Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which...Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1D NMR and 2D NMR as well as mass spectroscopic data. The absolute configurations of I and 2 were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2-c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.展开更多
基金Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201700375 or from the author.Acknowledgement We thank the National Natural Science Foundation of China （Nos. 21472251, 41276146）, the Key Project of Natural Science Foundation of Guangdong Province （No. 2016A030311026）, the Science ＆ Technology Plan Project of Guangdong Province of China （Nos. 2013B021100011, 2016A040403091）, the Special Financial Fund of Innovative Development of Marine Economic Demonstration Project （No. GD2012-D01- 001）, the China＇s Marine Commonweal Research Project （No. 201305017）, the Guangzhou Project of Science ＆ Technology Planning （No. 201300000062）, the Fundamental Research Funds for the Central Universities （No. 141gjc16） and the Supercomputing Center of Chinese Academy of Sciences （SCCAS） for generous support.
文摘Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1D NMR and 2D NMR as well as mass spectroscopic data. The absolute configurations of I and 2 were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2-c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.
