为了提高海上非均质稠油油田聚合物驱效果,采用疏水缔合聚合物AP-P4(特性黏数1800 m L/g、疏水基含量0.8%),通过双管并联岩心物理模拟实验研究了渗透率级差、注聚浓度、注聚时机对渤海稠油油藏早期注聚剖面返转的影响规律,比较了交替注...为了提高海上非均质稠油油田聚合物驱效果,采用疏水缔合聚合物AP-P4(特性黏数1800 m L/g、疏水基含量0.8%),通过双管并联岩心物理模拟实验研究了渗透率级差、注聚浓度、注聚时机对渤海稠油油藏早期注聚剖面返转的影响规律,比较了交替注入聚合物的类型和浓度、交替次数对提高采收率效果的影响。研究结果表明:聚合物驱适用于早期注聚(含水率小于80%)、渗透率级差小(﹤6)的油层条件,聚合物良好的注入性和合适的流度控制作用对提高稠油聚合物驱采收率十分重要;弱凝胶体系和聚合物体系交替注入对高渗层伤害大,提高采收率效果差;在相同聚合物用量条件下,高浓度(2250 mg/L×0.15 PV)与低浓度聚合物体系(1750 mg/L×0.15 PV)交替注入2个轮次比单一段塞注聚(聚合物用量1200 mg/L·PV)提高采收率4.3%,渤海稠油油藏开展高浓度/低浓度聚合物体系交替注入可改善稠油聚合物驱效果。展开更多
Cinobufacini, a compound extracted from bufo toad, is a traditional Chinese medicine(TCM) that has been shown to have efficacy in cancer treatment.The cinobufacini injection is widely used in patients with moderate an...Cinobufacini, a compound extracted from bufo toad, is a traditional Chinese medicine(TCM) that has been shown to have efficacy in cancer treatment.The cinobufacini injection is widely used in patients with moderate and advanced liver cancer in China.In the present study, we aimed to determine the effects of cinobufacini injection for this specific category of patients.A search for randomized control trials(RCTs) using cinobufacini was conducted in the PubMed, EMBASE, CENTRAL, and the other four major Chinese databases.The systematic review was performed according to the recommendations of the Cochrane collaboration, and the RevMan 5.3.software was used for statistical analysis.A random-effects model was used to perform the data.Risk ratios(RR) with corresponding 95% confidence interval were calculated according to Cochrane handbook.A total of 11 RCTs consisting of 728 patients were included.All of the trials demonstrated significantly improved total response rates, total response rates of Karnofsky Performance Score(KPS), 1-to 2-year survival rates, and quality of life in the intervention groups injected with cinobufacini.There was no statistically significant difference between the groups(cinobufacini versus no cinobufacini; cinobufacini plus transcatheter arterial chemoembolization(TACE) versus TACE only) in terms of the 6-month survival rate, clinical benefit rate and clinical benefit rate of KPS.This systematic review demonstrated the beneficial effects of cinobufacini injection in terms of total response rate and the 1-to 2-year survival rate in patients with moderate and advanced liver cancer.The efficacy for the cinobufacini injection group might be better than that of the control group for treatment of moderate and advanced liver cancer.Given that the majority of the trials were of low quality, more high-quality prospective RCTs with strict design in accordance with CONSORT for TCM are needed.展开更多
1.Objective Natural gas hydrates are considered as a potential alternative fuel resource to petroleum and gas (Chong ZR et al.,2016),which can be exploited by means of depressurization,thermal method,inhibitor injecti...1.Objective Natural gas hydrates are considered as a potential alternative fuel resource to petroleum and gas (Chong ZR et al.,2016),which can be exploited by means of depressurization,thermal method,inhibitor injection,etc.For the thermal method,gas hydrates are decomposed into water and methane when the reservoir is heated to above the equilibrium temperature of gas hydrate (Li X et al.,2016). However,the thermal recovery method needs a great deal of heat,and thus the feasibility of economic exploitation is reduced.展开更多
基金Science and Technology Project of Putian University,China(Grant No.2013035)
文摘Cinobufacini, a compound extracted from bufo toad, is a traditional Chinese medicine(TCM) that has been shown to have efficacy in cancer treatment.The cinobufacini injection is widely used in patients with moderate and advanced liver cancer in China.In the present study, we aimed to determine the effects of cinobufacini injection for this specific category of patients.A search for randomized control trials(RCTs) using cinobufacini was conducted in the PubMed, EMBASE, CENTRAL, and the other four major Chinese databases.The systematic review was performed according to the recommendations of the Cochrane collaboration, and the RevMan 5.3.software was used for statistical analysis.A random-effects model was used to perform the data.Risk ratios(RR) with corresponding 95% confidence interval were calculated according to Cochrane handbook.A total of 11 RCTs consisting of 728 patients were included.All of the trials demonstrated significantly improved total response rates, total response rates of Karnofsky Performance Score(KPS), 1-to 2-year survival rates, and quality of life in the intervention groups injected with cinobufacini.There was no statistically significant difference between the groups(cinobufacini versus no cinobufacini; cinobufacini plus transcatheter arterial chemoembolization(TACE) versus TACE only) in terms of the 6-month survival rate, clinical benefit rate and clinical benefit rate of KPS.This systematic review demonstrated the beneficial effects of cinobufacini injection in terms of total response rate and the 1-to 2-year survival rate in patients with moderate and advanced liver cancer.The efficacy for the cinobufacini injection group might be better than that of the control group for treatment of moderate and advanced liver cancer.Given that the majority of the trials were of low quality, more high-quality prospective RCTs with strict design in accordance with CONSORT for TCM are needed.
基金the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06020204)Natural Science Foundation of China (41606087 and 91858208)the Marine Geological Survey project of China Geological Survey (DD20160218).
文摘1.Objective Natural gas hydrates are considered as a potential alternative fuel resource to petroleum and gas (Chong ZR et al.,2016),which can be exploited by means of depressurization,thermal method,inhibitor injection,etc.For the thermal method,gas hydrates are decomposed into water and methane when the reservoir is heated to above the equilibrium temperature of gas hydrate (Li X et al.,2016). However,the thermal recovery method needs a great deal of heat,and thus the feasibility of economic exploitation is reduced.
