Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated ...Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. Tlle present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma （UCC）. Methods A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used ill the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results The expression of Bmi-l, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in tlle cervical neoplasia and normal colorectal mucosa （P〈0.05）. The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis （P〈0.01） and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization （P〈0.05）. Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features （P〉0.05）. The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients （P〈0.05）. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC （r=0.419, P=0.001）. Conclusions The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-I and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 ma展开更多
看点key feature科技探索之旅THE JOURNEY OF SCIENTIFIC AND TECHNOLOGICAL EXPLORATION无数的“窗”COUNTLESS"WINDOWS"“数字文明”“自然”“生活模式”"DIGITAL CIVILIZATION","NATURE","LIFES...看点key feature科技探索之旅THE JOURNEY OF SCIENTIFIC AND TECHNOLOGICAL EXPLORATION无数的“窗”COUNTLESS"WINDOWS"“数字文明”“自然”“生活模式”"DIGITAL CIVILIZATION","NATURE","LIFESTYLE"由Lenovo联想集团与UCCA Lab打造的「从未来到未来—数字文明艺术展」,通过“未来序曲”“奔腾时代”“数字新生”“瞬息万物”“遇见未来”5个篇章,为人们呈现了一场科技探索之旅。展开更多
目的:探讨多学科协作模式护理下宫颈癌(Uterine Cervical Carcinoma,UCC)患者康复期间生活质量与情绪变化,对其护理效果展开评价。方法:以河南人民医院2020年9月至2021年9月收治120例UCC患者为研究对象,以随机数列法分为观察组与对照组,...目的:探讨多学科协作模式护理下宫颈癌(Uterine Cervical Carcinoma,UCC)患者康复期间生活质量与情绪变化,对其护理效果展开评价。方法:以河南人民医院2020年9月至2021年9月收治120例UCC患者为研究对象,以随机数列法分为观察组与对照组,各60例。对照组予以常规护理,观察组予以多学科协作模式护理干预。于住院前和干预后3个月采用营养不良炎症评分(Malnutrition Inflammation Score,MIS)、应激压力应对量表(Mastery of Stress Instrument,MSI)、肿瘤患者生活质量测定量表(The European Organization For Reasearch&Treatment Of Cancer,EORTCQLQ-C30)评价营养指标、生活质量,并记录并发症数量。结果:住院次日,两组营养水平、生活质量指标、心理应激压力指标差异均无统计意义(均P>0.05)。护理3个月后,对患者营养水平的观察中,观察组MIS评分、体质量指数(Body Mass Index,BMI)、血清白蛋白(Blood Serum Albumin,BSA)、血红蛋白(Haemoglobin,HB)高于对照组,且护理后低于住院次日差异均有统计学意义(均P<0.05);观察组在生活质量(身体功能、角色功能、情绪功能、认知功能、社会功能)等方面均高于对照组,且护理后高于住院次日,差异均有统计学意义(均P<0.05);其他维度如生理痛苦、生活被干扰、负性情感、心理疾患等方面均低于对照组,且护理后低于住院次日,差异均有统计学意义(均P<0.05);社会支持、身体健康、生活满意度、心理应对、积极影响等方面高于对照组,且护理后高于住院次日,差异均有统计学意义(均P<0.05);观察组并发症发生率3.33%低于对照组16.67%,差异有统计学意义(P<0.05)。结论:采取多学科协作模式护理干预能提高UCC康复期间生活质量,同时积极调节情绪。展开更多
基金supported by a grant from the Social Development Projects of Guangdong Sci-Tech Planning(No. 2010B031600201)
文摘Objective Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. Tlle present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma （UCC）. Methods A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used ill the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed. Results The expression of Bmi-l, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in tlle cervical neoplasia and normal colorectal mucosa （P〈0.05）. The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis （P〈0.01） and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization （P〈0.05）. Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features （P〉0.05）. The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients （P〈0.05）. A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC （r=0.419, P=0.001）. Conclusions The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-I and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 ma
文摘看点key feature科技探索之旅THE JOURNEY OF SCIENTIFIC AND TECHNOLOGICAL EXPLORATION无数的“窗”COUNTLESS"WINDOWS"“数字文明”“自然”“生活模式”"DIGITAL CIVILIZATION","NATURE","LIFESTYLE"由Lenovo联想集团与UCCA Lab打造的「从未来到未来—数字文明艺术展」,通过“未来序曲”“奔腾时代”“数字新生”“瞬息万物”“遇见未来”5个篇章,为人们呈现了一场科技探索之旅。
文摘目的:探讨多学科协作模式护理下宫颈癌(Uterine Cervical Carcinoma,UCC)患者康复期间生活质量与情绪变化,对其护理效果展开评价。方法:以河南人民医院2020年9月至2021年9月收治120例UCC患者为研究对象,以随机数列法分为观察组与对照组,各60例。对照组予以常规护理,观察组予以多学科协作模式护理干预。于住院前和干预后3个月采用营养不良炎症评分(Malnutrition Inflammation Score,MIS)、应激压力应对量表(Mastery of Stress Instrument,MSI)、肿瘤患者生活质量测定量表(The European Organization For Reasearch&Treatment Of Cancer,EORTCQLQ-C30)评价营养指标、生活质量,并记录并发症数量。结果:住院次日,两组营养水平、生活质量指标、心理应激压力指标差异均无统计意义(均P>0.05)。护理3个月后,对患者营养水平的观察中,观察组MIS评分、体质量指数(Body Mass Index,BMI)、血清白蛋白(Blood Serum Albumin,BSA)、血红蛋白(Haemoglobin,HB)高于对照组,且护理后低于住院次日差异均有统计学意义(均P<0.05);观察组在生活质量(身体功能、角色功能、情绪功能、认知功能、社会功能)等方面均高于对照组,且护理后高于住院次日,差异均有统计学意义(均P<0.05);其他维度如生理痛苦、生活被干扰、负性情感、心理疾患等方面均低于对照组,且护理后低于住院次日,差异均有统计学意义(均P<0.05);社会支持、身体健康、生活满意度、心理应对、积极影响等方面高于对照组,且护理后高于住院次日,差异均有统计学意义(均P<0.05);观察组并发症发生率3.33%低于对照组16.67%,差异有统计学意义(P<0.05)。结论:采取多学科协作模式护理干预能提高UCC康复期间生活质量,同时积极调节情绪。
