Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness inc...Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness incisional wounds in the upper lips under ether anesthesia. Wound specimens were removedsuccessively 12,24,48,72h postwounding (PW) from fetus and 1,3,5,7d PW from adult rats for histologicalexamination. Results In the fetus, re-epithelialization of the skin wound was completed by 24h PW withoutapparent acute inflammatory response. Regenerated skin wound with normal architecture and elements wascompleted by 72h postoperation, indistinguishable from the surrounding normal skin. While in the adult rats, thewounds showed an acute inflammatory response resulting in thickened epithelia and scar formation. ConclusionFetal wound is characterized by rapid and eficient healing without scar formation followed by real skinregeneration.展开更多
文摘Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness incisional wounds in the upper lips under ether anesthesia. Wound specimens were removedsuccessively 12,24,48,72h postwounding (PW) from fetus and 1,3,5,7d PW from adult rats for histologicalexamination. Results In the fetus, re-epithelialization of the skin wound was completed by 24h PW withoutapparent acute inflammatory response. Regenerated skin wound with normal architecture and elements wascompleted by 72h postoperation, indistinguishable from the surrounding normal skin. While in the adult rats, thewounds showed an acute inflammatory response resulting in thickened epithelia and scar formation. ConclusionFetal wound is characterized by rapid and eficient healing without scar formation followed by real skinregeneration.
