BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the worl...BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by Guangzhou Ming Xing Pharmaceu cal Factory, Guangzhou, China) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B.展开更多
Group size and composition of blue sheep(Pseudois nayaur)were studied in the Helan Mountains, Ningxia Autonomous Region from November to December 2003.We scanned mountain slopes with binoculars and observed with 20-60...Group size and composition of blue sheep(Pseudois nayaur)were studied in the Helan Mountains, Ningxia Autonomous Region from November to December 2003.We scanned mountain slopes with binoculars and observed with 20-60× spotting-scope. A total of 310 herds of blue sheep and 1 336 individuals were observed during the study period. Blue sheep were frequently seen in small herds of 2 to 8 individuals, which represent 94.8% of total herds observed. Herds consisting of 9 individuals or more represented 5.2%. The largest herd we observed numbered 51 individuals. Mean group size was 4.2 individuals. Blue sheep herds can be divided into three types: male herds (composed solely of males), female herds (consisting of females with or without juveniles of both sexes), and mixed herds (including adult males, females, and subadults).Among the 310 herds, female herds were counted 150 times(48.4%), mixed herds 154 times(49.7%), and male herds 6 times(1.9%). Of 1 336 blue sheep classified by sex and age, adults, subadults and juveniles composed 64.1%,20.8%, and 15.1% respectively. The female:male ratio of adults was 1∶0.73. The ratio of adult females to juveniles was 1∶0.56, which is higher than the ratio recorded in spring (1∶0.43) or summer (1∶0.44).The results showed that the Helan Mountains State Nature Reserve has succeed in protecting blue sheep.展开更多
文摘BACKGROUND: Hepatitis B virus (HBV) infection, a glo- bal public health problem, is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. There are more than 350 million HBV carriers in the world and up to one million die annually due to hepatitis B associated liv- er disease. So far no optimal treatment is available for pa- tients with chronic hepatitis B. In the paper we investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B. METHODS: One hundred and twenty patients with chronic hepatitis B were randomly divided into matrine treatment group (n =60) and control group (n =60). The patients of the matrine group were given intramuscularly with matrine (an alkaloid extracted from a traditional Chinese herb Radix Sophorae Flavescentis by Guangzhou Ming Xing Pharmaceu cal Factory, Guangzhou, China) of 100 mg daily for 90 days in addition to conventional liver-protective drugs in- cluding glucurone, inosine, compound vitamin B and caryophyllin. The control group received conventional liv- er-protective drugs alone. Clinical manifestations and labo- ratory parameters including liver biochemistry and serum hepatitis B virus markers were monitored before and after treatment in the two groups. RESULTS: Significant differences were seen between the two groups in terms of improvement of clinical symptoms and signs, recovery of liver functions, and serum conver- sion from hepatitis Be antigen to HBe antibody and from positive to negative serum HBV DNA (P <0.05-0.01). The result of the matrine group was more marked than that of the control group. Serious side-effects were not observed except mild pain at the site of injection of matrine in a few patients. CONCLUSION: These results indicate that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B.
文摘Group size and composition of blue sheep(Pseudois nayaur)were studied in the Helan Mountains, Ningxia Autonomous Region from November to December 2003.We scanned mountain slopes with binoculars and observed with 20-60× spotting-scope. A total of 310 herds of blue sheep and 1 336 individuals were observed during the study period. Blue sheep were frequently seen in small herds of 2 to 8 individuals, which represent 94.8% of total herds observed. Herds consisting of 9 individuals or more represented 5.2%. The largest herd we observed numbered 51 individuals. Mean group size was 4.2 individuals. Blue sheep herds can be divided into three types: male herds (composed solely of males), female herds (consisting of females with or without juveniles of both sexes), and mixed herds (including adult males, females, and subadults).Among the 310 herds, female herds were counted 150 times(48.4%), mixed herds 154 times(49.7%), and male herds 6 times(1.9%). Of 1 336 blue sheep classified by sex and age, adults, subadults and juveniles composed 64.1%,20.8%, and 15.1% respectively. The female:male ratio of adults was 1∶0.73. The ratio of adult females to juveniles was 1∶0.56, which is higher than the ratio recorded in spring (1∶0.43) or summer (1∶0.44).The results showed that the Helan Mountains State Nature Reserve has succeed in protecting blue sheep.
