目的:建立测定甲硝唑口腔粘贴片释放度的方法,并对不同公司样品测定的释放曲线进行比较。方法:采用流通池法闭环系统,以磷酸盐缓冲液(p H 6.6)为溶出介质,流速为4 ml·min^-1,在规定时间点取样后采用HPLC法测定。比较不同公司样品...目的:建立测定甲硝唑口腔粘贴片释放度的方法,并对不同公司样品测定的释放曲线进行比较。方法:采用流通池法闭环系统,以磷酸盐缓冲液(p H 6.6)为溶出介质,流速为4 ml·min^-1,在规定时间点取样后采用HPLC法测定。比较不同公司样品在流通池法和篮法下的释放度。结果:甲硝唑在6.024~100.400μg·ml^-1浓度范围内线性关系良好(r=0.999 9),平均回收率为99.5%,RSD为0.48%(n=9)。经Weibull方程拟合后,不同公司样品测定的释放度拟合参数差异有统计学意义(P<0.01)。结论:不同公司甲硝唑口腔粘贴片的释放度存在差异,本法可用于甲硝唑口腔粘贴片的释放度检查。展开更多
Due to the energy demand and lack of supplied energy of Palestinian cities, wind resource assessment is important and necessary. The objective of the work is to analyze the wind speed data characteristics and wind pow...Due to the energy demand and lack of supplied energy of Palestinian cities, wind resource assessment is important and necessary. The objective of the work is to analyze the wind speed data characteristics and wind power potential at eastern Jerusalem that are collected at 10 m above ground level from 2008 to 2018. The variations of monthly, seasonal, and annual wind speed are analyzed, and the measured maximum, minimum, and mean values are presented in this study. Wind speed characteristics have been analyzed by the well-known Weibull distribution function, and used to evaluate the wind power of the proposed site. Moreover, the relationship between wind power and mean wind speed is fitted by a second-order polynomial. The shape parameter moderate values showed that wind speed was relatively steady at the site. The highest average maximum value was found to be 5.7 m/s in June-2008, whereas the mean maximum values ranged from 5.4 m/s in June to 3.8 m/s in November. The highest mean power value was found to be 31.66 w/m<sup>2</sup> in July with a maximum value of 23.18 w/m<sup>2</sup> in 2013. R<sup>2</sup> of the polynomial fit provides values of 95% for monthly mean and 96% for annual mean.展开更多
文摘目的:建立测定甲硝唑口腔粘贴片释放度的方法,并对不同公司样品测定的释放曲线进行比较。方法:采用流通池法闭环系统,以磷酸盐缓冲液(p H 6.6)为溶出介质,流速为4 ml·min^-1,在规定时间点取样后采用HPLC法测定。比较不同公司样品在流通池法和篮法下的释放度。结果:甲硝唑在6.024~100.400μg·ml^-1浓度范围内线性关系良好(r=0.999 9),平均回收率为99.5%,RSD为0.48%(n=9)。经Weibull方程拟合后,不同公司样品测定的释放度拟合参数差异有统计学意义(P<0.01)。结论:不同公司甲硝唑口腔粘贴片的释放度存在差异,本法可用于甲硝唑口腔粘贴片的释放度检查。
文摘Due to the energy demand and lack of supplied energy of Palestinian cities, wind resource assessment is important and necessary. The objective of the work is to analyze the wind speed data characteristics and wind power potential at eastern Jerusalem that are collected at 10 m above ground level from 2008 to 2018. The variations of monthly, seasonal, and annual wind speed are analyzed, and the measured maximum, minimum, and mean values are presented in this study. Wind speed characteristics have been analyzed by the well-known Weibull distribution function, and used to evaluate the wind power of the proposed site. Moreover, the relationship between wind power and mean wind speed is fitted by a second-order polynomial. The shape parameter moderate values showed that wind speed was relatively steady at the site. The highest average maximum value was found to be 5.7 m/s in June-2008, whereas the mean maximum values ranged from 5.4 m/s in June to 3.8 m/s in November. The highest mean power value was found to be 31.66 w/m<sup>2</sup> in July with a maximum value of 23.18 w/m<sup>2</sup> in 2013. R<sup>2</sup> of the polynomial fit provides values of 95% for monthly mean and 96% for annual mean.
