To get a better understanding of the location,pathophysiology,etiology and prognosis of multiple malignant tumors (MPMT),we evaluated the medical records of 22 patients with MPMT.Our results suggested that radiotherap...To get a better understanding of the location,pathophysiology,etiology and prognosis of multiple malignant tumors (MPMT),we evaluated the medical records of 22 patients with MPMT.Our results suggested that radiotherapy and chemotherapy might play an important role in the pathogenesis of MPMT and follow up is important in detecting a secondary primary malignant tumor (PMT) at an early stage.Surgical removal of tumors is the first choice therapy for MPMT.展开更多
目的探讨甲胎蛋白(AFP)阴性肝细胞癌(HCC)的CT特征,旨在提高临床诊断准确率。资料与方法回顾性分析124例经手术病理证实为HCC患者的术前CT资料,其中AFP阴性组53例,AFP阳性组71例。比较两组CT表现,包括肿瘤发病部位、数量、大小、强...目的探讨甲胎蛋白(AFP)阴性肝细胞癌(HCC)的CT特征,旨在提高临床诊断准确率。资料与方法回顾性分析124例经手术病理证实为HCC患者的术前CT资料,其中AFP阴性组53例,AFP阳性组71例。比较两组CT表现,包括肿瘤发病部位、数量、大小、强化模式,是否有包膜、脉管瘤栓、肝内转移、淋巴结转移、肝硬化、门静脉高压、腹水。结果 AFP阴性组中,CT强化模式表现为"快进快出"21例(39.6%)、"慢进快出"32例(60.4%);肿瘤〈3 cm 20例(37.7%),3~5 cm 12例(22.6%),≥5 cm 21例(39.6%),合并肝硬化3例(5.7%),脉管瘤栓8例(15.1%);发生在肝右叶35例(66.0%),肝左叶14例(26.4%),肝左、右叶3例(5.7%),肝门部1例(1.9%);单发47例(88.7%),多发6例(11.3%);有包膜2例(3.8%),肝内转移1例(1.9%),淋巴结转移5例(9.4%),门静脉高压2例(3.8%),腹水2例(3.8%)。与AFP阳性HCC组比较,肿瘤大小、脉管瘤栓、肝硬化差异有统计学意义(P〈0.05);发病部位、数量、强化模式、包膜、肝内转移、淋巴结转移、门静脉高压、腹水差异均无统计学意义(P〉0.05)。结论 AFP阴性HCC强化模式表现为"快进快出"或"慢进快出",与AFP阳性HCC类似,但其肿瘤体积较小,较少合并肝硬化及脉管瘤栓。展开更多
Sesquiterpenes in Eupatorium adenophorum are abundant in leaves and have great development potential as biopesticides. The toxicity of sesquiterpenes in immune cells and their corresponding immune functions are not fu...Sesquiterpenes in Eupatorium adenophorum are abundant in leaves and have great development potential as biopesticides. The toxicity of sesquiterpenes in immune cells and their corresponding immune functions are not fully understood. We evaluated the immunotoxicity of two cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA) and 9-oxo-10,11-dehydro-agerophorone(ODA) by using histopathology and toxicology methods in vitro and in vivo in lymphocytes and natural killer cells in Kunming mice. The mice were given single doses of 75, 150 and 300 mg kg^-1 body weight(BW) of DAOA/ODA every day for a week. S erious damage to the thymus and spleen was found in tissue images with clear lysis reduction numbers and a loosened arrangement of splenocytes and thymocytes to the mice treated with 150–300 mg kg^-1 DAOA/ODA. Mice cytology was also affected with significant cellular alterations, increased splenocytes apoptosis rates(P〈0.01), proliferation reduction(P〈0.05) and natural killer cells activities reduction(P〈0.05) when given 150–300 mg kg^-1 DAOA/ODA, the severities of which were dose-dependent. Howev er, a 75 mg kg^-1 dose of DAOA/ODA showed no change in tissue or cytology after the 7 day treatment, and therefore was considered to be within acceptable safety parameters. Taken together, cadinene sesquiterpenes, as a type of toxic botanical component, have low environmental risks in small doses and should be further studied for their use as biopesticides.展开更多
文摘To get a better understanding of the location,pathophysiology,etiology and prognosis of multiple malignant tumors (MPMT),we evaluated the medical records of 22 patients with MPMT.Our results suggested that radiotherapy and chemotherapy might play an important role in the pathogenesis of MPMT and follow up is important in detecting a secondary primary malignant tumor (PMT) at an early stage.Surgical removal of tumors is the first choice therapy for MPMT.
文摘目的探讨甲胎蛋白(AFP)阴性肝细胞癌(HCC)的CT特征,旨在提高临床诊断准确率。资料与方法回顾性分析124例经手术病理证实为HCC患者的术前CT资料,其中AFP阴性组53例,AFP阳性组71例。比较两组CT表现,包括肿瘤发病部位、数量、大小、强化模式,是否有包膜、脉管瘤栓、肝内转移、淋巴结转移、肝硬化、门静脉高压、腹水。结果 AFP阴性组中,CT强化模式表现为"快进快出"21例(39.6%)、"慢进快出"32例(60.4%);肿瘤〈3 cm 20例(37.7%),3~5 cm 12例(22.6%),≥5 cm 21例(39.6%),合并肝硬化3例(5.7%),脉管瘤栓8例(15.1%);发生在肝右叶35例(66.0%),肝左叶14例(26.4%),肝左、右叶3例(5.7%),肝门部1例(1.9%);单发47例(88.7%),多发6例(11.3%);有包膜2例(3.8%),肝内转移1例(1.9%),淋巴结转移5例(9.4%),门静脉高压2例(3.8%),腹水2例(3.8%)。与AFP阳性HCC组比较,肿瘤大小、脉管瘤栓、肝硬化差异有统计学意义(P〈0.05);发病部位、数量、强化模式、包膜、肝内转移、淋巴结转移、门静脉高压、腹水差异均无统计学意义(P〉0.05)。结论 AFP阴性HCC强化模式表现为"快进快出"或"慢进快出",与AFP阳性HCC类似,但其肿瘤体积较小,较少合并肝硬化及脉管瘤栓。
基金supported by the Special Non-profit Agricultural Industrial Research Fund of China (201103027)
文摘Sesquiterpenes in Eupatorium adenophorum are abundant in leaves and have great development potential as biopesticides. The toxicity of sesquiterpenes in immune cells and their corresponding immune functions are not fully understood. We evaluated the immunotoxicity of two cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA) and 9-oxo-10,11-dehydro-agerophorone(ODA) by using histopathology and toxicology methods in vitro and in vivo in lymphocytes and natural killer cells in Kunming mice. The mice were given single doses of 75, 150 and 300 mg kg^-1 body weight(BW) of DAOA/ODA every day for a week. S erious damage to the thymus and spleen was found in tissue images with clear lysis reduction numbers and a loosened arrangement of splenocytes and thymocytes to the mice treated with 150–300 mg kg^-1 DAOA/ODA. Mice cytology was also affected with significant cellular alterations, increased splenocytes apoptosis rates(P〈0.01), proliferation reduction(P〈0.05) and natural killer cells activities reduction(P〈0.05) when given 150–300 mg kg^-1 DAOA/ODA, the severities of which were dose-dependent. Howev er, a 75 mg kg^-1 dose of DAOA/ODA showed no change in tissue or cytology after the 7 day treatment, and therefore was considered to be within acceptable safety parameters. Taken together, cadinene sesquiterpenes, as a type of toxic botanical component, have low environmental risks in small doses and should be further studied for their use as biopesticides.