目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内...目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内径狭窄程度≥50%为支架内再狭窄标准,按有无再狭窄分为冠脉再狭窄组(42例)和冠脉未再狭窄组(226例)。比较两组间AIP、直接胆红素、间接胆红素、总胆红素等指标,并进一步研究AIP、血清胆红素与冠脉药物支架术后支架内再狭窄的相关性。结果冠脉血管内再狭窄组AIP值高于无再狭窄组(P<0.05);再狭窄组的总胆红素水平低于无再狭窄组(P<0.05)。结论 AIP促进冠状动脉支架内再狭窄,为其再狭窄的危险因子,而血清总胆红素则是冠状动脉支架内再狭窄的对抗因子,起保护作用。展开更多
目的分析艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者抗反转录病毒治疗(antiretroviral therapy,ART)48和96周后血脂和血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)变化,评估HIV感染者/AIDS患者ART治疗后患心血管疾病的危险...目的分析艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者抗反转录病毒治疗(antiretroviral therapy,ART)48和96周后血脂和血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)变化,评估HIV感染者/AIDS患者ART治疗后患心血管疾病的危险因素。方法测定男性HIV感染者/AIDS患者ART前后TC、TG、HDL-C和LDL-C,计算非HDL-C(NHC)、Castelli’s风险指数I和II(CRI-I,CRI-II)、胰岛素抵抗综合征(IRS)和AIP。结果 384例患者ART48和96周后,TC、TG、HDL-C、LDL-C和NHC浓度均升高,CRI-Ⅰ和CRI-Ⅱ比值降低,差异均有统计学意义(P<0.05);TC、TG、LDL-C和NHC异常发生率升高,差异均有统计学意义(P<0.05)。基线、ART 48和96周后,AIP在不同年龄段差异有统计学意义(P<0.05),且与年龄呈显著性正相关(r=0.208,0.183,0.170,P<0.01)。AIP在TG和HDL-C正常组和异常组差异均有统计学意义(P<0.05),且与基线TG呈显著性正相关(r=0.841,0.641,0.602,P<0.01),与基线HDL-C呈显著性负相关(r=-0.608,-0.390,-0.326,P<0.01),与CD4细胞数量、HIV-RNA病毒载量和基线TC、LDC-C无关。Logistic回归分析表明,相对18~<30岁,≥30岁HIV感染者/AIDS患者ART 48和96周后AIP值异常的危险因素(OR=2.02,95%CI:1.30~3.13,P<0.01;OR=1.77,95%CI:1.13~2.78,P<0.05)。结论 HIV感染者/AIDS患者ART后出现血脂异常,年龄是HIV感染者/AIDS患者血浆动脉粥样硬化的危险因素。特别≥30岁HIV感染者/AIDS患者在接受ART期间,应监测TC、TG、HDL-C和LDL-C水平,以减少心血管疾病的发生风险。展开更多
Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people...Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.展开更多
文摘目的研究血浆致动脉硬化指数(atherogenic index of plasma,AIP)、血清胆红素和药物涂层支架植入术后支架内再狭窄的关系。方法对268例行经皮冠脉支架植入术的患者进行冠脉造影,以支架腔内两端(距支架边缘≤5mm)或支架内加两端的管腔内径狭窄程度≥50%为支架内再狭窄标准,按有无再狭窄分为冠脉再狭窄组(42例)和冠脉未再狭窄组(226例)。比较两组间AIP、直接胆红素、间接胆红素、总胆红素等指标,并进一步研究AIP、血清胆红素与冠脉药物支架术后支架内再狭窄的相关性。结果冠脉血管内再狭窄组AIP值高于无再狭窄组(P<0.05);再狭窄组的总胆红素水平低于无再狭窄组(P<0.05)。结论 AIP促进冠状动脉支架内再狭窄,为其再狭窄的危险因子,而血清总胆红素则是冠状动脉支架内再狭窄的对抗因子,起保护作用。
文摘目的分析艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者抗反转录病毒治疗(antiretroviral therapy,ART)48和96周后血脂和血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)变化,评估HIV感染者/AIDS患者ART治疗后患心血管疾病的危险因素。方法测定男性HIV感染者/AIDS患者ART前后TC、TG、HDL-C和LDL-C,计算非HDL-C(NHC)、Castelli’s风险指数I和II(CRI-I,CRI-II)、胰岛素抵抗综合征(IRS)和AIP。结果 384例患者ART48和96周后,TC、TG、HDL-C、LDL-C和NHC浓度均升高,CRI-Ⅰ和CRI-Ⅱ比值降低,差异均有统计学意义(P<0.05);TC、TG、LDL-C和NHC异常发生率升高,差异均有统计学意义(P<0.05)。基线、ART 48和96周后,AIP在不同年龄段差异有统计学意义(P<0.05),且与年龄呈显著性正相关(r=0.208,0.183,0.170,P<0.01)。AIP在TG和HDL-C正常组和异常组差异均有统计学意义(P<0.05),且与基线TG呈显著性正相关(r=0.841,0.641,0.602,P<0.01),与基线HDL-C呈显著性负相关(r=-0.608,-0.390,-0.326,P<0.01),与CD4细胞数量、HIV-RNA病毒载量和基线TC、LDC-C无关。Logistic回归分析表明,相对18~<30岁,≥30岁HIV感染者/AIDS患者ART 48和96周后AIP值异常的危险因素(OR=2.02,95%CI:1.30~3.13,P<0.01;OR=1.77,95%CI:1.13~2.78,P<0.05)。结论 HIV感染者/AIDS患者ART后出现血脂异常,年龄是HIV感染者/AIDS患者血浆动脉粥样硬化的危险因素。特别≥30岁HIV感染者/AIDS患者在接受ART期间,应监测TC、TG、HDL-C和LDL-C水平,以减少心血管疾病的发生风险。
文摘Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.
