After detailed studies of leaf area, leaf shape index, petiole length, stomatal density, stomatal index, and carbon isotope discrimination of Ginkgo biloba L., growing in Northwest China, the change trends of these pa...After detailed studies of leaf area, leaf shape index, petiole length, stomatal density, stomatal index, and carbon isotope discrimination of Ginkgo biloba L., growing in Northwest China, the change trends of these parameters with an altitude gradient and their differences between sun and shade leaves were assessed. The results show that leaf area, petiole length, and stomatal parameters have no obvious linear relationship with altitude, but the carbon isotope discrimination shows a negative correlation with altitude, which has a potential to be an applicable paleo-altimeter. The results also suggest that the differences in stomatal density and stomatal index between sun and shade leaves had more influence on paleoelevation reconstruction than that in other parameters. Based on the linear and nonlinear correlations between carbon isotope discrimination and altitude, the paleoelevation evolution during the Middle Jurassic of the Yaojie Basin, Lanzhou in Gansu Province was estimated. The results show that the paleoelevation of the Yaojie Basin increased at first, and then decreased from the Aalenian to the early Bajocian and then to the late Bajocian in the Middle Jurassic.展开更多
目的筛选康北高原慢性阻塞性肺疾病急性加重患者发生静脉血栓栓塞症风险的预测因素,建立AECOPD发生VTE风险的联合预测模型并分析其预测效能。方法选择2018年1月-2022年9月因慢性阻塞性肺疾病急性加重在甘孜县人民医院住院治疗的患者71例...目的筛选康北高原慢性阻塞性肺疾病急性加重患者发生静脉血栓栓塞症风险的预测因素,建立AECOPD发生VTE风险的联合预测模型并分析其预测效能。方法选择2018年1月-2022年9月因慢性阻塞性肺疾病急性加重在甘孜县人民医院住院治疗的患者71例,根据是否发生VTE分为血栓组35例,对照组36例。收集患者的基本资料和检查、检验资料等相关参数数据,选出两组之间具有显著差异的指标。将上述单因素分析中有显著差异的指标纳入多因素分析,筛选出AECOPD发生VTE风险的独立影响因素,并构建预测模型。利用受试者工作特征(receiver operating characteristic,ROC)曲线评价各独立因素及预测模型的应用价值,计算曲线下面积及其敏感度与特异度,分析其预测效能,霍斯默-莱梅肖检验评价拟合度。结果单因素分析显示血栓组PPS评分、乳酸脱氢酶(LDH)、D-二聚体、降钙素原(PCT)均高于对照组(均P<0.05)。Logistic回归分析显示PPS评分、乳酸脱氢酶(LDH)、D-二聚体为AECOPD发生VTE的独立预测因素。三者联合构建的预测模型曲线下面积(area under curve,AUC)为0.944(95%CI:0.893~0.996),灵敏度、特异度均明显优于各单一指标(灵敏度为94.3%、特异度为83.3%),霍斯默-莱梅肖检验拟合度好(χ^(2)=11.915,P=0.155)。结论PPS评分、乳酸脱氢酶(LDH)、D-二聚体可能是预测康北高原AECOPD发生VTE的因素,且三者联合构建的预测模型对VTE风险预测具有很好效能,可为预测AECOPD发生VTE的风险提供参考。展开更多
BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injection...BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients impro展开更多
In the context of global warming,glaciers in the Asian High Mountains(AHMs)are shrinking at an accelerating rate.Projecting their future change is helpful for understanding the hydrological and climatic effects relate...In the context of global warming,glaciers in the Asian High Mountains(AHMs)are shrinking at an accelerating rate.Projecting their future change is helpful for understanding the hydrological and climatic effects related to glacier retreat.Here,we projected glacier change in the AHMs from 1979 to 2100 under shared socioeconomic pathway(SSP)scenarios from the perspective of temperature,equilibrium-line altitude(ELA),and accumulation area.The annual mean temperature in the AHMs increased by 1.26℃ from 1979 to 2014,corresponding to an increase of 210 m in the mean ELA and a decrease of 1.7×10^(4)km^(2) in the glacier accumulation area.Under the SSP2-4.5(SSP5-8.5)scenario,the annual mean temperature in the AHMs would increase by 2.84℃(3.38℃)in 2040–2060 relative to that in 1850–1900,leading to the mean ELA reaching an elevation of5661 m(5777 m).The accumulation area in the AHMs decreased by 46.3%from 1995 to 2014 and was projected to decrease by60.1%in 2040–2060.Moreover,the annual mean temperature in the AHMs was projected to increase by 3.76℃(6.44℃)in2080–2100 relative to that in 1850–1900,corresponding to the ELA reaching an elevation of 5821 m(6245 m)and the accumulation area decreasing to 1.8×10^(4)km^(2)(0.5×10^(4)km^(2)).These data suggest that the conditions for glacier development will disappear in most of the AHMs,except for extreme high-altitude regions in the Tianshan,Pamir,and Himalaya Mountains.Under the SSP2-4.5(SSP5-8.5)scenario,when the global mean temperature increases 1.5℃(2℃)above pre-industrial levels,the annual mean temperature will increase by 2.12℃(2.86℃)and the accumulation area will decrease by 15%(48%)in the AHMs compared with that in 1995–2015.Therefore,a 1.5℃ increase in global warming would keep 40%more of the glacial accumulation area(1.5×10^(4)km^(2))in the AHMs compared to a 2℃ increase in global warming.展开更多
Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examin...Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examine whether(i)there are sex-related responses of tree-ring growth to climate in dioecious trees;(ii)these responses could be changed with altitude elevation.Methods The tree-ring width and basal area increment(BAI)were measured over the past 30 years(1982-2011),and the sexual differences in relationship between BAI and time span and correlations between ring width and climatic factors were investigated in Populus cathayana trees at two altitude sites(1,450 m and 1,750 m a.s.l.)in Xiaowutai Mountain,Hebei,north China.Important Findings The BAI was increased over the past 30 years.Trees at high-altitude sites had significantly lower mean ring width and mean BAI than those trees at low-altitude sites(P<0.001).In addition,sexual dif-ferences in tree-ring growth and its response to climate were more pronounced by altitude elevation.Male trees had a significantly larger mean ring width and mean BAI than did females at high-alti-tude sites,whereas no significant sexual differences in these traits were detected at low-altitude sites.Female trees were sensitive to previous October-November temperatures at high altitude but to current February and April precipitation at low altitude(P<0.05),whereas male trees were sensitive to current June temperature at high altitude but to January precipitation at low altitude(P<0.05).Our results indicated that the responses of tree-ring growth to cli-mate are sex dependent and can be changed with altitude elevation.展开更多
基金Supported by National Basic Research Program of China (Grant No. 2006CB701401)National Natural Science Foundation of China (Grant Nos. 40802008, 40772012 and 40502005)+1 种基金Research Fund for the Doctoral Program of Higher Education (Grant No. 200807301005)Science and Technology Program of Gansu Province (Grant No. 0806RJYA016)
文摘After detailed studies of leaf area, leaf shape index, petiole length, stomatal density, stomatal index, and carbon isotope discrimination of Ginkgo biloba L., growing in Northwest China, the change trends of these parameters with an altitude gradient and their differences between sun and shade leaves were assessed. The results show that leaf area, petiole length, and stomatal parameters have no obvious linear relationship with altitude, but the carbon isotope discrimination shows a negative correlation with altitude, which has a potential to be an applicable paleo-altimeter. The results also suggest that the differences in stomatal density and stomatal index between sun and shade leaves had more influence on paleoelevation reconstruction than that in other parameters. Based on the linear and nonlinear correlations between carbon isotope discrimination and altitude, the paleoelevation evolution during the Middle Jurassic of the Yaojie Basin, Lanzhou in Gansu Province was estimated. The results show that the paleoelevation of the Yaojie Basin increased at first, and then decreased from the Aalenian to the early Bajocian and then to the late Bajocian in the Middle Jurassic.
文摘目的筛选康北高原慢性阻塞性肺疾病急性加重患者发生静脉血栓栓塞症风险的预测因素,建立AECOPD发生VTE风险的联合预测模型并分析其预测效能。方法选择2018年1月-2022年9月因慢性阻塞性肺疾病急性加重在甘孜县人民医院住院治疗的患者71例,根据是否发生VTE分为血栓组35例,对照组36例。收集患者的基本资料和检查、检验资料等相关参数数据,选出两组之间具有显著差异的指标。将上述单因素分析中有显著差异的指标纳入多因素分析,筛选出AECOPD发生VTE风险的独立影响因素,并构建预测模型。利用受试者工作特征(receiver operating characteristic,ROC)曲线评价各独立因素及预测模型的应用价值,计算曲线下面积及其敏感度与特异度,分析其预测效能,霍斯默-莱梅肖检验评价拟合度。结果单因素分析显示血栓组PPS评分、乳酸脱氢酶(LDH)、D-二聚体、降钙素原(PCT)均高于对照组(均P<0.05)。Logistic回归分析显示PPS评分、乳酸脱氢酶(LDH)、D-二聚体为AECOPD发生VTE的独立预测因素。三者联合构建的预测模型曲线下面积(area under curve,AUC)为0.944(95%CI:0.893~0.996),灵敏度、特异度均明显优于各单一指标(灵敏度为94.3%、特异度为83.3%),霍斯默-莱梅肖检验拟合度好(χ^(2)=11.915,P=0.155)。结论PPS评分、乳酸脱氢酶(LDH)、D-二聚体可能是预测康北高原AECOPD发生VTE的因素,且三者联合构建的预测模型对VTE风险预测具有很好效能,可为预测AECOPD发生VTE的风险提供参考。
文摘BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients impro
基金supported by the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program(Grant No.2019QZKK0201)the National Natural Science Foundation of China(Grant No.41571062)。
文摘In the context of global warming,glaciers in the Asian High Mountains(AHMs)are shrinking at an accelerating rate.Projecting their future change is helpful for understanding the hydrological and climatic effects related to glacier retreat.Here,we projected glacier change in the AHMs from 1979 to 2100 under shared socioeconomic pathway(SSP)scenarios from the perspective of temperature,equilibrium-line altitude(ELA),and accumulation area.The annual mean temperature in the AHMs increased by 1.26℃ from 1979 to 2014,corresponding to an increase of 210 m in the mean ELA and a decrease of 1.7×10^(4)km^(2) in the glacier accumulation area.Under the SSP2-4.5(SSP5-8.5)scenario,the annual mean temperature in the AHMs would increase by 2.84℃(3.38℃)in 2040–2060 relative to that in 1850–1900,leading to the mean ELA reaching an elevation of5661 m(5777 m).The accumulation area in the AHMs decreased by 46.3%from 1995 to 2014 and was projected to decrease by60.1%in 2040–2060.Moreover,the annual mean temperature in the AHMs was projected to increase by 3.76℃(6.44℃)in2080–2100 relative to that in 1850–1900,corresponding to the ELA reaching an elevation of 5821 m(6245 m)and the accumulation area decreasing to 1.8×10^(4)km^(2)(0.5×10^(4)km^(2)).These data suggest that the conditions for glacier development will disappear in most of the AHMs,except for extreme high-altitude regions in the Tianshan,Pamir,and Himalaya Mountains.Under the SSP2-4.5(SSP5-8.5)scenario,when the global mean temperature increases 1.5℃(2℃)above pre-industrial levels,the annual mean temperature will increase by 2.12℃(2.86℃)and the accumulation area will decrease by 15%(48%)in the AHMs compared with that in 1995–2015.Therefore,a 1.5℃ increase in global warming would keep 40%more of the glacial accumulation area(1.5×10^(4)km^(2))in the AHMs compared to a 2℃ increase in global warming.
基金This research was supported by the National Natural Science Foundation of China(31170389 and 31370596)the Innovative Team Foundation of the Sichuan Provincial Department of Education(14TD0015).
文摘Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examine whether(i)there are sex-related responses of tree-ring growth to climate in dioecious trees;(ii)these responses could be changed with altitude elevation.Methods The tree-ring width and basal area increment(BAI)were measured over the past 30 years(1982-2011),and the sexual differences in relationship between BAI and time span and correlations between ring width and climatic factors were investigated in Populus cathayana trees at two altitude sites(1,450 m and 1,750 m a.s.l.)in Xiaowutai Mountain,Hebei,north China.Important Findings The BAI was increased over the past 30 years.Trees at high-altitude sites had significantly lower mean ring width and mean BAI than those trees at low-altitude sites(P<0.001).In addition,sexual dif-ferences in tree-ring growth and its response to climate were more pronounced by altitude elevation.Male trees had a significantly larger mean ring width and mean BAI than did females at high-alti-tude sites,whereas no significant sexual differences in these traits were detected at low-altitude sites.Female trees were sensitive to previous October-November temperatures at high altitude but to current February and April precipitation at low altitude(P<0.05),whereas male trees were sensitive to current June temperature at high altitude but to January precipitation at low altitude(P<0.05).Our results indicated that the responses of tree-ring growth to cli-mate are sex dependent and can be changed with altitude elevation.
