Aim: To determine the incidence of anemia in type-2 diabetic patients with normal renal function and assess the association of other factors related to diabetes with the risk of anemia. Methods: The study group compri...Aim: To determine the incidence of anemia in type-2 diabetic patients with normal renal function and assess the association of other factors related to diabetes with the risk of anemia. Methods: The study group comprised 72 patients with type-2 diabetes. Patients were divided into groups according to glycemic control, gender and age. Serum creatinine, hematocrit, hemoglobin concentration, blood glucose and glycated hemoglobin (HbA1c) of subjects were measured. The presence of anemia was defined by a he- moglobin level 7.5%) compared to those with controlled diabetes (≤7.5%) and in patients of age ≥ 60 yrs compared to those of age < 60 yrs (p < 0.05). The odds of anemia was similar in males and females (p = 0.26). Conclusion: This study indicated that poor glycemic control and old age are associated with the incidence of anemia in type-2 diabetics with normal renal function. Our findings suggest that treatment criteria for diabetes should include routine hematological tests and take into consideration the inevitable consequences of ageing, and poor glycemic control.展开更多
Facial ageing is a gradual process which could be due to intrinsic and extrinsic causes, it ultimately results in the appearance of gravity-induced tissue ptosis, wrinkles, epidermal and dermal atrophy, dryness, senil...Facial ageing is a gradual process which could be due to intrinsic and extrinsic causes, it ultimately results in the appearance of gravity-induced tissue ptosis, wrinkles, epidermal and dermal atrophy, dryness, senile lentigo, flushing, telangiectasia, and enlarged pores. Mesobotox treatment is a technique of microinjections of diluted Botulinum toxin type A (BTX) to preserve the facial mobility in order to preserve the natural beauty. BTX treatment enhances the aesthetic improvements attained with IPL. Ten patients of age ranging between 40 - 60 years old ( mean 45±10.3 years) with skin type ranging between (III - V) were treated using BTX and Intense Pulsed Light (IPL) using cutoff filter 550 nm with a fluence of 25 J/cm2 together as a combination therapy. All patients received standard IPL treatment and were assigned to receive eight 0.1 mL intradermal injections of BTX in each cheek (8 U total dose). Vertical lines within the forehead also received five 0.1 mL intradermal injections of BTX. Small wrinkles and fine lines, erythema, apparent pore size, skin texture, and overall appearance were evaluated after one week. A significantly higher proportion of patients showed improvement in small wrinkles and erythema with IPL plus BTX compared with the baseline demonstrated by computerized image analysis. In conclusion, A combined therapy of mesobotx and IPL is an effective and safe treatment for fine wrinkles, telangiectasia, flushing.展开更多
Quaternary Ag-In-Ga-S(AIGS)quantum dot(QD)is considered a promising,spectral-tunable,and environmentally friendly luminescent display material.However,the more complex surface defect states of AIGS QDs resulting from ...Quaternary Ag-In-Ga-S(AIGS)quantum dot(QD)is considered a promising,spectral-tunable,and environmentally friendly luminescent display material.However,the more complex surface defect states of AIGS QDs resulting from the coexistence of multiple elements lead to a low(<60%)photoluminescence quantum yield(PLQY).Here,we develop a novel convenient method to introduce Z-type ligands ZnX_(2)(X=Cl,Br,I)for passivating the surface defects of AIGS QDs to dramatically enhance the PLQY and stability without affecting the crystalline structure and morphology.Results show that the addition of ZnCl_(2) during the purified process of AIGS QDs leads to a 3-fold increase of PLQY(from 28.5% to 87%).Impressively,the highest PLQY is up to a recorded value of 92%,which is comparable to typical heavy metal QDs.Exciton dynamics studies have shown that the rapid annihilation process of excitons in treated QDs is inhibited.We also confirm that the improvement in PLQY is a result of the effective passivation of the non-coordinating atom on the QD surface by building a new bonding between sulfur dangling and Zn2+.The realization of high PLQY will further promote the application of AIGS QDs in luminescent displays.展开更多
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating m...The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating mechanism is dependent on reactive oxygen species. In pathological conditions, transient receptor potential melastatin 2 is overactivated, leading to a Ca~(2+) influx that alters cell homeostasis and promotes cell death. The role of transient receptor potential melastatin 2 in neurodegenerative diseases, including Alzheimer's disease and ischemia, has already been described and reviewed. However, data on transient receptor potential melastatin 2 involvement in Parkinson's disease pathology has emerged only in recent years and the issue lacks review studies that focus specifically on this topic. The present review aims to elucidate the role of the transient receptor potential melastatin 2 channel in Parkinson's disease by reviewing, summarizing, and discussing the in vitro, in vivo, and human studies published until August 2022. Here we describe fourteen studies that evaluated the transient receptor potential melastatin 2 channel in Parkinson's disease. The Parkinson's disease model used, transient receptor potential melastatin 2 antagonist and genetic approaches, and the main outcomes reported were discussed. The studies described transient receptor potential melastatin 2 activation and enhanced expression in different Parkinson's disease models. They also evidenced protective and restorative effects when using transient receptor potential melastatin 2 antagonists, knockout, or silencing. This review provides a literature overview and suggests where there is a need for more research. As a perspective point, this review shows evidence that supports transient receptor potential melastatin 2 as a pharmacological target for Parkinson's disease in the future.展开更多
This paper deals with the geology and geochemistry of the Gacun and Laochang large-sized marine volcanic rock-type Ag deposits in the Sanjiang(Tri-River) area of southwestern China and of the continental volcanic-subv...This paper deals with the geology and geochemistry of the Gacun and Laochang large-sized marine volcanic rock-type Ag deposits in the Sanjiang(Tri-River) area of southwestern China and of the continental volcanic-subvolcanic rock-type Ag deposits in the Tianshan area of Xinjiang, and in the East area,China. It is considered that the marine volcanic rock-type Ag deposits occur mainly in the second-ordered volcano-sedimentary basins developed in island-arc and rift tectonic environments.The Ag deposits show an obvious zonation,with vein-network mineralization in the lower parts and hot water sedimentary rock-hosted stratified mineralization in the upper parts. From the Earth抯 surface downwards the ore-forming elements follows the order of As(Au)→Ag,Pb,Zn→Cu. The whole rock Rb-Sr isotopic isochron age of layered orebodies in the Gacun deposit is 204±14 Ma, indicating that the main stage of mineralization is Late Triassic in age. The continental volcanic-subvolcanic (porphyry) rock-type Ag deposits were formed later than the country rocks. The ores exhibit disseminated, veinlet disseminated, network and lumped structures. In addition, this study also deals with the geochemical characteristics of the continental volcanic-subvolcanic rock-type Ag deposits and the relations between Ag deposits or silver itself and fluorite, halogen-family elements and manganese.展开更多
文摘Aim: To determine the incidence of anemia in type-2 diabetic patients with normal renal function and assess the association of other factors related to diabetes with the risk of anemia. Methods: The study group comprised 72 patients with type-2 diabetes. Patients were divided into groups according to glycemic control, gender and age. Serum creatinine, hematocrit, hemoglobin concentration, blood glucose and glycated hemoglobin (HbA1c) of subjects were measured. The presence of anemia was defined by a he- moglobin level 7.5%) compared to those with controlled diabetes (≤7.5%) and in patients of age ≥ 60 yrs compared to those of age < 60 yrs (p < 0.05). The odds of anemia was similar in males and females (p = 0.26). Conclusion: This study indicated that poor glycemic control and old age are associated with the incidence of anemia in type-2 diabetics with normal renal function. Our findings suggest that treatment criteria for diabetes should include routine hematological tests and take into consideration the inevitable consequences of ageing, and poor glycemic control.
文摘Facial ageing is a gradual process which could be due to intrinsic and extrinsic causes, it ultimately results in the appearance of gravity-induced tissue ptosis, wrinkles, epidermal and dermal atrophy, dryness, senile lentigo, flushing, telangiectasia, and enlarged pores. Mesobotox treatment is a technique of microinjections of diluted Botulinum toxin type A (BTX) to preserve the facial mobility in order to preserve the natural beauty. BTX treatment enhances the aesthetic improvements attained with IPL. Ten patients of age ranging between 40 - 60 years old ( mean 45±10.3 years) with skin type ranging between (III - V) were treated using BTX and Intense Pulsed Light (IPL) using cutoff filter 550 nm with a fluence of 25 J/cm2 together as a combination therapy. All patients received standard IPL treatment and were assigned to receive eight 0.1 mL intradermal injections of BTX in each cheek (8 U total dose). Vertical lines within the forehead also received five 0.1 mL intradermal injections of BTX. Small wrinkles and fine lines, erythema, apparent pore size, skin texture, and overall appearance were evaluated after one week. A significantly higher proportion of patients showed improvement in small wrinkles and erythema with IPL plus BTX compared with the baseline demonstrated by computerized image analysis. In conclusion, A combined therapy of mesobotx and IPL is an effective and safe treatment for fine wrinkles, telangiectasia, flushing.
基金supported by the National Natural Science Foundation of China(Nos.62374089,61904081 and 51672132)the Natural Science Foundation of Jiangsu Province(No.BK20190449)+1 种基金the Postdoctoral Research Funding Program of Jiangsu Province(No.2020Z144)the Fundamental Research Funds for the Central Universities(No.30923010928).
文摘Quaternary Ag-In-Ga-S(AIGS)quantum dot(QD)is considered a promising,spectral-tunable,and environmentally friendly luminescent display material.However,the more complex surface defect states of AIGS QDs resulting from the coexistence of multiple elements lead to a low(<60%)photoluminescence quantum yield(PLQY).Here,we develop a novel convenient method to introduce Z-type ligands ZnX_(2)(X=Cl,Br,I)for passivating the surface defects of AIGS QDs to dramatically enhance the PLQY and stability without affecting the crystalline structure and morphology.Results show that the addition of ZnCl_(2) during the purified process of AIGS QDs leads to a 3-fold increase of PLQY(from 28.5% to 87%).Impressively,the highest PLQY is up to a recorded value of 92%,which is comparable to typical heavy metal QDs.Exciton dynamics studies have shown that the rapid annihilation process of excitons in treated QDs is inhibited.We also confirm that the improvement in PLQY is a result of the effective passivation of the non-coordinating atom on the QD surface by building a new bonding between sulfur dangling and Zn2+.The realization of high PLQY will further promote the application of AIGS QDs in luminescent displays.
基金funded by Coordination for the Improvement of Higher Education Personnel (CAPES,Brazil-Finance Code 001,to LRB)the S?o Paulo Research Foundation(FAPESP,Brazil,project#2018/07366-4)+1 种基金The National Council for Scientific and Technological Development (CNPq,Brazil,project#303006/2018-8,to LRB)a PhD fellowship from FAPESP under Grant Agreement No 2020/02109-3。
文摘The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating mechanism is dependent on reactive oxygen species. In pathological conditions, transient receptor potential melastatin 2 is overactivated, leading to a Ca~(2+) influx that alters cell homeostasis and promotes cell death. The role of transient receptor potential melastatin 2 in neurodegenerative diseases, including Alzheimer's disease and ischemia, has already been described and reviewed. However, data on transient receptor potential melastatin 2 involvement in Parkinson's disease pathology has emerged only in recent years and the issue lacks review studies that focus specifically on this topic. The present review aims to elucidate the role of the transient receptor potential melastatin 2 channel in Parkinson's disease by reviewing, summarizing, and discussing the in vitro, in vivo, and human studies published until August 2022. Here we describe fourteen studies that evaluated the transient receptor potential melastatin 2 channel in Parkinson's disease. The Parkinson's disease model used, transient receptor potential melastatin 2 antagonist and genetic approaches, and the main outcomes reported were discussed. The studies described transient receptor potential melastatin 2 activation and enhanced expression in different Parkinson's disease models. They also evidenced protective and restorative effects when using transient receptor potential melastatin 2 antagonists, knockout, or silencing. This review provides a literature overview and suggests where there is a need for more research. As a perspective point, this review shows evidence that supports transient receptor potential melastatin 2 as a pharmacological target for Parkinson's disease in the future.
文摘This paper deals with the geology and geochemistry of the Gacun and Laochang large-sized marine volcanic rock-type Ag deposits in the Sanjiang(Tri-River) area of southwestern China and of the continental volcanic-subvolcanic rock-type Ag deposits in the Tianshan area of Xinjiang, and in the East area,China. It is considered that the marine volcanic rock-type Ag deposits occur mainly in the second-ordered volcano-sedimentary basins developed in island-arc and rift tectonic environments.The Ag deposits show an obvious zonation,with vein-network mineralization in the lower parts and hot water sedimentary rock-hosted stratified mineralization in the upper parts. From the Earth抯 surface downwards the ore-forming elements follows the order of As(Au)→Ag,Pb,Zn→Cu. The whole rock Rb-Sr isotopic isochron age of layered orebodies in the Gacun deposit is 204±14 Ma, indicating that the main stage of mineralization is Late Triassic in age. The continental volcanic-subvolcanic (porphyry) rock-type Ag deposits were formed later than the country rocks. The ores exhibit disseminated, veinlet disseminated, network and lumped structures. In addition, this study also deals with the geochemical characteristics of the continental volcanic-subvolcanic rock-type Ag deposits and the relations between Ag deposits or silver itself and fluorite, halogen-family elements and manganese.
