AIM： To explore the effect of Astraga/us mongholicus polysaccharide （APS） on gene expression and mitogenactivated protein kinase （MAPK） transcriptional activity in intestinal epithelial cells （IEC）. METHODS： I...AIM： To explore the effect of Astraga/us mongholicus polysaccharide （APS） on gene expression and mitogenactivated protein kinase （MAPK） transcriptional activity in intestinal epithelial cells （IEC）. METHODS： IEC were divided into control group, lipopolysaccharide （LPS） group, LPS＋ 50 μg/mL APS group, LPS＋ 100 μg/mL APS group, LPS＋ 200 μg/mL APS group, and LPS＋ 500 μg/mL APS group. Levels of mRNAs in LPS-induced inflammatory factors, tumor necrosis factor （TNF）-α and interleukin （IL）-8, were measured by reverse transcription-polymerase chain reaction. MAPK protein level was measured by Western blotting. RESULTS： The levels of TNF-α and IL-8 mRNAs were significantly higher in IEC with LPS-induced damage than in control cells. APS significantly abrogated the LPS-induced expression of the TNF-α and IL-8 genes. APS did not block the activation of extracellular signal- regulated kinase or c Jun amino-terminal kinase, but inhibited the activation of p38, suggesting that APS inhibits LPS-induced production of TNF-α and IL-8 mRNAs, possibly by suppressing the p38 signaling pathway.CONCLUSION： APS-modulated bacterial productmediated p38 signaling represents an attractive strategy for prevention and treatment of intestinal inflammation.展开更多
Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness fr...Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness framework and a system of heterogeneous indicators, this paper investigates the competitiveness of China and the US in terms of current status, historic change and global environment. Our research led to the following findings： core factors determine the level of competitiveness for China and the US; the national competitiveness of both countries is evolving towards structural homogeneity; and China and the US lead most countries in many common areas. China has the potential to overtake the US in competitiveness in the future. We suggest that China increase its competitiveness by promoting its advantages, addressing its weaknesses and focusing on core areas.展开更多
The China-Japan relationship has swung between deterioration and improvement in the 21st century while Japanese leaders'cognition and Japanese public opinion remain operative at a deep level.The return of the bila...The China-Japan relationship has swung between deterioration and improvement in the 21st century while Japanese leaders'cognition and Japanese public opinion remain operative at a deep level.The return of the bilateral relationship in 2018 to the normal development track was aided by Japan's shift toward coordination,China's re-shaped policy,and a boost by the Trump administration.Though the China-Japan relationship will continue improving in the short run,it is unlikely“deterioratiomimprovcment”cycles will end since too many glaring structural contradictions exist.While memories of their intense history and today's territorial issues linger,the fluctuation of Japan*s diplomatic options and weak Japanese public opinion for improved relations with China will continue the same cyclical,but not forward,momentum.展开更多
文摘AIM： To explore the effect of Astraga/us mongholicus polysaccharide （APS） on gene expression and mitogenactivated protein kinase （MAPK） transcriptional activity in intestinal epithelial cells （IEC）. METHODS： IEC were divided into control group, lipopolysaccharide （LPS） group, LPS＋ 50 μg/mL APS group, LPS＋ 100 μg/mL APS group, LPS＋ 200 μg/mL APS group, and LPS＋ 500 μg/mL APS group. Levels of mRNAs in LPS-induced inflammatory factors, tumor necrosis factor （TNF）-α and interleukin （IL）-8, were measured by reverse transcription-polymerase chain reaction. MAPK protein level was measured by Western blotting. RESULTS： The levels of TNF-α and IL-8 mRNAs were significantly higher in IEC with LPS-induced damage than in control cells. APS significantly abrogated the LPS-induced expression of the TNF-α and IL-8 genes. APS did not block the activation of extracellular signal- regulated kinase or c Jun amino-terminal kinase, but inhibited the activation of p38, suggesting that APS inhibits LPS-induced production of TNF-α and IL-8 mRNAs, possibly by suppressing the p38 signaling pathway.CONCLUSION： APS-modulated bacterial productmediated p38 signaling represents an attractive strategy for prevention and treatment of intestinal inflammation.
文摘Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness framework and a system of heterogeneous indicators, this paper investigates the competitiveness of China and the US in terms of current status, historic change and global environment. Our research led to the following findings： core factors determine the level of competitiveness for China and the US; the national competitiveness of both countries is evolving towards structural homogeneity; and China and the US lead most countries in many common areas. China has the potential to overtake the US in competitiveness in the future. We suggest that China increase its competitiveness by promoting its advantages, addressing its weaknesses and focusing on core areas.
基金This paper is part of a project he chaired,Studies on the Building of the Belt and Road and China's Neighborhood Diplomacy,which was funded by National Social Science Fund Project 2017010186.
文摘The China-Japan relationship has swung between deterioration and improvement in the 21st century while Japanese leaders'cognition and Japanese public opinion remain operative at a deep level.The return of the bilateral relationship in 2018 to the normal development track was aided by Japan's shift toward coordination,China's re-shaped policy,and a boost by the Trump administration.Though the China-Japan relationship will continue improving in the short run,it is unlikely“deterioratiomimprovcment”cycles will end since too many glaring structural contradictions exist.While memories of their intense history and today's territorial issues linger,the fluctuation of Japan*s diplomatic options and weak Japanese public opinion for improved relations with China will continue the same cyclical,but not forward,momentum.
