The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task....The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task. In this work, we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl glycinamide(NAGA) and carboxybetaine acrylamide(CBAA) in the absence of any chemical crosslinker, which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope. The hydrogel possessed the superior mechanical performances: high tensile strength(～1.13 MPa), large stretchability(～1200%), and excellent compressive strength(～9 MPa) at high monomer concentration and NAGA/CBAA ratio. Introduction of CBAA could promote the self-healability, thermoplasticity of suparmolecular polymer hydrogels at lower temperatures, meanwhile dramatically improving anti-fouling property.Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel. This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51325305,51733006)
文摘The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task. In this work, we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl glycinamide(NAGA) and carboxybetaine acrylamide(CBAA) in the absence of any chemical crosslinker, which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope. The hydrogel possessed the superior mechanical performances: high tensile strength(～1.13 MPa), large stretchability(～1200%), and excellent compressive strength(～9 MPa) at high monomer concentration and NAGA/CBAA ratio. Introduction of CBAA could promote the self-healability, thermoplasticity of suparmolecular polymer hydrogels at lower temperatures, meanwhile dramatically improving anti-fouling property.Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel. This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues.
文摘类风湿关节炎(rheumatoid arthritis,RA)是一种慢性自身免疫性疾病,该病可引起不可逆转的关节畸形,早期诊断和治疗可延缓疾病的进展。瓜氨酸化、氨甲酰化、氧化及乙酰化是蛋白质翻译后修饰产生的新表位,B细胞针对这些新表位发生免疫应答而产生相应的自身抗体。文章就抗瓜氨酸蛋白抗体(anti citrulline protein antibodies,ACPA)、氨甲酰化抗体,氧化型Ⅱ型胶原抗体、乙酰化抗体在RA实验室诊断中的作用进行综述,以期为RA早期标志物识别和疗效指标评价提供一定的依据。
