Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to as...Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to assess COVID-19 vaccine uptake and acceptance, and associated factors among selected community members in two states in southwestern Nigeria. Method: We conducted a cross-sectional study using a multistage sampling technique. Fifty catchment settlements of 10 health facilities in each of Oyo and Ogun States targeted for a COVID-19 infection prevention and control intervention were randomly selected. Four households were targeted per settlement. All households that refused access were replaced, to ensure a minimum of four households randomly selected per settlement. The primary household decision-maker was interviewed in each household. Information elicited included respondents’ sociodemographic characteristics, health history, knowledge, risk and benefit perception about the COVID-19 vaccine, vaccine uptake, and willingness to be vaccinated. The study was conducted from July–August 2021. Data were analyzed using SPSS IBM version 23. Result: Four hundred household decision-makers were surveyed in Oyo and Ogun states, after replacement. The mean age of the respondents was 43.0 ± 11.0 years. The majority, 346 (86.5%) had heard about COVID-19 vaccination, but only 47 (13.6%) had received a COVID-19 vaccination. Of the 299 respondents who reported not receiving a COVID-19 vaccination, 166 (55.5%) were willing to be vaccinated. In univariate analysis, respondents who were female had tertiary education, perceived that COVID-19 vaccines are free and accessible, perceived that COVID-19 vaccines have minimal side effects, and perceived higher benefits of COVID-19 vaccination had higher odds of being vaccinated. In contrast, younger respondents, respondents with higher knowledge scores on COVID-19 preventive measures, and with chronic illness had lower likelihoods of being vaccinated. In multivariate analy展开更多
Introduction: Pregnant women are a highly vulnerable population for COVID-19 with increased risk of hospitalization, intensive-care unit admission, invasive ventilation support, and mortality. Objective: This study de...Introduction: Pregnant women are a highly vulnerable population for COVID-19 with increased risk of hospitalization, intensive-care unit admission, invasive ventilation support, and mortality. Objective: This study determined the socio-demographic and economic factors associated with the uptake of COVID-19 vaccine among pregnant women utilizing antenatal care services in Pumwani Maternity Hospital, Nairobi County-Kenya. Methods: The study was carried out from 15 June to 23 July 2023. Systematic sampling was used to select 302 women from whom data was collected through face-to-face interviews using a pre-tested semi-structured questionnaire. Data was analyzed using SPSS software in which bivariate and multivariate logistic regression analyses were done at a significance level of p Results: A total of 302 pregnant women participated in the study. Of these, 105 (34.8%) were aged between twenty-six (26) and thirty (30) years. The mean age of the women was 28.60 ± (SD = 5.297). The uptake of the COVID-19 vaccine was 41.1%. The common side effects reported to be associated with the vaccines were fever, headache, joint pain, vomiting and skin rash. Uptake of the COVID-19 vaccine was significantly associated with being married (AOR = 3.65, 95% CI: 0.62 - 1.80, p = 0.001), having a secondary level of education (AOR = 3.78, 95% CI: 0.99 - 2.88, p = 0.001) and being employed (COR = 2.66, 95% CI: 1.31 - 3.06, p = 0.001). Conclusion: COVID-19 vaccination uptake remains low among pregnant women in seeking ANC in Nairobi. The individual factors associated with the uptake of COVID-19 vaccine among pregnant Women at Pumwani maternity hospital in Nairobi County were being married, having secondary level of education and being employed. Integration of the COVID-19 vaccine with other routine vaccinations as per the national immunization program in Kenya and the enhancement of education regarding the safety and efficacy of the COVID-19 vaccine in pregnancy and breastfeeding and economic empowerment of women are recommended.展开更多
Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane ves...Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction"(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4<not restricted to maturation via antibody modifying”(Normandy),thereby overcoming the MUO phenomenon.We also proved the applicability of this nanovaccine in identifying the human tumor neoantigens through rapid antigen display.In summary,this engineered OMV represents a powerful nanocarrier for personalized cancer vaccines,and this antibody modification strategy provides a reference to remodel the DC uptake pattern in nanocarrier design.展开更多
Objective:To examine COVID-19 vaccine uptake and its determinants among teenagers and their parents in Zhejiang,China.Methods:An online cross-sectional study was conducted among parents of teenagers in Zhejiang,China ...Objective:To examine COVID-19 vaccine uptake and its determinants among teenagers and their parents in Zhejiang,China.Methods:An online cross-sectional study was conducted among parents of teenagers in Zhejiang,China from May 1 to 31,2022.Data were interpreted via univariate and multivariate analyses using the statistical package for the social sciences(SPSS)program.Results:A total of 11115(96.11%)participants and 11449(99.00%)of their children in Zhejiang,China had been vaccinated against COVID-19.Children whose parents did not receive COVID-19 vaccination were 19 times(aOR 18.96,95%CI 12.36-29.08)more likely to be unvaccinated than their counterparts.In addition,children with no previous influenza vaccination,those whose parents doubted the COVID-19 vaccine’s safety or effectiveness,were 6.11 times(aOR 6.11,95%CI 2.80-13.34),8.27 times(aOR 8.27,95%CI 5.33-12.83),and 2.69 times(aOR 2.69,95%CI 1.11-6.50)more likely to be unvaccinated than their counterparts,respectively.COVID-19 vaccine uptake varied between different sociodemographic groups.However,the odds of receiving the COVID-19 vaccine decreased as age and education level increased.The main refusal reasons claimed by participants were that they had medical conditions that may not qualify them for vaccination(53.78%),followed by safety concerns about the vaccine(13.56%),not knowing where to get vaccinated(6.44%),and concerns about fertility issues(5.56%).Conclusions:Despite a highly encouraging level of COVID-19 vaccine uptake in Zhejiang,China,the elderly and highly educated people had lower COVID-19 vaccine uptake.It is suggested that tailored health education strategies should be taken to increase the COVID-19 vaccine uptake in such groups.Furthermore,with vaccination rates at such a high level,the pandemic is still ongoing,and public confidence in vaccines may decline.Thus,sufficient evidence-based information regarding COVID-19 vaccines should be provided to the public.展开更多
Rotavirus infection is recognized as a major cause of non-bacterial gastroenteritis infection affecting the stomach and intestinal tract in infants and young children worldwide leading to diarrhoea and vomiting. Most ...Rotavirus infection is recognized as a major cause of non-bacterial gastroenteritis infection affecting the stomach and intestinal tract in infants and young children worldwide leading to diarrhoea and vomiting. Most of the children would have had rotavirus infection by the time they are five years old. The disease is highly contagious and unpredictable as it can lead to dehydration due to severe loss of body fluid and consequently to death. World Health Organization recommended the use of two vaccines, RotaTeqR and RotarixTM to be used in countries with high diarrhoea related mortality in under-five children. In Zambia rotavirus vaccine (RotarixTM) was rolled out to other parts of the country in its immunization program on 27th November 2013 after a successful pilot study in Lusaka in 2012 to reduce on diarrhoea caused by rotavirus infection among under-five children which had caused 9% of deaths. The objectives for this study were to establish uptake of rotavirus vaccine among under-fives and factors that shaped its adoption and acceptability at community level in Ndola, Zambia. Study design was cross sectional analytic community based which was conducted from 1st March 2017 to 28th September 2017 to compare factors that contributed to its uptake. Sample size consisted of 380 respondents who were parents/guardians to under-five children aged 3 - 36 months residing in two homogenous selected communities. Purposive sampling was used to select study sites and respondents. This paper used triangulation method of data collection which included checklist, structured interview schedule and discussion guide tools. Statistical Package for Social Science (SPSS) was used for quantitative data analysis and Atlas.ti for qualitative data obtained from Focus Group Discussions (FGD) using hermeneutics theoretical frames to identify linkages and associations of variables. Results have shown that majority (85.3%) of under-fives received two recommended rotavirus vaccine (high uptake). Under-fives aged between 13 - 18 months were展开更多
AIM To evaluate the uptake of a mandatory meningococcal, a highly recommended influenza, and an optional pneumococcal vaccine, and to explore the key factors affecting vaccination rate among health care workers(HCWs) ...AIM To evaluate the uptake of a mandatory meningococcal, a highly recommended influenza, and an optional pneumococcal vaccine, and to explore the key factors affecting vaccination rate among health care workers(HCWs) during the Hajj.METHODS An anonymous cross-sectional online survey was distributed among HCWs and trainees who worked or volunteered at the Hajj 2015-2017 through their line managers, or by visiting their hospitals and healthcare centres in Makkah and Mina. Overseas HCWs who accompanied the pilgrims or those who work in foreign Hajj medical missions were excluded. Pearson's χ2 test was used to compare categorical variables and odds ratio(OR) was calculated by "risk estimate" statistics along with 95% confidence interval(95%CI).RESULTS A total of 138 respondents aged 20 to 59(median 25.6) years with a male to female ratio of 2.5:1 participated in the survey. Only 11.6%(16/138) participants reported receiving all three vaccines, 15.2%(21/138) did not receive any vaccine, 76.1%(105/138) received meningococcal, 68.1%(94/138) influenza and 13.8%(19/138) pneumococcal vaccine. Females were more likely to receive a vaccine than males(OR 3.6, 95%CI: 1.0-12.7, P < 0.05). Willingness to follow health authority's recommendation was the main reason for receipt of vaccine(78.8%) while believing that they were up-to-date with vaccination(39.8%) was the prime reason for non-receipt. CONCLUSION Some HCWs at Hajj miss out the compulsory and highly recommended vaccines; lack of awareness is a key barrier and authority's advice is an important motivator. Health education followed by stringent measures may be required to improve their vaccination rate.展开更多
Rotavirus infection is a highly infectious public health concern among under-five children characterized mainly by diarrhoea, vomiting and fever spread through oral fecal route from contaminated water, food and object...Rotavirus infection is a highly infectious public health concern among under-five children characterized mainly by diarrhoea, vomiting and fever spread through oral fecal route from contaminated water, food and objects. Diarrhoea ranks third among the common causes of mortality in Zambia among under-fives which accounts for about 9%. Statistics obtained at Ndola District Health Management Office revealed that in spite of high coverage of rotavirus vaccine, diarrhoea incidence had risen over the years from 2011 to 2015 by 32.9/1000. Currently stool is not routinely tested for rotavirus infection, making it difficult to determine its incidence and effectiveness of rotavirus vaccine (RotarixTM), an intervention that was put in place on 27th November 2013 to mitigate diarrhoea disease. The objective of this study is to determine incidence of rotavirus infection among under-fives attending health centres in selected communities of Ndola. Purposive sampling was used to select 380 under-fives aged 3 months - 36 months who presented at health facilities with diarrhoea, vomiting and fever. Stool specimen was tested for rotavirus infection using Combi-Strip Rapid Diagnostic Test. The study was conducted at specified period in time from 1st March 2017 to 28th September 2017 to determine relationships and associations among suspected variables using cross-sectional analytic community based study design. Statistical Package for Social Science software was used for data analysis. Tests used included Pearson’s Chi-square and logistic regression. Results have revealed 11% incidence rate of rotavirus infection and significant statistical association among severity categories of rotavirus infection with uptake of rotavirus vaccine (p ≤ 0.001). Children who took two recommended doses of the vaccine 185 (59.5%) were more likely to have mild category (<7 score) of rotavirus infection. In conclusion, results clearly indicate that rotavirus vaccine reduces incidence and if a child has diarrhoea it is less severe which yields good o展开更多
The COVID-19 pandemic severely impacted long-term care facilities resulting in the death of approximately 8%of residents nationwide as of March 2021.As COVID-19 case rates declined and state and county restrictions we...The COVID-19 pandemic severely impacted long-term care facilities resulting in the death of approximately 8%of residents nationwide as of March 2021.As COVID-19 case rates declined and state and county restrictions were lifted in spring 2021,facility managers,local and state health agencies were challenged with defining their own policies moving forward to appropriately mitigate disease transmission.The continued emergence of variants of concern and variable vaccineuptake across facilitieshighlighted the need for a readily available tool that can beemployed at the facility-level to determine best practices for mitigation and ensure resident and staff safety.To assist leadership in determining the impact of various infection surveillance and response strategies,we developed an agent-based model and an online dashboard interface that simulates COVID-19 infection within congregate care settings under various mitigation measures.This dashboard quantifies the continued risk for COVID-19 infections within a facility given a designated testing schedule and vaccine requirements.Key findings were that choice of COVID-19 diagnostic(ex.nasal swab qRT-PCR vs rapid antigen)and testing cadence has less impact on attack rate and staff workdays missed than does vaccination rates among staff and residents.Specifically,low vaccine uptake among staff at long-term care facilities puts staff and residents at risk of ongoing COVID-19 outbreaks.Here we present our model and dashboard as an exemplar of a tool for state public health officials and facility directors to gain insights from an infectious disease model that can directly inform policy decisions in the midst of a pandemic.展开更多
文摘Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to assess COVID-19 vaccine uptake and acceptance, and associated factors among selected community members in two states in southwestern Nigeria. Method: We conducted a cross-sectional study using a multistage sampling technique. Fifty catchment settlements of 10 health facilities in each of Oyo and Ogun States targeted for a COVID-19 infection prevention and control intervention were randomly selected. Four households were targeted per settlement. All households that refused access were replaced, to ensure a minimum of four households randomly selected per settlement. The primary household decision-maker was interviewed in each household. Information elicited included respondents’ sociodemographic characteristics, health history, knowledge, risk and benefit perception about the COVID-19 vaccine, vaccine uptake, and willingness to be vaccinated. The study was conducted from July–August 2021. Data were analyzed using SPSS IBM version 23. Result: Four hundred household decision-makers were surveyed in Oyo and Ogun states, after replacement. The mean age of the respondents was 43.0 ± 11.0 years. The majority, 346 (86.5%) had heard about COVID-19 vaccination, but only 47 (13.6%) had received a COVID-19 vaccination. Of the 299 respondents who reported not receiving a COVID-19 vaccination, 166 (55.5%) were willing to be vaccinated. In univariate analysis, respondents who were female had tertiary education, perceived that COVID-19 vaccines are free and accessible, perceived that COVID-19 vaccines have minimal side effects, and perceived higher benefits of COVID-19 vaccination had higher odds of being vaccinated. In contrast, younger respondents, respondents with higher knowledge scores on COVID-19 preventive measures, and with chronic illness had lower likelihoods of being vaccinated. In multivariate analy
文摘Introduction: Pregnant women are a highly vulnerable population for COVID-19 with increased risk of hospitalization, intensive-care unit admission, invasive ventilation support, and mortality. Objective: This study determined the socio-demographic and economic factors associated with the uptake of COVID-19 vaccine among pregnant women utilizing antenatal care services in Pumwani Maternity Hospital, Nairobi County-Kenya. Methods: The study was carried out from 15 June to 23 July 2023. Systematic sampling was used to select 302 women from whom data was collected through face-to-face interviews using a pre-tested semi-structured questionnaire. Data was analyzed using SPSS software in which bivariate and multivariate logistic regression analyses were done at a significance level of p Results: A total of 302 pregnant women participated in the study. Of these, 105 (34.8%) were aged between twenty-six (26) and thirty (30) years. The mean age of the women was 28.60 ± (SD = 5.297). The uptake of the COVID-19 vaccine was 41.1%. The common side effects reported to be associated with the vaccines were fever, headache, joint pain, vomiting and skin rash. Uptake of the COVID-19 vaccine was significantly associated with being married (AOR = 3.65, 95% CI: 0.62 - 1.80, p = 0.001), having a secondary level of education (AOR = 3.78, 95% CI: 0.99 - 2.88, p = 0.001) and being employed (COR = 2.66, 95% CI: 1.31 - 3.06, p = 0.001). Conclusion: COVID-19 vaccination uptake remains low among pregnant women in seeking ANC in Nairobi. The individual factors associated with the uptake of COVID-19 vaccine among pregnant Women at Pumwani maternity hospital in Nairobi County were being married, having secondary level of education and being employed. Integration of the COVID-19 vaccine with other routine vaccinations as per the national immunization program in Kenya and the enhancement of education regarding the safety and efficacy of the COVID-19 vaccine in pregnancy and breastfeeding and economic empowerment of women are recommended.
基金the National Key R&D Program of China(Grants No.2018YFA0208900,2018YFE0205300,and 2021YFA0909900)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB36000000)+5 种基金the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-010)the Beijing Natural Science Foundation of China(Grant No.Z200020)the Beijing Nova Program(Z201100006820031)the National Natural Science Foundation of China(Grants No.32171384,31800838,31820103004,31730032,and 51861145302)the Key Research Project of Frontier Science of the Chinese Academy of Sciences(Grant No.QYZDJ-SSW-SLH022)the Innovation Research Group of National Natural Science Foundation(Grant No.11621505).
文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction"(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4<not restricted to maturation via antibody modifying”(Normandy),thereby overcoming the MUO phenomenon.We also proved the applicability of this nanovaccine in identifying the human tumor neoantigens through rapid antigen display.In summary,this engineered OMV represents a powerful nanocarrier for personalized cancer vaccines,and this antibody modification strategy provides a reference to remodel the DC uptake pattern in nanocarrier design.
基金support of the Zhejiang Medicine and Health Technology project (2022KY716)
文摘Objective:To examine COVID-19 vaccine uptake and its determinants among teenagers and their parents in Zhejiang,China.Methods:An online cross-sectional study was conducted among parents of teenagers in Zhejiang,China from May 1 to 31,2022.Data were interpreted via univariate and multivariate analyses using the statistical package for the social sciences(SPSS)program.Results:A total of 11115(96.11%)participants and 11449(99.00%)of their children in Zhejiang,China had been vaccinated against COVID-19.Children whose parents did not receive COVID-19 vaccination were 19 times(aOR 18.96,95%CI 12.36-29.08)more likely to be unvaccinated than their counterparts.In addition,children with no previous influenza vaccination,those whose parents doubted the COVID-19 vaccine’s safety or effectiveness,were 6.11 times(aOR 6.11,95%CI 2.80-13.34),8.27 times(aOR 8.27,95%CI 5.33-12.83),and 2.69 times(aOR 2.69,95%CI 1.11-6.50)more likely to be unvaccinated than their counterparts,respectively.COVID-19 vaccine uptake varied between different sociodemographic groups.However,the odds of receiving the COVID-19 vaccine decreased as age and education level increased.The main refusal reasons claimed by participants were that they had medical conditions that may not qualify them for vaccination(53.78%),followed by safety concerns about the vaccine(13.56%),not knowing where to get vaccinated(6.44%),and concerns about fertility issues(5.56%).Conclusions:Despite a highly encouraging level of COVID-19 vaccine uptake in Zhejiang,China,the elderly and highly educated people had lower COVID-19 vaccine uptake.It is suggested that tailored health education strategies should be taken to increase the COVID-19 vaccine uptake in such groups.Furthermore,with vaccination rates at such a high level,the pandemic is still ongoing,and public confidence in vaccines may decline.Thus,sufficient evidence-based information regarding COVID-19 vaccines should be provided to the public.
文摘Rotavirus infection is recognized as a major cause of non-bacterial gastroenteritis infection affecting the stomach and intestinal tract in infants and young children worldwide leading to diarrhoea and vomiting. Most of the children would have had rotavirus infection by the time they are five years old. The disease is highly contagious and unpredictable as it can lead to dehydration due to severe loss of body fluid and consequently to death. World Health Organization recommended the use of two vaccines, RotaTeqR and RotarixTM to be used in countries with high diarrhoea related mortality in under-five children. In Zambia rotavirus vaccine (RotarixTM) was rolled out to other parts of the country in its immunization program on 27th November 2013 after a successful pilot study in Lusaka in 2012 to reduce on diarrhoea caused by rotavirus infection among under-five children which had caused 9% of deaths. The objectives for this study were to establish uptake of rotavirus vaccine among under-fives and factors that shaped its adoption and acceptability at community level in Ndola, Zambia. Study design was cross sectional analytic community based which was conducted from 1st March 2017 to 28th September 2017 to compare factors that contributed to its uptake. Sample size consisted of 380 respondents who were parents/guardians to under-five children aged 3 - 36 months residing in two homogenous selected communities. Purposive sampling was used to select study sites and respondents. This paper used triangulation method of data collection which included checklist, structured interview schedule and discussion guide tools. Statistical Package for Social Science (SPSS) was used for quantitative data analysis and Atlas.ti for qualitative data obtained from Focus Group Discussions (FGD) using hermeneutics theoretical frames to identify linkages and associations of variables. Results have shown that majority (85.3%) of under-fives received two recommended rotavirus vaccine (high uptake). Under-fives aged between 13 - 18 months were
文摘AIM To evaluate the uptake of a mandatory meningococcal, a highly recommended influenza, and an optional pneumococcal vaccine, and to explore the key factors affecting vaccination rate among health care workers(HCWs) during the Hajj.METHODS An anonymous cross-sectional online survey was distributed among HCWs and trainees who worked or volunteered at the Hajj 2015-2017 through their line managers, or by visiting their hospitals and healthcare centres in Makkah and Mina. Overseas HCWs who accompanied the pilgrims or those who work in foreign Hajj medical missions were excluded. Pearson's χ2 test was used to compare categorical variables and odds ratio(OR) was calculated by "risk estimate" statistics along with 95% confidence interval(95%CI).RESULTS A total of 138 respondents aged 20 to 59(median 25.6) years with a male to female ratio of 2.5:1 participated in the survey. Only 11.6%(16/138) participants reported receiving all three vaccines, 15.2%(21/138) did not receive any vaccine, 76.1%(105/138) received meningococcal, 68.1%(94/138) influenza and 13.8%(19/138) pneumococcal vaccine. Females were more likely to receive a vaccine than males(OR 3.6, 95%CI: 1.0-12.7, P < 0.05). Willingness to follow health authority's recommendation was the main reason for receipt of vaccine(78.8%) while believing that they were up-to-date with vaccination(39.8%) was the prime reason for non-receipt. CONCLUSION Some HCWs at Hajj miss out the compulsory and highly recommended vaccines; lack of awareness is a key barrier and authority's advice is an important motivator. Health education followed by stringent measures may be required to improve their vaccination rate.
文摘Rotavirus infection is a highly infectious public health concern among under-five children characterized mainly by diarrhoea, vomiting and fever spread through oral fecal route from contaminated water, food and objects. Diarrhoea ranks third among the common causes of mortality in Zambia among under-fives which accounts for about 9%. Statistics obtained at Ndola District Health Management Office revealed that in spite of high coverage of rotavirus vaccine, diarrhoea incidence had risen over the years from 2011 to 2015 by 32.9/1000. Currently stool is not routinely tested for rotavirus infection, making it difficult to determine its incidence and effectiveness of rotavirus vaccine (RotarixTM), an intervention that was put in place on 27th November 2013 to mitigate diarrhoea disease. The objective of this study is to determine incidence of rotavirus infection among under-fives attending health centres in selected communities of Ndola. Purposive sampling was used to select 380 under-fives aged 3 months - 36 months who presented at health facilities with diarrhoea, vomiting and fever. Stool specimen was tested for rotavirus infection using Combi-Strip Rapid Diagnostic Test. The study was conducted at specified period in time from 1st March 2017 to 28th September 2017 to determine relationships and associations among suspected variables using cross-sectional analytic community based study design. Statistical Package for Social Science software was used for data analysis. Tests used included Pearson’s Chi-square and logistic regression. Results have revealed 11% incidence rate of rotavirus infection and significant statistical association among severity categories of rotavirus infection with uptake of rotavirus vaccine (p ≤ 0.001). Children who took two recommended doses of the vaccine 185 (59.5%) were more likely to have mild category (<7 score) of rotavirus infection. In conclusion, results clearly indicate that rotavirus vaccine reduces incidence and if a child has diarrhoea it is less severe which yields good o
基金This work was supported by Colorado State University's Center for Healthy Aging,the Office of the Vice President for Research,the College of Health and Human Sciences,the College of Natural Sciences,the College of Veterinary Medicine and Biomedical Sciences,and the Walter Scott Jr College of Engineering.It was also supported by Colorado Department of Public Health and the Environment,COVID-19 Epidemic Modeling Services(RFAA 202000011320).
文摘The COVID-19 pandemic severely impacted long-term care facilities resulting in the death of approximately 8%of residents nationwide as of March 2021.As COVID-19 case rates declined and state and county restrictions were lifted in spring 2021,facility managers,local and state health agencies were challenged with defining their own policies moving forward to appropriately mitigate disease transmission.The continued emergence of variants of concern and variable vaccineuptake across facilitieshighlighted the need for a readily available tool that can beemployed at the facility-level to determine best practices for mitigation and ensure resident and staff safety.To assist leadership in determining the impact of various infection surveillance and response strategies,we developed an agent-based model and an online dashboard interface that simulates COVID-19 infection within congregate care settings under various mitigation measures.This dashboard quantifies the continued risk for COVID-19 infections within a facility given a designated testing schedule and vaccine requirements.Key findings were that choice of COVID-19 diagnostic(ex.nasal swab qRT-PCR vs rapid antigen)and testing cadence has less impact on attack rate and staff workdays missed than does vaccination rates among staff and residents.Specifically,low vaccine uptake among staff at long-term care facilities puts staff and residents at risk of ongoing COVID-19 outbreaks.Here we present our model and dashboard as an exemplar of a tool for state public health officials and facility directors to gain insights from an infectious disease model that can directly inform policy decisions in the midst of a pandemic.
