Zygomycetes are phylogenetically early diverging,ecologically diverse,industrially valuable,agriculturally beneficial,and clinically pathogenic fungi.Although new phyla and subphyla have been constantly established to...Zygomycetes are phylogenetically early diverging,ecologically diverse,industrially valuable,agriculturally beneficial,and clinically pathogenic fungi.Although new phyla and subphyla have been constantly established to accommodate spe-cific members and a subkingdom Mucoromyceta,comprising Calcarisporiellomycota,Glomeromycota,Mortierellomycota and Mucoromycota,was erected to unite core zygomycetous fungi,phylogenetic relationships within phyla have not been well resolved.Taking account of the information of monophyly and divergence time estimated from ITS and LSU rDNA sequences,the present study updates the classification framework of the phylum Mucoromycota from the class down to the generic rank:three classes,three orders,20 families(including five new families Circinellaceae,Protomycocladaceae,Rhizomucoraceae,Syzygitaceae and Thermomucoraceae)and 64 genera.The taxonomic hierarchy was calibrated with estimated divergence times:phylum earlier than 617 Mya,classes and orders earlier than 547 Mya,families earlier than 199 Mya,and genera earlier than 12 Mya.Along with this outline,all genera of Mucoromycota are annotated and 58 new species are described.In addition,three new combinations are proposed.In this study,we update the taxonomic backbone of the phylum Mucoromycota and reinforce its phylogeny.We also contribute numerous new taxa and enrich the diversity of Mucoromycota.展开更多
BACKGROUND Coronavirus disease 2019(COVID-19)patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections.There is a possibility that such infections are missed or misdi...BACKGROUND Coronavirus disease 2019(COVID-19)patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections.There is a possibility that such infections are missed or misdiagnosed,in which case patients may suffer higher morbidity and mortality.COVID-19 infection,aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections.Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients.CASE SUMMARY We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery.All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19.The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5±14.5(7–30)d.All patients underwent debridement and were started on antifungal therapy.One patient was referred to a higher center for further management,but the others responded well to treatment and showed signs of improvement at the last follow-up.CONCLUSION Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival.展开更多
基金This study was supported by the National Natural Science Foundation of China(Grant Nos.31970009,32170012 and 32000010)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,Grant No.2019QZKK0503)the Third Xinjiang Scientific Expedition and Research Program(STEP,Grant No.2021XJKK0505).
文摘Zygomycetes are phylogenetically early diverging,ecologically diverse,industrially valuable,agriculturally beneficial,and clinically pathogenic fungi.Although new phyla and subphyla have been constantly established to accommodate spe-cific members and a subkingdom Mucoromyceta,comprising Calcarisporiellomycota,Glomeromycota,Mortierellomycota and Mucoromycota,was erected to unite core zygomycetous fungi,phylogenetic relationships within phyla have not been well resolved.Taking account of the information of monophyly and divergence time estimated from ITS and LSU rDNA sequences,the present study updates the classification framework of the phylum Mucoromycota from the class down to the generic rank:three classes,three orders,20 families(including five new families Circinellaceae,Protomycocladaceae,Rhizomucoraceae,Syzygitaceae and Thermomucoraceae)and 64 genera.The taxonomic hierarchy was calibrated with estimated divergence times:phylum earlier than 617 Mya,classes and orders earlier than 547 Mya,families earlier than 199 Mya,and genera earlier than 12 Mya.Along with this outline,all genera of Mucoromycota are annotated and 58 new species are described.In addition,three new combinations are proposed.In this study,we update the taxonomic backbone of the phylum Mucoromycota and reinforce its phylogeny.We also contribute numerous new taxa and enrich the diversity of Mucoromycota.
文摘BACKGROUND Coronavirus disease 2019(COVID-19)patients who suffer severe infection or comorbidities have an increased risk of developing fungal infections.There is a possibility that such infections are missed or misdiagnosed,in which case patients may suffer higher morbidity and mortality.COVID-19 infection,aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal infections.Mucormycosis is one of the opportunistic fungal infections that may affect treated COVID patients.CASE SUMMARY We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 recovery.All the patients had diabetes and a history of systemic corticosteroids for treatment of COVID-19.The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5±14.5(7–30)d.All patients underwent debridement and were started on antifungal therapy.One patient was referred to a higher center for further management,but the others responded well to treatment and showed signs of improvement at the last follow-up.CONCLUSION Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival.
