目的:评价综合疗法(联合盐酸米诺环素、宽谱强脉冲光和含青刺果油屏障修复霜)治疗玫瑰痤疮的临床有效性和安全性。方法:回顾性分析2021年1月-2021年6月就诊于上海交通大学医学院附属第九人民医院皮肤科门诊,主要表现为红斑、丘疹和毛细...目的:评价综合疗法(联合盐酸米诺环素、宽谱强脉冲光和含青刺果油屏障修复霜)治疗玫瑰痤疮的临床有效性和安全性。方法:回顾性分析2021年1月-2021年6月就诊于上海交通大学医学院附属第九人民医院皮肤科门诊,主要表现为红斑、丘疹和毛细血管扩张的玫瑰痤疮患者20例。给予患者口服盐酸米诺环素50 mg,2次/日,连续4周;联合宽谱强脉冲光(Broad band light,BBL)治疗,1次/月,共3次;同时给予患者含青刺果油皮肤屏障修复剂进行日常护肤。治疗3个月后随访1个月,评估治疗有效性和安全性。结果:治疗后,患者治疗有效率为95%,持久性红斑、毛细血管扩张、丘疹和脓疱的治疗评均分较治疗前明显降低(P<0.05)。所有患者治疗期间均未出现严重不良反应。结论:针对以持久性红斑、毛细血管扩张、丘疹和脓疱为主要表现的玫瑰痤疮,盐酸米诺环素、BBL联合含青刺果油屏障修复霜的综合疗法安全有效。展开更多
Aim: To evaluate the possible advantages of dermo-cosmetic products formulated with thermal spring water instead of deionized water. We studied the effect of a dermo-cosmetic product on skin barrier recovery after inj...Aim: To evaluate the possible advantages of dermo-cosmetic products formulated with thermal spring water instead of deionized water. We studied the effect of a dermo-cosmetic product on skin barrier recovery after injury. In one test the product was formulated with de-ionized water and again using the identical product formulated with thermal spring water. Study Design/Methods: Stratum corneum of human skin explants was removed (and not removed for the control) with an ether/acetone mixture. A cosmetic product, either formulated with de-ionized or thermal spring water, was then topically applied on the explants. After a 5-day incubation period, epidermal expression of aquaporine-3, filaggrin, claudin-4 and claudin-6 was studied by using immunohistochemical techniques. Results: The formulation containing de-ionized water seemed to act on the epidermal expression of filaggrin and claudin-4. When thermal spring water was used to make the formulation, we noted that this expression was greatly enhanced. The formulation containing thermal spring water also acted to increase aquaporin-3 and claudin-6 expression. Conclusion: The use of thermal spring water in cosmetic formulations would appear to contribute to the cosmetic product’s efficacy. It was also interesting to note that this study revealed claudin-6 expression in human skin for the first time.展开更多
文摘目的:评价综合疗法(联合盐酸米诺环素、宽谱强脉冲光和含青刺果油屏障修复霜)治疗玫瑰痤疮的临床有效性和安全性。方法:回顾性分析2021年1月-2021年6月就诊于上海交通大学医学院附属第九人民医院皮肤科门诊,主要表现为红斑、丘疹和毛细血管扩张的玫瑰痤疮患者20例。给予患者口服盐酸米诺环素50 mg,2次/日,连续4周;联合宽谱强脉冲光(Broad band light,BBL)治疗,1次/月,共3次;同时给予患者含青刺果油皮肤屏障修复剂进行日常护肤。治疗3个月后随访1个月,评估治疗有效性和安全性。结果:治疗后,患者治疗有效率为95%,持久性红斑、毛细血管扩张、丘疹和脓疱的治疗评均分较治疗前明显降低(P<0.05)。所有患者治疗期间均未出现严重不良反应。结论:针对以持久性红斑、毛细血管扩张、丘疹和脓疱为主要表现的玫瑰痤疮,盐酸米诺环素、BBL联合含青刺果油屏障修复霜的综合疗法安全有效。
文摘Aim: To evaluate the possible advantages of dermo-cosmetic products formulated with thermal spring water instead of deionized water. We studied the effect of a dermo-cosmetic product on skin barrier recovery after injury. In one test the product was formulated with de-ionized water and again using the identical product formulated with thermal spring water. Study Design/Methods: Stratum corneum of human skin explants was removed (and not removed for the control) with an ether/acetone mixture. A cosmetic product, either formulated with de-ionized or thermal spring water, was then topically applied on the explants. After a 5-day incubation period, epidermal expression of aquaporine-3, filaggrin, claudin-4 and claudin-6 was studied by using immunohistochemical techniques. Results: The formulation containing de-ionized water seemed to act on the epidermal expression of filaggrin and claudin-4. When thermal spring water was used to make the formulation, we noted that this expression was greatly enhanced. The formulation containing thermal spring water also acted to increase aquaporin-3 and claudin-6 expression. Conclusion: The use of thermal spring water in cosmetic formulations would appear to contribute to the cosmetic product’s efficacy. It was also interesting to note that this study revealed claudin-6 expression in human skin for the first time.
