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Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection 被引量:18
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作者 Ke-Da Shi Feng Ji 《World Journal of Gastroenterology》 SCIE CAS 2017年第6期931-934,共4页
Endoscopic submucosal dissection (ESD) of superficial esophageal cancer has been increasingly used as an alternative to surgery because it is minimally invasiveand has a high rate of en bloc resection. However, a high... Endoscopic submucosal dissection (ESD) of superficial esophageal cancer has been increasingly used as an alternative to surgery because it is minimally invasiveand has a high rate of en bloc resection. However, a high rate of esophageal stricture is observed after ESD for large lesions, which can dramatically decrease the patient's quality of life. Stricture prevention is necessary to allow for endoscopic therapy to expand. We, herein, review the most recent evidence and discuss the role of the metallic self-expandable stent and the biodegradable stent in esophageal stricture prevention. Limited studies suggested that prophylactic stenting could reduce the stricture rate without increasing the number of complications. In addition, the number of bougie dilation procedures was significantly lower with stent placement. Esophageal stenting is a promising option for post-ESD stricture prevention. However, current evidence is too preliminary to formulate practice standards. Future studies are needed to further validate the efficacy and safety of prophylactic stenting and determine the best strategy for stricture prevention. Stent migration is the most common complication. A new stent that has advantages of a low migration rate and minimal tissue reaction will need to be developed. Therefore, randomized controlled trials with long-term follow-up periods are required before prophylactic stenting could be considered a valid option to prevent post-ESD stricture. 展开更多
关键词 biodegradable stent Stricture prevention Esophageal stricture Metallic self-expandable stent Endoscopic submucosal dissection
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生物可降解镁合金支架研究现状 被引量:15
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作者 陈华 赵仙先 《介入放射学杂志》 CSCD 北大核心 2011年第1期62-64,共3页
目前介入治疗中主要以金属永久性支架为主,这类支架存在血栓形成和再狭窄的问题。生物可降解镁合金支架开始成为关注的焦点和热点,它理论上克服了永久性支架的缺点,是未来支架发展方向之一。相信在不久的将来,生物可降解镁合金支架在许... 目前介入治疗中主要以金属永久性支架为主,这类支架存在血栓形成和再狭窄的问题。生物可降解镁合金支架开始成为关注的焦点和热点,它理论上克服了永久性支架的缺点,是未来支架发展方向之一。相信在不久的将来,生物可降解镁合金支架在许多疾病中都将得到广泛应用。 展开更多
关键词 生物可降解支架 镁合金 再狭窄
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生物可降解支架在良性管腔狭窄成形术中应用的研究进展 被引量:13
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作者 朱悦琦 程英升 李明华 《介入放射学杂志》 CSCD 2008年第9期675-680,共6页
支架成形术在介入治疗中占有非常重要的地位。目前临床应用主要以永久性支架为主,具有炎性增生和再狭窄等并发症存在,难以在良性狭窄性病变及儿童病例中广泛应用。生物可降解支架从理论上克服了永久性支架的缺点,具有很大的临床应用前... 支架成形术在介入治疗中占有非常重要的地位。目前临床应用主要以永久性支架为主,具有炎性增生和再狭窄等并发症存在,难以在良性狭窄性病变及儿童病例中广泛应用。生物可降解支架从理论上克服了永久性支架的缺点,具有很大的临床应用前景。目前生物可降解支架技术已经日趋成熟,通过动物实验和初步临床应用,取得了较为满意的效果。相信在不久的将来,生物可降解支架在许多良性疾病中都将得到广泛应用,从而成为永久性支架以外很好的补充治疗手段。 展开更多
关键词 生物可降解支架 左旋聚乳酸 自增强左旋聚乳酸 镁合金支架
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Vascular restoration therapy and bioresorbable vascular scaffold 被引量:11
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作者 Yunbing Wang Xingdong Zhang 《Regenerative Biomaterials》 SCIE 2014年第1期49-55,共7页
This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s,metallic bare metal stent and metallic drug-eluting s... This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s,metallic bare metal stent and metallic drug-eluting stent technologies in 1990s and 2000s,to bioresorbable vascular scaffold(BVS)technology in large-scale development in recent years.The history,the current stage,the challenges and the future of BVS development are discussed in detail as the best available approach for vascular restoration therapy.The criteria of materials selection,design and processing principles of BVS,and the corresponding clinical trial results are also summarized in this article. 展开更多
关键词 bioresorbable vascular scaffold vascular restoration therapy vascular reparative therapy vascular disease bioresorbable/biodegradable material drug-eluting stent drug-eluting biodegradable stent drug-eluting bioresorbable scaffold
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可降解血管支架结构设计及优化的研究进展 被引量:11
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作者 彭坤 李婧 +2 位作者 王斯睿 夏骏 乔爱科 《中国生物医学工程学报》 CAS CSCD 北大核心 2019年第3期367-374,共8页
可降解血管支架具有完全可吸收性和良好的生物相容性,可避免永久性支架易导致血管再狭窄、药物洗脱支架面临迟发性支架内血栓等的问题,引领介入治疗领域的'第四代'革新。然而,可降解支架服役过程中表现出支撑力不够、降解过快... 可降解血管支架具有完全可吸收性和良好的生物相容性,可避免永久性支架易导致血管再狭窄、药物洗脱支架面临迟发性支架内血栓等的问题,引领介入治疗领域的'第四代'革新。然而,可降解支架服役过程中表现出支撑力不够、降解过快等力学性能不足的问题,使其距临床应用还有一段距离。针对这个问题,支架的结构设计及优化是提高支架支撑性能、延长可降解支架服役时间的有效方法。支架的结构设计及优化也是一个复杂过程,涉及力学性能之间的相互平衡、血流动力学以及腐蚀过程中支架支撑性能变化等问题。综述可降解支架结构设计及优化的国内外研究现状,并在此基础上阐述可降解支架结构设计及优化研究面临的挑战,展望可降解支架结构设计及优化研究的发展方向。 展开更多
关键词 生物降解支架 优化设计 有限元分析
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生物可降解血管支架研究进展 被引量:10
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作者 皇甫强 袁思波 +6 位作者 韩建业 于振涛 余森 张亚峰 麻西群 刘春潮 程军 《中国材料进展》 CAS CSCD 北大核心 2015年第5期396-400,共5页
尽管目前介入用血管支架各类药物涂层技术较从前已经获得长足的进步,涂层支架的临床使用数量也远远超过了裸支架,但远期疗效仍有待继续验证。无论何种药物涂层支架,当其被植入生物体内一段时间后,表面携带的功能药物涂层都会被生物体逐... 尽管目前介入用血管支架各类药物涂层技术较从前已经获得长足的进步,涂层支架的临床使用数量也远远超过了裸支架,但远期疗效仍有待继续验证。无论何种药物涂层支架,当其被植入生物体内一段时间后,表面携带的功能药物涂层都会被生物体逐渐吸收而最终露出裸支架,因此并不能彻底改善现有支架所存在的诸多问题。因此,生物可降解支架应运而生,由于其具有独特的可降解性,随着植入时间的延长而逐渐在生物体内被完全降解,最终代谢出体外,同时,血管自有的部分原始功能也得到一定恢复,如同从未被植入过支架一般。重点论述了国内外镁合金、纯铁、聚乳酸、锌合金几种不同材质的生物可降解血管支架研究现状,并分析了各材质可降解支架现存的主要问题,希望对介入用生物可降解血管支架的发展和应用起到一定的积极作用。 展开更多
关键词 生物可降解 镁合金 纯铁 聚乳酸 锌合金 支架
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可降解聚合物血管支架体外力学性能测试实验研究 被引量:9
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作者 魏云波 王敏杰 +1 位作者 赵丹阳 李红霞 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2019年第4期604-612,共9页
体外力学性能测试是评估血管支架安全性和有效性的主要手段,其性能指标具有重要的临床意义。本文对比分析了可降解聚合物血管支架径向支撑性能测试的平面压缩法、V型槽压缩法和径向压缩法,并研究了压缩速率和压缩周向位置对支撑性能测... 体外力学性能测试是评估血管支架安全性和有效性的主要手段,其性能指标具有重要的临床意义。本文对比分析了可降解聚合物血管支架径向支撑性能测试的平面压缩法、V型槽压缩法和径向压缩法,并研究了压缩速率和压缩周向位置对支撑性能测试结果的影响,采用三点弯曲法研究了压缩速率和压缩周向位置对柔顺性能测试结果的影响。选取最优测试方案,测试了本文在不同外径(1.4、1.7、2.4 mm)下设计的三种支架和生物可降解聚合物血管支架(BVS)(BVS1.1,Abbott Vascular,美国)的支撑性能和柔顺性能。结果表明,三种支撑性能测试方法得到的压缩载荷—压缩位移曲线整体趋势一致,但归一化支撑力差异较大;平面压缩法更适合对不同外径、不同结构血管支架的支撑性能进行对比测试;压缩速率对支撑性能和柔顺性能测试结果无显著影响;压缩周向位置对采用平面压缩法、V型槽压缩法测试支撑性能和采用三点弯曲法测试柔顺性能有较大影响。综合比较,本文所设计的三种支架相对BVS支架其径向支撑性能均有不同程度的提高。本研究对血管支架的力学性能测试具有一定的指导意义和参考价值。 展开更多
关键词 生物可降解聚合物 血管支架 体外性能测试 径向支撑性能 柔顺性能
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新型可降解食管支架动物实验研究 被引量:9
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作者 颜波 施瑞华 +2 位作者 冯亚东 冷德嵘 狄镇海 《介入放射学杂志》 CSCD 北大核心 2016年第2期155-159,共5页
目的通过动物实验探讨新型可降解食管支架的安全性和降解性能。方法用模具以医用聚对二氧环己酮(PPD0)编制成新型分段的可降解食管支架。选择实验用巴马猪9头,植入新型可降解食管支架。术后每周1次胃镜检查,直至支架降解滑落。胃镜... 目的通过动物实验探讨新型可降解食管支架的安全性和降解性能。方法用模具以医用聚对二氧环己酮(PPD0)编制成新型分段的可降解食管支架。选择实验用巴马猪9头,植入新型可降解食管支架。术后每周1次胃镜检查,直至支架降解滑落。胃镜下观察支架降解情况、周围黏膜增生情况及可能的并发症。结果术后第3周支架颜色渐由蓝色变成灰白色,支架丝材变细,支架网眼增大明显;第7周支架丝材发生断裂现象;第8周支架完全降解滑落。支架植入后食管组织开始增生,3周时增生达顶点,4~7周时增生渐减轻,8周时食管黏膜恢复正常。结论新型PPDO可降解食管支架是安全的,均未发生严重并发症,支架所致食管组织增生反应可恢复,有一定的临床应用前景。 展开更多
关键词 食管肿瘤 可降解支架 动物实验
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高径向支撑性可生物降解聚合物血管支架结构设计与力学性能分析 被引量:9
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作者 魏云波 赵丹阳 +1 位作者 王敏杰 李红霞 《中国机械工程》 EI CAS CSCD 北大核心 2020年第9期1098-1107,1130,共11页
在研究血管支架支撑单元夹角与其径向支撑强度关系的基础上,提出采用不等高支撑环以利于增大扩张后支撑单元夹角进而提高支架径向支撑强度的设计方法,根据该方法设计了三种可降解聚合物血管支架结构。采用有限元方法对比分析了该三种支... 在研究血管支架支撑单元夹角与其径向支撑强度关系的基础上,提出采用不等高支撑环以利于增大扩张后支撑单元夹角进而提高支架径向支撑强度的设计方法,根据该方法设计了三种可降解聚合物血管支架结构。采用有限元方法对比分析了该三种支架和雅培生物可降解支架(BVS)的径向支撑强度、径向回缩率、轴向短缩率与弯曲刚度,研究了支架结构对这些性能的影响规律。所设计的J型支架(JS)、开放式C型支架(OCS)和密闭式C型支架(CCS)的径向支撑强度相对BVS的径向支撑强度分别提高了14%、34%和42%,同时设计的三种支架的径向回缩率相对BVS的径向回缩率减小了约21%,且均未发生轴向短缩;采用开放式连接形式的JS、OCS的弯曲刚度与BVS的弯曲刚度相当,相比密闭式CCS减小了约73%。影响径向支撑强度和径向回缩率的主要因素是支撑环的结构形式,采用不等高支撑环可有效改善径向支撑强度和径向回缩率;影响轴向短缩率的主要因素是桥筋的结构形式和桥筋的连接位置,采用具有弯曲结构的桥筋且桥筋连接位置位于支撑单元直线段的中间处可避免支架发生轴向短缩;影响弯曲刚度的主要因素是桥筋与支撑环的连接形式,采用开放式连接的支架弯曲刚度更小。 展开更多
关键词 可生物降解聚合物 血管支架 径向支撑强度 径向回缩 轴向短缩 弯曲刚度
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Short-term safety and efficacy of the biodegradable iron stent in mini-swine coronary arteries 被引量:7
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作者 WU Chao QIU Hong +7 位作者 HU Xiao-ying RUAN Ying-mao TIAN Yi CHU Yan XU Xin-lin XU Liang TANG Yue GAO Run-lin 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第24期4752-4757,共6页
Background To overcome the drawbacks of permanent years. The bioabsorbable polymer vascular scaffold (BVS) stents, biodegradable stents have been studied in recent was the first bioabsorbable stent to undergo clinic... Background To overcome the drawbacks of permanent years. The bioabsorbable polymer vascular scaffold (BVS) stents, biodegradable stents have been studied in recent was the first bioabsorbable stent to undergo clinical trials, demonstrating safety and feasibility in the ABSORB studies. Iron can potentially serve as the biomatedal for biodegradable stents. This study aimed to assess the short4erm safety and efficacy of a biodegradable iron stent in mini-swine coronary arteries. Methods Eight iron stents and eight cobalt chromium alloy (VISION) control stents were randomly implanted into the LAD and RCA of eight healthy mini-swine, respectively. Two stents of the same metal base were implanted into one animal. At 28 days the animals were sacrificed after coronary angiography, and histopathological examinations were performed. Results Histomorphometric measurements showed that mean neointimal thickness ((0.46±0.17) mm vs. (0.45±0.18) mm, P=0.878), neointimal area ((2.55±0.91) mm2 vs. (3.04±1.15) mm2, P=0.360) and percentage of area stenosis ((44.50±11.40)% vs. (46.00±17.95)%, P=0.845) were not significantly different between the iron stents and VISION stents. There was no inflammation, thrombosis or necrosis in either group. The scanning electron microscopy (SEM) intimal injury scores (0.75±1.04 vs. 0.88±0.99, P=0.809) and number of proliferating cell nuclear antigen (PCNA) positive staining cells were not significantly different between the two groups. The percentage of neointimal coverage by SEM examination was numerically higher in iron stents than in VISION stents ((84.38±14.50)% vs. (65.00±22.04)%, P=0.057), but the difference was not statistically significant. Iron staining in the tissue surrounding the iron stents at 28 days was positive and the vascular wall adjacent to the iron stent had a brownish tinge, consistent with iron degradation. No abnormal histopathological changes were detected in coronary arteries or major organs. Conc 展开更多
关键词 biodegradable iron stent mini-swine coronary artery histomorphometry
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冠状动脉血管支架的研究现状 被引量:1
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作者 李盼 冯静 +4 位作者 许博轩 王志超 房德磊 曹琳 张峻霞 《医疗卫生装备》 CAS 2023年第6期92-100,共9页
阐述了冠状动脉血管支架的发展历程,介绍了金属永久性支架、覆膜及涂层支架和生物可降解支架的研究现状,分析了各种支架的特点、适用场合及不足,指出了生物可降解支架对人体没有明显副作用,具有较大的发展潜力,应在创新设计、性能、制... 阐述了冠状动脉血管支架的发展历程,介绍了金属永久性支架、覆膜及涂层支架和生物可降解支架的研究现状,分析了各种支架的特点、适用场合及不足,指出了生物可降解支架对人体没有明显副作用,具有较大的发展潜力,应在创新设计、性能、制造方面进行突破。 展开更多
关键词 冠状动脉 血管介入手术 血管支架 金属永久性支架 覆膜支架 涂层支架 生物可降解支架
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Structural and mechanical aspects of hypoeutectic Zn–Mg binary alloys for biodegradable vascular stent applications 被引量:8
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作者 W.Pachla S.Przybysz +4 位作者 A.Jarzębska M.Bieda K.Sztwiertnia M.Kulczyk J.Skiba 《Bioactive Materials》 SCIE 2021年第1期26-44,共19页
The study is concerned with the mechanical properties of Zn and three Zn–Mg double alloys with Mg concentrations:0.5%,1.0%and 1.5%in the form of rods with a diameter of 5 mm as potential materials for use in biodegra... The study is concerned with the mechanical properties of Zn and three Zn–Mg double alloys with Mg concentrations:0.5%,1.0%and 1.5%in the form of rods with a diameter of 5 mm as potential materials for use in biodegradable medical implants,such as vascular stents.The materials were cast,next conventionally hot extruded at 250°C and finally,hydrostatically extruded(HE)at ambient temperature.Occasionally HE process was carried at liquid nitrogen temperature or in combination with the ECAP process.After HE,the microstructure of the alloys was made up of fine-grainedαZn of mean grain size~1μm in a 2-phase coat of 50–200 nm nanograins of the fineαZn+Mg2Zn11 eutectic.The 3 to 4-fold reduction of grain size as a result of HE allowed an increase in yield strength from 100%to over 200%,elongation to fracture from 100%to thirty fold and hardness over 50%compared to the best literature results for similar alloys.Exceptions accounted for elongation to fracture in case of Zn-0.5 Mg alloy and hardness in case of Zn-1.5 Mg alloy,both of which fell by 20%.For the Zn-0.5 Mg and Zn–1Mg alloys,after immersion tests,no corrosive degradation of plasticity was observed.Achieving these properties was the result of generating large plastic deformations at ambient temperature due to the application of high pressure forming with the cumulative HE method.The results showed that Zn–Mg binary alloys after HE have mechanical and corrosive characteristics,qualifying them for applications in biodegradable implants,including vascular stents. 展开更多
关键词 biodegradable Zn alloys Hydrostatic extrusion Microstructure Mechanical properties Vascular stent
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Silicone-covered biodegradable magnesium stent for treating benign esophageal stricture in a rabbit model 被引量:6
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作者 Kai Yang Jun Cao +3 位作者 Tian-Wen Yuan Yue-Qi Zhu Bi Zhou Ying-Sheng Cheng 《World Journal of Gastroenterology》 SCIE CAS 2019年第25期3207-3217,共11页
BACKGROUND Stent insertion can effective alleviate the symptoms of benign esophageal strictures(BES).Magnesium alloy stents are a good candidate because of biological safety,but show a poor corrosion resistance and a ... BACKGROUND Stent insertion can effective alleviate the symptoms of benign esophageal strictures(BES).Magnesium alloy stents are a good candidate because of biological safety,but show a poor corrosion resistance and a quick loss of mechanical support in vivo.AIM To test the therapeutic and adverse effects of a silicone-covered magnesium alloy biodegradable esophageal stent.METHODS Fifteen rabbits underwent silicone-covered biodegradable magnesium stent insertion into the benign esophageal stricture under fluoroscopic guidance(stent group).The wall reconstruction and tissue reaction of stenotic esophagus in the stent group were compared with those of six esophageal stricture models(control group).Esophagography was performed at 1,2,and 3 weeks.Four,six,and five rabbits in the stent group and two rabbits in the control groups were euthanized,respectively,at each time point for histological examination.RESULTS All stent insertions were well tolerated.The esophageal diameters at immediately,1,2 and 3 wk were 9.8±0.3 mm,9.7±0.7 mm,9.4±0.8 mm,and 9.2±0.5 mm,respectively(vs 4.9±0.3 mm before stent insertion;P<0.05).Magnesium stents migrated in eight rabbits[one at 1 wk(1/15),three at 2 wk(3/11),and four at 3 wk(4/5)].Esophageal wall remodeling(thinner epithelial and smooth muscle layers)was found significantly thinner in the stent group than in the control group(P<0.05).Esophageal injury and collagen deposition following stent insertion were similar and did not differ compared to rabbits with esophageal stricture and normal rabbits(P>0.05).CONCLUSION Esophageal silicone-covered biodegradable magnesium stent insertion is feasible for BES without causing severe injury or tissue reaction.Our study suggests that insertion of silicone-covered magnesium esophageal stent is a promising approach for treating BES. 展开更多
关键词 BENIGN ESOPHAGEAL STRICTURE biodegradable stent MAGNESIUM Silicone membrane
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生物可降解冠状动脉支架的研究进展 被引量:7
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作者 沈莹冉 周永新 《外科研究与新技术》 2014年第4期267-274,共8页
在如今的老龄化社会中,冠心病已成为人类健康的一大杀手,血管支架作为心血管介入治疗的最主要的器械,其效能决定了介入手术的成败。冠状动脉冠脉支架的发展先后经历了裸金属支架、药物洗脱支架和生物可降解支架3个时代。该文通过归纳目... 在如今的老龄化社会中,冠心病已成为人类健康的一大杀手,血管支架作为心血管介入治疗的最主要的器械,其效能决定了介入手术的成败。冠状动脉冠脉支架的发展先后经历了裸金属支架、药物洗脱支架和生物可降解支架3个时代。该文通过归纳目前使用的生物可降解支架的临床试验,来阐述可降解冠脉支架大体的发展历程,指出目前疗效及所面临的难题,并对支架发展的未来作一展望。 展开更多
关键词 冠状动脉支架 生物可降解支架 聚合物 支架
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支架成形术在食管良恶性狭窄中的应用进展 被引量:5
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作者 李烽 程英升 《世界华人消化杂志》 CAS 北大核心 2008年第25期2841-2847,共7页
支架成形术目前已广泛用于改善晚期食管癌所致的吞咽困难.随着食管支架的不断改进,现在有许多新的支架用于临床治疗.这些支架在原来的基础上增加抗反流瓣膜、装有可回收装置或载有125I颗粒等以及出现生物可降解支架.支架的改进能减少并... 支架成形术目前已广泛用于改善晚期食管癌所致的吞咽困难.随着食管支架的不断改进,现在有许多新的支架用于临床治疗.这些支架在原来的基础上增加抗反流瓣膜、装有可回收装置或载有125I颗粒等以及出现生物可降解支架.支架的改进能减少并发症并提高生存率.许多非手术性姑息方法如腔内激光治疗、光动力疗法、电凝及腔内近距离放射治疗都用来治疗食管狭窄,但最迅速缓解症状的方法就是食管支架成形术.支架治疗良性食管狭窄的报道也不断增多,应用暂时性支架及生物可降解支架可以很好地改善效果. 展开更多
关键词 食管狭窄 支架 生物可降解支架
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Impact of biodegradable versus durable polymer drug-eluting stents on clinical outcomes in patients with coronary artery disease: a meta-analysis of 15 randomized trials 被引量:5
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作者 Zhang Yaojun Tian Nailiang +11 位作者 Dong Shengjie Ye Fei Li Minghui Christos V.Bourantas Javaid Iqbal Yoshinobu Onuma Takashi Muramatsu Roberto Diletti Hector M. Garcia-Garcia Xu Bo Patrick W. Serruys Chen Shaoliang 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第11期2159-2166,共8页
Background Drug eluting stents (DESs) made with biodegradable polymer have been developed in an attempt to improve clinical outcomes.However,the impact of biodegradable polymers on clinical events and stent thrombos... Background Drug eluting stents (DESs) made with biodegradable polymer have been developed in an attempt to improve clinical outcomes.However,the impact of biodegradable polymers on clinical events and stent thrombosis (ST) remains controversial.Methods We searched Medline,the Cochrane Library and other internet sources,without language or date restrictions for articles comparing clinical outcomes between biodegradable polymer DES and durable polymer DES.Safety endpoints were ST (definite,definite/probable),mortality,and myocardial infarction (MI).Efficacy endpoints were major adverse cardiac event (MACE) and target lesion revascularization (TLR).Results We identified 15 randomized controlled trials (n=17 068) with a weighted mean follow-up of 20.6 months.There was no statistical difference in the incidence of definite/probable ST between durable polymer-and biodegradable polymerDES; relative risk (RR) 0.83; 95% confidence interval (CI) 0.62-1.11; P=0.22.Biodegradable polymer DES had similar rates of definite ST (RR 0.94,95% CI 0.66-1.33,P=0.72),mortality (RR 0.94,95% C/0.82-1.09,P=0.43),MI (RR 1.08,95% CI 0.92-1.26.P=0.35),MACE (RR 0.99,95% CI 0.91-1.09,P=0.85),and TLR (RR,0.94,95% CI 0.83-1.06,P=0.30) compared with durable polymer DES.Based on the stratified analysis of the included trials,the treatment effect on definite ST was different at different follow-up times:≤1 year favoring durable polymer DES and 〉1 year favoring biodegradable polymer DES.Conclusions Biodegradable polymer DES has similar safety and efficacy for treating patients with coronary artery disease compared with durable polymer DES.Further data with longer term follow-up are warranted to confirm the potential benefits of biodegradable polymer DES. 展开更多
关键词 biodegradable polymer durable polymer stent thrombosis META-ANALYSIS
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A review on biodegradable materials for cardiovascular stent application 被引量:5
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作者 Li-Da HOU Zhen LI +3 位作者 Yu PAN Muhammadlqbal SABIR Yu-Feng ZHENG Li LI 《Frontiers of Materials Science》 SCIE CSCD 2016年第3期238-259,共22页
A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researcher;~ and engineers diverted to investigate biodegradable mat... A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researcher;~ and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials. 展开更多
关键词 biodegradable materials magnesium alloy POLYMERS biodegradablestent cardiovascular stent
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生物全降解冠状动脉支架的研究进展 被引量:5
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作者 冯高科 任珊 +2 位作者 郑晓新 易欣 蒋学俊 《医学综述》 2012年第24期4130-4134,共5页
现有研究表明金属支架置入术对冠心病患者的近期疗效显著,但仍存在金属材料组织相容性差、血栓源性强、再狭窄率高及支架永久存留等缺点,远期效果不理想。而新一代生物全降解支架不仅能提供类似金属支架的支撑力度,且能克服上述缺点,还... 现有研究表明金属支架置入术对冠心病患者的近期疗效显著,但仍存在金属材料组织相容性差、血栓源性强、再狭窄率高及支架永久存留等缺点,远期效果不理想。而新一代生物全降解支架不仅能提供类似金属支架的支撑力度,且能克服上述缺点,还可作为药物缓释的载体,达到有效降低支架置入术后局部血管急性闭塞和再狭窄发生率的目的。生物全降解冠状动脉支架研制应用已不断取得进展,现主要介绍已进入临床试验阶段的几种主要生物全降解支架的研究进展,并探讨其未来研发方向及临床应用前景。 展开更多
关键词 生物可降解支架 介入治疗 冠状动脉支架 镁合金支架 聚合物
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A review on biodegradable biliary stents: materials and future trends 被引量:4
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作者 Ge Song Hugh Q.Zhao +1 位作者 Qing Liu Zhongyong Fan 《Bioactive Materials》 SCIE 2022年第11期488-495,共8页
Biliary stricture is defined as the reduction and narrowing of the bile duct lumen, which can be caused by many factors such as cancer and inflammation. Biliary stent placement can effectively alleviate benign and mal... Biliary stricture is defined as the reduction and narrowing of the bile duct lumen, which can be caused by many factors such as cancer and inflammation. Biliary stent placement can effectively alleviate benign and malignant biliary strictures. However, the commonly used plastic or metallic biliary stents are far from ideal and do not satisfy all clinical requirements,although several types of biodegradable biliary stents have been developed and used clinically. In this review, we summarized current development status of biodegradable stents with the emphasis on the stent materials. We also presented the future development trends based on the published literature. 展开更多
关键词 biodegradable biliary stent Biliary strictures POLYDIOXANONE Poly(L-lactic acid) Drug-eluting stent
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生物可降解输尿管支架管研究进展 被引量:5
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作者 杨刚刚 陈方 谢华 《中国医疗设备》 2017年第2期16-19,共4页
输尿管支架管被用于泌尿外科临床已有30余年的历史。由于制成材料本身的不可降解和生物相容性,其在临床的应用存在一些缺点和问题。这也使得人们在可降解输尿管支架管领域进行了较多地探索。目前,可降解输尿管支架管的应用仍存在一些不... 输尿管支架管被用于泌尿外科临床已有30余年的历史。由于制成材料本身的不可降解和生物相容性,其在临床的应用存在一些缺点和问题。这也使得人们在可降解输尿管支架管领域进行了较多地探索。目前,可降解输尿管支架管的应用仍存在一些不安全因素,如降解的无序性、耗时长、产物大等。本文主要论述可降解输尿管在降解材料和制备工艺方面的研究进展。 展开更多
关键词 输尿管 支架管 生物可降解材料 生物可溶性 输尿管支架管
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