The new hydroxyethyl starch,voluven(HES130/0.4),through optimization of substitutional level and molecular weight distribution,not only has good pharmacological characteristics such as broader clinical applications,hi...The new hydroxyethyl starch,voluven(HES130/0.4),through optimization of substitutional level and molecular weight distribution,not only has good pharmacological characteristics such as broader clinical applications,higher safety and fewer side effects,but also has the feature in some aspects just like micro-circulation and the supply of oxygen in tissue.So it makes promising prospects in clinical management of volume.This article summarized the security,the side effects,the unique pharmacological characteristics and clinical applications of voluven as well as liquid treatment.展开更多
目的:探讨体外受精-胚胎移植周期(IVF-ET)取卵日应用中药或万汶干预对预防卵巢过度刺激综合征(OHSS)及临床结局的影响。方法:采用前瞻性队列研究,将74例在本中心行IVF-ET或单精子卵胞浆内注射(ICSI-ET)的患者,在促排卵注射人绒毛膜促性...目的:探讨体外受精-胚胎移植周期(IVF-ET)取卵日应用中药或万汶干预对预防卵巢过度刺激综合征(OHSS)及临床结局的影响。方法:采用前瞻性队列研究,将74例在本中心行IVF-ET或单精子卵胞浆内注射(ICSI-ET)的患者,在促排卵注射人绒毛膜促性腺激素(HCG)日发现有OHSS高风险的妇女分为3组:中药组(24例)、万汶组(24例)和中药与万汶联合组(简称联合组,26例),取卵日开始中药组予温阳健脾中药(五苓散合五皮饮加味)共7 d,万汶组予万汶针每天500 m L,共3 d,联合组二者合用。比较这3组的实验室检查结果及临床结局,动态监测HCG注射日、取卵日、胚胎移植日的血清血管内皮生长因子(VEGF)、白介素-6(IL-6)及一氧化氮(NO)水平。结果:万汶组的临床妊娠率(为72.22%)高于中药组(为52.63%)和联合组(为58.82%),但差异无统计学意义(P>0.05)。3组均无重度OHSS发生,轻、中度的OHSS发生率差异无统计学意义(P>0.05),VEGF、IL-6和NO的变化趋势比较差异均无统计学意义(P>0.05)。结论:取卵日运用中药和万汶,均可避免重度OHSS的发生,测定VEGF、IL-6和NO的变化趋势相同,单独用万汶针则临床妊娠率有升高趋势,联合用药并没有改善临床和实验室结局。展开更多
文摘The new hydroxyethyl starch,voluven(HES130/0.4),through optimization of substitutional level and molecular weight distribution,not only has good pharmacological characteristics such as broader clinical applications,higher safety and fewer side effects,but also has the feature in some aspects just like micro-circulation and the supply of oxygen in tissue.So it makes promising prospects in clinical management of volume.This article summarized the security,the side effects,the unique pharmacological characteristics and clinical applications of voluven as well as liquid treatment.
文摘目的:探讨体外受精-胚胎移植周期(IVF-ET)取卵日应用中药或万汶干预对预防卵巢过度刺激综合征(OHSS)及临床结局的影响。方法:采用前瞻性队列研究,将74例在本中心行IVF-ET或单精子卵胞浆内注射(ICSI-ET)的患者,在促排卵注射人绒毛膜促性腺激素(HCG)日发现有OHSS高风险的妇女分为3组:中药组(24例)、万汶组(24例)和中药与万汶联合组(简称联合组,26例),取卵日开始中药组予温阳健脾中药(五苓散合五皮饮加味)共7 d,万汶组予万汶针每天500 m L,共3 d,联合组二者合用。比较这3组的实验室检查结果及临床结局,动态监测HCG注射日、取卵日、胚胎移植日的血清血管内皮生长因子(VEGF)、白介素-6(IL-6)及一氧化氮(NO)水平。结果:万汶组的临床妊娠率(为72.22%)高于中药组(为52.63%)和联合组(为58.82%),但差异无统计学意义(P>0.05)。3组均无重度OHSS发生,轻、中度的OHSS发生率差异无统计学意义(P>0.05),VEGF、IL-6和NO的变化趋势比较差异均无统计学意义(P>0.05)。结论:取卵日运用中药和万汶,均可避免重度OHSS的发生,测定VEGF、IL-6和NO的变化趋势相同,单独用万汶针则临床妊娠率有升高趋势,联合用药并没有改善临床和实验室结局。
