseudorotaxane can be formed by varying the host concentration. UV-vis absorption titration experiments at different pH values demonstrate that interesting pK_a shifts of the bis-benzimidazole derivatives can be induced by the host-guest complexation.The associated constants were calculated to be 2.81×10^4 L/mol and 9.06×10^6 L/mol for the[2]pseudorotaxanes and ｜3]pseudorotaxanes,respectively.Furthermore,X-ray diffraction studies of the solid state structures provide unequivocal proof of the host concentration dependent pseudorotaxane,which is strongly in line with the evidences in solution.
基金supported by Wuhan City Department of Education(No.2009K106)
文摘A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95μmol/L （mononuclear tumor cell line （U937）） and 5.58 μmol/L （cervical cancer cell （HeLa））. Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA.
基金Supported by the National Natural Science Foundation of China(No.51474086)Natural Science Foundation-Steel and Iron Foundation of Hebei Province(B2015209299)Undergraduate Innovation Programs of North China University of Science and Technology(No.X2015004)
文摘Two zinc（II） complexes, namely, [Zn（L1）Cl2]2 （1） and {[Zn（L2）（tbta）]·3H2O}n （2） （L1 = 1,3-bis（2-methylbenzimidazol-1-ylmethyl）benzene, H2tbta = tetrabromoterephthalic acid, L2 = 1,3-bis（2-methylbenzimidazol-1-yl）-2-propanol） have been successfully obtained under hydrothermal conditions. Complex 1 displays binuclear structure which is further extended into a 1D supramolecular chain through π–π stacking. Complex 2 features 2D （4,4） network based on L2/tbta2– double linker. The thermal stability, fluorescence properties and catalytic activities of two complexes for degradation of Methyl orange in a Fenton-like process were discussed.
基金Project supported by the National Natural Science Foundation of China(No.51474086)Natural Science Foundation-Steel and Iron Foundation of Hebei Province(B2015209299)
文摘Two new three-dimensional coordination polymers, namely [Mn（L）（bpdc）]n（1）, [Mn（L）0.5（ndc）]n（2）（L = 1,4-bis（2-methylbenzimidazole）butane, H2 bpdc = 4,4＇-biphenyldicarboxylic acid, H2 ndc = 2,6-naphthalenedicarboxylic acid） have been successfully synthesized under hydrothermal conditions. Two complexes were characterized by physico-chemical, spectroscopic methods and single-crystal X-ray diffraction. Complex 1 shows a 3D → 3D 5-fold interpenetrated network with a 4-connected uninodal dia topology. Complex 2 possesses a 3D → 3D 3-fold interpenetrating architecture with a binodal（4,5）-connected xah topology. The fluorescence and thermal properties of the title complexes were discussed.
基金supported by the Starting Research Fund from Hebei United University(35398599)the Natural Science Foundation of Hebei Province(B2014209182)
文摘A new Ni(II) coordination polymer [Ni(L)2(SCN)2]n(L = 1,4-bis(benzimidazol-1-yl)butane) was synthesized hydrothermally and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group C2/c with a = 9.4760(3), b = 24.0408(8), c = 16.5871(5) A, β = 99.832(3)°, V = 3723.2(2) A3, Z = 4, Dc = 1.348 g/cm3, F(000) = 1576, the final R = 0.0486 and w R = 0.0936 for 2938 observed reflections with I 】 2σ(I) for the complex. Structural analysis shows that the coordination polymer possesses a 2D(4,4) layer structure which is composed of Ni(II) centers bridged by L ligand with two kinds of conformations and further assembled into a 3D supramolecular network via π-π stacking interactions. In addition, the fluorescence and catalytic properties, for the degradation of Congo red, of the complex were investigated.
基金supported by the Cultivation Fund of the Key Scientific and Technical Innovation Project,Ministry of Education of China (No.708084)the Special Fund for Basic Scientific Research of Central Colleges,Chang’an University (No.CHD2009JC022)
文摘The title compound,[Zn2（H2C4BIm）（ox）2]·2H2O（1,H2C4BIm = 2,2＇-（1,4-bu-tanediyl）bis（1H-benzimidazole）,has been synthesized by the hydrothermal reaction of Zn（NO3）2·6H2O with H2C4BIm and Na2C2O4 in water solution.It crystallizes in the triclinic system,space group P1 with a = 9.445（9）,b = 9.598（9）,c = 14.962（14） ,α = 72.160（10）,β = 79.905（12）,γ = 83.680（11）°,Mr = 633.18,V = 1269（2） 3,Z = 2,Dc = 1.657 g/cm3,F（000） = 644,μ = 1.953 mm-1,the final R = 0.0671 and wR = 0.1689.X-ray crystal structure analysis revealed that 1 is a 3D network with（203）2（20）3 topology in which the ZnII atom can be considered as a 3-connected node and both ox2-and H2C4BIm serve as the linear linkers.
基金financially supported by the Natural Science Foundation of Guangxi Province(No.2010GXNSF)Youth Science Foundation of Guangxi Medical University(No.02604001015)
文摘One new benzimidazole derivative copper（II） complex 1（C10H6Cu N2, Mr = 217.71） has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a = 17.417（2）, b = 8.9963（8）, c = 11.3432（9） ？, V = 1777.3（3） ？3, Z = 8, μ（Mo Kα） = 2.403, F（000） = 872, Dc = 1.627 g/cm3. The final R = 0.0598 for 1153 observed reflections with I 〉 2σ（I） and w R = 0.17 for all data. The in vitro anti-cancer activities of 1, Cu Cl2 and the benzimidazole ligand L were investigated using human cervical（Hela） and hepatocellular carcinoma（Hep-G2） cancer cell lines. The copper（II） complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper（II） salt.
文摘Four kinds of cycloalkanedione were prepared from bis\|benzimidazole methiodide salt and bis\|Grignard reagent, the addition\|hydrolysis reaction of bis\|benzimidazole methiodide salt with bis\|Grignard reagent is reported and a novel method for the preparation of various kinds of cycloalkanedione is provided.
基金supported by the project of teaching quality and teaching reform of Yunnan Province(2073010023)the project of Yunnan Provincial Department of Education(2016ZDX132,2015Y435)
文摘Two new coordination polymers [Cu_2(bbim)(dpa)_2(C_2H_5OH)_2](1), [Co(dpa)_2(bbbm)](2)(H_2dpa = diphenic acid, bbim = 1,1?-(1,6-hexanediyl)bis-1H-benzimidazole, bbbm = 1,1?-(1,4-butanediyl)bis-1 H-benzimidazole) constructed from bis(benzimidazole)-based ligands with different lengths and diphenic acid co-ligand have been synthesized under solvothermal conditions.Complex 1 possesses Cu-dpa helical chains. The adjacent chains are connected by the bbim ligands into two-dimensional(2D) 3-connected(63) topology. Differently, the layer structure of 2 was consisted by one-dimensional chains containing alternated 8-and 18-membered rings. Furthermore,the thermal stability and fluorescence property for all crystalline materials have been investigated.
文摘Mn(bzimpy) 2 (1) [bzimpy=2,6 bis(benzimidazol 2 yl)pyridine], a mononuclear manganese(II) complex, was synthesized by the reaction of Mn(OOCMe) 2 with bzimpy in absolute ethanol. The complex was structurally characterized by elemental analysis, cyclic voltammetry, and X ray crystallography. In the complex, the manganese nitrogen distances were different, and the geometry and the metal ion environment showed the distortion. The cyclic voltammetric measurements have been performed to assess its redox characteristics. The presence of oxidation wave at +0.62 V and +0.81 V vs. SCE or +0.8 V and +1.0 V vs. NHE suggested that this complex could catalyze the oxidation of water, therefore, simulate the water oxidizing complex (WOC) of photosystem II (PS II). The measurements of photoreduction of 2,6 dichlorophenolindophenol (DCPIP), and oxygen evolution in the manganese depleted and the complex 1 reconstituted PS II preparations just support our conjecture.
