Background: With the appearance of the SARS-CoV-2 Omicron variant the high rate of vaccination breakthroughs showed that current vaccines against COVID-19 can no longer provide adequate protection against infection. H...Background: With the appearance of the SARS-CoV-2 Omicron variant the high rate of vaccination breakthroughs showed that current vaccines against COVID-19 can no longer provide adequate protection against infection. However, it is still assumed that vaccination might have a positive effect on the course of the disease. In Germany, general practitioners and specialists are usually the first treatment providers for acute illnesses. In addition, patients with infections of the upper respiratory tract often primarily consult an ear, nose and throat specialist. Most of the Omicron-infected people have a mild course of the disease and, if necessary, receive medical care on an outpatient basis. Little is known about the effectiveness of corona vaccinations on Omicron infections in relation to the clinical symptoms. In our outpatient office, we recorded a sharp increase of corona positive Omicron-infections in the beginning of 2022, despite of vaccinations against COVID-19. In a retrospective analysis, we evaluated the data of our SARS-CoV-2 tested patients with regard to clinical symptoms reported and vaccination status. The focus was particularly on the question to what extent the vaccination status in the case of Omicron infections influences the symptoms of the disease. Methods: We retrospectively evaluated the data of all patients in the first quarter of 2022 who were suspected for COVID-19. At that time, the Omicron variant was dominant in Germany. Clinical symptoms, cycle threshold (Ct) values, and the vaccination status were recorded. Symptomatic patients who tested negative for SARS-CoV-2 served as a control group. Results: Of the total cohort (n = 353), 241 (68%) patients were tested SARS-CoV-2 positive. The symptoms of the corona-positive patients were essentially similar to those of a mild to moderate cold, but compared to SARS-CoV-2-negative patients (n = 69) with a clear shift in favor of fever (35% versus 16%), cough (76% versus 52%) and increased feeling of illness (59% versus 43%), respectively. Ct value展开更多
目的分析黄山市祁门县及徽州区婴幼儿卡介苗(BCG)接种效果。方法对黄山市祁门县及徽州区两县区接种BCG 12周的婴幼儿进行BCG纯蛋白衍生物(purified protein derivatives of BCG,BCG-PPD)试验,并对试验结果进行统计学分析。结果黄山市两...目的分析黄山市祁门县及徽州区婴幼儿卡介苗(BCG)接种效果。方法对黄山市祁门县及徽州区两县区接种BCG 12周的婴幼儿进行BCG纯蛋白衍生物(purified protein derivatives of BCG,BCG-PPD)试验,并对试验结果进行统计学分析。结果黄山市两县区婴幼儿卡痕率99.03%、BCG-PPD阳性率89.37%。祁门县婴幼儿BCG-PPD阳性率(93.46%)明显高于徽州区(85.00%),城市婴幼儿BCG-PPD阳性率(95.19%)明显高于农村(83.50%),差异均有统计学意义(P<0.01);男性婴幼儿BCG-PPD试验阳性率(89.00%)与女性(89.72%)差异无统计学意义(P>0.05);两县区婴幼儿卡痕均径为4.32 mm,卡痕均径≥3 mm BCG-PPD阳性率(92.49%)明显高于卡痕均径<3 mm的阳性率(73.53%),差异有统计学意义(P<0.01);在城市二级以上医院产科接种室接种的婴幼儿的BCGPPD阳性率与各预防接种门诊差异无统计学意义(P>0.05)。结论黄山市两县区BCG接种质量总体较好,但存在城市与农村间接种质量不平衡现象;卡痕均径大小可作为BCG接种质量参考依据之一。展开更多
文摘Background: With the appearance of the SARS-CoV-2 Omicron variant the high rate of vaccination breakthroughs showed that current vaccines against COVID-19 can no longer provide adequate protection against infection. However, it is still assumed that vaccination might have a positive effect on the course of the disease. In Germany, general practitioners and specialists are usually the first treatment providers for acute illnesses. In addition, patients with infections of the upper respiratory tract often primarily consult an ear, nose and throat specialist. Most of the Omicron-infected people have a mild course of the disease and, if necessary, receive medical care on an outpatient basis. Little is known about the effectiveness of corona vaccinations on Omicron infections in relation to the clinical symptoms. In our outpatient office, we recorded a sharp increase of corona positive Omicron-infections in the beginning of 2022, despite of vaccinations against COVID-19. In a retrospective analysis, we evaluated the data of our SARS-CoV-2 tested patients with regard to clinical symptoms reported and vaccination status. The focus was particularly on the question to what extent the vaccination status in the case of Omicron infections influences the symptoms of the disease. Methods: We retrospectively evaluated the data of all patients in the first quarter of 2022 who were suspected for COVID-19. At that time, the Omicron variant was dominant in Germany. Clinical symptoms, cycle threshold (Ct) values, and the vaccination status were recorded. Symptomatic patients who tested negative for SARS-CoV-2 served as a control group. Results: Of the total cohort (n = 353), 241 (68%) patients were tested SARS-CoV-2 positive. The symptoms of the corona-positive patients were essentially similar to those of a mild to moderate cold, but compared to SARS-CoV-2-negative patients (n = 69) with a clear shift in favor of fever (35% versus 16%), cough (76% versus 52%) and increased feeling of illness (59% versus 43%), respectively. Ct value
文摘目的分析黄山市祁门县及徽州区婴幼儿卡介苗(BCG)接种效果。方法对黄山市祁门县及徽州区两县区接种BCG 12周的婴幼儿进行BCG纯蛋白衍生物(purified protein derivatives of BCG,BCG-PPD)试验,并对试验结果进行统计学分析。结果黄山市两县区婴幼儿卡痕率99.03%、BCG-PPD阳性率89.37%。祁门县婴幼儿BCG-PPD阳性率(93.46%)明显高于徽州区(85.00%),城市婴幼儿BCG-PPD阳性率(95.19%)明显高于农村(83.50%),差异均有统计学意义(P<0.01);男性婴幼儿BCG-PPD试验阳性率(89.00%)与女性(89.72%)差异无统计学意义(P>0.05);两县区婴幼儿卡痕均径为4.32 mm,卡痕均径≥3 mm BCG-PPD阳性率(92.49%)明显高于卡痕均径<3 mm的阳性率(73.53%),差异有统计学意义(P<0.01);在城市二级以上医院产科接种室接种的婴幼儿的BCGPPD阳性率与各预防接种门诊差异无统计学意义(P>0.05)。结论黄山市两县区BCG接种质量总体较好,但存在城市与农村间接种质量不平衡现象;卡痕均径大小可作为BCG接种质量参考依据之一。
