目的 分析2013—2022年苏州市2型糖尿病流行趋势和归因于室外PM_(2.5)的2型糖尿病早死寿命损失。方法 选取死亡数、死亡率、早死寿命损失年(years of early life lost,YLL)和每千人寿命损失年(YLL率)指标,应用全球疾病负担研究2021年(GB...目的 分析2013—2022年苏州市2型糖尿病流行趋势和归因于室外PM_(2.5)的2型糖尿病早死寿命损失。方法 选取死亡数、死亡率、早死寿命损失年(years of early life lost,YLL)和每千人寿命损失年(YLL率)指标,应用全球疾病负担研究2021年(GBD 2021)数据,结合苏州市2型糖尿病死亡信息进行分析。结果 2013—2022年苏州市因2型糖尿病导致的死亡人数、死亡率、YLL和YLL率出现上升趋势,归因PM_(2.5)的2型糖尿病死亡人数、YLL和YLL率同样呈现上升趋势(P<0.001)。归因于PM_(2.5)的2型糖尿病死亡人数合计3 887例,YLL为61 974人年,YLL率为0.89‰。结论 2型糖尿病严重威胁了苏州市居民健康,归因于室外PM_(2.5)的疾病负担呈现不断上升趋势,针对2型糖尿病开展三级预防和改善空气质量对提高居民健康有重要意义。展开更多
目的胃癌是我国高发高致死的一类消化系统恶性肿瘤,对社会和个人造成了沉重的疾病负担。为更全面了解胃癌,本研究分析了我国肿瘤登记地区胃癌的死亡和寿命损失模式,为我国胃癌的防控和预测工作提供依据。方法利用国家肿瘤登记中心发布的...目的胃癌是我国高发高致死的一类消化系统恶性肿瘤,对社会和个人造成了沉重的疾病负担。为更全面了解胃癌,本研究分析了我国肿瘤登记地区胃癌的死亡和寿命损失模式,为我国胃癌的防控和预测工作提供依据。方法利用国家肿瘤登记中心发布的《2016年中国肿瘤登记年报》中的胃癌相关数据,计算胃癌年龄别、性别和城乡死亡率以及潜在减寿年(potential years of life lost,PYLL)和早死所致寿命损失(years of life lost,YLL)等指标。结果2013年中国胃癌死亡率为24.1/10^5,中标率为14.9/10^5,世标率为14.8/10^5,男性高于女性、农村高于城市,均P<0.05。胃癌造成PYLL率为1.5/千人,标化PYLL率为1.1/千人。PYLL随年龄增加不断升高。男性PYLL高出女性约2.1倍,农村约为城市的1.2倍。胃癌的YLL率为2.9/千人,标化YLL率为2.2/千人。YLL随年龄增加先升后降,在70~<80岁达到高峰。男性YLL高出女性约2.0倍,农村约为城市的1.3倍。结论中国胃癌死亡情况严峻,“早死”现象在男性和农村地区较严重,胃癌寿命损失存在年龄、性别和城乡差异。展开更多
Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billio...Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.展开更多
目的对2012—2021年归因于大气细颗粒物(fine particulate matter,PM_(2.5))暴露的苏州市脑卒中疾病负担进行分析。方法采用2019年全球疾病负担研究(global burden of disease 2019,GBD2019)数据,分析死亡数、死亡率、早死寿命损失年(ye...目的对2012—2021年归因于大气细颗粒物(fine particulate matter,PM_(2.5))暴露的苏州市脑卒中疾病负担进行分析。方法采用2019年全球疾病负担研究(global burden of disease 2019,GBD2019)数据,分析死亡数、死亡率、早死寿命损失年(years of life lost,YLL)和每千人寿命损失年(YLL率)来分析归因于PM_(2.5)的苏州市脑卒中早死寿命损失情况。结果2012—2021年苏州市25岁以上人群因脑卒中导致的死亡人数、死亡率、YLL和YLL率均呈现上升趋势(均P<0.01);归因于PM_(2.5)的脑卒中死亡人数累计26513例,YLL为402215人年,YLL率为7.45‰,均为男性显著高于女性。随着年份的增加,归因PM_(2.5)的脑卒中死亡人数、YLL和YLL率均呈现下降趋势(均P<0.01)。如果苏州市维持在国家一级标准水平(15μg/m^(3)),则在过去10年可以减少脑卒中死亡13541人、YLL 201689人年。结论归因于PM_(2.5)的脑卒中寿命损失严重危害苏州市居民健康,其疾病负担在不同性别、年龄人群中存在差异。随着大气PM_(2.5)不断降低,归因于PM_(2.5)的脑卒中疾病负担不断下降,进一步改善空气质量对提高居民健康具有重要意义。展开更多
Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related ...Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related excess mortality remain understudied.In particular,the effects of climate change on aging populations have not been well studied,and may result in significantly underestimation of heat effects.In this study,we took four climate change scenarios of Tier-1 in CMIP6,which were combinations of Shared Socioeconomic Pathways(SSPs)and Representative Concentration Pathways(RCPs).We used the exposure-response functions derived from previous studies combined with baseline age-specific non-accidental mortality rates to project heat-related excess mortality.Then,we employed the Logarithmic Mean Divisia Index(LMDI)method to decompose the impacts of climate change,population growth,and aging on heat-related excess mortality.Finally,we multiplied the heat-related Years of Life Lost(YLL)with the Value of a Statistical Life Year(VSLY)to quantify the economic burden of premature mortality.We found that the heat-related excess mortality would be concentrated in central China and in the densely populated south-eastern coastal regions.When aging is considered,heat-related excess mortality will become 2.8–6.7 times than that without considering aging in 2081–2100 under different scenarios.The contribution analysis showed that the effect of aging on heat-related deaths would be much higher than that of climate change.Our findings highlighted that aging would lead to a severe increase of heat-related deaths and suggesting that regional-specific policies should be formulated in response to heat-related risks.展开更多
Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high cos...Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high costs. Accurate projections of diabetes burden are essential for health planning so the aim of this study was to calculate the burden of diabetes in Razavikhorasan population, in Iran. Methodology: We used Disability Adjusted Life Years (DALYs) index using computer model (DisMod) for assessment of burden of diabetes and complications in Razavikhorasan province in Iran in year 2010-2011. Results: Burden of diabetes in Razavikhorasan population was 64,733 DALY in year 2010-2011. The total Years Life Lost (YLL) from diabetes mellitus was 62,883 (34,216 in men and 28,667 in women) due to premature death and the total Years Life Disability (YLD) was 1850. Conclusion: Diabetes mellitus and lesser forms of glucose intolerance can now be found in almost every population and epidemiological evidences suggest that, without effective prevention and control programs, diabetes will continue to increase and therefore advances in all levels of prevention may help reduce the number of people with diabetes.展开更多
目的 掌握2012—2021年南京市浦口区居民伤害死亡及因早死导致的疾病负担情况,为制定防控策略提供依据。方法 应用Excel 2007、SPSS 20.0计算伤害粗死亡率、标化死亡率、过早死亡损失寿命年(years of life lost, YLL)、YLL率、平均减寿...目的 掌握2012—2021年南京市浦口区居民伤害死亡及因早死导致的疾病负担情况,为制定防控策略提供依据。方法 应用Excel 2007、SPSS 20.0计算伤害粗死亡率、标化死亡率、过早死亡损失寿命年(years of life lost, YLL)、YLL率、平均减寿年(average years of lifelost, AYLL)等指标,运用Joinpoint模型计算以上指标的年度变化百分比(APC)。结果 2012—2021年浦口区伤害粗死亡率为37.61/10万,标化死亡率为31.15/10万。女性标化死亡率呈现上升趋势(APC=3.90%,t=4.57,P<0.01),男性伤害粗死亡率高于女性(χ^(2)=62.53,P<0.05)。全人群前3位伤害死亡率为运输事故、跌落和自杀,男性运输事故粗死亡率高于女性(χ^(2)=105.63,P<0.05);女性跌落粗死亡率高于男性(χ^(2)=13.37,P<0.05);跌落的标化死亡率呈逐年上升趋势(APC=12.10%,t=4.80,P<0.01)。伤害死亡率随年龄增长呈上升趋势(χ^(2)_(趋势)=1 977.71,P<0.01),前3位伤害死因0~14岁组为溺水、运输事故和意外窒息,15~44岁组为运输事故、自杀和溺水,45~64岁组为运输事故、自杀和跌落,≥65岁组为跌落、运输事故和自杀。导致的YLL为72 476人年,YLL率为10.77‰,女性YLL呈逐年上升趋势(APC=3.62%,t=4.07,P<0.01)。2012—2021年浦口区居民伤害死亡导致的AYLL为22.14人年,男性(APC=-5.40%,t=-6.80,P<0.01)和女性(APC=-4.80%,t=-3.11,P=0.01)的AYLL均呈现下降趋势。结论 伤害给浦口区居民健康带来严重的疾病负担,应加大老年人和儿童伤害预防干预投入,降低伤害事件、致残及死亡的发生。展开更多
文摘目的 分析2013—2022年苏州市2型糖尿病流行趋势和归因于室外PM_(2.5)的2型糖尿病早死寿命损失。方法 选取死亡数、死亡率、早死寿命损失年(years of early life lost,YLL)和每千人寿命损失年(YLL率)指标,应用全球疾病负担研究2021年(GBD 2021)数据,结合苏州市2型糖尿病死亡信息进行分析。结果 2013—2022年苏州市因2型糖尿病导致的死亡人数、死亡率、YLL和YLL率出现上升趋势,归因PM_(2.5)的2型糖尿病死亡人数、YLL和YLL率同样呈现上升趋势(P<0.001)。归因于PM_(2.5)的2型糖尿病死亡人数合计3 887例,YLL为61 974人年,YLL率为0.89‰。结论 2型糖尿病严重威胁了苏州市居民健康,归因于室外PM_(2.5)的疾病负担呈现不断上升趋势,针对2型糖尿病开展三级预防和改善空气质量对提高居民健康有重要意义。
文摘目的胃癌是我国高发高致死的一类消化系统恶性肿瘤,对社会和个人造成了沉重的疾病负担。为更全面了解胃癌,本研究分析了我国肿瘤登记地区胃癌的死亡和寿命损失模式,为我国胃癌的防控和预测工作提供依据。方法利用国家肿瘤登记中心发布的《2016年中国肿瘤登记年报》中的胃癌相关数据,计算胃癌年龄别、性别和城乡死亡率以及潜在减寿年(potential years of life lost,PYLL)和早死所致寿命损失(years of life lost,YLL)等指标。结果2013年中国胃癌死亡率为24.1/10^5,中标率为14.9/10^5,世标率为14.8/10^5,男性高于女性、农村高于城市,均P<0.05。胃癌造成PYLL率为1.5/千人,标化PYLL率为1.1/千人。PYLL随年龄增加不断升高。男性PYLL高出女性约2.1倍,农村约为城市的1.2倍。胃癌的YLL率为2.9/千人,标化YLL率为2.2/千人。YLL随年龄增加先升后降,在70~<80岁达到高峰。男性YLL高出女性约2.0倍,农村约为城市的1.3倍。结论中国胃癌死亡情况严峻,“早死”现象在男性和农村地区较严重,胃癌寿命损失存在年龄、性别和城乡差异。
文摘Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.
文摘目的对2012—2021年归因于大气细颗粒物(fine particulate matter,PM_(2.5))暴露的苏州市脑卒中疾病负担进行分析。方法采用2019年全球疾病负担研究(global burden of disease 2019,GBD2019)数据,分析死亡数、死亡率、早死寿命损失年(years of life lost,YLL)和每千人寿命损失年(YLL率)来分析归因于PM_(2.5)的苏州市脑卒中早死寿命损失情况。结果2012—2021年苏州市25岁以上人群因脑卒中导致的死亡人数、死亡率、YLL和YLL率均呈现上升趋势(均P<0.01);归因于PM_(2.5)的脑卒中死亡人数累计26513例,YLL为402215人年,YLL率为7.45‰,均为男性显著高于女性。随着年份的增加,归因PM_(2.5)的脑卒中死亡人数、YLL和YLL率均呈现下降趋势(均P<0.01)。如果苏州市维持在国家一级标准水平(15μg/m^(3)),则在过去10年可以减少脑卒中死亡13541人、YLL 201689人年。结论归因于PM_(2.5)的脑卒中寿命损失严重危害苏州市居民健康,其疾病负担在不同性别、年龄人群中存在差异。随着大气PM_(2.5)不断降低,归因于PM_(2.5)的脑卒中疾病负担不断下降,进一步改善空气质量对提高居民健康具有重要意义。
基金supported by the National Natural Science Foundation of China(No.72091514)the Energy Foundation(No.G-2206-33982)+1 种基金the Tsinghua-Toyota Joint Research Fund,Wellcome Trust(No.209734/Z/17/Z)the GEIGC Science and Technology Project in the framework of the“Research on Comprehensive Path Evaluation Methods and Practical Models for the Synergetic Development of Global Energy,Atmospheric Environment and Human Health”(No.SGGEIG00JYJS2100056).
文摘Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related excess mortality remain understudied.In particular,the effects of climate change on aging populations have not been well studied,and may result in significantly underestimation of heat effects.In this study,we took four climate change scenarios of Tier-1 in CMIP6,which were combinations of Shared Socioeconomic Pathways(SSPs)and Representative Concentration Pathways(RCPs).We used the exposure-response functions derived from previous studies combined with baseline age-specific non-accidental mortality rates to project heat-related excess mortality.Then,we employed the Logarithmic Mean Divisia Index(LMDI)method to decompose the impacts of climate change,population growth,and aging on heat-related excess mortality.Finally,we multiplied the heat-related Years of Life Lost(YLL)with the Value of a Statistical Life Year(VSLY)to quantify the economic burden of premature mortality.We found that the heat-related excess mortality would be concentrated in central China and in the densely populated south-eastern coastal regions.When aging is considered,heat-related excess mortality will become 2.8–6.7 times than that without considering aging in 2081–2100 under different scenarios.The contribution analysis showed that the effect of aging on heat-related deaths would be much higher than that of climate change.Our findings highlighted that aging would lead to a severe increase of heat-related deaths and suggesting that regional-specific policies should be formulated in response to heat-related risks.
文摘Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high costs. Accurate projections of diabetes burden are essential for health planning so the aim of this study was to calculate the burden of diabetes in Razavikhorasan population, in Iran. Methodology: We used Disability Adjusted Life Years (DALYs) index using computer model (DisMod) for assessment of burden of diabetes and complications in Razavikhorasan province in Iran in year 2010-2011. Results: Burden of diabetes in Razavikhorasan population was 64,733 DALY in year 2010-2011. The total Years Life Lost (YLL) from diabetes mellitus was 62,883 (34,216 in men and 28,667 in women) due to premature death and the total Years Life Disability (YLD) was 1850. Conclusion: Diabetes mellitus and lesser forms of glucose intolerance can now be found in almost every population and epidemiological evidences suggest that, without effective prevention and control programs, diabetes will continue to increase and therefore advances in all levels of prevention may help reduce the number of people with diabetes.
文摘目的 掌握2012—2021年南京市浦口区居民伤害死亡及因早死导致的疾病负担情况,为制定防控策略提供依据。方法 应用Excel 2007、SPSS 20.0计算伤害粗死亡率、标化死亡率、过早死亡损失寿命年(years of life lost, YLL)、YLL率、平均减寿年(average years of lifelost, AYLL)等指标,运用Joinpoint模型计算以上指标的年度变化百分比(APC)。结果 2012—2021年浦口区伤害粗死亡率为37.61/10万,标化死亡率为31.15/10万。女性标化死亡率呈现上升趋势(APC=3.90%,t=4.57,P<0.01),男性伤害粗死亡率高于女性(χ^(2)=62.53,P<0.05)。全人群前3位伤害死亡率为运输事故、跌落和自杀,男性运输事故粗死亡率高于女性(χ^(2)=105.63,P<0.05);女性跌落粗死亡率高于男性(χ^(2)=13.37,P<0.05);跌落的标化死亡率呈逐年上升趋势(APC=12.10%,t=4.80,P<0.01)。伤害死亡率随年龄增长呈上升趋势(χ^(2)_(趋势)=1 977.71,P<0.01),前3位伤害死因0~14岁组为溺水、运输事故和意外窒息,15~44岁组为运输事故、自杀和溺水,45~64岁组为运输事故、自杀和跌落,≥65岁组为跌落、运输事故和自杀。导致的YLL为72 476人年,YLL率为10.77‰,女性YLL呈逐年上升趋势(APC=3.62%,t=4.07,P<0.01)。2012—2021年浦口区居民伤害死亡导致的AYLL为22.14人年,男性(APC=-5.40%,t=-6.80,P<0.01)和女性(APC=-4.80%,t=-3.11,P=0.01)的AYLL均呈现下降趋势。结论 伤害给浦口区居民健康带来严重的疾病负担,应加大老年人和儿童伤害预防干预投入,降低伤害事件、致残及死亡的发生。
