Background Early and accurate assessment of right ventricular changes in patients with Chronic obstructive pulmonary disease(COPD)is of great value,because these changes are important factors affecting the prognosis o...Background Early and accurate assessment of right ventricular changes in patients with Chronic obstructive pulmonary disease(COPD)is of great value,because these changes are important factors affecting the prognosis of patients with COPD. This study aimed to investigate the changes of right ventricular structure and function by electrocardiography in COPD patients,and to evaluate the correlations of pulmonary function,COPD assessment test(CAT)score with the changes. Methods According to the"ABCD"2016 Global initiative for chronic obstructive pulmonary disease(GOLD)update,stable COPD patients were divided into four groups:GOLD A group,GOLD B group,GOLD C group,and GOLD D group. There were 30 patients of each group enrolled from December 2016 to December 2017 in Guangdong General Hospital. During the same period,30 physical examination volunteers were enrolled as the healthy control group. Pulmonary function and echocardiography were performed in all subjects. All COPD patients completed CAT test. One-way ANOVA and SNK-q test were used to analyze the differences in parameters of right ventricular structure and function between different GOLD groups and healthy controls. Pearson correlation analysis was used to analyze the relation between CAT score,forced expiratory volume in one second(FEV1)and echocardiographic parameters. Results Compared with control group,right ventricular wall thickness(RVWT)was significantly thicker in patients of GOLD A,B and C groups(P<0.001),but not for GOLD D group. In sharp contrast,only in the patients of GOLD D group,right ventricular basal diameter(RV basal diameter)and right ventricular outflow tract(RVOT)(2.84±0.56 cm and 4.63±0.54 cm)were significantly longer than those in healthy controls and other GOLD groups(P<0.001).The patients of GOLD C and D groups had higher E/A ratio and E/e′ ratio compared with control group,GOLD A and B groups(P<0.001). But only in GOLD D group,the fractional area change(FAC)and tricuspid annular plane systolic excursion(TAPSE)were decreased signifi展开更多
目的观察妊娠期高血压疾病(HDCP)患者的左心室结构和功能变化,并探讨其与新生儿生长发育的相关性。方法87例HDCP患者,其中66例妊娠期高血压患者(HDP组)、21例子痫前期患者(子痫前期组),另选择50例正常妊娠孕妇为对照组,超声心动图观察...目的观察妊娠期高血压疾病(HDCP)患者的左心室结构和功能变化,并探讨其与新生儿生长发育的相关性。方法87例HDCP患者,其中66例妊娠期高血压患者(HDP组)、21例子痫前期患者(子痫前期组),另选择50例正常妊娠孕妇为对照组,超声心动图观察三组左心室结构和功能,追踪其妊娠结局,记录新生儿出生5 min Apgar评分、出生体质量、头围和身长。Pearson相关性分析HDCP患者左心室结构和功能参数与新生儿Apgar评分、出生体质量、头围和身长的相关性。结果与HDP组、对照组比较,子痫前期组左心室舒张末期内径(LVEDD)、室间隔厚度(IVST)高,左心室舒张早期充盈峰最大充盈速度和舒张晚期充盈峰最大峰值速度(E/A)比值低(P<0.05);与对照组比较,HDP组E/A低(P均<0.05)。与HDP组、对照组比较,子痫前期组新生儿出生5 min Apgar评分、出生体质量、头围、身长低(P均<0.05)。子痫前期患者LVEDD与新生儿出生5 min Apgar评分、出生体质量呈负相关(P均<0.05),E/A比值与新生儿出生5 min Apgar评分、出生体质量呈正相关(P均<0.05)。结论HDCP患者尤其是子痫前期患者存在明显左心室结构和功能受损,左心室结构和功能受损与新生儿低出生体质量和Apgar评分有关。积极治疗HDCP保护患者心功能有助于改善新生儿结局。展开更多
基金supported by the National Nature Science Fund(No.81300034)
文摘Background Early and accurate assessment of right ventricular changes in patients with Chronic obstructive pulmonary disease(COPD)is of great value,because these changes are important factors affecting the prognosis of patients with COPD. This study aimed to investigate the changes of right ventricular structure and function by electrocardiography in COPD patients,and to evaluate the correlations of pulmonary function,COPD assessment test(CAT)score with the changes. Methods According to the"ABCD"2016 Global initiative for chronic obstructive pulmonary disease(GOLD)update,stable COPD patients were divided into four groups:GOLD A group,GOLD B group,GOLD C group,and GOLD D group. There were 30 patients of each group enrolled from December 2016 to December 2017 in Guangdong General Hospital. During the same period,30 physical examination volunteers were enrolled as the healthy control group. Pulmonary function and echocardiography were performed in all subjects. All COPD patients completed CAT test. One-way ANOVA and SNK-q test were used to analyze the differences in parameters of right ventricular structure and function between different GOLD groups and healthy controls. Pearson correlation analysis was used to analyze the relation between CAT score,forced expiratory volume in one second(FEV1)and echocardiographic parameters. Results Compared with control group,right ventricular wall thickness(RVWT)was significantly thicker in patients of GOLD A,B and C groups(P<0.001),but not for GOLD D group. In sharp contrast,only in the patients of GOLD D group,right ventricular basal diameter(RV basal diameter)and right ventricular outflow tract(RVOT)(2.84±0.56 cm and 4.63±0.54 cm)were significantly longer than those in healthy controls and other GOLD groups(P<0.001).The patients of GOLD C and D groups had higher E/A ratio and E/e′ ratio compared with control group,GOLD A and B groups(P<0.001). But only in GOLD D group,the fractional area change(FAC)and tricuspid annular plane systolic excursion(TAPSE)were decreased signifi
文摘目的观察妊娠期高血压疾病(HDCP)患者的左心室结构和功能变化,并探讨其与新生儿生长发育的相关性。方法87例HDCP患者,其中66例妊娠期高血压患者(HDP组)、21例子痫前期患者(子痫前期组),另选择50例正常妊娠孕妇为对照组,超声心动图观察三组左心室结构和功能,追踪其妊娠结局,记录新生儿出生5 min Apgar评分、出生体质量、头围和身长。Pearson相关性分析HDCP患者左心室结构和功能参数与新生儿Apgar评分、出生体质量、头围和身长的相关性。结果与HDP组、对照组比较,子痫前期组左心室舒张末期内径(LVEDD)、室间隔厚度(IVST)高,左心室舒张早期充盈峰最大充盈速度和舒张晚期充盈峰最大峰值速度(E/A)比值低(P<0.05);与对照组比较,HDP组E/A低(P均<0.05)。与HDP组、对照组比较,子痫前期组新生儿出生5 min Apgar评分、出生体质量、头围、身长低(P均<0.05)。子痫前期患者LVEDD与新生儿出生5 min Apgar评分、出生体质量呈负相关(P均<0.05),E/A比值与新生儿出生5 min Apgar评分、出生体质量呈正相关(P均<0.05)。结论HDCP患者尤其是子痫前期患者存在明显左心室结构和功能受损,左心室结构和功能受损与新生儿低出生体质量和Apgar评分有关。积极治疗HDCP保护患者心功能有助于改善新生儿结局。
