Title compounds 2′,2′-dimethylcholesta-2,4-dien[3,2-b]-pyran-4′-one （3）, 2′,2′-dimethyl-3β-substituted cholesta-4,6-dien[7,6- b]-pyran-4′-one （6a,b） and （6c） were prepared by the cyclization of 2-acetylch...Title compounds 2′,2′-dimethylcholesta-2,4-dien[3,2-b]-pyran-4′-one （3）, 2′,2′-dimethyl-3β-substituted cholesta-4,6-dien[7,6- b]-pyran-4′-one （6a,b） and （6c） were prepared by the cyclization of 2-acetylcholesta-2,4-dien-3-ol （2）, 6-acetyl-3β-substituted- cholesta-4,6-dien-7-ol （Sa,b） and （5c） respectively, with pyrrolidine, dry benzene and dry acetone using Dean Stark separator through conventional heating. Furthermore, compounds were also found to be active against Mycobacterium tuberculosis.展开更多
Tetrahydroquinoline was prepared by direct electrolysis-reduction quinolines in yield 43.9%. N- acetyl-tetrahydroquinoline was synthesized by acetylation of tetrahydroquinoline with acetic oxide. The synthetic procedu...Tetrahydroquinoline was prepared by direct electrolysis-reduction quinolines in yield 43.9%. N- acetyl-tetrahydroquinoline was synthesized by acetylation of tetrahydroquinoline with acetic oxide. The synthetic procedures have advantages of simplicity in equipment and mild reaction conditions.展开更多
文摘Title compounds 2′,2′-dimethylcholesta-2,4-dien[3,2-b]-pyran-4′-one （3）, 2′,2′-dimethyl-3β-substituted cholesta-4,6-dien[7,6- b]-pyran-4′-one （6a,b） and （6c） were prepared by the cyclization of 2-acetylcholesta-2,4-dien-3-ol （2）, 6-acetyl-3β-substituted- cholesta-4,6-dien-7-ol （Sa,b） and （5c） respectively, with pyrrolidine, dry benzene and dry acetone using Dean Stark separator through conventional heating. Furthermore, compounds were also found to be active against Mycobacterium tuberculosis.
文摘Tetrahydroquinoline was prepared by direct electrolysis-reduction quinolines in yield 43.9%. N- acetyl-tetrahydroquinoline was synthesized by acetylation of tetrahydroquinoline with acetic oxide. The synthetic procedures have advantages of simplicity in equipment and mild reaction conditions.
