Elastography-based liver stiffness measurement(LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver di...Elastography-based liver stiffness measurement(LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver disease(ACLD). The presence of varices and especially of varices needing treatment(VNT) indicates distinct prognostic stages in patients with compensated ACLD(cACLD). The Baveno VI guidelines suggested a simple algorithm based on LSM < 20 kPa(by transient elastography, TE) and platelet count > 150 G/L for ruling-out VNT in patients with cACLD. These(and other) TE-based LSM cut-offs have been evaluated for VNT screening in different liver disease etiologies. Novel point shear-wave elastography(pSWE) and two-dimensional shear wave elastography(2D-SWE) methodologies for LSM have also been evaluated for their ability to screen for "any" varices and for VNT. Finally, the measurement of spleen stiffness(SSM) by elastography(mainly by pSWE and 2D-SWE) may represent another valuable screening tool for varices. Here, we summarize the current literature on elastography-based prediction of "any" varices and VNT. Finally,we have summarized the published LSM and SSM cut-offs in clinically useful scale cards.展开更多
Einstein guessed that the macroscopic electromagnetic wave is built by thousands of photons, however, no one has offered a theory about how the macroscopic electromagnetic wave is built from photons. A concrete theory...Einstein guessed that the macroscopic electromagnetic wave is built by thousands of photons, however, no one has offered a theory about how the macroscopic electromagnetic wave is built from photons. A concrete theory about photons is needed to answer this question. Current theory for photons is Maxwell’s equation which has the solution of waves, but it is difficult to describe the photon as a particle. There is the paradox problem of wave-particle duality. This article offers one solution to solve this problem by introducing the normalized mutual energy flow. The interaction of the retarded wave and advanced wave produce the mutual energy flow. The mutual energy flow satisfies the mutual energy flow theorem. The mutual energy flow theorem tells us that the energy that goes through each surface between the emitter and the absorber is all same. That means the mutual energy flow is different in comparison to the waves. The wave, for example, the retarded wave, its amplitude is decreased with the distance from the source to the point of the field. The mutual energy flow does not decrease. The author noticed this and claimed that the photon is the mutual energy flow. In this article the author updated this claim that the photon is the normalized mutual energy flow. Here the normalization of mutual energy flow will normalize the mutual energy flow to the energy of a photon, which is E = hf. E is the energy of the photon;h is Planck constant;f is the frequency of the light. This normalization is similar to the normalization in quantum mechanics. After this normalization the relation between an electromagnetic wave and photon as a particle becomes clear. This article will prove that the macroscopic wave of an electromagnetic field can be built by thousands of normalized mutual energy flows, which describes the photons. The mutual energy flow is an interaction of the retarded wave and the advanced wave. The retarded wave and the advanced wave satisfy the Maxwell equations. There are two additional waves which are the t展开更多
A critical challenge of any blast simulation facility is in producing the widest possible pressure-impulse range for matching against equivalent high-explosive events.Shock tubes and blast simulators are often constra...A critical challenge of any blast simulation facility is in producing the widest possible pressure-impulse range for matching against equivalent high-explosive events.Shock tubes and blast simulators are often constrained with the lack of effective ways to control blast wave profiles and as a result have a limited performance range.Some wave shaping techniques employed in some facilities are reviewed but often necessitate extensive geometric modifications,inadvertently cause flow anomalies,and/or are only applicable under very specific configurations.This paper investigates controlled venting as an expedient way for waveforms to be tuned without requiring extensive modifications to the driver or existing geometry and could be widely applied by existing and future blast simulation and shock tube facilities.The use of controlled venting is demonstrated experimentally using the Advanced Blast Simulator(shock tube)at the Australian National Facility of Physical Blast Simulation and via numerical flow simulations with Computational Fluid Dynamics.Controlled venting is determined as an effective method for mitigating the impact of re-reflected waves within the blast simulator.This control method also allows for the adjustment of parameters such as tuning the peak overpressure,the positive phase duration,and modifying the magnitude of the negative phase and the secondary shock of the blast waves.This paper is concluded with an illustration of the potential expanded performance range of the Australian blast simulation facility when controlled venting for blast waveform tailoring as presented in this paper is applied.展开更多
A new and falsifiable realist interpretation of quantum mechanics is examined in relation to the sum over histories concept, pilot wave theory and the many-worlds interpretation. This electric charge/transactional mod...A new and falsifiable realist interpretation of quantum mechanics is examined in relation to the sum over histories concept, pilot wave theory and the many-worlds interpretation. This electric charge/transactional model explains how the single electron double-slit experiment produces extremely localized endpoints from diffracted wavicles, why these endpoints are scattered around the entire surface of the absorber screen, and why these points of contact result in the characteristic fringe pattern as they accumulate. Advanced waves and substantive electric charge effects in the double-slit experiment are postulated, then this hypothesis is supported by a quantitative analysis of electron emission in comparison to lightning. The wider implications if advanced waves and electric charge distribution prove to be significant factors in the double-slit experiment are discussed, including possible parallels with meteorological and neurological phenomena.展开更多
To improve retrieval accuracy, this paper studies wave effects on retrieved wind field from a scatterometer. First, the advanced scatterometer （ASCAT） data and buoy data of the National Data Buoy Center （NDBC） are...To improve retrieval accuracy, this paper studies wave effects on retrieved wind field from a scatterometer. First, the advanced scatterometer （ASCAT） data and buoy data of the National Data Buoy Center （NDBC） are collocated. Buoy wind speed is converted into neutral wind at 10 m height. Then, ASCAT data are com- pared with the buoy data for the wind speed and direction. Subsequently, the errors between the ASCAT and the buoy wind as a function of each wave parameter are used to analyze the wave effects. Wave param- eters include dominant wave period （dpd）, significant wave height （swh）, average wave period （apd） and the angle between the dominant wave direction （dwd） and the wind direction. Collocated data are divided into sub-datasets according to the different intervals of each wave parameter. A root mean square error （RMSE） for the wind speed and a mean absolute error （MAE） for the wind direction are calculated from the sub-datasets, which are considered as the function of wave parameters. Finally, optimal wave conditions on wind retrieved from the ASCAT are determined based on the error analyses. The results show the ocean wave parameters have correlative relationships with the RMSE of the retrieved wind speed and the MAE of the retrieved wind direction. The optimal wave conditions are presented in terms of dpd, swh, apd and angle.展开更多
Advanced nuclear reactors offer safe, clean, and reliable energy at the global scale. The development of such devices relies heavily upon computational models, from the pre-conceptual stages through detailed design, l...Advanced nuclear reactors offer safe, clean, and reliable energy at the global scale. The development of such devices relies heavily upon computational models, from the pre-conceptual stages through detailed design, licensing, and operation. An integrated reactor modeling framework that enables seamless communication, coupling, automation, and continuous development brings significant new capabilities and efficiencies to the practice of reactor design. In such a system, key performance metrics （e.g., optimal fuel management, peak cladding temperature in design-basis accidents, levelized cost of electricity） can be explicitly linked to design inputs （e.g., assembly duct thickness, tolerances）, enabling an exceptional level of design consistency. Coupled with high-performance computing, thousands of integrated cases can be executed simultaneously to analyze the full system, perform complete sensitivity studies, and efficiently and robustly evaluate various design tradeoffs. TerraPower has developed such a tool-the Advanced Reactor Modeling Interface （ARMI） code system-and has deployed it to support the TerraPower Traveling Wave Reactor design and other innovative energy products currently under development. The ARMI code system employs pre-existing tools with strong pedigrees alongside many new physics and data management modules necessary for innovative design. Verification and validation against previous and new physical measurements, which remain an essential element of any sound design, are being carried out. This paper summarizes the integrated core engineering tools and practices in production at TerraPower.展开更多
The validation and assessment of Envisat advanced synthetic aperture radar (ASAR) ocean wave spectra products are important to their application in ocean wave numerical predictions. Six-year ASAR wave spectra data are...The validation and assessment of Envisat advanced synthetic aperture radar (ASAR) ocean wave spectra products are important to their application in ocean wave numerical predictions. Six-year ASAR wave spectra data are compared with one-dimensional (1D) wave spectra of 55 co-located moored buoy observations in the northern Pacific Ocean. The ASAR wave spectra data are firstly quality control filtered and spatio-temporal matched with buoy data. The comparisons are then performed in terms of 1D wave spectra, significant wave height (SWH) and mean wave period (MWP) in different spatio-temporal offsets respectively. SWH comparison results show the evident dependence of SWH biases on wind speed and the ASAR SWH saturation effect. The ASAR wave spectra tend to underestimate SWH at high wind speeds and overestimate SWH at low wind speeds. MWP comparison results show that MWP has a systematic bias and therefore it should be bias-modified before used. The comparisons of 1D wave spectra show that both wave spectra agree better at low frequencies than at high frequencies, which indicates the ASAR data cannot resolve the high frequency waves.展开更多
The availability of ever stronger,laser-generated electromagnetic fields underpins continuing progress in the study and application of nonlinear phenomena in basic physical systems,ranging from molecules and atoms to ...The availability of ever stronger,laser-generated electromagnetic fields underpins continuing progress in the study and application of nonlinear phenomena in basic physical systems,ranging from molecules and atoms to relativistic plasmas and quantum electrodynamics.This raises the question:how far will we be able to go with future lasers?One exciting prospect is the attainment of field strengths approaching the Schwinger critical field Ecr in the laboratory frame,such that the field invariant E^(2)−c^(2)B^(2)>E_(cr)^(2) is reached.The feasibility of doing so has been questioned,on the basis that cascade generation of dense electron–positron plasma would inevitably lead to absorption or screening of the incident light.Here we discuss the potential for future lasers to overcome such obstacles,by combining the concept of multiple colliding laser pulses with that of frequency upshifting via a tailored laser–plasma interaction.This compresses the electromagnetic field energy into a region of nanometre size and attosecond duration,which increases the field magnitude at fixed power but also suppresses pair cascades.Our results indicate that laser facilities with peak power of tens of PW could be capable of reaching Ecr.Such a scenario opens up prospects for the experimental investigation of phenomena previously considered to occur only in the most extreme environments in the universe.展开更多
Multiphasic multidetector computed tomography(CT)forms the mainstay for the characterization of renal masses whereas magnetic resonance imaging(MRI)acts as a problem-solving tool in some cases.However,a few of the ren...Multiphasic multidetector computed tomography(CT)forms the mainstay for the characterization of renal masses whereas magnetic resonance imaging(MRI)acts as a problem-solving tool in some cases.However,a few of the renal masses remain indeterminate even after evaluation by conventional imaging methods.To overcome the deficiency in current imaging techniques,advanced imaging methods have been devised and are being tested.This review will cover the role of contrast-enhanced ultrasonography,shear wave elastography,dual-energy CT,perfusion CT,MR perfusion,diffusion-weighted MRI,blood oxygen leveldependent MRI,MR spectroscopy,positron emission tomography(PET)/prostate-specific membrane antigen-PET in the characterization of renal masses.展开更多
文摘Elastography-based liver stiffness measurement(LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver disease(ACLD). The presence of varices and especially of varices needing treatment(VNT) indicates distinct prognostic stages in patients with compensated ACLD(cACLD). The Baveno VI guidelines suggested a simple algorithm based on LSM < 20 kPa(by transient elastography, TE) and platelet count > 150 G/L for ruling-out VNT in patients with cACLD. These(and other) TE-based LSM cut-offs have been evaluated for VNT screening in different liver disease etiologies. Novel point shear-wave elastography(pSWE) and two-dimensional shear wave elastography(2D-SWE) methodologies for LSM have also been evaluated for their ability to screen for "any" varices and for VNT. Finally, the measurement of spleen stiffness(SSM) by elastography(mainly by pSWE and 2D-SWE) may represent another valuable screening tool for varices. Here, we summarize the current literature on elastography-based prediction of "any" varices and VNT. Finally,we have summarized the published LSM and SSM cut-offs in clinically useful scale cards.
文摘Einstein guessed that the macroscopic electromagnetic wave is built by thousands of photons, however, no one has offered a theory about how the macroscopic electromagnetic wave is built from photons. A concrete theory about photons is needed to answer this question. Current theory for photons is Maxwell’s equation which has the solution of waves, but it is difficult to describe the photon as a particle. There is the paradox problem of wave-particle duality. This article offers one solution to solve this problem by introducing the normalized mutual energy flow. The interaction of the retarded wave and advanced wave produce the mutual energy flow. The mutual energy flow satisfies the mutual energy flow theorem. The mutual energy flow theorem tells us that the energy that goes through each surface between the emitter and the absorber is all same. That means the mutual energy flow is different in comparison to the waves. The wave, for example, the retarded wave, its amplitude is decreased with the distance from the source to the point of the field. The mutual energy flow does not decrease. The author noticed this and claimed that the photon is the mutual energy flow. In this article the author updated this claim that the photon is the normalized mutual energy flow. Here the normalization of mutual energy flow will normalize the mutual energy flow to the energy of a photon, which is E = hf. E is the energy of the photon;h is Planck constant;f is the frequency of the light. This normalization is similar to the normalization in quantum mechanics. After this normalization the relation between an electromagnetic wave and photon as a particle becomes clear. This article will prove that the macroscopic wave of an electromagnetic field can be built by thousands of normalized mutual energy flows, which describes the photons. The mutual energy flow is an interaction of the retarded wave and the advanced wave. The retarded wave and the advanced wave satisfy the Maxwell equations. There are two additional waves which are the t
基金funded partially by the Australian Government through the Australian Research Council’s Linkage Infrastructure,Equipment and Facilities (LIEF)funding scheme (LE130100133)。
文摘A critical challenge of any blast simulation facility is in producing the widest possible pressure-impulse range for matching against equivalent high-explosive events.Shock tubes and blast simulators are often constrained with the lack of effective ways to control blast wave profiles and as a result have a limited performance range.Some wave shaping techniques employed in some facilities are reviewed but often necessitate extensive geometric modifications,inadvertently cause flow anomalies,and/or are only applicable under very specific configurations.This paper investigates controlled venting as an expedient way for waveforms to be tuned without requiring extensive modifications to the driver or existing geometry and could be widely applied by existing and future blast simulation and shock tube facilities.The use of controlled venting is demonstrated experimentally using the Advanced Blast Simulator(shock tube)at the Australian National Facility of Physical Blast Simulation and via numerical flow simulations with Computational Fluid Dynamics.Controlled venting is determined as an effective method for mitigating the impact of re-reflected waves within the blast simulator.This control method also allows for the adjustment of parameters such as tuning the peak overpressure,the positive phase duration,and modifying the magnitude of the negative phase and the secondary shock of the blast waves.This paper is concluded with an illustration of the potential expanded performance range of the Australian blast simulation facility when controlled venting for blast waveform tailoring as presented in this paper is applied.
文摘A new and falsifiable realist interpretation of quantum mechanics is examined in relation to the sum over histories concept, pilot wave theory and the many-worlds interpretation. This electric charge/transactional model explains how the single electron double-slit experiment produces extremely localized endpoints from diffracted wavicles, why these endpoints are scattered around the entire surface of the absorber screen, and why these points of contact result in the characteristic fringe pattern as they accumulate. Advanced waves and substantive electric charge effects in the double-slit experiment are postulated, then this hypothesis is supported by a quantitative analysis of electron emission in comparison to lightning. The wider implications if advanced waves and electric charge distribution prove to be significant factors in the double-slit experiment are discussed, including possible parallels with meteorological and neurological phenomena.
基金The National Natural Science Youth Foundation of China under contract Nos 41306191 and 41306192the National High Tech-nology Development Program(863 Program) of China under contract No.2013AA09A505the Scientific Research Fund of the Second Institute of Oceanography,State Oceanic Administration of China under contract No.JG1317
文摘To improve retrieval accuracy, this paper studies wave effects on retrieved wind field from a scatterometer. First, the advanced scatterometer （ASCAT） data and buoy data of the National Data Buoy Center （NDBC） are collocated. Buoy wind speed is converted into neutral wind at 10 m height. Then, ASCAT data are com- pared with the buoy data for the wind speed and direction. Subsequently, the errors between the ASCAT and the buoy wind as a function of each wave parameter are used to analyze the wave effects. Wave param- eters include dominant wave period （dpd）, significant wave height （swh）, average wave period （apd） and the angle between the dominant wave direction （dwd） and the wind direction. Collocated data are divided into sub-datasets according to the different intervals of each wave parameter. A root mean square error （RMSE） for the wind speed and a mean absolute error （MAE） for the wind direction are calculated from the sub-datasets, which are considered as the function of wave parameters. Finally, optimal wave conditions on wind retrieved from the ASCAT are determined based on the error analyses. The results show the ocean wave parameters have correlative relationships with the RMSE of the retrieved wind speed and the MAE of the retrieved wind direction. The optimal wave conditions are presented in terms of dpd, swh, apd and angle.
文摘Advanced nuclear reactors offer safe, clean, and reliable energy at the global scale. The development of such devices relies heavily upon computational models, from the pre-conceptual stages through detailed design, licensing, and operation. An integrated reactor modeling framework that enables seamless communication, coupling, automation, and continuous development brings significant new capabilities and efficiencies to the practice of reactor design. In such a system, key performance metrics （e.g., optimal fuel management, peak cladding temperature in design-basis accidents, levelized cost of electricity） can be explicitly linked to design inputs （e.g., assembly duct thickness, tolerances）, enabling an exceptional level of design consistency. Coupled with high-performance computing, thousands of integrated cases can be executed simultaneously to analyze the full system, perform complete sensitivity studies, and efficiently and robustly evaluate various design tradeoffs. TerraPower has developed such a tool-the Advanced Reactor Modeling Interface （ARMI） code system-and has deployed it to support the TerraPower Traveling Wave Reactor design and other innovative energy products currently under development. The ARMI code system employs pre-existing tools with strong pedigrees alongside many new physics and data management modules necessary for innovative design. Verification and validation against previous and new physical measurements, which remain an essential element of any sound design, are being carried out. This paper summarizes the integrated core engineering tools and practices in production at TerraPower.
基金Supported by the Special Fund for Marine Commonweal Scientific Research of China (No.200705027)
文摘The validation and assessment of Envisat advanced synthetic aperture radar (ASAR) ocean wave spectra products are important to their application in ocean wave numerical predictions. Six-year ASAR wave spectra data are compared with one-dimensional (1D) wave spectra of 55 co-located moored buoy observations in the northern Pacific Ocean. The ASAR wave spectra data are firstly quality control filtered and spatio-temporal matched with buoy data. The comparisons are then performed in terms of 1D wave spectra, significant wave height (SWH) and mean wave period (MWP) in different spatio-temporal offsets respectively. SWH comparison results show the evident dependence of SWH biases on wind speed and the ASAR SWH saturation effect. The ASAR wave spectra tend to underestimate SWH at high wind speeds and overestimate SWH at low wind speeds. MWP comparison results show that MWP has a systematic bias and therefore it should be bias-modified before used. The comparisons of 1D wave spectra show that both wave spectra agree better at low frequencies than at high frequencies, which indicates the ASAR data cannot resolve the high frequency waves.
基金This research was supported by the Swedish Research Council Grants Nos.2016-03329 and 2020-06768(T.G.B.and M.M.)2017-05148(A.G.),as well as the U.S.Department of Energy Office of Science Offices of High Energy Physics and Fusion Energy Sciences(through LaserNetUS)+1 种基金under Contract No.DE-AC02-05CH11231(S.S.B.)Simulations were performed on resources provided by the Swedish National Infrastructure for Computing(SNIC).
文摘The availability of ever stronger,laser-generated electromagnetic fields underpins continuing progress in the study and application of nonlinear phenomena in basic physical systems,ranging from molecules and atoms to relativistic plasmas and quantum electrodynamics.This raises the question:how far will we be able to go with future lasers?One exciting prospect is the attainment of field strengths approaching the Schwinger critical field Ecr in the laboratory frame,such that the field invariant E^(2)−c^(2)B^(2)>E_(cr)^(2) is reached.The feasibility of doing so has been questioned,on the basis that cascade generation of dense electron–positron plasma would inevitably lead to absorption or screening of the incident light.Here we discuss the potential for future lasers to overcome such obstacles,by combining the concept of multiple colliding laser pulses with that of frequency upshifting via a tailored laser–plasma interaction.This compresses the electromagnetic field energy into a region of nanometre size and attosecond duration,which increases the field magnitude at fixed power but also suppresses pair cascades.Our results indicate that laser facilities with peak power of tens of PW could be capable of reaching Ecr.Such a scenario opens up prospects for the experimental investigation of phenomena previously considered to occur only in the most extreme environments in the universe.
文摘Multiphasic multidetector computed tomography(CT)forms the mainstay for the characterization of renal masses whereas magnetic resonance imaging(MRI)acts as a problem-solving tool in some cases.However,a few of the renal masses remain indeterminate even after evaluation by conventional imaging methods.To overcome the deficiency in current imaging techniques,advanced imaging methods have been devised and are being tested.This review will cover the role of contrast-enhanced ultrasonography,shear wave elastography,dual-energy CT,perfusion CT,MR perfusion,diffusion-weighted MRI,blood oxygen leveldependent MRI,MR spectroscopy,positron emission tomography(PET)/prostate-specific membrane antigen-PET in the characterization of renal masses.
