Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on...Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci （QTLs）. However, the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs. In certain cases, this approach might be technically difficult because of close linkage between genes separately responsible for desirable and undesirable traits.展开更多
Rumors are a type of false information, a consequence of an asymmetrical informational structure. This paper focuses on the social mechanisms of rumor fulfilling. Rumors with important contents related to people’s pe...Rumors are a type of false information, a consequence of an asymmetrical informational structure. This paper focuses on the social mechanisms of rumor fulfilling. Rumors with important contents related to people’s personal interests win acceptance through changing people’s expected payoffs, misleading people to the belief that acceptance of the rumor would beneficially outperform rejection of it. Nevertheless, it is risky to believe rumors; therefore, people make their decision whether to believe a rumor or not by referring to other people’s choices. An analysis was performed first within a game model that incorporated the variables of an individual’s expectancy and other people’s impact to predict whether the individual would accept or reject a rumor. Another analysis followed to further examine the functions of some dynamic mechanisms in rumor fulfilling when group pressure and network effects were introduced. Finally, an exploratory discussion on how to prevent rumors and erase their effects via information management strategies was presented.展开更多
TiO2 particles coated with polystyrene which were prepared via in situ polymerization and oil green dye were dispersed in tetrachloroethylene and xylene, the mixture came to be electrophoretic ink and was encapsulated...TiO2 particles coated with polystyrene which were prepared via in situ polymerization and oil green dye were dispersed in tetrachloroethylene and xylene, the mixture came to be electrophoretic ink and was encapsulated in to microcapsules by complex coacervation from gelatin and a hydrolyzed copolymer of styrene and maleic anhydride（SMA）. It was demonstrated that the membranes of the microcapsules were formed from nano sized coacervate droplets resulting from gelation and hydrolyzed SMA, which leads to a compact membrane structure. Microcapsules were characterized in terms of microstructure, morphologies by scanning electron microscopy（SEM）. Electrophoretic display prototype was prepared by coating electrophoretic ink microcapsules slurry on ITO glass with nearly single layer and sealed by UV curable adhesives. The characters “Zheda” in Chinese was firstly displayed at a low volt 9 V D.C..展开更多
Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve ...Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve rice productivity is to enlarge rice growth areas, such as the northward expansion of the growth region in Heilongjiang Province, the northernmost region of China （Li et al., 2015）. However, the northward cultivation is accompanied with daylength extension and temperature decrease, which are unfavor- able for rice, a tropical short-day plant, to complete flowering and seed setting. Thus, the need for early-maturing rice cultivars with extremely low photoperiod sensitivity is urgent.展开更多
Growing evidence suggests close associations between periodontitis and atherosclerosis.To further understand the pathological relationships of these associations,we developed periodontitis with ligature placement arou...Growing evidence suggests close associations between periodontitis and atherosclerosis.To further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/P.g.LPS) in Apolipoprotein E knock out mice and studied the atherogenesis process in these animals.The mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and atherosclerosis.Controls did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/P.g.LPS showed severe periodontitis,systemic inflammation,and aortic plaque formation.The aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell markers.The severity of periodontitis was slightly higher in mice receiving ligature/P.g.LPS than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/P.g.LPS.These observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe periodontitis.In vitro,P.g.LPS enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells.Moreover,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial cells.Taken together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.展开更多
Facilities connectivity is a priority area for implementing the Belt and Road Initiative(BRI). The "China-Europe Railway Express"(CER Express) mode of transport organization links China with Europe by fast-t...Facilities connectivity is a priority area for implementing the Belt and Road Initiative(BRI). The "China-Europe Railway Express"(CER Express) mode of transport organization links China with Europe by fast-track cargo rail. A major instance of facilities connectivity related to this project is an important practical and symbolic instance of BRI transport cooperation. The strategic significance of the CER Express and a number of operational issues are outlined, as are the implications of limited market potential for costs and competitiveness. A "hub-and-spoke" organizational model that can generate scale economies and reduce costs is proposed. To examine the establishment of an organizational model of this kind, the economic hinterlands of Alashankou, Erenhot, and Manzhouli are identified under high-, mediumand low-cost scenarios using an analytical methodology that determines distance and economic costs, and a number of transport hubs(that include Harbin, Zhengzhou, and Lanzhou) are identified. The results found that the cost of the routes from 314 Chinese cities to Moscow is the lowest via Manzhouli in the high-and medium-cost scenarios, but the routes change via Erenhot in the low-cost scenario. A number of policy recommendations should follow up.展开更多
The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes.First,faecal and salivary samples were collected from periodontally healthy participants(P...The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes.First,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA sequencing.Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups.Notably,more saliva-sourced microbes were observed in the faecal samples of the SP group.Then,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group.In the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression.The m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP group.To further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice.We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h.Thus,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.展开更多
A new method for array calibration of array gain and phase uncertainties, which severely degrade the performance of spatial spectrum estimation, is presented. The method is based on the idea of the instrumental sensor...A new method for array calibration of array gain and phase uncertainties, which severely degrade the performance of spatial spectrum estimation, is presented. The method is based on the idea of the instrumental sensors method （ISM）, two well-calibrated sensors are added into the original array. By applying the principle of estimation of signal parameters via rotational invariance techniques （ESPRIT）, the direction-of-arrivals （DOAs） and uncertainties can be estimated simultaneously through eigen-decomposition. Compared with the conventional ones, this new method has less computational complexity while has higher estimation precision, what＇s more, it can overcome the problem of ambiguity. Both theoretical analysis and computer simulations show the effectiveness of the proposed method.展开更多
基金supported by Genetically Modified Breeding Major Projects(No.2016ZX08010-002-008)the National Natural Science Foundation of China(Nos.31501239 and 31401454)
文摘Most of the important agronomic traits in crop plants, such as yield, quality and stress response, are quantitative and jointly controlled by many genomic loci or major genes. Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci （QTLs）. However, the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs. In certain cases, this approach might be technically difficult because of close linkage between genes separately responsible for desirable and undesirable traits.
文摘Rumors are a type of false information, a consequence of an asymmetrical informational structure. This paper focuses on the social mechanisms of rumor fulfilling. Rumors with important contents related to people’s personal interests win acceptance through changing people’s expected payoffs, misleading people to the belief that acceptance of the rumor would beneficially outperform rejection of it. Nevertheless, it is risky to believe rumors; therefore, people make their decision whether to believe a rumor or not by referring to other people’s choices. An analysis was performed first within a game model that incorporated the variables of an individual’s expectancy and other people’s impact to predict whether the individual would accept or reject a rumor. Another analysis followed to further examine the functions of some dynamic mechanisms in rumor fulfilling when group pressure and network effects were introduced. Finally, an exploratory discussion on how to prevent rumors and erase their effects via information management strategies was presented.
文摘TiO2 particles coated with polystyrene which were prepared via in situ polymerization and oil green dye were dispersed in tetrachloroethylene and xylene, the mixture came to be electrophoretic ink and was encapsulated in to microcapsules by complex coacervation from gelatin and a hydrolyzed copolymer of styrene and maleic anhydride（SMA）. It was demonstrated that the membranes of the microcapsules were formed from nano sized coacervate droplets resulting from gelation and hydrolyzed SMA, which leads to a compact membrane structure. Microcapsules were characterized in terms of microstructure, morphologies by scanning electron microscopy（SEM）. Electrophoretic display prototype was prepared by coating electrophoretic ink microcapsules slurry on ITO glass with nearly single layer and sealed by UV curable adhesives. The characters “Zheda” in Chinese was firstly displayed at a low volt 9 V D.C..
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDA08040101)the Hundred Talents Program of Chinese Academy of Sciences to Q.Y. Bu+1 种基金the Natural Science Foundation of Heilongjiang (No.ZD2015005)Excellent Academic Leaders of Harbin (No.RC2014XK002003)
文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve rice productivity is to enlarge rice growth areas, such as the northward expansion of the growth region in Heilongjiang Province, the northernmost region of China （Li et al., 2015）. However, the northward cultivation is accompanied with daylength extension and temperature decrease, which are unfavor- able for rice, a tropical short-day plant, to complete flowering and seed setting. Thus, the need for early-maturing rice cultivars with extremely low photoperiod sensitivity is urgent.
基金supported, in part, by the research funds awarded from the UCLA Chancellor’s Office (N.-H.P.)NIH/NIDCR DE 023348 (R.H.K. and N.-H.P.)NIH/NHLBI HL30568 (K.I.B.)
文摘Growing evidence suggests close associations between periodontitis and atherosclerosis.To further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/P.g.LPS) in Apolipoprotein E knock out mice and studied the atherogenesis process in these animals.The mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and atherosclerosis.Controls did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/P.g.LPS showed severe periodontitis,systemic inflammation,and aortic plaque formation.The aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell markers.The severity of periodontitis was slightly higher in mice receiving ligature/P.g.LPS than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/P.g.LPS.These observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe periodontitis.In vitro,P.g.LPS enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells.Moreover,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial cells.Taken together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.
基金A Category of Strategic Priority Research National Program of the Chinese Academy of Sciences,No.XDA20010101National Natural Science Foundation of China,No.41722103Ministry of Education of Humanities and Social Science Youth Fund Project,No.17YJC790064
文摘Facilities connectivity is a priority area for implementing the Belt and Road Initiative(BRI). The "China-Europe Railway Express"(CER Express) mode of transport organization links China with Europe by fast-track cargo rail. A major instance of facilities connectivity related to this project is an important practical and symbolic instance of BRI transport cooperation. The strategic significance of the CER Express and a number of operational issues are outlined, as are the implications of limited market potential for costs and competitiveness. A "hub-and-spoke" organizational model that can generate scale economies and reduce costs is proposed. To examine the establishment of an organizational model of this kind, the economic hinterlands of Alashankou, Erenhot, and Manzhouli are identified under high-, mediumand low-cost scenarios using an analytical methodology that determines distance and economic costs, and a number of transport hubs(that include Harbin, Zhengzhou, and Lanzhou) are identified. The results found that the cost of the routes from 314 Chinese cities to Moscow is the lowest via Manzhouli in the high-and medium-cost scenarios, but the routes change via Erenhot in the low-cost scenario. A number of policy recommendations should follow up.
基金supported by the National Science Foundation of China(No.81970939)the Nanjing Clinical Research Center for Oral Diseases(No.2019060009)。
文摘The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes.First,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA sequencing.Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups.Notably,more saliva-sourced microbes were observed in the faecal samples of the SP group.Then,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group.In the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression.The m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP group.To further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice.We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h.Thus,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.
文摘A new method for array calibration of array gain and phase uncertainties, which severely degrade the performance of spatial spectrum estimation, is presented. The method is based on the idea of the instrumental sensors method （ISM）, two well-calibrated sensors are added into the original array. By applying the principle of estimation of signal parameters via rotational invariance techniques （ESPRIT）, the direction-of-arrivals （DOAs） and uncertainties can be estimated simultaneously through eigen-decomposition. Compared with the conventional ones, this new method has less computational complexity while has higher estimation precision, what＇s more, it can overcome the problem of ambiguity. Both theoretical analysis and computer simulations show the effectiveness of the proposed method.
