Cell–cell aggregation is one of the most well-known modes of intercellular communication.The aggregation also plays a vital role in the formation of multicellularity,thus manipulating the growth and development of or...Cell–cell aggregation is one of the most well-known modes of intercellular communication.The aggregation also plays a vital role in the formation of multicellularity,thus manipulating the growth and development of organisms.In the past decades,cell–cell aggregation-related bioprocesses and molecular mechanisms have attracted enormous interest from scientists in biology,and bioengineering.People have developed a series of strategies to artificially regulate cell–cell aggregation through chemical–biological approaches.To date,not only the chemical reagents such as coordination compounds and polymers but also the biomacromolecules such as proteins and nucleic acids,are employed as the“cell glue”to achieve the control of the cell aggregation.So it is meaningful to review the recent advances of the chemical–biological approaches in cell–cell aggregation manipulation.In this review,we discuss the mechanisms and features of recently developed strategies to control cell–cell aggregation.We introduce molecules and designs relying on chemical reactions and biological conjugations respectively,and talk about their advantages and suitable applications.A perspective on the challenges in future applications in cell manipulation and cell-based therapy is also proposed.We expect this review could inspire innovative work on manipulating cell–cell aggregation and further modulate cell–cell interactions in the research of bio/chemical fields.展开更多
We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to selfassemble into nanoparticles(NPs)in water with size range from21–32nm to 55–68nm to 95–106 nm.Excepted for size,these ...We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to selfassemble into nanoparticles(NPs)in water with size range from21–32nm to 55–68nm to 95–106 nm.Excepted for size,these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape,surface charge,and luminescent properties,and moreover,after covalent capture of the acrylate hydrophilic heads,the resulting cross-linked NPs(cNPs I–III)own excellent in vivo stability,which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration.展开更多
基金Nankai University,Grant/Award Number:63211050NationalNatural Science Foundation of China,Grant/Award Numbers:21874075,22074068,591859123。
文摘Cell–cell aggregation is one of the most well-known modes of intercellular communication.The aggregation also plays a vital role in the formation of multicellularity,thus manipulating the growth and development of organisms.In the past decades,cell–cell aggregation-related bioprocesses and molecular mechanisms have attracted enormous interest from scientists in biology,and bioengineering.People have developed a series of strategies to artificially regulate cell–cell aggregation through chemical–biological approaches.To date,not only the chemical reagents such as coordination compounds and polymers but also the biomacromolecules such as proteins and nucleic acids,are employed as the“cell glue”to achieve the control of the cell aggregation.So it is meaningful to review the recent advances of the chemical–biological approaches in cell–cell aggregation manipulation.In this review,we discuss the mechanisms and features of recently developed strategies to control cell–cell aggregation.We introduce molecules and designs relying on chemical reactions and biological conjugations respectively,and talk about their advantages and suitable applications.A perspective on the challenges in future applications in cell manipulation and cell-based therapy is also proposed.We expect this review could inspire innovative work on manipulating cell–cell aggregation and further modulate cell–cell interactions in the research of bio/chemical fields.
基金supported by the National Natural Science Foundation of China(Nos.21372170 and 51703145)the Excellent Young Foundation of Sichuan Province(2016JQ0028)+1 种基金Applied Basic Research Project of Sichuan Province(15JC0440)the Discipline Development Foundation of Science and Technology on Surface Physics and Chemistry Laboratory(Nos.XKFZ201505 and XKFZ201506).
文摘We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to selfassemble into nanoparticles(NPs)in water with size range from21–32nm to 55–68nm to 95–106 nm.Excepted for size,these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape,surface charge,and luminescent properties,and moreover,after covalent capture of the acrylate hydrophilic heads,the resulting cross-linked NPs(cNPs I–III)own excellent in vivo stability,which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration.
