The title compound trans-4-[（5-（2,4-dichlorophenoxy）-3-methyl- 1-phenyl-1H-pyrazol-4-yl）methyleneamino]- 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 （C28H23Cl2N5O2, Mr = 532.41） has been synthesized and its...The title compound trans-4-[（5-（2,4-dichlorophenoxy）-3-methyl- 1-phenyl-1H-pyrazol-4-yl）methyleneamino]- 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 （C28H23Cl2N5O2, Mr = 532.41） has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1- with a = 8.9438（4）, b = 11.6065（5）, c = 14.2215（6）A, α = 112.566（1）, β = 92.324（2）, γ = 102.91（1）°, V= 1315.65（10） A^3, Z = 2, Dc = 1.344 g/cm^3,μ（MoKa） = 0.282 mm^-1, λ = 0.71073 A, F（000） = 552, the final R = 0.0587 and wR = 0.1578 for 5071 observed reflections （I 〉 2σ（I））. X-ray analysis reveals that the product is a thermodynamically stable trans isomer. Intra- and intermolecular C（ 12）-H（12）…O（1） and C（28）-H（28）...O（1）# 1 hydrogen bonds were observed in the title compound.展开更多
A new ureido-substituted amino acid,conopsamide A（1）,has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea.Its structure was elucidated by extensive spectroscopic analysis,and the absolute...A new ureido-substituted amino acid,conopsamide A（1）,has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea.Its structure was elucidated by extensive spectroscopic analysis,and the absolute configuration was assigned by Marfey＇s method.The new compound was evaluated for in vitro assay for HDACl（Histone Deacetylase 1） inhibitory activity.展开更多
基金the Science Research Foundation of Henan Institute of Science and Technology (No. 06036)
文摘The title compound trans-4-[（5-（2,4-dichlorophenoxy）-3-methyl- 1-phenyl-1H-pyrazol-4-yl）methyleneamino]- 1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one 3 （C28H23Cl2N5O2, Mr = 532.41） has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1- with a = 8.9438（4）, b = 11.6065（5）, c = 14.2215（6）A, α = 112.566（1）, β = 92.324（2）, γ = 102.91（1）°, V= 1315.65（10） A^3, Z = 2, Dc = 1.344 g/cm^3,μ（MoKa） = 0.282 mm^-1, λ = 0.71073 A, F（000） = 552, the final R = 0.0587 and wR = 0.1578 for 5071 observed reflections （I 〉 2σ（I））. X-ray analysis reveals that the product is a thermodynamically stable trans isomer. Intra- and intermolecular C（ 12）-H（12）…O（1） and C（28）-H（28）...O（1）# 1 hydrogen bonds were observed in the title compound.
基金This work was supported by grants from National Natural Science Foundation of China ( No. 39825109) and National Key Project of Basic Science Research (No. G1999054007).
基金Financial support from the National Natural Science Foundation of China (No. 81522050)Beijing outstanding talents cultivation fund (No. 2013D009008000002)the Natural Science Foundation of Qinghai Province (No. 2014-ZJ-923)
文摘A new ureido-substituted amino acid,conopsamide A（1）,has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea.Its structure was elucidated by extensive spectroscopic analysis,and the absolute configuration was assigned by Marfey＇s method.The new compound was evaluated for in vitro assay for HDACl（Histone Deacetylase 1） inhibitory activity.
基金the National Natural Science Foundation of China(21101127,21073141)National Defense Pre-Research Foundation of China(9140A28020111BQ3401)National Defense Pre-Research Foundation of China(A3120110005)~~
