Background： Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma （NPC） patients. In this study, we evaluated the T cell response to melanoma-associated ...Background： Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma （NPC） patients. In this study, we evaluated the T cell response to melanoma-associated antigen （MAGE）-A1, MAGE-A3, or synovial sarcoma X-2 （SSX-2） in the peripheral blood of treatment-naive NPC patients. The relationship of responses among the three proteins and the human leukocyte antigen （HLA）-A types were analyzed to provide evidence of designing novel therapy. Methods： Sixty-one NPC patients admitted into the Tumor Hospital affiliated to the Xinjiang Medical University between March 2015 and July 2016 were enrolled. Mononuclear cells were isolated from the peripheral blood before any treatment. HLA-A alleles were typed with Sanger sequence-based typing technique. The T cell response to the MAGE-A1, MAGE-A3, or SSX-2 was evaluated with the Enzyme-Linked ImmunoSpot assay. Mann-Whitney U-test was used to compare the T cell responses from different groups. Spearman＇s rank correlation was used to analyze the relationship of T cell responses. Results： HLA-A＊02：01, A＊02：07, and A＊24：02 were the three most frequent alleles （18.9%, 12.3%, and 11.5%, respectively） among the 22 detected alleles. 31.1%, 19.7%, and 16.4% of the patients displayed MAGE-A1, MAGE-A3, or SSX-2-specific T cell response, respectively. The magnitudes of response to the three proteins were 32.5, 38.0, and 28.7 SFC/106 peripheral blood mononuclear cells, respectively. The T cell response against the three proteins correlated with each other to different extent. The percentage of A＊02：01 and A＊24：02 carriers were significantly higher in patients responding to any of the three proteins compared to the nonresponders. Conclusion： MAGE-A1, MAGE-A3, or SSX-2-specific T cell responses were detectable in a subgroup of NPC patients, the frequency and magnitude of which were correlated.展开更多
The recent discoveries of pulsed X-ray emission from three ultraluminous X-ray （ULX） sources have finally enabled us to recognize a subclass within the ULX class： the great pretenders, neutron stars （NSs） that ap...The recent discoveries of pulsed X-ray emission from three ultraluminous X-ray （ULX） sources have finally enabled us to recognize a subclass within the ULX class： the great pretenders, neutron stars （NSs） that appear to emit X-ray radiation at isotropic luminosities Lx = 7 × 10^39 erg s-1 _ 1 ×10^41 erg s-i only because their emissions are strongly beamed toward our direction and our sight lines are offset by only a few degrees from their magnetic-dipole axes. The three known pretenders appear to be stronger emitters than the presumed black holes of the ULX class, such as Holmberg II ＆ IX X-1, IC10 X-1 and NGC 300 X-1. For these three NSs, we have adopted a single reasonable assumption, that their brightest observed outbursts unfold at the Eddington rate, and we have calculated both their propeller states and their surface magnetic-field magnitudes. We find that the results are not at all different from those recently obtained for the Magellanic Be/X-ray pulsars： the three NSs reveal modest magnetic fields of about 0.3-0.4TG and beamed propeller-line X-ray luminosities of 1036 - 1037 erg s-1, substantially below the Eddington limit.展开更多
So far quite a few ultraluminous X-ray(ULX) pulsars have been discovered.In this work,we construct a super-Eddington,magnetic accretion disk model to estimate the dipole magnetic field of eight ULX pulsars based on th...So far quite a few ultraluminous X-ray(ULX) pulsars have been discovered.In this work,we construct a super-Eddington,magnetic accretion disk model to estimate the dipole magnetic field of eight ULX pulsars based on their observed spin-up variations and luminosities.We obtain two branches of dipole magnetic field solutions.They are distributed in the range of B-(0.156-64.5) × 10^(10) G and-(0.275-79.0) × 10^(13) G corresponding to the low-and high-B solutions respectively.The low magnetic field solutions correspond to the state that the neutron stars are far away from the spin equilibrium,and the high magnetic field solutions are close to the spin equilibrium.The ultra-strong magnetic fields derived in Be-type ULX pulsars imply that the accretion mode in Be-type ULX pulsars could be more complicated than in the persistent ULX pulsars and may not be accounted for by the magnetized accretion disk model.We suggest that the transition between the accretor and the propeller regimes may be used to distinguish between the low-and high-B magnetic field solutions in addition to the detection of the cyclotron resonance scattering features.展开更多
We examine systematically the observed X-ray luminosity jumps(or flares) from quiescent states in millisecond binary pulsars(MSBPs) and high-mass X-ray binary pulsars(HMXBPs). We rely on the published X-ray light curv...We examine systematically the observed X-ray luminosity jumps(or flares) from quiescent states in millisecond binary pulsars(MSBPs) and high-mass X-ray binary pulsars(HMXBPs). We rely on the published X-ray light curves of seven pulsars: four HMXBPs, two MSBPs and the ultraluminous X-ray pulsar M82 X-2. We discuss the physics of their flaring activities or lack thereof, paying special attention to their emission properties when they are found on the propeller line, inside the Corbet gap or near the light-cylinder barrier. We provide guiding principles for future interpretations of faint X-ray observations, as well as a method of constraining the propeller lines and the dipolar surface magnetic fields of pulsars using a variety of quiescent states. In the process, we clarify some disturbing inaccuracies that have made their way into the published literature.展开更多
Two-photon laser-induced fluorescence spectrum (TP-LIF) of NO is obtained with a Nd:YAG pumped optical parametric generator and amplifier as radiation source. Spectral intensity distribution shows that the electronic ...Two-photon laser-induced fluorescence spectrum (TP-LIF) of NO is obtained with a Nd:YAG pumped optical parametric generator and amplifier as radiation source. Spectral intensity distribution shows that the electronic transition moment for NO (A2 X2II) transition varies significantly with inter-nuclear distance. The variation relationship of the electronic transition moment versus inter-nuclear distance is deduced with polyminal fit procedure. The spontaneous radiative coefficients for NO (A2X2II) transition from v' = 0,1 are obtained by combing this transition moment variation with the measurements of spontaneous radiative lifetime.展开更多
The product rotational polarizations of reaction Li-SHF→LiF-kH at different collision energies, as well as at the different vibrational states and rotational states, are calculated by using the quasi-classical trajec...The product rotational polarizations of reaction Li-SHF→LiF-kH at different collision energies, as well as at the different vibrational states and rotational states, are calculated by using the quasi-classical trajectory method based on a new potential energy surface constructed by Aguado et al. [J. Chem. Phys. 119（2003） 10088]. We investigate the Mignment and the orientation of the product molecule by calculating the P（θr, φr） distribu- tions describing polar angle distribution, the P（θr） distributions describing the k-j＇ correlation and the P（φr） distributions describing the k-k＇-j＇ correlation. We also explore the dependence of reaction probabilities and cross sections on the rotational and vibrational quantum number of the title reaction. It is concluded that the vibrational state has more important impact on the angular distribution, reaction probability and cross section.展开更多
The potential energy curves （PECs） of BO molecule, including ∑^＋and ∏ symmetries with doublet spin multiplicities, are obtained employing multi-reference configuration interaction （MRCI） method and Dunning＇s c...The potential energy curves （PECs） of BO molecule, including ∑^＋and ∏ symmetries with doublet spin multiplicities, are obtained employing multi-reference configuration interaction （MRCI） method and Dunning＇s correlation consistent basis sets. The analytical potential energy functions （APEFs） are fitted using the Murrell-Sorbie （MS） function and the least square method. Based on the PECs, the spectroscopic constants of the states have been determined and compared with the theoretical and experimental results available to affirm the accuracy and liability of the calculations. The root-mean-square （RMS） errors between the fitted results and the ab initio values are too little in comparison with the chemical accuracy （349.755 cm^-1）. It is shown that the present APEFs are accurate and can display the interaction between the atoms well. The present APEFs can be used to construct more complicated APEF or do some dynamic investigations.展开更多
文摘Background： Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma （NPC） patients. In this study, we evaluated the T cell response to melanoma-associated antigen （MAGE）-A1, MAGE-A3, or synovial sarcoma X-2 （SSX-2） in the peripheral blood of treatment-naive NPC patients. The relationship of responses among the three proteins and the human leukocyte antigen （HLA）-A types were analyzed to provide evidence of designing novel therapy. Methods： Sixty-one NPC patients admitted into the Tumor Hospital affiliated to the Xinjiang Medical University between March 2015 and July 2016 were enrolled. Mononuclear cells were isolated from the peripheral blood before any treatment. HLA-A alleles were typed with Sanger sequence-based typing technique. The T cell response to the MAGE-A1, MAGE-A3, or SSX-2 was evaluated with the Enzyme-Linked ImmunoSpot assay. Mann-Whitney U-test was used to compare the T cell responses from different groups. Spearman＇s rank correlation was used to analyze the relationship of T cell responses. Results： HLA-A＊02：01, A＊02：07, and A＊24：02 were the three most frequent alleles （18.9%, 12.3%, and 11.5%, respectively） among the 22 detected alleles. 31.1%, 19.7%, and 16.4% of the patients displayed MAGE-A1, MAGE-A3, or SSX-2-specific T cell response, respectively. The magnitudes of response to the three proteins were 32.5, 38.0, and 28.7 SFC/106 peripheral blood mononuclear cells, respectively. The T cell response against the three proteins correlated with each other to different extent. The percentage of A＊02：01 and A＊24：02 carriers were significantly higher in patients responding to any of the three proteins compared to the nonresponders. Conclusion： MAGE-A1, MAGE-A3, or SSX-2-specific T cell responses were detectable in a subgroup of NPC patients, the frequency and magnitude of which were correlated.
基金DMC,SGTL and RC were supported by NASA grant NNX14-AF77GDK was supported by a NASA ADAP grant
文摘The recent discoveries of pulsed X-ray emission from three ultraluminous X-ray （ULX） sources have finally enabled us to recognize a subclass within the ULX class： the great pretenders, neutron stars （NSs） that appear to emit X-ray radiation at isotropic luminosities Lx = 7 × 10^39 erg s-1 _ 1 ×10^41 erg s-i only because their emissions are strongly beamed toward our direction and our sight lines are offset by only a few degrees from their magnetic-dipole axes. The three known pretenders appear to be stronger emitters than the presumed black holes of the ULX class, such as Holmberg II ＆ IX X-1, IC10 X-1 and NGC 300 X-1. For these three NSs, we have adopted a single reasonable assumption, that their brightest observed outbursts unfold at the Eddington rate, and we have calculated both their propeller states and their surface magnetic-field magnitudes. We find that the results are not at all different from those recently obtained for the Magellanic Be/X-ray pulsars： the three NSs reveal modest magnetic fields of about 0.3-0.4TG and beamed propeller-line X-ray luminosities of 1036 - 1037 erg s-1, substantially below the Eddington limit.
基金supported by the National Key Research and Development Program of China (2016YFA0400803)the National Natural Science Foundation of China under grant Nos.11773015 and 10241301Project U1838201 supported by NSFC and CAS。
文摘So far quite a few ultraluminous X-ray(ULX) pulsars have been discovered.In this work,we construct a super-Eddington,magnetic accretion disk model to estimate the dipole magnetic field of eight ULX pulsars based on their observed spin-up variations and luminosities.We obtain two branches of dipole magnetic field solutions.They are distributed in the range of B-(0.156-64.5) × 10^(10) G and-(0.275-79.0) × 10^(13) G corresponding to the low-and high-B solutions respectively.The low magnetic field solutions correspond to the state that the neutron stars are far away from the spin equilibrium,and the high magnetic field solutions are close to the spin equilibrium.The ultra-strong magnetic fields derived in Be-type ULX pulsars imply that the accretion mode in Be-type ULX pulsars could be more complicated than in the persistent ULX pulsars and may not be accounted for by the magnetized accretion disk model.We suggest that the transition between the accretor and the propeller regimes may be used to distinguish between the low-and high-B magnetic field solutions in addition to the detection of the cyclotron resonance scattering features.
基金supported by NASA grant NNX14-AF77Gsupported by a NASA ADAP grant
文摘We examine systematically the observed X-ray luminosity jumps(or flares) from quiescent states in millisecond binary pulsars(MSBPs) and high-mass X-ray binary pulsars(HMXBPs). We rely on the published X-ray light curves of seven pulsars: four HMXBPs, two MSBPs and the ultraluminous X-ray pulsar M82 X-2. We discuss the physics of their flaring activities or lack thereof, paying special attention to their emission properties when they are found on the propeller line, inside the Corbet gap or near the light-cylinder barrier. We provide guiding principles for future interpretations of faint X-ray observations, as well as a method of constraining the propeller lines and the dipolar surface magnetic fields of pulsars using a variety of quiescent states. In the process, we clarify some disturbing inaccuracies that have made their way into the published literature.
基金This work was supported by the Natural Science Foun-dation of Hebei Province,China (Grant No,102090)
文摘Two-photon laser-induced fluorescence spectrum (TP-LIF) of NO is obtained with a Nd:YAG pumped optical parametric generator and amplifier as radiation source. Spectral intensity distribution shows that the electronic transition moment for NO (A2 X2II) transition varies significantly with inter-nuclear distance. The variation relationship of the electronic transition moment versus inter-nuclear distance is deduced with polyminal fit procedure. The spontaneous radiative coefficients for NO (A2X2II) transition from v' = 0,1 are obtained by combing this transition moment variation with the measurements of spontaneous radiative lifetime.
基金Supported by the National Natural Science Foundation of China under Grants No 11274205
文摘The product rotational polarizations of reaction Li-SHF→LiF-kH at different collision energies, as well as at the different vibrational states and rotational states, are calculated by using the quasi-classical trajectory method based on a new potential energy surface constructed by Aguado et al. [J. Chem. Phys. 119（2003） 10088]. We investigate the Mignment and the orientation of the product molecule by calculating the P（θr, φr） distribu- tions describing polar angle distribution, the P（θr） distributions describing the k-j＇ correlation and the P（φr） distributions describing the k-k＇-j＇ correlation. We also explore the dependence of reaction probabilities and cross sections on the rotational and vibrational quantum number of the title reaction. It is concluded that the vibrational state has more important impact on the angular distribution, reaction probability and cross section.
基金supported by the National Natural Science Foundation of China under Grant No. 10674114
文摘The potential energy curves （PECs） of BO molecule, including ∑^＋and ∏ symmetries with doublet spin multiplicities, are obtained employing multi-reference configuration interaction （MRCI） method and Dunning＇s correlation consistent basis sets. The analytical potential energy functions （APEFs） are fitted using the Murrell-Sorbie （MS） function and the least square method. Based on the PECs, the spectroscopic constants of the states have been determined and compared with the theoretical and experimental results available to affirm the accuracy and liability of the calculations. The root-mean-square （RMS） errors between the fitted results and the ab initio values are too little in comparison with the chemical accuracy （349.755 cm^-1）. It is shown that the present APEFs are accurate and can display the interaction between the atoms well. The present APEFs can be used to construct more complicated APEF or do some dynamic investigations.
