Several studies have investigated the association between CYP2C19 polymorphism and clinical outcomes of patients treated with clopidogrel, but few have noticed the difference in association between Westerners and Asia...Several studies have investigated the association between CYP2C19 polymorphism and clinical outcomes of patients treated with clopidogrel, but few have noticed the difference in association between Westerners and Asians. We searched MEDLINE, EMBASE and Cochrane Library database and conducted a systematic review and meta-analysis. Thirty-six studies involving 44 655 patients with coronary artery disease（CAD） treated with clopidogrel were included, of which more than 68% had undergone percutaneous coronary intervention（PCI）. The primary outcome of our interest was the recurrence of major adverse cardiovascular events（MACE） in those CAD patients. Firstly, we found that the distribution of reduced-function CYP2C19 allele varied between Westerners and Asians. Among Asians, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 42.5% and 10%, respectively. While among Westerners, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 25.5% and 2.4%, respectively. Secondly, the impact of CYP2C19 polymorphism on clinical outcomes of patients treated with clopidogrel varied with races. Among Asians, only 2 reduced-function CYP2C19 mutant allele carriers had the reduced effect of clopidogrel. And the reduced effect was significant only after the 30 th day of treatment. While among Westerners, both 1 and 2 reduced-function CYP2C19 allele carriers had the reduced effect, and it mainly occurred within the first 30 days. Thirdly, the safety of clopidogrel was almost the same among races. Reduced-function allele non-carriers had higher risk for total bleeding but did not have higher risk for major bleeding. It is suggested that CYP2C19 polymorphism affects the efficacy of clopidogrel differently among Westerners and Asians.展开更多
Finding clusters based on density represents a significant class of clustering algorithms.These methods can discover clusters of various shapes and sizes.The most studied algorithm in this class is theDensity-Based Sp...Finding clusters based on density represents a significant class of clustering algorithms.These methods can discover clusters of various shapes and sizes.The most studied algorithm in this class is theDensity-Based Spatial Clustering of Applications with Noise(DBSCAN).It identifies clusters by grouping the densely connected objects into one group and discarding the noise objects.It requires two input parameters:epsilon(fixed neighborhood radius)and MinPts(the lowest number of objects in epsilon).However,it can’t handle clusters of various densities since it uses a global value for epsilon.This article proposes an adaptation of the DBSCAN method so it can discover clusters of varied densities besides reducing the required number of input parameters to only one.Only user input in the proposed method is the MinPts.Epsilon on the other hand,is computed automatically based on statistical information of the dataset.The proposed method finds the core distance for each object in the dataset,takes the average of these distances as the first value of epsilon,and finds the clusters satisfying this density level.The remaining unclustered objects will be clustered using a new value of epsilon that equals the average core distances of unclustered objects.This process continues until all objects have been clustered or the remaining unclustered objects are less than 0.006 of the dataset’s size.The proposed method requires MinPts only as an input parameter because epsilon is computed from data.Benchmark datasets were used to evaluate the effectiveness of the proposed method that produced promising results.Practical experiments demonstrate that the outstanding ability of the proposed method to detect clusters of different densities even if there is no separation between them.The accuracy of the method ranges from 92%to 100%for the experimented datasets.展开更多
Lipid oxidation in salt-dried yellow croaker(Pseudosciaena polyactis) was evaluated during processing with commonly used analytical indices, such as the peroxide value(POV), the thiobarbituric acid reactive substances...Lipid oxidation in salt-dried yellow croaker(Pseudosciaena polyactis) was evaluated during processing with commonly used analytical indices, such as the peroxide value(POV), the thiobarbituric acid reactive substances(TBARS) value, and oxidative-relative lipoxygenase(LOX) activity. Additionally, fatty acids were analyzed using gas chromatography-mass spectrometry. Both POV and TBARS increased significantly(P < 0.05) at the rinsing stage. POV reached its peak value of 3.63 meq O_2 per kg sample at the drying stage, whereas TBARS constantly increased from 0.05 to 0.20 mg MDA per kg sample. Processing of salt-dried yellow croaker had an extremely significant(P < 0.01) effect on LOX activity. Twenty-six fatty acids were identified. Combined eicosapentaenoic acid(EPA; C20:5n3) and docosahexaenoic acid(DHA; C22:6n3) content varied between(19.20 ±0.37) mg g^(-1) and(23.45 ± 1.05) mg g^(-1). The polyunsaturated fatty acid/saturated fatty acid(PUFA/SFA) ratio in yellow croaker was 0.73–1.10, and the n-6/n-3 PUFA ratio was approximately 0.13–0.20. The contents of most fatty acids varied significantly(P <0.05) during the different processing stages, and these differences were caused by lipid oxidation. C18:0, C16:1n7, C19:0, and C22:6n3 showed clear changes in principle component one of a principle components analysis. These fatty acids are potential markers for evaluating lipid oxidation in fish muscle because there was a significant correlation between these markers and TBARS and LOX activity(P < 0.05) with Pearson's coefficients > 0.931.展开更多
Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying...Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying birds that were randomly allotted to dietary treatments. The four experimental diets had five replicates each and three birds per repli-cate. Diet 1 contained 14% crude protein (CP), while diet 2 contained 15% CP, diets 3 and 4 contained 16% and 17% CP respectively. The experimental birds were fed for 10 weeks and the data collected were statistically analysed. Apparent variations recorded for all the performance characteristics such as Egg number, Hen-day production, Feed Conversion Ratio (FCR) and weight gain were significantly different (p < 0.05). The best FCR value were recorded by birds fed 17% CP (3.45), while the highest weight gain mean value were also recorded by birds fed 17% CP value. Findings indicated a direct relationship between dietary crude protein values and performance.展开更多
Gas diffusion in the shale matrix has a dominant effect on late-stage production from shale gas reservoirs.However,adequate research on the mechanisms and contributions of gas diffusion for varied pore size population...Gas diffusion in the shale matrix has a dominant effect on late-stage production from shale gas reservoirs.However,adequate research on the mechanisms and contributions of gas diffusion for varied pore size populations in shale matrix under recreated in situ stress is lacking.We report gas-diffusion measurements under constant in situ stress but variable gas pressures for contrasting non-adsorbent(helium(He))and adsorbed(methane(CH_(4)))gases to investigate the impact of effective stress on the evolution of dominant mechanisms of diffusion.An intact sample replicates true pore-network topology and diffusion paths.An integrated diffusion model is proposed that combines the effects of slip flow,Knudsen flow,and surface diffusion to constrain the evolution of these flow regimes and their respective contributions to the observational data.Finally,a probability density function(PDF)is employed to separate the gas content distributions of macropores and micropores from the total gas content and to investigate gas contributions in various pores.The results reveal that the diffusion coefficients of both He and CH_(4) in macropores and micropores increase with gas pressure but decrease with increasing effective stress.The diffusion coefficients of He and CH_(4) are different in macropores but remain nearly the same in micropores.The diffusion coefficients of slip flow and surface diffusion increase with decreasing effective stress except for CH_(4) diffusion in the micropores,while the evolution of Knudsen diffusion shows the opposite trend.Slip flow plays a dominant role in He and CH_(4) diffusion within macropores(pore size 45 nm).Knudsen diffusion gradually becomes significant for He diffusion in the micropores(pore size 4 nm),conversely,for CH_(4) diffusion in the micropores,surface diffusion becomes significant.Related to gas production from reservoirs,the contributions of the micropores will increase gradually with the duration of gas recovery,indicating the significant role of gas diffusion in micropores to steady 展开更多
The disc cutters of shield machines exhibit unsatisfactory adaptability and performance during the soft–hard varied strata tunneling process.To analyze the rotation state,cutting performance,and adaptability of disc ...The disc cutters of shield machines exhibit unsatisfactory adaptability and performance during the soft–hard varied strata tunneling process.To analyze the rotation state,cutting performance,and adaptability of disc cutters during shield tunneling in soft–hard varied strata,the Holmquist Johnson Cook and Federal Highway Administration constitutive models are introduced to numerically simulate the failure process of materials on the excavation face and to calculate the load of disc cutters.Additionally,the parameters of the models are modified based on laboratory disc cutter excavation test results.The results of numerical calculation can reflect the load level and the behavior of the disc cutters during operation.The tangential loads of the disc cutters during the cutting of four typical soft-strata excavation face models are numerically calculated,thus providing reference values for the starting torque of the disc cutters.A greater penetration is suggested for soft-strata tunneling to allow the disc cutters to rotate smoothly and continuously as well as to guarantee a better cutting effect.The disc cutters in the center of the cutterhead should be specified with a lower starting torque to prevent uneven wear,rotation stagnation,cutterhead clogging,and other adverse phenomena.展开更多
High intensity focused ultrasound（HIFU） has shown a great promise in noninvasive cancer therapy. The impact of acoustic cavitation on the lesion formation induced by HIFU is investigated both experimentally and theo...High intensity focused ultrasound（HIFU） has shown a great promise in noninvasive cancer therapy. The impact of acoustic cavitation on the lesion formation induced by HIFU is investigated both experimentally and theoretically in transparent protein-containing gel and ex vivo liver tissue samples. A numerical model that accounts for nonlinear acoustic propagation and heat transfer is used to simulate the lesion formation induced by the thermal effect. The results showed that lesions could be induced in the samples exposed to HIFU with various acoustic pressures and pulse lengths. The measured areas of lesions formed in the lateral direction were comparable to the simulated results, while much larger discrepancy was observed between the experimental and simulated data for the areas of longitudinal lesion cross-section. Meanwhile,a series of stripe-wiped-off B-mode pictures were obtained by using a special imaging processing method so that HIFUinduced cavitation bubble activities could be monitored in real-time and quantitatively analyzed as the functions of acoustic pressure and pulse length. The results indicated that, unlike the lateral area of HIFU-induced lesion that was less affected by the cavitation activity, the longitudinal cross-section of HIFU-induced lesion was significantly influenced by the generation of cavitation bubbles through the temperature elevation resulting from HIFU exposures. Therefore, considering the clinical safety in HIFU treatments, more attention should be paid on the lesion formation in the longitudinal direction to avoid uncontrollable variation resulting from HIFU-induced cavitation activity.展开更多
Parts with varied curvature features play increasingly critical roles in engineering, and are often machined under high-speed continuous-path running mode to ensure the machining efficiency. However, the continuous-pa...Parts with varied curvature features play increasingly critical roles in engineering, and are often machined under high-speed continuous-path running mode to ensure the machining efficiency. However, the continuous-path running trajectory error is significant during high-feed-speed machining, which seriously restricts the machining precision for such parts with varied curvature features. In order to reduce the continuous-path running trajectory error without sacrificing the machining efficiency, a pre-compensation method for the trajectory error is proposed. Based on the formation mechanism of the continuous-path running trajectory error analyzed, this error is estimated in advance by approximating the desired toolpath with spline curves. Then, an iterative error pre-compensation method is presented. By machining with the regenerated toolpath after pre-compensation instead of the uncompensated toolpath, the continuous-path running trajectory error can be effectively decreased without the reduction of the feed speed. To demonstrate the feasibility of the proposed pre-compensation method, a heart curve toolpath that possesses varied curvature features is employed. Experimental results indicate that compared with the uncompensated processing trajectory, the maximum and average machining errors for the pre-compensated processing trajectory are reduced by 67.19% and 82.30%, respectively. An easy to implement solution for high efficiency and high precision machining of the parts with varied curvature features is provided.展开更多
Based on the model test of podded propulsor in straight forward motion, the paper presents the results of the effects of geometric parameters on the propulsive characteristics of podded propulsors in viscous flow. Thr...Based on the model test of podded propulsor in straight forward motion, the paper presents the results of the effects of geometric parameters on the propulsive characteristics of podded propulsors in viscous flow. Three main geometrical parameters, i.e. pod diameter, strut distance from the propeller plane, and the maximum thickness of strut are studied with systematically varied geometry while the parameters of propeller blades are fixed. The RANS approach is adopted to study the steady perfomaance using the Huent software package. While the interactions of the propeller blades with the pod and strut are time-dependent by nature, the mixing plane model is employed to predict the steady perfomlance. In considera- tion of the complexity, the research does not deal with the effects of the combination of such three main parameters.展开更多
This paper presents a semi-analytical method to solve one dimensional consolidation problem by taking consideration of varied compressibility of soil under cyclic loading. In the method, soil stratum is divided equall...This paper presents a semi-analytical method to solve one dimensional consolidation problem by taking consideration of varied compressibility of soil under cyclic loading. In the method, soil stratum is divided equally into n layers while load and consolidation time are also divided into small parts and time intervals accordingly. The problem of one-dimensional consolidation of soil stratum under cyclic loading can then be dealt with at each time interval as one-dimensional linear consolidation of multi-layered soils under constant loading. The compression or rebounding of each soil layer can be judged by the effective stress of the layer. When the effective stress is larger than that in the last time interval, the soil layer is compressed, and when it is smaller, the soil layer rebounds. Thus, appropriate compressibility can be chosen and the consolidation of the layered system can be analyzed by the available analytical linear consolidation theory. Based on the semi-analytical method, a computer program was developed and the behavior of one-dimensional consolidation of soil with varied compressibility under cyclic loading was investigated, and compared with the available consolidation theory which takes no consideration of varied compressibility of soil under cyclic loading. The results showed that by taking the variable compressibility into account, the rate of consolidation of soil was greater than the one predicted by conventional consolidation theory.展开更多
In the context of global carbon cycle management, accurate knowledge of carbon content in forests is a relevant issue in contemporary forest ecology. We measured the above-ground and soil carbon pools in the darkconif...In the context of global carbon cycle management, accurate knowledge of carbon content in forests is a relevant issue in contemporary forest ecology. We measured the above-ground and soil carbon pools in the darkconiferous boreal taiga. We compared measured carbon pools to those calculated from the forest inventory records containing volume stock and species composition data. The inventory data heavily underestimated the pools in the study area（Stolby State Nature Reserve, central Krasnoyarsk Territory, Russian Federation）. The carbon pool estimated from the forest inventory data varied from 25（t ha-1）（low-density stands） to 73（t ha-1）（highly stocked stands）. Our estimates ranged from 59（t ha-1）（lowdensity stands） to 147（t ha-1）（highly stocked stands）. Our values included living trees, standing deadwood, living cover, brushwood and litter. We found that the proportion of biomass carbon（living trees）： soil carbon varied from99：1 to 8：2 for fully stocked and low-density forest stands,respectively. This contradicts the common understanding that the biomass in the boreal forests represents only16–20 % of the total carbon pool, with the balance being the soil carbon pool.展开更多
The built-in electric fields within a varied doping GaAs photocathode may promote the transport of electrons from the bulk to the surface, thus the quantum efficiency of the cathode can be enhanced remarkably. But thi...The built-in electric fields within a varied doping GaAs photocathode may promote the transport of electrons from the bulk to the surface, thus the quantum efficiency of the cathode can be enhanced remarkably. But this enhancement, which might be due to the increase in either the number or the energy of electrons reaching the surface, is not clear at present. In this paper, the energy distributions of electrons in a varied doping photocathode and uniform doping photocathode before and after escaping from the cathode surface are analysed, and the number of electrons escaping from the surface in different cases is calculated for the two kinds of photocathodes. The results indicate that the varied doping structure can not only increase the number of electrons reaching the surface but also cause an offset of the electron energy distribution to high energy. That is the root reason for the enhancement of the quantum efficiency of a varied doping GaAs photocathode.展开更多
Monolithic integration of four 1.55-μm-range InGaAsP/InP distributed feedback （DFB） lasers using varied ridge width with a 4 x 1-multimode-interference （MMI） optical combiner and a semiconductor optical amplifier...Monolithic integration of four 1.55-μm-range InGaAsP/InP distributed feedback （DFB） lasers using varied ridge width with a 4 x 1-multimode-interference （MMI） optical combiner and a semiconductor optical amplifier （SOA） is demon- strated. The average output power and the threshold current are 1.8 mW and 35 mA, respectively, when the injection current of the SOA is 100 mA, with a side mode suppression ratio （SMSR） exceeding 40 dB. The four channels have a 1-nm average channel spacing and can operate separately or simultaneously.展开更多
Betula luminifera is a commercial tree species that is emerging as a new model system for tree genomics research. A draft genomic sequence is expected to be publicly available in the near future, which means that an e...Betula luminifera is a commercial tree species that is emerging as a new model system for tree genomics research. A draft genomic sequence is expected to be publicly available in the near future, which means that an explosion of gene expression studies awaits. Thus, the work of selecting appropriate reference genes for q PCR normalization in different tissues or under various experimental conditions is extremely valuable. In this study, ten candidate genes were analyzed in B. luminifera subjected to different abiotic stresses and at various flowering stages.The expression stability of these genes was evaluated using three distinct algorithms implemented using ge Norm,Norm Finder and Best Keeper. The best-ranked reference genes varied across different sample sets, though RPL39,MDH and EF1 a were determined as the most stable by the three programs among all tested samples. RPL39 and EF1 a should be appropriate for normalization in N-starved roots,while the combination of RPL39 and MDH should be appropriate for N-starved stems and EF1 a and MDH should be appropriate in N-starved leaves. In PEG-treated（osmotic） roots, MDH was the most suitable, whereas EF1 a was suitable for PEG-treated stems and leaves. TUA was also stably expressed levels in PEG-treated plants. The combination of RPL39 and TUB should be appropriate for heat-stressed leaves and flowering stage. For reference gene validation, the expression levels of SOD and NFYA-3were investigated. This work will be beneficial to future studies on gene expression under different abiotic stress conditions and flowering status in B. luminifera.展开更多
Platycladus orientalis is one of the most popular afforestation species and greening species for water management in arid and semi-arid regions of northern China. We applied various models to estimate and validate art...Platycladus orientalis is one of the most popular afforestation species and greening species for water management in arid and semi-arid regions of northern China. We applied various models to estimate and validate artificial P. orientalis forest evapotranspiration features with the goal of accurately estimating the water use of a P.orientalis plantation. The American Society of Civil Engineers Evapotranspiration–Penman–Monteith model（APM） and FAO56–Penman–Monteith model（FPM） are extensively applied for vegetation evapotranspiration estimation because their reliability has been validated by many scholars. The Priestley–Taylor model（PT） and Hargreaves model（HS） require only the daily maximum temperature,daily minimum temperature and solar radiation to estimate evapotranspiration and are thus widely applied to grasslands but not to forests. We used the Energy Balance Bowen Ratio（EBBR） system to validate the accuracy of the four models. The results indicated that：（1） Compared to the EBBR measurement annual value, APM was the most accurate, followed by FPM, and PT;（2） During the year, the accuracies of the four models varied. APM and FPM underestimated evapotranspiration during June, July and August, whereas PT and HS overestimated evapotranspiration during this period. In the rest of the year, the estimation accuracies were reversed;（3） An analysis of the possible reasons indicated that wind speed, air temperature and precipitation were the most important contributors.High temperatures were measured in June, July and August, which led to an overestimation by PT and HS because these two models only calculated the temperature and radiation without vegetation information. Underestimation also occurred when a low temperature was recorded. Though APM and FPM addressed both meteorological and vegetation factors, slight deviations still existed; and（4） The two models were modified based on EBBR-measured data. Relative humidity was introduced into PT, and parameter ‘‘A’�展开更多
We tackle the problem of a biped running over varied and unknown terrain.Running is a necessary skill for a biped moving fast,but it increases the challenge of dynamic balance,especially when a biped is running on var...We tackle the problem of a biped running over varied and unknown terrain.Running is a necessary skill for a biped moving fast,but it increases the challenge of dynamic balance,especially when a biped is running on varied terrain without terrain information(due to the difficulty and cost of obtaining the terrain information in a timely manner).To address this issue,a new dynamic indicator called the sustainable running criterion is developed.The main idea is to sustain a running motion without falling by maintaining the system states within a running-feasible set,instead of running on a periodic limit cycle gait in the traditional way.To meet the precondition of the criterion,the angular moment about the center of gravity(COG) is restrained close to zero at the end of the stance phase.Then to ensure a small state jump at touchdown on the unknown terrain,the velocity of the swing foot is restrained within a specific range at the end of the flight phase.Finally,the position and velocity of the COG are driven into the running-feasible set.A five-link biped with underactuated point foot is considered in simulations.It is able to run over upward and downward terrain with a height difference of 0.15 m,which shows the effectiveness of our control scheme.展开更多
基金supported by grants from National Natural Science Foundation of China(Nos.81371311 and 81101905)New Century Excellent Talents in University of China(No.NCET-10-0406)
文摘Several studies have investigated the association between CYP2C19 polymorphism and clinical outcomes of patients treated with clopidogrel, but few have noticed the difference in association between Westerners and Asians. We searched MEDLINE, EMBASE and Cochrane Library database and conducted a systematic review and meta-analysis. Thirty-six studies involving 44 655 patients with coronary artery disease（CAD） treated with clopidogrel were included, of which more than 68% had undergone percutaneous coronary intervention（PCI）. The primary outcome of our interest was the recurrence of major adverse cardiovascular events（MACE） in those CAD patients. Firstly, we found that the distribution of reduced-function CYP2C19 allele varied between Westerners and Asians. Among Asians, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 42.5% and 10%, respectively. While among Westerners, 1 and 2 reduced-function CYP2C19 mutant allele carriers accounted for 25.5% and 2.4%, respectively. Secondly, the impact of CYP2C19 polymorphism on clinical outcomes of patients treated with clopidogrel varied with races. Among Asians, only 2 reduced-function CYP2C19 mutant allele carriers had the reduced effect of clopidogrel. And the reduced effect was significant only after the 30 th day of treatment. While among Westerners, both 1 and 2 reduced-function CYP2C19 allele carriers had the reduced effect, and it mainly occurred within the first 30 days. Thirdly, the safety of clopidogrel was almost the same among races. Reduced-function allele non-carriers had higher risk for total bleeding but did not have higher risk for major bleeding. It is suggested that CYP2C19 polymorphism affects the efficacy of clopidogrel differently among Westerners and Asians.
基金The author extends his appreciation to theDeputyship forResearch&Innovation,Ministry of Education in Saudi Arabia for funding this research work through the project number(IFPSAU-2021/01/17758).
文摘Finding clusters based on density represents a significant class of clustering algorithms.These methods can discover clusters of various shapes and sizes.The most studied algorithm in this class is theDensity-Based Spatial Clustering of Applications with Noise(DBSCAN).It identifies clusters by grouping the densely connected objects into one group and discarding the noise objects.It requires two input parameters:epsilon(fixed neighborhood radius)and MinPts(the lowest number of objects in epsilon).However,it can’t handle clusters of various densities since it uses a global value for epsilon.This article proposes an adaptation of the DBSCAN method so it can discover clusters of varied densities besides reducing the required number of input parameters to only one.Only user input in the proposed method is the MinPts.Epsilon on the other hand,is computed automatically based on statistical information of the dataset.The proposed method finds the core distance for each object in the dataset,takes the average of these distances as the first value of epsilon,and finds the clusters satisfying this density level.The remaining unclustered objects will be clustered using a new value of epsilon that equals the average core distances of unclustered objects.This process continues until all objects have been clustered or the remaining unclustered objects are less than 0.006 of the dataset’s size.The proposed method requires MinPts only as an input parameter because epsilon is computed from data.Benchmark datasets were used to evaluate the effectiveness of the proposed method that produced promising results.Practical experiments demonstrate that the outstanding ability of the proposed method to detect clusters of different densities even if there is no separation between them.The accuracy of the method ranges from 92%to 100%for the experimented datasets.
基金the National Natural Science Foundation of China (Nos. 31371800 and 31571869)Earmarked Fund for Modern Agro-Industry Technology Research System (No. CARS-49-G27)Special Promotion of Guangdong Marine Fishery Science and Technology (Nos. A201301C01 and A201503)
文摘Lipid oxidation in salt-dried yellow croaker(Pseudosciaena polyactis) was evaluated during processing with commonly used analytical indices, such as the peroxide value(POV), the thiobarbituric acid reactive substances(TBARS) value, and oxidative-relative lipoxygenase(LOX) activity. Additionally, fatty acids were analyzed using gas chromatography-mass spectrometry. Both POV and TBARS increased significantly(P < 0.05) at the rinsing stage. POV reached its peak value of 3.63 meq O_2 per kg sample at the drying stage, whereas TBARS constantly increased from 0.05 to 0.20 mg MDA per kg sample. Processing of salt-dried yellow croaker had an extremely significant(P < 0.01) effect on LOX activity. Twenty-six fatty acids were identified. Combined eicosapentaenoic acid(EPA; C20:5n3) and docosahexaenoic acid(DHA; C22:6n3) content varied between(19.20 ±0.37) mg g^(-1) and(23.45 ± 1.05) mg g^(-1). The polyunsaturated fatty acid/saturated fatty acid(PUFA/SFA) ratio in yellow croaker was 0.73–1.10, and the n-6/n-3 PUFA ratio was approximately 0.13–0.20. The contents of most fatty acids varied significantly(P <0.05) during the different processing stages, and these differences were caused by lipid oxidation. C18:0, C16:1n7, C19:0, and C22:6n3 showed clear changes in principle component one of a principle components analysis. These fatty acids are potential markers for evaluating lipid oxidation in fish muscle because there was a significant correlation between these markers and TBARS and LOX activity(P < 0.05) with Pearson's coefficients > 0.931.
文摘Four diets were formulated to study the influence of varying crude protein levels on the performance, egg quality, serum and haematological characteristics at the first phase of laying cycle of sixty Bovan Nera laying birds that were randomly allotted to dietary treatments. The four experimental diets had five replicates each and three birds per repli-cate. Diet 1 contained 14% crude protein (CP), while diet 2 contained 15% CP, diets 3 and 4 contained 16% and 17% CP respectively. The experimental birds were fed for 10 weeks and the data collected were statistically analysed. Apparent variations recorded for all the performance characteristics such as Egg number, Hen-day production, Feed Conversion Ratio (FCR) and weight gain were significantly different (p < 0.05). The best FCR value were recorded by birds fed 17% CP (3.45), while the highest weight gain mean value were also recorded by birds fed 17% CP value. Findings indicated a direct relationship between dietary crude protein values and performance.
基金Open Foundation of National Energy shale gas R&D(experiment)center(2022-KFKT-12)the research delivered partial results under the support of the National Key R&D Program of China(2021YFC2902101)+2 种基金National Natural Science Foundation of China(12002081)the National Natural Science Foundation of China(Grant No.12002081)the 111 Project(B17009).
文摘Gas diffusion in the shale matrix has a dominant effect on late-stage production from shale gas reservoirs.However,adequate research on the mechanisms and contributions of gas diffusion for varied pore size populations in shale matrix under recreated in situ stress is lacking.We report gas-diffusion measurements under constant in situ stress but variable gas pressures for contrasting non-adsorbent(helium(He))and adsorbed(methane(CH_(4)))gases to investigate the impact of effective stress on the evolution of dominant mechanisms of diffusion.An intact sample replicates true pore-network topology and diffusion paths.An integrated diffusion model is proposed that combines the effects of slip flow,Knudsen flow,and surface diffusion to constrain the evolution of these flow regimes and their respective contributions to the observational data.Finally,a probability density function(PDF)is employed to separate the gas content distributions of macropores and micropores from the total gas content and to investigate gas contributions in various pores.The results reveal that the diffusion coefficients of both He and CH_(4) in macropores and micropores increase with gas pressure but decrease with increasing effective stress.The diffusion coefficients of He and CH_(4) are different in macropores but remain nearly the same in micropores.The diffusion coefficients of slip flow and surface diffusion increase with decreasing effective stress except for CH_(4) diffusion in the micropores,while the evolution of Knudsen diffusion shows the opposite trend.Slip flow plays a dominant role in He and CH_(4) diffusion within macropores(pore size 45 nm).Knudsen diffusion gradually becomes significant for He diffusion in the micropores(pore size 4 nm),conversely,for CH_(4) diffusion in the micropores,surface diffusion becomes significant.Related to gas production from reservoirs,the contributions of the micropores will increase gradually with the duration of gas recovery,indicating the significant role of gas diffusion in micropores to steady
基金The authors gratefully acknowledge the financial support provided by the National Key R&D Program of China(No.2020YFF0426370)the National Natural Science Foundation of China(Grant No.51978040).
文摘The disc cutters of shield machines exhibit unsatisfactory adaptability and performance during the soft–hard varied strata tunneling process.To analyze the rotation state,cutting performance,and adaptability of disc cutters during shield tunneling in soft–hard varied strata,the Holmquist Johnson Cook and Federal Highway Administration constitutive models are introduced to numerically simulate the failure process of materials on the excavation face and to calculate the load of disc cutters.Additionally,the parameters of the models are modified based on laboratory disc cutter excavation test results.The results of numerical calculation can reflect the load level and the behavior of the disc cutters during operation.The tangential loads of the disc cutters during the cutting of four typical soft-strata excavation face models are numerically calculated,thus providing reference values for the starting torque of the disc cutters.A greater penetration is suggested for soft-strata tunneling to allow the disc cutters to rotate smoothly and continuously as well as to guarantee a better cutting effect.The disc cutters in the center of the cutterhead should be specified with a lower starting torque to prevent uneven wear,rotation stagnation,cutterhead clogging,and other adverse phenomena.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11374155,11674173,11474001,11474161,81627802,and 81527803)Qing Lan Project,China
文摘High intensity focused ultrasound（HIFU） has shown a great promise in noninvasive cancer therapy. The impact of acoustic cavitation on the lesion formation induced by HIFU is investigated both experimentally and theoretically in transparent protein-containing gel and ex vivo liver tissue samples. A numerical model that accounts for nonlinear acoustic propagation and heat transfer is used to simulate the lesion formation induced by the thermal effect. The results showed that lesions could be induced in the samples exposed to HIFU with various acoustic pressures and pulse lengths. The measured areas of lesions formed in the lateral direction were comparable to the simulated results, while much larger discrepancy was observed between the experimental and simulated data for the areas of longitudinal lesion cross-section. Meanwhile,a series of stripe-wiped-off B-mode pictures were obtained by using a special imaging processing method so that HIFUinduced cavitation bubble activities could be monitored in real-time and quantitatively analyzed as the functions of acoustic pressure and pulse length. The results indicated that, unlike the lateral area of HIFU-induced lesion that was less affected by the cavitation activity, the longitudinal cross-section of HIFU-induced lesion was significantly influenced by the generation of cavitation bubbles through the temperature elevation resulting from HIFU exposures. Therefore, considering the clinical safety in HIFU treatments, more attention should be paid on the lesion formation in the longitudinal direction to avoid uncontrollable variation resulting from HIFU-induced cavitation activity.
基金Supported by National Natural Science Foundation of China(Grant Nos.51575087,51205041)Science Fund for Creative Research Groups(Grant No.51321004)+1 种基金Basic Research Foundation of Key Laboratory of Liaoning Educational Committee,China(Grant No.LZ2014003)Research Project of Ministry of Education of China(Grant No.113018A)
文摘Parts with varied curvature features play increasingly critical roles in engineering, and are often machined under high-speed continuous-path running mode to ensure the machining efficiency. However, the continuous-path running trajectory error is significant during high-feed-speed machining, which seriously restricts the machining precision for such parts with varied curvature features. In order to reduce the continuous-path running trajectory error without sacrificing the machining efficiency, a pre-compensation method for the trajectory error is proposed. Based on the formation mechanism of the continuous-path running trajectory error analyzed, this error is estimated in advance by approximating the desired toolpath with spline curves. Then, an iterative error pre-compensation method is presented. By machining with the regenerated toolpath after pre-compensation instead of the uncompensated toolpath, the continuous-path running trajectory error can be effectively decreased without the reduction of the feed speed. To demonstrate the feasibility of the proposed pre-compensation method, a heart curve toolpath that possesses varied curvature features is employed. Experimental results indicate that compared with the uncompensated processing trajectory, the maximum and average machining errors for the pre-compensated processing trajectory are reduced by 67.19% and 82.30%, respectively. An easy to implement solution for high efficiency and high precision machining of the parts with varied curvature features is provided.
基金supported by the Fundamental Research Funds for the Central Universities (Grant No.HEUCFT1001)the"Knowledge-based Ship Design Hyper-Integrated Plat form(KSHIP)",a Key Project of the Ministry of Education and the Ministry of Finance of China
文摘Based on the model test of podded propulsor in straight forward motion, the paper presents the results of the effects of geometric parameters on the propulsive characteristics of podded propulsors in viscous flow. Three main geometrical parameters, i.e. pod diameter, strut distance from the propeller plane, and the maximum thickness of strut are studied with systematically varied geometry while the parameters of propeller blades are fixed. The RANS approach is adopted to study the steady perfomaance using the Huent software package. While the interactions of the propeller blades with the pod and strut are time-dependent by nature, the mixing plane model is employed to predict the steady perfomlance. In considera- tion of the complexity, the research does not deal with the effects of the combination of such three main parameters.
文摘This paper presents a semi-analytical method to solve one dimensional consolidation problem by taking consideration of varied compressibility of soil under cyclic loading. In the method, soil stratum is divided equally into n layers while load and consolidation time are also divided into small parts and time intervals accordingly. The problem of one-dimensional consolidation of soil stratum under cyclic loading can then be dealt with at each time interval as one-dimensional linear consolidation of multi-layered soils under constant loading. The compression or rebounding of each soil layer can be judged by the effective stress of the layer. When the effective stress is larger than that in the last time interval, the soil layer is compressed, and when it is smaller, the soil layer rebounds. Thus, appropriate compressibility can be chosen and the consolidation of the layered system can be analyzed by the available analytical linear consolidation theory. Based on the semi-analytical method, a computer program was developed and the behavior of one-dimensional consolidation of soil with varied compressibility under cyclic loading was investigated, and compared with the available consolidation theory which takes no consideration of varied compressibility of soil under cyclic loading. The results showed that by taking the variable compressibility into account, the rate of consolidation of soil was greater than the one predicted by conventional consolidation theory.
基金supported by Russian Foundation for Basic Research,research grant 14-05-00831
文摘In the context of global carbon cycle management, accurate knowledge of carbon content in forests is a relevant issue in contemporary forest ecology. We measured the above-ground and soil carbon pools in the darkconiferous boreal taiga. We compared measured carbon pools to those calculated from the forest inventory records containing volume stock and species composition data. The inventory data heavily underestimated the pools in the study area（Stolby State Nature Reserve, central Krasnoyarsk Territory, Russian Federation）. The carbon pool estimated from the forest inventory data varied from 25（t ha-1）（low-density stands） to 73（t ha-1）（highly stocked stands）. Our estimates ranged from 59（t ha-1）（lowdensity stands） to 147（t ha-1）（highly stocked stands）. Our values included living trees, standing deadwood, living cover, brushwood and litter. We found that the proportion of biomass carbon（living trees）： soil carbon varied from99：1 to 8：2 for fully stocked and low-density forest stands,respectively. This contradicts the common understanding that the biomass in the boreal forests represents only16–20 % of the total carbon pool, with the balance being the soil carbon pool.
基金supported by the National Natural Science Foundation of China (Grant No.60678043) the Research and Innovation Plan for Graduate Students of Jiangsu Higher Education Institutions of China (Grant No. CX09B-096Z)
文摘The built-in electric fields within a varied doping GaAs photocathode may promote the transport of electrons from the bulk to the surface, thus the quantum efficiency of the cathode can be enhanced remarkably. But this enhancement, which might be due to the increase in either the number or the energy of electrons reaching the surface, is not clear at present. In this paper, the energy distributions of electrons in a varied doping photocathode and uniform doping photocathode before and after escaping from the cathode surface are analysed, and the number of electrons escaping from the surface in different cases is calculated for the two kinds of photocathodes. The results indicate that the varied doping structure can not only increase the number of electrons reaching the surface but also cause an offset of the electron energy distribution to high energy. That is the root reason for the enhancement of the quantum efficiency of a varied doping GaAs photocathode.
基金Project supported by the National High Technology Research and Pevelopment Program of China (Grant Nos. 2011AA010303 and 2012AA012203)the National Basic Research Program of China (Grant No. 2011CB301702)the National Natural Science Foundation of China (Grant Nos. 61021003 and 61090392)
文摘Monolithic integration of four 1.55-μm-range InGaAsP/InP distributed feedback （DFB） lasers using varied ridge width with a 4 x 1-multimode-interference （MMI） optical combiner and a semiconductor optical amplifier （SOA） is demon- strated. The average output power and the threshold current are 1.8 mW and 35 mA, respectively, when the injection current of the SOA is 100 mA, with a side mode suppression ratio （SMSR） exceeding 40 dB. The four channels have a 1-nm average channel spacing and can operate separately or simultaneously.
基金financially supported by the National Natural Science Foundation of China(No.31300566)Zhejiang Province Science and Technology Support Program(No.2012C12908-8)
文摘Betula luminifera is a commercial tree species that is emerging as a new model system for tree genomics research. A draft genomic sequence is expected to be publicly available in the near future, which means that an explosion of gene expression studies awaits. Thus, the work of selecting appropriate reference genes for q PCR normalization in different tissues or under various experimental conditions is extremely valuable. In this study, ten candidate genes were analyzed in B. luminifera subjected to different abiotic stresses and at various flowering stages.The expression stability of these genes was evaluated using three distinct algorithms implemented using ge Norm,Norm Finder and Best Keeper. The best-ranked reference genes varied across different sample sets, though RPL39,MDH and EF1 a were determined as the most stable by the three programs among all tested samples. RPL39 and EF1 a should be appropriate for normalization in N-starved roots,while the combination of RPL39 and MDH should be appropriate for N-starved stems and EF1 a and MDH should be appropriate in N-starved leaves. In PEG-treated（osmotic） roots, MDH was the most suitable, whereas EF1 a was suitable for PEG-treated stems and leaves. TUA was also stably expressed levels in PEG-treated plants. The combination of RPL39 and TUB should be appropriate for heat-stressed leaves and flowering stage. For reference gene validation, the expression levels of SOD and NFYA-3were investigated. This work will be beneficial to future studies on gene expression under different abiotic stress conditions and flowering status in B. luminifera.
基金financially supported by the 131Talent project from Tianjin government(No.401008002)
文摘Platycladus orientalis is one of the most popular afforestation species and greening species for water management in arid and semi-arid regions of northern China. We applied various models to estimate and validate artificial P. orientalis forest evapotranspiration features with the goal of accurately estimating the water use of a P.orientalis plantation. The American Society of Civil Engineers Evapotranspiration–Penman–Monteith model（APM） and FAO56–Penman–Monteith model（FPM） are extensively applied for vegetation evapotranspiration estimation because their reliability has been validated by many scholars. The Priestley–Taylor model（PT） and Hargreaves model（HS） require only the daily maximum temperature,daily minimum temperature and solar radiation to estimate evapotranspiration and are thus widely applied to grasslands but not to forests. We used the Energy Balance Bowen Ratio（EBBR） system to validate the accuracy of the four models. The results indicated that：（1） Compared to the EBBR measurement annual value, APM was the most accurate, followed by FPM, and PT;（2） During the year, the accuracies of the four models varied. APM and FPM underestimated evapotranspiration during June, July and August, whereas PT and HS overestimated evapotranspiration during this period. In the rest of the year, the estimation accuracies were reversed;（3） An analysis of the possible reasons indicated that wind speed, air temperature and precipitation were the most important contributors.High temperatures were measured in June, July and August, which led to an overestimation by PT and HS because these two models only calculated the temperature and radiation without vegetation information. Underestimation also occurred when a low temperature was recorded. Though APM and FPM addressed both meteorological and vegetation factors, slight deviations still existed; and（4） The two models were modified based on EBBR-measured data. Relative humidity was introduced into PT, and parameter ‘‘A’�
基金Project supported by the National Natural Science Foundation of China （No. 61175106）
文摘We tackle the problem of a biped running over varied and unknown terrain.Running is a necessary skill for a biped moving fast,but it increases the challenge of dynamic balance,especially when a biped is running on varied terrain without terrain information(due to the difficulty and cost of obtaining the terrain information in a timely manner).To address this issue,a new dynamic indicator called the sustainable running criterion is developed.The main idea is to sustain a running motion without falling by maintaining the system states within a running-feasible set,instead of running on a periodic limit cycle gait in the traditional way.To meet the precondition of the criterion,the angular moment about the center of gravity(COG) is restrained close to zero at the end of the stance phase.Then to ensure a small state jump at touchdown on the unknown terrain,the velocity of the swing foot is restrained within a specific range at the end of the flight phase.Finally,the position and velocity of the COG are driven into the running-feasible set.A five-link biped with underactuated point foot is considered in simulations.It is able to run over upward and downward terrain with a height difference of 0.15 m,which shows the effectiveness of our control scheme.
