Stable lubrication is essential to slider/disk interface of computer hard disk drive. Inert lubricant perfluoropolyether (PFPE) on magnetic hard disk in computer is still prone to catalytic decomposition by Al_2O_3, w...Stable lubrication is essential to slider/disk interface of computer hard disk drive. Inert lubricant perfluoropolyether (PFPE) on magnetic hard disk in computer is still prone to catalytic decomposition by Al_2O_3, which is one of the materials in slider. A partial fluorinated hexaphenoxy cyclotriphosphazene chemical, X-1 P, was analyzed to research on its function to reduce the cata- lytic decomposition of lubricant. The surface free energy of X-1 P coated on head surface was also investigated. Contact start-stop (CSS) tester was employed to investigate the reflow effective of X-1 P on lubricant PFPE. Results indicate that thermal stability and reflow of lubricant will be im- proved in the presence of X-1 P on the slider.展开更多
以减毒鼠伤寒沙门菌X 4550为载体,构建编码缺失跨膜区和疏水区的山羊痘病毒P32基因的新型口服活载体D N A疫苗,通过体外传代培养、大剂量接种试验、免疫组织化学试验、ELISA等对其安全性、稳定性、免疫原性及免疫效果等进行综合检测评...以减毒鼠伤寒沙门菌X 4550为载体,构建编码缺失跨膜区和疏水区的山羊痘病毒P32基因的新型口服活载体D N A疫苗,通过体外传代培养、大剂量接种试验、免疫组织化学试验、ELISA等对其安全性、稳定性、免疫原性及免疫效果等进行综合检测评价。结果表明,X4550/pVAX1-P32在体外可稳定传代100代以上,小鼠口服1×10^(10)CF U X4550/pVAX1-P32后存活率为100%,接种后第10天仍能从脾中分离到X4550/pVAX1-P32,表明X4550/pVAX1-P32在体内外均具有良好的安全性和稳定性。免疫组织化学试验结果显示免疫小鼠脾细胞内有黄褐色粗颗粒,表明X4550能将pVAX1-P32有效递呈至免疫效应细胞并在其内表达具有生物活性的P32蛋白。ELISA结果显示,X4550/pVAX1-P32免疫组的抗体水平显著高于pVAX1-P32免疫组(0.01<P<0.05),且X4550/pVAX1-P32免疫组能诱导持续时间更长的抗体水平(P<0.01),表明活载体疫苗X4550/pVAX1-P32具有良好的免疫原性,能够诱导机体产生持久的、高水平的免疫应答,这为羊痘新型疫苗的研究和应用奠定了基础。展开更多
文摘Stable lubrication is essential to slider/disk interface of computer hard disk drive. Inert lubricant perfluoropolyether (PFPE) on magnetic hard disk in computer is still prone to catalytic decomposition by Al_2O_3, which is one of the materials in slider. A partial fluorinated hexaphenoxy cyclotriphosphazene chemical, X-1 P, was analyzed to research on its function to reduce the cata- lytic decomposition of lubricant. The surface free energy of X-1 P coated on head surface was also investigated. Contact start-stop (CSS) tester was employed to investigate the reflow effective of X-1 P on lubricant PFPE. Results indicate that thermal stability and reflow of lubricant will be im- proved in the presence of X-1 P on the slider.
文摘纳米技术在过去的几年里取得了巨大的进展.关注其两个主要方面:纳米级的薄膜润滑与纳米表面改性研究.薄膜润滑(thinfilmlubrication,TFL)的研究进展包括薄膜润滑测试技术、薄膜润滑的膜厚 工况相关特性、机理探索以及数学计算预测模型等方面.介绍了降低极尖沉降(pole tip recession,PTR)的技术,使用含有氮磷的环状化合物———X 1P来提高润滑剂的热稳定性的方法,以及使用纳米粒子的化学机械抛光技术.这些研究成果揭示了现代纳米技术的一些重要特征.
文摘以减毒鼠伤寒沙门菌X 4550为载体,构建编码缺失跨膜区和疏水区的山羊痘病毒P32基因的新型口服活载体D N A疫苗,通过体外传代培养、大剂量接种试验、免疫组织化学试验、ELISA等对其安全性、稳定性、免疫原性及免疫效果等进行综合检测评价。结果表明,X4550/pVAX1-P32在体外可稳定传代100代以上,小鼠口服1×10^(10)CF U X4550/pVAX1-P32后存活率为100%,接种后第10天仍能从脾中分离到X4550/pVAX1-P32,表明X4550/pVAX1-P32在体内外均具有良好的安全性和稳定性。免疫组织化学试验结果显示免疫小鼠脾细胞内有黄褐色粗颗粒,表明X4550能将pVAX1-P32有效递呈至免疫效应细胞并在其内表达具有生物活性的P32蛋白。ELISA结果显示,X4550/pVAX1-P32免疫组的抗体水平显著高于pVAX1-P32免疫组(0.01<P<0.05),且X4550/pVAX1-P32免疫组能诱导持续时间更长的抗体水平(P<0.01),表明活载体疫苗X4550/pVAX1-P32具有良好的免疫原性,能够诱导机体产生持久的、高水平的免疫应答,这为羊痘新型疫苗的研究和应用奠定了基础。
