目的探讨超声引导下髂筋膜间隙阻滞复合浅全麻在老年髋关节置换术中的麻醉效果及对术后恢复的影响。方法选取2019年3月至2020年3月于我院行髋关节置换术的106例老年患者,按照随机数字法分为对照组和观察组各53例,对照组给予单纯全身麻醉...目的探讨超声引导下髂筋膜间隙阻滞复合浅全麻在老年髋关节置换术中的麻醉效果及对术后恢复的影响。方法选取2019年3月至2020年3月于我院行髋关节置换术的106例老年患者,按照随机数字法分为对照组和观察组各53例,对照组给予单纯全身麻醉,观察组给予超声引导下髂筋膜间隙阻滞复合浅全麻。比较两组患者自主呼吸恢复时间、苏醒时间、下床活动时间、住院时间、疼痛程度(VAS)评分、髋关节功能(Harris)评分及不良反应发生率,并记录两组入室时(T0)、切片(T1)、扩髓腔(T2)、术毕时(T3)的血流动力学指标,术前、术毕和术后24 h的血糖(GLU)、乳酸(LAC)、皮质醇(Cor)水平变化。结果与对照组比较,观察组自主呼吸恢复时间、苏醒时间、下床活动时间及住院时间较短;术后6、12、24 h的VAS评分较低,T1、T2、T3时心率、平均动脉压较低,术毕和术后24 h GLU、LAC、Cor水平较低;出院时Harris评分较高;不良反应发生率较低,差异均有统计学意义(P<0.05)。结论超声引导下髂筋膜间隙阻滞复合浅全麻在老年髋关节置换术中的麻醉效果显著,可有效缓解疼痛程度,维持血流动力学平稳,降低应激水平,减少不良反应,促进髋关节功能恢复。展开更多
Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controll...Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.展开更多
文摘目的探讨超声引导下髂筋膜间隙阻滞复合浅全麻在老年髋关节置换术中的麻醉效果及对术后恢复的影响。方法选取2019年3月至2020年3月于我院行髋关节置换术的106例老年患者,按照随机数字法分为对照组和观察组各53例,对照组给予单纯全身麻醉,观察组给予超声引导下髂筋膜间隙阻滞复合浅全麻。比较两组患者自主呼吸恢复时间、苏醒时间、下床活动时间、住院时间、疼痛程度(VAS)评分、髋关节功能(Harris)评分及不良反应发生率,并记录两组入室时(T0)、切片(T1)、扩髓腔(T2)、术毕时(T3)的血流动力学指标,术前、术毕和术后24 h的血糖(GLU)、乳酸(LAC)、皮质醇(Cor)水平变化。结果与对照组比较,观察组自主呼吸恢复时间、苏醒时间、下床活动时间及住院时间较短;术后6、12、24 h的VAS评分较低,T1、T2、T3时心率、平均动脉压较低,术毕和术后24 h GLU、LAC、Cor水平较低;出院时Harris评分较高;不良反应发生率较低,差异均有统计学意义(P<0.05)。结论超声引导下髂筋膜间隙阻滞复合浅全麻在老年髋关节置换术中的麻醉效果显著,可有效缓解疼痛程度,维持血流动力学平稳,降低应激水平,减少不良反应,促进髋关节功能恢复。
基金supported by the National Natural Science Foundation of China,No.81671891
文摘Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.
