目的了解血红蛋白New York（Hb New York）的血液学和分子特征，为地中海贫血筛查提供参考数据。方法采用毛细管电泳检测30691份样本，对筛查出Hb New York的携带样本分别进行DNA测序和血细胞分析，采用跨越缺口-PCR、反向斑点杂交方法...目的了解血红蛋白New York（Hb New York）的血液学和分子特征，为地中海贫血筛查提供参考数据。方法采用毛细管电泳检测30691份样本，对筛查出Hb New York的携带样本分别进行DNA测序和血细胞分析，采用跨越缺口-PCR、反向斑点杂交方法检测中国人常见的α和β珠蛋白基因突变类型。结果广西地区人群Hb New York的发生率为0．12％。32例单纯Hb New York杂合子红细胞平均体积（MCV）、红细胞平均血红蛋白含量（MCH）、HbNewYork和HbA：的含量为（91．00±5．19）n、（29．42±2．04）pg、（44．10±3．12）％、（2．80±0．29）％，4例HbNewY0rk合并SEA缺失杂合子为（68．20±5．26）fl、（21．78±2．15）Pg、（36．60±2．00）％、（2．90±0．14）％，2例Hb New York合并WS杂合子为（83．90±2．69）n、（27．70±1．70）pg、（39．70±1．70）％、（3．50±0．21）％，差异均有统计学意义（P值均〈0．05）。其中单纯Hb New York杂合子和Hb New York合并WS杂合子的HGB、MCV、MCH水平未见异常，而Hb New York合并SEA缺失杂合子表现轻度贫血或MCV、MCH降低。结论广西地区人群Hb New York以杂合子多见，未见纯合子。不同Hb New York杂合子血液学特征不同，单纯Hb New York杂合子血液学表型正常，合并其他类型地中海贫血时Hb New York可表现贫血。展开更多
目的对34例异常血红蛋白Hb New York患者进行基因诊断并分析其血液学特征。方法应用血常规检测和血红蛋白电泳对所有采集的外周血标本进行分析,使用gap-PCR、PCR-RDB和DNA测序方法对所有提取的DNA标本进行β珠蛋白基因的鉴定。结果经基...目的对34例异常血红蛋白Hb New York患者进行基因诊断并分析其血液学特征。方法应用血常规检测和血红蛋白电泳对所有采集的外周血标本进行分析,使用gap-PCR、PCR-RDB和DNA测序方法对所有提取的DNA标本进行β珠蛋白基因的鉴定。结果经基因检测,25例病例为单纯的Hb New York杂合子,其红细胞参数表现为正常或轻度降低,血红蛋白电泳提示43.9%~52.0%的Hb K异常带;1例为Hb New York合并β0-地中海贫血,表现为明显降低的红细胞参数和升高的Hb K(91.8%);8例为Hb New York合并α-地中海贫血,其血液学特征也有不同的改变。结论单纯的Hb New York杂合子无明显的临床表现,但合并其他地中海贫血时可改变其血液学特征。展开更多
This is a 54-year-old patient admitted for the management of urinary leakage through the anus that had been occurring for a month, in whom the diagnosis of a prostatorectal fistula was made. The fistula was successful...This is a 54-year-old patient admitted for the management of urinary leakage through the anus that had been occurring for a month, in whom the diagnosis of a prostatorectal fistula was made. The fistula was successfully treated by a transanorectal approach using the York Masson procedure.展开更多
Objective: This case report aimed to highlight intersections of TB and Cardiovasular diseases which carry high morbidity and mortality rates. Methods: We are reporting the surgical management of forty seven years fema...Objective: This case report aimed to highlight intersections of TB and Cardiovasular diseases which carry high morbidity and mortality rates. Methods: We are reporting the surgical management of forty seven years female who had back ground history of IDDM (Insulin dependent diabetic Mellitus), ESRD (End stage renal disease) on HD (haemodialysis) also she had left subclavian artery stenosis, and paroxysmal atrial fibrillation. She was diagnosed with mitral valve infective endocarditis and found accidently to have an open pulmonary tuberculosis (TB) on the day before surgery. Results: She was started on first line anti-TB treatment. She was isolated in her private room and airborne precautions measures applied. The patient underwent a tissue Mitral Valve replacement and tricuspid valve repair annuloplasty. Special precautions were applied in Theatre and on cardiopulmonary bypass Machine guided by KAMC-J disinfection protocol. The patient made good recovery postoperatively. She was discharged well on day 7 post operatively. Conclusion: Intersections of TB and cardiovasular diseases carry high morbidity and mortality rates. Early diagnosis and early anti tuberculosis treatment can surely improve the patient prognosis. Our decontamination and disinfective procedures are recommended. Cases like this should be monitored long term for the development of further cardiovascular complication.展开更多
Novelty pervades the biosphere.In some cases,potentially irreversible abiotic and/or biotic changes have led to the crossing of thresholds and thus the formation of“novel ecosystems.”Their widespread emergence(parti...Novelty pervades the biosphere.In some cases,potentially irreversible abiotic and/or biotic changes have led to the crossing of thresholds and thus the formation of“novel ecosystems.”Their widespread emergence(particularly on land)and the presence of continued environmental change challenge a traditional restoration goal of restoring an historical ecosystem.Instead,we argue that restoration could broaden its frame of reference to consider how novel ecosystems might be used to maintain global biodiversity and provide ecosystem services and,in doing so,save potentially wasted efforts in attempting to fulfil traditional goals.Here we explore this contention in more depth by addressing:Are novel ecosystems innovative planning or lowering the bar?We show that novel ecosystems were not innovative planning in their original conception.On the contrary,they were recognized as ecosystems that were recalcitrant to traditional restoration approaches,coupled with an awareness that they had arisen inadvertently through deliberate human activity,either on-or off-site.Their recalcitrance to traditional restoration suggests that alternative goals may exist for these ecosystems using sometimes innovative intervention.This management may include biodiversity conservation or restoration for ecological function.We elucidate the latter aspect with reference to an experiment in the wheatbelt of Western Australia—The Ridgefield Multiple Ecosystem Services Experiment—the design of which has been informed by ecological theory and the acceptance of novelty as an ecosystem component.Although novel ecosystems do provide opportunities to broaden restoration planning and practice,and ultimately maintain and conserve global biodiversity in this era of environmental change,they necessarily“lower the bar”in restoration if the bar is considered to be the historical ecosystem.However,in these times of flux,such a bar is increasingly untenable.Instead,careful and appropriate interventions are required at local,regional,and global scales.展开更多
In this paper, we build up a three-dimensional model for CO2 storage in the deep reservoir. And this paper gives the mathematical formalism of combined geochemical and multi-phase flow. The results give us the informa...In this paper, we build up a three-dimensional model for CO2 storage in the deep reservoir. And this paper gives the mathematical formalism of combined geochemical and multi-phase flow. The results give us the information about geochemical changing caused by CO2 injection into aqueous, the dissolution or precipitation of reservoir minerals caused by aqueous components change, the change of water density, also the differences between this model and the simulation model without considering geochemical. The basic data for simulation is from York Reservoir.展开更多
AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this stu...AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.展开更多
COVID-19 cripples the restaurant industry as a crucial socioeconomic sector that contributes immensely to the global economy.However,what the current literature less explored is to quantify the effect of COVID-19 on r...COVID-19 cripples the restaurant industry as a crucial socioeconomic sector that contributes immensely to the global economy.However,what the current literature less explored is to quantify the effect of COVID-19 on restaurant visitation and revenue at different spatial scales,as well as its relationship with the neighborhood character-istics of customers’origins.Based on the Point of Interest(POI)measures derived from SafeGraph data providing mobility records of 45 million cell phone users in the US,our study takes Lower Manhattan,New York City,as the pilot study,and aims to examine 1)the change of restaurant visitations and revenue in the period prior to and after the COVID-19 outbreak,2)the areas where restaurant customers live,and 3)the association between the neighborhood characteristics of these areas and lost customers.By doing so,we provide a geographic information system-based analytical frame-work integrating the big data mining,web crawling techniques,and spatial-economic modelling.Our analytical framework can be implemented to estimate the broader effect of COVID-19 on other industries and can be augmented in a financially monitoring manner in response to future pandemics or public emergencies.展开更多
The COVID-19 pandemic has ravaged global health and national economies worldwide.Testing and isolation are effective control strategies to mitigate the transmission of COVID-19,especially in the early stage of the dis...The COVID-19 pandemic has ravaged global health and national economies worldwide.Testing and isolation are effective control strategies to mitigate the transmission of COVID-19,especially in the early stage of the disease outbreak.In this paper,we develop a deterministic model to investigate the impact of testing and compliance with isolation on the transmission of COVID-19.We derive the control reproduction number R_(C),which gives the threshold for disease elimination or prevalence.Using data from New York State in the early stage of the disease outbreak,we estimate R_(C)=7:989.Both elasticity and sensitivity analyses show that testing and compliance with isolation are significant in reducing R_(C) and disease prevalence.Simulation reveals that only high testing volume combined with a large proportion of individuals complying with isolation have great impact on mitigating the transmission.The testing starting date is also crucial:the earlier testing is implemented,the more impact it has on reducing the infection.The results obtained here would also be helpful in developing guidelines of early control strategies for pandemics similar to COVID-19.展开更多
Saul Bellow’s novel Seize the Day combines the psychological narrative of Jewish immigrants in the“Happy Age”of the United States and the daily life narrative of modern New York urbanites,revealing the living state...Saul Bellow’s novel Seize the Day combines the psychological narrative of Jewish immigrants in the“Happy Age”of the United States and the daily life narrative of modern New York urbanites,revealing the living state of modern urbanites-powerless to the outside world,nowhere to live in the material and spiritual world.They have an unresolved personal pursuit and a“dangling”destiny,which alludes to the problems plaguing modern urban people and the decay of American society.By comparing the characteristics and fate of the protagonist Wilhelm with the character Job in the Bible,this article helps to deepen the understanding of the plights of the protagonist as“Modern Job”,and realize the influence of the American urban society on Jewishness and personal survival in that period.展开更多
SARS-CoV-2, a novel coronavirus that causes the human disease COVID-19, was determined to be the cause of a cluster of pneumonia cases in Wuhan, China which began in December 2019 [1]. The first case in the United Sta...SARS-CoV-2, a novel coronavirus that causes the human disease COVID-19, was determined to be the cause of a cluster of pneumonia cases in Wuhan, China which began in December 2019 [1]. The first case in the United States reportedly occurred on 20 January 2020 in Washington state in a patient with a history of travel to Wuhan [2]. We report an earlier case of COVID-19 in Queens, New York in November 2019. While it is not perfectly clear from the initial November 2019 emergency department case presentation, if the patient had influenza alone, COVID-19 alone, or combined influenza and COVID-19 infection, presenting lung lesions and constitutional symptoms, later follow-up antibody and immune cell analyses, and the possibility of false-positive RIDT, do strongly suggest initial COVID-19 infection (with or without initial influenza infection). This clinical paper becomes important, because it may describe the earliest now-reported COVID-19 case in the United States, and because emergency department and post-emergency department treatments contributed to a successful patient outcome.展开更多
Capillary zone electrophoresis (CZE) is a sensitive and rapid technique for determining traces of inorganic cations in water samples. CZE with indirect UV-diode array detection (CZE-DAD) was utilized to identify sever...Capillary zone electrophoresis (CZE) is a sensitive and rapid technique for determining traces of inorganic cations in water samples. CZE with indirect UV-diode array detection (CZE-DAD) was utilized to identify several inorganic cations in natural, potable, and wastewater samples. A pH 4.35 background electrolyte system was employed and consisted of 15 mM imidazole, 8 mM malonic acid, 2 mM 18-crown-6 ether as complexing agents, 10% v/v methanol as an organic modifier with indirect absorbance reference at 214 nm. The CZE method involved electromigration injection at 5 kV for 5 s, a separation voltage of 20 kV at 25℃, and a detection wavelength of 280 nm. Six main cations (ammonium , potassium K+, calcium Ca2+, sodium Na+, magnesium Mg2+, and lead Pb2+) were tested, and all but lead, were detected in the water samples at concentrations between 0.03 and 755 ppm with a detection limit ranging between 0.023 and 0.084 ppm. The successful evaluation of the proposed methodology allowed us to reliably detect and separate six metal ions in different water samples without any pretreatment. All water samples were collected from Northern New York towns and the Raquette River water system, the third longest river in New York State and the largest watershed of the central and western Adirondacks.展开更多
Background:Regulatory policy(RP)is known as a major factor to improve health care system performance.A significant difference in maternal mortality rates(MMRs)was observed between New York city(NYC)and Shanghai(SH),bo...Background:Regulatory policy(RP)is known as a major factor to improve health care system performance.A significant difference in maternal mortality rates(MMRs)was observed between New York city(NYC)and Shanghai(SH),both first-class international metropolises.This study aims to adopt a quantitative evaluation model to analyze whether RP differences contribute to the different MMRs of the two cities.Methods:Based on collection of all publicly released policy documents regarding maternal health in the two cities,we assessed and compared the status of their maternal health care RPs from 2006 to 2017 through a series of quantitative indicators as regulatory elements coverage rate(RECR),departmental responsibility clarity rate(DRCR),and accountability mechanism clarity rate(AMCR),based on two characteristics of comprehensiveness and effectiveness of RPs.Pearson correlation analysis,principal component analysis,and linear regression analysis were used to test the relationships between the indicators and MMR in SH and NYC.Results:By 2017,disparities of maternal health care RP are found between SH and NYC,from the indicators of RECR(100%vs.77.0%),DRCR(38.9%vs.45.1%),and AMCR(29.2%vs.22.5%).From 2006 to 2017,RECR,DRCR,and AMCR in SH have shown a higher growth of 8.7%,53.2%,and 45.2%,compared with growth of 25.0%,12.5%,and 2.9%in NYC.The three indicators were found all negatively correlated with MMR in SH(Coefficients=-0.831,-0.833,and-0.909,and P<0.01),while only RECR and DRCR had negative correlation with MMR in NYC(Coefficients=-0.736 and-0.683,and P<0.05).Linear regression showed that the principal components of the three indicators were found with significant impact on MMRs both in SH(R=0.914,R2=0.836,P<0.001)and NYC(R=0.854,R2=0.357,P=0.04).Conclusion:Compared with NYC,the more comprehensive and effective maternal health care RPs in SH had a stronger impact on MMR control,which contributed to the differences between the two cities’MMRs to some extent.The methods and indicators we adopted for assessment are reasonabl展开更多
Starting in the 1960s,a great deal of effort and capital was invested in an endeavor to significantlyimprove the quality of surface water around the United States,particularly in metropolises like New YorkCity,New Yor...Starting in the 1960s,a great deal of effort and capital was invested in an endeavor to significantlyimprove the quality of surface water around the United States,particularly in metropolises like New YorkCity,New York.The Hudson River has been at the forefront of these efforts and has benefited immenselyfrom this campaign.In parts of the developing world,such as China,similar efforts are beginning to gatherthe same type of momentum.Within the past decade,the Huangpu River,which flows through Shanghaiinto the Yangtze Estuary of China,has been a target for ecological restoration and management.It is possibleto draw parallels between the cleanup efforts involved in improving the environmental conditions of theHuangpu and Hudson Rivers.Using the methodologies of series comparison(SCM),water quality index(WQI)modeling,consideration of ecological engineering,and policy strategy design,we comparativelystudied the topography,functions,environmental conditions,ecological engineering countermeasures,andmanagement policies of the two rivers to assist future forecasting of ecological restoration efforts in China.展开更多
目的通过扩增阻滞突变系统PCR(ARMS-PCR)检测Hb New York病,并对阳性患者进行表型分析。方法用毛细管电泳筛查出可疑Hb New York患者,用ARMS-PCR和基因测序技术同时对可疑阳性患者进行检测,并对确诊患者进行表型分析。结果在23 026例标...目的通过扩增阻滞突变系统PCR(ARMS-PCR)检测Hb New York病,并对阳性患者进行表型分析。方法用毛细管电泳筛查出可疑Hb New York患者,用ARMS-PCR和基因测序技术同时对可疑阳性患者进行检测,并对确诊患者进行表型分析。结果在23 026例标本中共筛检出可疑Hb New York病例28例,用ARMS-PCR和基因测序技术确诊24例,二者吻合率达100%。结论 ARMS-PCR可快速检测Hb New York病,适于推广应用。展开更多
Two pieces of news reports on Yangtze Sunken Ship event are analyzed in this essay to prove the influence of context model in news reports discourse by comparative analysis approach. Through illustrating the different...Two pieces of news reports on Yangtze Sunken Ship event are analyzed in this essay to prove the influence of context model in news reports discourse by comparative analysis approach. Through illustrating the different expressions in these reports discourse, the process how cognition(or context model) influences and determines the production and understanding of discourse has been demonstrated.展开更多
文摘目的了解血红蛋白New York（Hb New York）的血液学和分子特征，为地中海贫血筛查提供参考数据。方法采用毛细管电泳检测30691份样本，对筛查出Hb New York的携带样本分别进行DNA测序和血细胞分析，采用跨越缺口-PCR、反向斑点杂交方法检测中国人常见的α和β珠蛋白基因突变类型。结果广西地区人群Hb New York的发生率为0．12％。32例单纯Hb New York杂合子红细胞平均体积（MCV）、红细胞平均血红蛋白含量（MCH）、HbNewYork和HbA：的含量为（91．00±5．19）n、（29．42±2．04）pg、（44．10±3．12）％、（2．80±0．29）％，4例HbNewY0rk合并SEA缺失杂合子为（68．20±5．26）fl、（21．78±2．15）Pg、（36．60±2．00）％、（2．90±0．14）％，2例Hb New York合并WS杂合子为（83．90±2．69）n、（27．70±1．70）pg、（39．70±1．70）％、（3．50±0．21）％，差异均有统计学意义（P值均〈0．05）。其中单纯Hb New York杂合子和Hb New York合并WS杂合子的HGB、MCV、MCH水平未见异常，而Hb New York合并SEA缺失杂合子表现轻度贫血或MCV、MCH降低。结论广西地区人群Hb New York以杂合子多见，未见纯合子。不同Hb New York杂合子血液学特征不同，单纯Hb New York杂合子血液学表型正常，合并其他类型地中海贫血时Hb New York可表现贫血。
文摘目的对34例异常血红蛋白Hb New York患者进行基因诊断并分析其血液学特征。方法应用血常规检测和血红蛋白电泳对所有采集的外周血标本进行分析,使用gap-PCR、PCR-RDB和DNA测序方法对所有提取的DNA标本进行β珠蛋白基因的鉴定。结果经基因检测,25例病例为单纯的Hb New York杂合子,其红细胞参数表现为正常或轻度降低,血红蛋白电泳提示43.9%~52.0%的Hb K异常带;1例为Hb New York合并β0-地中海贫血,表现为明显降低的红细胞参数和升高的Hb K(91.8%);8例为Hb New York合并α-地中海贫血,其血液学特征也有不同的改变。结论单纯的Hb New York杂合子无明显的临床表现,但合并其他地中海贫血时可改变其血液学特征。
文摘This is a 54-year-old patient admitted for the management of urinary leakage through the anus that had been occurring for a month, in whom the diagnosis of a prostatorectal fistula was made. The fistula was successfully treated by a transanorectal approach using the York Masson procedure.
文摘Objective: This case report aimed to highlight intersections of TB and Cardiovasular diseases which carry high morbidity and mortality rates. Methods: We are reporting the surgical management of forty seven years female who had back ground history of IDDM (Insulin dependent diabetic Mellitus), ESRD (End stage renal disease) on HD (haemodialysis) also she had left subclavian artery stenosis, and paroxysmal atrial fibrillation. She was diagnosed with mitral valve infective endocarditis and found accidently to have an open pulmonary tuberculosis (TB) on the day before surgery. Results: She was started on first line anti-TB treatment. She was isolated in her private room and airborne precautions measures applied. The patient underwent a tissue Mitral Valve replacement and tricuspid valve repair annuloplasty. Special precautions were applied in Theatre and on cardiopulmonary bypass Machine guided by KAMC-J disinfection protocol. The patient made good recovery postoperatively. She was discharged well on day 7 post operatively. Conclusion: Intersections of TB and cardiovasular diseases carry high morbidity and mortality rates. Early diagnosis and early anti tuberculosis treatment can surely improve the patient prognosis. Our decontamination and disinfective procedures are recommended. Cases like this should be monitored long term for the development of further cardiovascular complication.
基金We thank the Australian Research Council for funding,through a Laureate Fellowship to RJH.We also thank the organizers and participants at the Novel Ecosystems special session of the inaugural SERA Conference for comments on MPP’s presentation,where ideas featured in this paper were discussed.We especially thank Kris Hulvey for her willingness to share ideas featured in this manuscript and her comments on previous drafts.Finally,we appreciate the diligence and comments from two anonymous reviewers and P.Audet on a previous version of this manuscript.
文摘Novelty pervades the biosphere.In some cases,potentially irreversible abiotic and/or biotic changes have led to the crossing of thresholds and thus the formation of“novel ecosystems.”Their widespread emergence(particularly on land)and the presence of continued environmental change challenge a traditional restoration goal of restoring an historical ecosystem.Instead,we argue that restoration could broaden its frame of reference to consider how novel ecosystems might be used to maintain global biodiversity and provide ecosystem services and,in doing so,save potentially wasted efforts in attempting to fulfil traditional goals.Here we explore this contention in more depth by addressing:Are novel ecosystems innovative planning or lowering the bar?We show that novel ecosystems were not innovative planning in their original conception.On the contrary,they were recognized as ecosystems that were recalcitrant to traditional restoration approaches,coupled with an awareness that they had arisen inadvertently through deliberate human activity,either on-or off-site.Their recalcitrance to traditional restoration suggests that alternative goals may exist for these ecosystems using sometimes innovative intervention.This management may include biodiversity conservation or restoration for ecological function.We elucidate the latter aspect with reference to an experiment in the wheatbelt of Western Australia—The Ridgefield Multiple Ecosystem Services Experiment—the design of which has been informed by ecological theory and the acceptance of novelty as an ecosystem component.Although novel ecosystems do provide opportunities to broaden restoration planning and practice,and ultimately maintain and conserve global biodiversity in this era of environmental change,they necessarily“lower the bar”in restoration if the bar is considered to be the historical ecosystem.However,in these times of flux,such a bar is increasingly untenable.Instead,careful and appropriate interventions are required at local,regional,and global scales.
基金Supported by the National Natural Science Foundation of China （50904073） and CNPC Innovation Foundation （2008D-5006-02-06）.
文摘In this paper, we build up a three-dimensional model for CO2 storage in the deep reservoir. And this paper gives the mathematical formalism of combined geochemical and multi-phase flow. The results give us the information about geochemical changing caused by CO2 injection into aqueous, the dissolution or precipitation of reservoir minerals caused by aqueous components change, the change of water density, also the differences between this model and the simulation model without considering geochemical. The basic data for simulation is from York Reservoir.
基金Supported by Grant-in-Aid for research by Kitasato University Medical Center,No.H25-0006 and the JSPS,KAKENHI,No.26670609 to Futawatari Nthe JSPS,KAKENHI,No.21700510 and No.17K16578,Takeda Science Foundation and Kitasato University Research Grant for Young Researchers to Fukuyama T
文摘AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.
基金This study was funded by the National Science Foundation(Grant#2028791).
文摘COVID-19 cripples the restaurant industry as a crucial socioeconomic sector that contributes immensely to the global economy.However,what the current literature less explored is to quantify the effect of COVID-19 on restaurant visitation and revenue at different spatial scales,as well as its relationship with the neighborhood character-istics of customers’origins.Based on the Point of Interest(POI)measures derived from SafeGraph data providing mobility records of 45 million cell phone users in the US,our study takes Lower Manhattan,New York City,as the pilot study,and aims to examine 1)the change of restaurant visitations and revenue in the period prior to and after the COVID-19 outbreak,2)the areas where restaurant customers live,and 3)the association between the neighborhood characteristics of these areas and lost customers.By doing so,we provide a geographic information system-based analytical frame-work integrating the big data mining,web crawling techniques,and spatial-economic modelling.Our analytical framework can be implemented to estimate the broader effect of COVID-19 on other industries and can be augmented in a financially monitoring manner in response to future pandemics or public emergencies.
基金The authors thank the Department of Mathematics at the University of Central Florida,which received funding through the NSF Grant DMS-2132585 to provide support to organize and participate in the“CBMS Conference:Interface of Mathe-matical Biology and linear Algebra"where this research was initiated and developedLN.was partially funded by the Charles Phelps Taft Research Center at the University of Cincinnati,the research of PvdD is partially supported by an NSERC DiscoveryGrant 2016-03677the research ofW.Z.is supported by Simons Foundation,Award Number:714029.
文摘The COVID-19 pandemic has ravaged global health and national economies worldwide.Testing and isolation are effective control strategies to mitigate the transmission of COVID-19,especially in the early stage of the disease outbreak.In this paper,we develop a deterministic model to investigate the impact of testing and compliance with isolation on the transmission of COVID-19.We derive the control reproduction number R_(C),which gives the threshold for disease elimination or prevalence.Using data from New York State in the early stage of the disease outbreak,we estimate R_(C)=7:989.Both elasticity and sensitivity analyses show that testing and compliance with isolation are significant in reducing R_(C) and disease prevalence.Simulation reveals that only high testing volume combined with a large proportion of individuals complying with isolation have great impact on mitigating the transmission.The testing starting date is also crucial:the earlier testing is implemented,the more impact it has on reducing the infection.The results obtained here would also be helpful in developing guidelines of early control strategies for pandemics similar to COVID-19.
文摘Saul Bellow’s novel Seize the Day combines the psychological narrative of Jewish immigrants in the“Happy Age”of the United States and the daily life narrative of modern New York urbanites,revealing the living state of modern urbanites-powerless to the outside world,nowhere to live in the material and spiritual world.They have an unresolved personal pursuit and a“dangling”destiny,which alludes to the problems plaguing modern urban people and the decay of American society.By comparing the characteristics and fate of the protagonist Wilhelm with the character Job in the Bible,this article helps to deepen the understanding of the plights of the protagonist as“Modern Job”,and realize the influence of the American urban society on Jewishness and personal survival in that period.
文摘SARS-CoV-2, a novel coronavirus that causes the human disease COVID-19, was determined to be the cause of a cluster of pneumonia cases in Wuhan, China which began in December 2019 [1]. The first case in the United States reportedly occurred on 20 January 2020 in Washington state in a patient with a history of travel to Wuhan [2]. We report an earlier case of COVID-19 in Queens, New York in November 2019. While it is not perfectly clear from the initial November 2019 emergency department case presentation, if the patient had influenza alone, COVID-19 alone, or combined influenza and COVID-19 infection, presenting lung lesions and constitutional symptoms, later follow-up antibody and immune cell analyses, and the possibility of false-positive RIDT, do strongly suggest initial COVID-19 infection (with or without initial influenza infection). This clinical paper becomes important, because it may describe the earliest now-reported COVID-19 case in the United States, and because emergency department and post-emergency department treatments contributed to a successful patient outcome.
文摘Capillary zone electrophoresis (CZE) is a sensitive and rapid technique for determining traces of inorganic cations in water samples. CZE with indirect UV-diode array detection (CZE-DAD) was utilized to identify several inorganic cations in natural, potable, and wastewater samples. A pH 4.35 background electrolyte system was employed and consisted of 15 mM imidazole, 8 mM malonic acid, 2 mM 18-crown-6 ether as complexing agents, 10% v/v methanol as an organic modifier with indirect absorbance reference at 214 nm. The CZE method involved electromigration injection at 5 kV for 5 s, a separation voltage of 20 kV at 25℃, and a detection wavelength of 280 nm. Six main cations (ammonium , potassium K+, calcium Ca2+, sodium Na+, magnesium Mg2+, and lead Pb2+) were tested, and all but lead, were detected in the water samples at concentrations between 0.03 and 755 ppm with a detection limit ranging between 0.023 and 0.084 ppm. The successful evaluation of the proposed methodology allowed us to reliably detect and separate six metal ions in different water samples without any pretreatment. All water samples were collected from Northern New York towns and the Raquette River water system, the third longest river in New York State and the largest watershed of the central and western Adirondacks.
基金funded by the Three-Year Action Plan of Shanghai Municipality Strengthens Public Health System Construction 2015-2017(No.GWIV-32)the National Natural Science Foundation Project(No.71774031)and the Health-related Major Social Risk Early Warning Collaborative Innovation Center Research Fund,a Sub-project of the National"Twelfth Five-Year"Science and Technology Support(No.2014BAI08B01).
文摘Background:Regulatory policy(RP)is known as a major factor to improve health care system performance.A significant difference in maternal mortality rates(MMRs)was observed between New York city(NYC)and Shanghai(SH),both first-class international metropolises.This study aims to adopt a quantitative evaluation model to analyze whether RP differences contribute to the different MMRs of the two cities.Methods:Based on collection of all publicly released policy documents regarding maternal health in the two cities,we assessed and compared the status of their maternal health care RPs from 2006 to 2017 through a series of quantitative indicators as regulatory elements coverage rate(RECR),departmental responsibility clarity rate(DRCR),and accountability mechanism clarity rate(AMCR),based on two characteristics of comprehensiveness and effectiveness of RPs.Pearson correlation analysis,principal component analysis,and linear regression analysis were used to test the relationships between the indicators and MMR in SH and NYC.Results:By 2017,disparities of maternal health care RP are found between SH and NYC,from the indicators of RECR(100%vs.77.0%),DRCR(38.9%vs.45.1%),and AMCR(29.2%vs.22.5%).From 2006 to 2017,RECR,DRCR,and AMCR in SH have shown a higher growth of 8.7%,53.2%,and 45.2%,compared with growth of 25.0%,12.5%,and 2.9%in NYC.The three indicators were found all negatively correlated with MMR in SH(Coefficients=-0.831,-0.833,and-0.909,and P<0.01),while only RECR and DRCR had negative correlation with MMR in NYC(Coefficients=-0.736 and-0.683,and P<0.05).Linear regression showed that the principal components of the three indicators were found with significant impact on MMRs both in SH(R=0.914,R2=0.836,P<0.001)and NYC(R=0.854,R2=0.357,P=0.04).Conclusion:Compared with NYC,the more comprehensive and effective maternal health care RPs in SH had a stronger impact on MMR control,which contributed to the differences between the two cities’MMRs to some extent.The methods and indicators we adopted for assessment are reasonabl
基金supported by the Major Project Foundation of China National Social Science(14ZDB140)Fudan-UK Tyndall Foundat ion(FTC98503B03a,Urban Growth i1)+2 种基金the PhD Station Foundation Project of China National Education Minis-try(No.20060246024)the Scientific Innovation Project of Shanghai Municipal Education Commission(No.08ZZ03)the Youth Leadership Program(LINCS)of the State Department,USA,the Foundation of Foho Development Zone,Wujiang,Jiangshu,China,and the Think Tank Program of Fudan University(2015).
文摘Starting in the 1960s,a great deal of effort and capital was invested in an endeavor to significantlyimprove the quality of surface water around the United States,particularly in metropolises like New YorkCity,New York.The Hudson River has been at the forefront of these efforts and has benefited immenselyfrom this campaign.In parts of the developing world,such as China,similar efforts are beginning to gatherthe same type of momentum.Within the past decade,the Huangpu River,which flows through Shanghaiinto the Yangtze Estuary of China,has been a target for ecological restoration and management.It is possibleto draw parallels between the cleanup efforts involved in improving the environmental conditions of theHuangpu and Hudson Rivers.Using the methodologies of series comparison(SCM),water quality index(WQI)modeling,consideration of ecological engineering,and policy strategy design,we comparativelystudied the topography,functions,environmental conditions,ecological engineering countermeasures,andmanagement policies of the two rivers to assist future forecasting of ecological restoration efforts in China.
文摘目的通过扩增阻滞突变系统PCR(ARMS-PCR)检测Hb New York病,并对阳性患者进行表型分析。方法用毛细管电泳筛查出可疑Hb New York患者,用ARMS-PCR和基因测序技术同时对可疑阳性患者进行检测,并对确诊患者进行表型分析。结果在23 026例标本中共筛检出可疑Hb New York病例28例,用ARMS-PCR和基因测序技术确诊24例,二者吻合率达100%。结论 ARMS-PCR可快速检测Hb New York病,适于推广应用。
文摘Two pieces of news reports on Yangtze Sunken Ship event are analyzed in this essay to prove the influence of context model in news reports discourse by comparative analysis approach. Through illustrating the different expressions in these reports discourse, the process how cognition(or context model) influences and determines the production and understanding of discourse has been demonstrated.
