A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain mo...A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain morphology in patients with low back pain or neck and upper back pain, we investi- gated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry. A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain. In these patients, there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens, right pallidum, right caudate nucleus, and left amygdala. In upper back pain patients, reduced cortical gray matter volume was found in the left precentral and left postcen- tral cortices. Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients. Subcortical gray matter volume in- creases are found only in patients with low back pain.展开更多
目的探究恶性肺上叶后段占位性病变电子计算机断层扫描(computed tomography,CT)良性表现的危险因素,为临床诊断提供理论依据。方法回顾性研究首都医科大学宣武医院及首都医科大学附属北京友谊医院平谷医院胸外科2011年1月1日至2016年12...目的探究恶性肺上叶后段占位性病变电子计算机断层扫描(computed tomography,CT)良性表现的危险因素,为临床诊断提供理论依据。方法回顾性研究首都医科大学宣武医院及首都医科大学附属北京友谊医院平谷医院胸外科2011年1月1日至2016年12月31日肺上叶后段占位性病变CT良性表现病人139例。计算各年份恶性肺上叶后段占位性病变CT良性影像表现的发生率;对比病人的各项临床资料,并采用Logistic回归分析危险因素。结果各年恶性肺上叶后段占位性病变CT良性影像表现的发生率分别为8.33%、11.11%、19.05%、26.92%、34.38%、40.00%;Logistic回归显示:年龄、吸烟、右位病变、单光子弥散计算机断层成像术(single-photon emission computed tomography,SPECT)放射凝聚征阳性、癌胚抗原(carcino-embryonic antigen,CEA)、细胞角蛋白19片段21-1(cytokeratin protein fragment 21-1,CYFRA21-1)及神经元特异性烯醇化酶(neuron specific enolase,NSE)异常,为恶性肺上叶后段占位性病变CT良性表现的危险因素,OR(95%CI)分别是1.123(1.038~1.215)、5.951(1.778~9.919)、3.547(1.104~10.397)、3.565(1.096~11.598)、18.638(4.974~29.843)、7.357(2.265~13.010)、7.639(3.107~14.697)。结论恶性肺上叶后段占位性病变CT良性影像表现的发生率较高,值得重视;危险因素为老龄、吸烟、右位病变、SPECT放射凝聚征阳性及肺癌相关肿瘤标志物异常,临床医师需谨慎对待,早发现、早治疗,以提高病人生存率。展开更多
基金supported partially by two grants from the National Natural Science Foundation of China,No.30870686 and 81371530
文摘A reduction in gray matter volume is common in patients with chronic back pain, and different types of pain are associated with gray matter abnormalities in distinct brain regions. To examine differ- ences in brain morphology in patients with low back pain or neck and upper back pain, we investi- gated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry. A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain. In these patients, there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens, right pallidum, right caudate nucleus, and left amygdala. In upper back pain patients, reduced cortical gray matter volume was found in the left precentral and left postcen- tral cortices. Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients. Subcortical gray matter volume in- creases are found only in patients with low back pain.
文摘目的探究恶性肺上叶后段占位性病变电子计算机断层扫描(computed tomography,CT)良性表现的危险因素,为临床诊断提供理论依据。方法回顾性研究首都医科大学宣武医院及首都医科大学附属北京友谊医院平谷医院胸外科2011年1月1日至2016年12月31日肺上叶后段占位性病变CT良性表现病人139例。计算各年份恶性肺上叶后段占位性病变CT良性影像表现的发生率;对比病人的各项临床资料,并采用Logistic回归分析危险因素。结果各年恶性肺上叶后段占位性病变CT良性影像表现的发生率分别为8.33%、11.11%、19.05%、26.92%、34.38%、40.00%;Logistic回归显示:年龄、吸烟、右位病变、单光子弥散计算机断层成像术(single-photon emission computed tomography,SPECT)放射凝聚征阳性、癌胚抗原(carcino-embryonic antigen,CEA)、细胞角蛋白19片段21-1(cytokeratin protein fragment 21-1,CYFRA21-1)及神经元特异性烯醇化酶(neuron specific enolase,NSE)异常,为恶性肺上叶后段占位性病变CT良性表现的危险因素,OR(95%CI)分别是1.123(1.038~1.215)、5.951(1.778~9.919)、3.547(1.104~10.397)、3.565(1.096~11.598)、18.638(4.974~29.843)、7.357(2.265~13.010)、7.639(3.107~14.697)。结论恶性肺上叶后段占位性病变CT良性影像表现的发生率较高,值得重视;危险因素为老龄、吸烟、右位病变、SPECT放射凝聚征阳性及肺癌相关肿瘤标志物异常,临床医师需谨慎对待,早发现、早治疗,以提高病人生存率。
