Objective:To study the differences in the body pain and trauma degree between uniportal and three-portal video-assisted thoracoscopic surgery for the treatment of lung cancer.Methods:A total of 108 patients with non-s...Objective:To study the differences in the body pain and trauma degree between uniportal and three-portal video-assisted thoracoscopic surgery for the treatment of lung cancer.Methods:A total of 108 patients with non-small cell lung cancer who received radical operation in our hospital between February 2013 and February 2016 were selected and divided into the uniportal group (n=52) who received uniportal video-assisted thoracoscopic surgery and the three-portal group (n=56) who received three-portal video-assisted thoracoscopic surgery after the operation methods and related laboratory results were reviewed. Before operation and 24 h after operation, the differences in serum levels of pain mediators, oxidative stress indexes and inflammation indexes were compared between the two groups of patients.Results: Before operation, the differences in serum levels of pain mediators, oxidative stress indexes and inflammation indexes were not statistically significant between the two groups of patients. 24 h after operation, serum pain mediators NE, DA and 5-HT levels of observation group were lower than those of control group;oxidative stress indexes MDA and O2- levels were lower than those of control group while SOD and GSH-Px levels were higher than those of control group;inflammation indexes IL-6, IL-8, CRP and TNF-α levels were lower than those of control group.Conclusion: Uniportal video-assisted thoracoscopic surgery for the treatment of lung cancer causes less surgery trauma, and patients' postoperative pain and systemic inflammatory stress response are lighter.展开更多
目的探讨右美托咪定对胸腔镜手术单肺通气(OLV)患者氧化应激状态的影响。方法将42例接受胸腔镜肺叶切除术的患者平均随机分为对照组及治疗组,其中治疗组在麻醉过程中给接受右美托咪定静脉注射治疗。收集患者血清及肺组织标本,检测OLV前...目的探讨右美托咪定对胸腔镜手术单肺通气(OLV)患者氧化应激状态的影响。方法将42例接受胸腔镜肺叶切除术的患者平均随机分为对照组及治疗组,其中治疗组在麻醉过程中给接受右美托咪定静脉注射治疗。收集患者血清及肺组织标本,检测OLV前,麻醉诱导开始后30及60 min血气指标;酶联免疫吸附法血清中C-反应蛋白(CRP)、丙二醛(MDA)及总抗氧化能力(T-AOC)水平;放射免疫法检测两组患者肺组织匀浆内黄嘌呤氧化酶(XOD),超氧化物歧化酶(SOD),髓过氧化物酶(MPO)以及过氧化氢酶(CAT)的水平。结果与对照组相比,治疗组患者OLV开始后60 min PaO2/FiO2显著升高(P<0.05);血清内CRP及MDA水平显著降低(P<0.05),T-AOC水平显著升高(P<0.05);与对照组相比,治疗组患者肺组织匀浆内XOD及MPO水平显著降低(P<0.05),而SOD及CAT水平显著升高(P<0.05)。结论右美托咪定能够通过改善氧合水平而显著降低胸腔镜手术单肺通气患者体内氧化应激程度。展开更多
基金Projects of Natural Science Foundation of China No:81373941.
文摘Objective:To study the differences in the body pain and trauma degree between uniportal and three-portal video-assisted thoracoscopic surgery for the treatment of lung cancer.Methods:A total of 108 patients with non-small cell lung cancer who received radical operation in our hospital between February 2013 and February 2016 were selected and divided into the uniportal group (n=52) who received uniportal video-assisted thoracoscopic surgery and the three-portal group (n=56) who received three-portal video-assisted thoracoscopic surgery after the operation methods and related laboratory results were reviewed. Before operation and 24 h after operation, the differences in serum levels of pain mediators, oxidative stress indexes and inflammation indexes were compared between the two groups of patients.Results: Before operation, the differences in serum levels of pain mediators, oxidative stress indexes and inflammation indexes were not statistically significant between the two groups of patients. 24 h after operation, serum pain mediators NE, DA and 5-HT levels of observation group were lower than those of control group;oxidative stress indexes MDA and O2- levels were lower than those of control group while SOD and GSH-Px levels were higher than those of control group;inflammation indexes IL-6, IL-8, CRP and TNF-α levels were lower than those of control group.Conclusion: Uniportal video-assisted thoracoscopic surgery for the treatment of lung cancer causes less surgery trauma, and patients' postoperative pain and systemic inflammatory stress response are lighter.
文摘目的探讨右美托咪定对胸腔镜手术单肺通气(OLV)患者氧化应激状态的影响。方法将42例接受胸腔镜肺叶切除术的患者平均随机分为对照组及治疗组,其中治疗组在麻醉过程中给接受右美托咪定静脉注射治疗。收集患者血清及肺组织标本,检测OLV前,麻醉诱导开始后30及60 min血气指标;酶联免疫吸附法血清中C-反应蛋白(CRP)、丙二醛(MDA)及总抗氧化能力(T-AOC)水平;放射免疫法检测两组患者肺组织匀浆内黄嘌呤氧化酶(XOD),超氧化物歧化酶(SOD),髓过氧化物酶(MPO)以及过氧化氢酶(CAT)的水平。结果与对照组相比,治疗组患者OLV开始后60 min PaO2/FiO2显著升高(P<0.05);血清内CRP及MDA水平显著降低(P<0.05),T-AOC水平显著升高(P<0.05);与对照组相比,治疗组患者肺组织匀浆内XOD及MPO水平显著降低(P<0.05),而SOD及CAT水平显著升高(P<0.05)。结论右美托咪定能够通过改善氧合水平而显著降低胸腔镜手术单肺通气患者体内氧化应激程度。
