A new eudesmanolide and a new aromatic derivative were isolated from the roots of Carpesium cernuun. Their structures were elucidated as 13-hydroxy-5,7(11)-eudesmadien-12,8-olide and 3-methyl-8-acetoxy-9,10-diisobuty...A new eudesmanolide and a new aromatic derivative were isolated from the roots of Carpesium cernuun. Their structures were elucidated as 13-hydroxy-5,7(11)-eudesmadien-12,8-olide and 3-methyl-8-acetoxy-9,10-diisobutyryloxy-p-cymene by spectral methods (EIMS, FAB-MS, 1D and 2D NMR).展开更多
Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were prepared.Their compositions and structures were identified by elemental analysis,IR,and 1H NMR.They have been examined for their antiba... Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were prepared.Their compositions and structures were identified by elemental analysis,IR,and 1H NMR.They have been examined for their antibacterial action against Staphylococcua aurens and Escherichia coli.These compounds showed higher activity than the aromatic derivatives of ct-amino acid which were reported previously.The general conclusion to be drawn is that the distance between amino and carboxylic group in these molecules could affect their antibacterial activity.Furthermore,those compounds with p-methyl substituent in phenyl ring exhibit higher activity than the others,and all the compounds exhibit higher activity against Escherichia coli and against Staphylococcua aureus.展开更多
以具有活血化瘀作用的中药有效成分阿魏酸为先导物,按生物电子等排原理,设计合成了6个((吡啶-3-基)甲氧基)芳酸衍生物,其结构经IR,1 H NMR,13 C NMR及MS确证。体外药效筛选结果显示,部分((吡啶-3-基)甲氧基)芳酸衍生物对二磷酸腺苷(ADP...以具有活血化瘀作用的中药有效成分阿魏酸为先导物,按生物电子等排原理,设计合成了6个((吡啶-3-基)甲氧基)芳酸衍生物,其结构经IR,1 H NMR,13 C NMR及MS确证。体外药效筛选结果显示,部分((吡啶-3-基)甲氧基)芳酸衍生物对二磷酸腺苷(ADP)诱导的血小板聚集具有较好的抑制活性,其中化合物1a的抑制作用明显强于阳性对照药奥扎格雷钠。展开更多
基金This work was financially supported by the National Natural Science Foundation of China NO.29972017the Foundation of Ministry of Education of China for Doctoral Program NO.98073003National Key Basic Research Development Plan NO.G1998051113.
文摘A new eudesmanolide and a new aromatic derivative were isolated from the roots of Carpesium cernuun. Their structures were elucidated as 13-hydroxy-5,7(11)-eudesmadien-12,8-olide and 3-methyl-8-acetoxy-9,10-diisobutyryloxy-p-cymene by spectral methods (EIMS, FAB-MS, 1D and 2D NMR).
文摘 Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were prepared.Their compositions and structures were identified by elemental analysis,IR,and 1H NMR.They have been examined for their antibacterial action against Staphylococcua aurens and Escherichia coli.These compounds showed higher activity than the aromatic derivatives of ct-amino acid which were reported previously.The general conclusion to be drawn is that the distance between amino and carboxylic group in these molecules could affect their antibacterial activity.Furthermore,those compounds with p-methyl substituent in phenyl ring exhibit higher activity than the others,and all the compounds exhibit higher activity against Escherichia coli and against Staphylococcua aureus.
文摘以具有活血化瘀作用的中药有效成分阿魏酸为先导物,按生物电子等排原理,设计合成了6个((吡啶-3-基)甲氧基)芳酸衍生物,其结构经IR,1 H NMR,13 C NMR及MS确证。体外药效筛选结果显示,部分((吡啶-3-基)甲氧基)芳酸衍生物对二磷酸腺苷(ADP)诱导的血小板聚集具有较好的抑制活性,其中化合物1a的抑制作用明显强于阳性对照药奥扎格雷钠。
