Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting a...Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and bloodbrain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points（20 μL, twice a day, for 2 days） and mild induced hypothermia（6 hours） are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury.展开更多
Chronic heart failure （CHF）, a clinical syndrome resulting from the consequences of various cardiovascular diseases （CVDs）, is increasingly becoming a global cause of morbidity and mortality. We had earlier demons...Chronic heart failure （CHF）, a clinical syndrome resulting from the consequences of various cardiovascular diseases （CVDs）, is increasingly becoming a global cause of morbidity and mortality. We had earlier demonstrated that a 4-day forest bathing trip can provide an adjunctive therapeutic influence on patients with CHF. To further investigate the duration of the impact and the optimal frequency of forest bathing trips in patients with CHF, we recruited those subjects who had experienced the first forest bathing trip again after 4 weeks and randomly categorized them into two groups, namely, the urban control group （city） and the forest bathing group （forest）. After a second 4-day forest bathing trip, we observed a steady decline in the brain natriuretic peptide levels, a biomarker of heart failure, and an attenuated inflammatory response as well as oxidative stress. Thus, this exploratory study demonstrated the additive benefits of twice forest bathing trips in elderly patients with CHF, which could further pave the way for analyzing the effects of such interventions in CVDs.展开更多
A method of measuring the velocity of fast moving object by charge coupled device （CCD） shadow photograph system is developed. This system consists of high resolution orthogonal CCD cameras, time detecting device an...A method of measuring the velocity of fast moving object by charge coupled device （CCD） shadow photograph system is developed. This system consists of high resolution orthogonal CCD cameras, time detecting device and the pulsed laser which can generate two short laser pulses with adjustable interval more than 100 μs. Experiments are conducted to measure the velocity of the flying steel ball. The results show that the proposed velocity measurement is effective in modem ballistic measurement.展开更多
To avoid the long time required for conventional sexual crossing, transgenic tobacco (Nicotiana tabacum L.) plants harboring phbA gene (encoding 3_ketothiolase) were used as the target plant for the second transfo...To avoid the long time required for conventional sexual crossing, transgenic tobacco (Nicotiana tabacum L.) plants harboring phbA gene (encoding 3_ketothiolase) were used as the target plant for the second transformation mediated by Agrobacterium tumefaciens (Smith et Townsend) Conn LBA4404 containing pZCB which was constructed by linking phbB (encoding acetoacetyl_CoA reductase), phbC (encoding PHB synthase) and ctp sequence to pBIB_HYG under the control of CaMV 35S promoter. The hygromycin resistant transformants were morphologically normal and stable integration of phbB and phbC was confirmed by PCR and PCR_Southern. Moreover, RT_PCR_DNA hybridization analysis showed that 6.67% of the transformed tobacco plants could express both phbB and phbC at transcriptional level.展开更多
To promote effectively dynamic recrystallization and obtain a homogeneous distribution of ultrafine grain size in strip finish rolling process,the behavior of static and dynamic recrystallization must be appropriately...To promote effectively dynamic recrystallization and obtain a homogeneous distribution of ultrafine grain size in strip finish rolling process,the behavior of static and dynamic recrystallization must be appropriately designed to provide an ultrafine austenite microstructure without mixed grain size.The design of rolling schedule was analyzed based on the control of the recrystallization behavior to achieve ultrafine grain size in the strip rolling process of niobium microalloyed steel.The experimental simulations were presented to validate the twice dynamic recrystallization design to achieve ultrafine grain size control.展开更多
CsPbI_(2)Br perovskite solar cell has been extensively studied due to its exceptional thermal stability and relatively stable perovskite phase structure.However,the presence of bromine leads to a rapid crystallization...CsPbI_(2)Br perovskite solar cell has been extensively studied due to its exceptional thermal stability and relatively stable perovskite phase structure.However,the presence of bromine leads to a rapid crystallization rate of CsPbI_(2)Br films,resulting in small grain size and high defect density.Additionally,CsPbI_(2)Br demonstrates poor light absorption due to its wide bandgap.Therefore,it is crucial to control the crystallization rate and increase the film thickness to reduce defect density,enhance light absorption,and improve photovoltaic performance.In this study,we utilized a PbAc_(2)-incorporated twice spincoating(PTS) process to address these issues.Initially,PbAc_(2) was added to the CsPbI_(2)Br precursor solution to form a CsPbI_(2)Br film,which was then coated with the CsPbI_(2)Br precursor solution to produce the PTS film,Ac^(-)can delay the perovskite crystallization,leading to the formation of thicker and denser CsPbI_(2)Br films.Moreover,lone-pair electrons of the oxygen atom provided by Ac^(-)formed coordination bonds with under-coordinated Pb~(2+) ions to fill halogen ion vacancies,thereby reducing the defect density.Ultimately,the PTS CsPbI_(2)Br device achieved a peak power conversion efficiency(PCE) of 16.19% and maintained 96.7% of its initial PCE over 1500 h at room temperature under 25% relative humidity without any encapsulation.展开更多
Droplet migration in plane Poiseuille flow is numerically investigated with a dissipative particle dynamics method.The single droplet deformation in the channel flow is first studied to verify the current method and t...Droplet migration in plane Poiseuille flow is numerically investigated with a dissipative particle dynamics method.The single droplet deformation in the channel flow is first studied to verify the current method and the physical model.The effect of the viscosity ratio between the droplet and the solvent and the effect of the confinement are systematically investigated.The droplet is in an off-centerline equilibrium position with a specific selection of the parameters.A large viscosity ratio makes the droplet locate in a near-wall equilibrium position,and a large capillary number makes the droplet migrate to the near-centerline region of the channel.For the droplet migration at the same Capillary number,there is a critical width of the channel,which is less than twice of the droplet diameter,and the droplet will only migrate to the channel centerline if the width is less than this critical value.展开更多
In this article, the risk process perturbed by diffusion under interest force is considered, the continuity and twice continuous differentiability for Фδ（u,w） are discussed,the Feller expression and the integro-di...In this article, the risk process perturbed by diffusion under interest force is considered, the continuity and twice continuous differentiability for Фδ（u,w） are discussed,the Feller expression and the integro-differential equation satisfied by Фδ （u ,w） are derived. Finally, the decomposition of Фδ（u,w） is discussed, and some properties of each decomposed part of Фδ（u,w） are obtained. The results can be reduced to some ones in Gerber and Landry＇s,Tsai and Willmot＇s, and Wang＇s works by letting parameter δ and （or） a be zero.展开更多
Until now, harvesting of flap elevations from the ipsilateral thigh twice in the same patient in two operations has not been reported. We harvested thigh flaps twice from the ipsilateral thigh of a single patient in s...Until now, harvesting of flap elevations from the ipsilateral thigh twice in the same patient in two operations has not been reported. We harvested thigh flaps twice from the ipsilateral thigh of a single patient in separate operations. A 44-year-old man had skin defects of the right thumb and the left middle finger. In the first operation, his right thumb was reconstructed by the hemi-pulp flap. The anterolateral thigh flap harvested from the left thigh transferred to the donor site defect of the hemi-pulp flap. Sixteen days after the first operation, another anterolateral thigh flap harvested from the left thigh transferred to the defect of the left middle finger. This operative procedure is very useful for cases requiring multi-flap transfer.展开更多
A new type of double function optical circulator for double fibers is proposed in this paper. Two fiber tips and lens twice are employed in this kind of device as the coupling system for what is believed to be the fir...A new type of double function optical circulator for double fibers is proposed in this paper. Two fiber tips and lens twice are employed in this kind of device as the coupling system for what is believed to be the first time. Because two fiber tips and lens twice are used, the function of optical circulator is duplicated in comparison with conventional optical circulator with single fiber tip. Thus the optical circulator has a low cost and a small volume comparatively. Excess loss of the coupling system and the misalignment of the lens twice in angular error and the position error to the developed circulator are analyzed and discussed by using Gauss wave and double integral in theory. The analysis results show that the excess loss is zero when each distance is equal to f between every adjacent： fraction and without misalignment error in the coupling system. In addition, the excess loss is increasing with increment of the distance error and the angular error. The errors of the angular of the optical axis to lens and the distance between the SL to lens are the main source of the excess loss. The higher the errors are, the higher the excess loss is. It＇s very important for reducing the misalignment errors in the coupling system with high ratio of coupling to achieve low excess loss. Details of design and excess loss in the coupling system of this circulator are presented.展开更多
A study in cytotoxicity of gentamyein to tissue-cultured bovine corneal endothelial cells and rabbit corneal epithelial cells is reported. When the cultured cells reached confluence, they were exposed to tissue cultur...A study in cytotoxicity of gentamyein to tissue-cultured bovine corneal endothelial cells and rabbit corneal epithelial cells is reported. When the cultured cells reached confluence, they were exposed to tissue culture media containing gentamycin for 6 hours. We founl that 0.5% gentamycin caused significant damage to corneal epithelial cells---diffuse plasmolysis, with scattered cell necrosis and 5% loss.While corneal endothelial cells were exposed to 1.6 mg/ml gentamycin, extensive cell loss (approximate- ly 15%) was observed. The damaged cells recovered their normal morphology after 24 hours. When the concentration of gentamycin increased twice, serious damage to cells occured. The area of cell loss reached 40%, and the recovery of cellular morphology Was much slower. This study demonstrates that gentamycin potential cytotoxicity to corneal epithelium and endothelium, suggesting that gentamycin should be rationally used in the treatment of ocular diseases.展开更多
Due to the arid climate,flat terrain,certain irrigation sources and high popularization of mechanical harvest in Hexi Irrigation Area of Gansu Province,the widely adopted half film-flat-mulching for corn cultivation f...Due to the arid climate,flat terrain,certain irrigation sources and high popularization of mechanical harvest in Hexi Irrigation Area of Gansu Province,the widely adopted half film-flat-mulching for corn cultivation faces serious adverse situations,such as high soil compactness,strong film-soil adhesion,significant straw stubble and thick covering accumulation on film.Therefore,a new kind of segmented combination upper-side-discharge straw-returning and bundle self-unloading integrated corn residual film recycling machine was proposed.The scheme was characterized by small volume,low resistance,low complexity and film-impurities twice separation.It is constructed based on the concept of module subsection combination.It was composed of film surface straw cleaning device and the followed residual film recycling machine,in terms of function,any usage requirements of separate and joint operations can be satisfied.The film surface straw cleaning device is responsible for the removal of vertical corn straw and ground covering beyond the film.Although its stubble cutter roller obtuse-angle Lshaped blades paired single-helix arrangement is simple,it runs smoothly and the straw crushing effect is good enough.The layout that upper-side-discharge straw-returning cross-range screw conveyor auger is back and beyond the stubble cutter roller,eliminates the common connecting transportation mechanism between crushing and straw-returning section,so that,the system structure can be optimized and the efficiency has been significantly improved.The integrated residual film recycling machine is composed of triangular pyramid arc two-stage wing(TPATSW)type film lifting shovel,rod-tooth-belt type film-impurities separation device and semi-enclosed shaftless bundle film collector.Among them,TPATSW type film lifting shovel has good corn root whisker cutting effect,low soil contact resistance and small soil congestion area,but its ability to lift film is strong,more importantly,the special segmented configuration of shovel handle and the bo展开更多
The demand for effective interventions to improve domain-specific academic outcomes for individuals with special needs at either end of the spectrum has existed for some time.Since the earlier contributions to the lit...The demand for effective interventions to improve domain-specific academic outcomes for individuals with special needs at either end of the spectrum has existed for some time.Since the earlier contributions to the literature documenting gifted individuals who were simultaneously exhibiting disabilities,there has been some progress in our understanding.We now know that in individuals with both gifts and disabilities,potentially,either or both of the exceptionalities can obscure the effects of the other,which significantly delays the average time to receive a diagnosis.Such delays in diagnosis detrimentally impact the the form of effective interventions without a diagnosis.The purpose of this paper is t quality of life across various domains because there can be no opportunity to receive help in o determine whether effective interventions exist to improve domain-specific(i.e.,social,emotional,or academic)outcomes for people with both gifts and disabilities.A query was performed using evidence databases TRIP and PDQ for“twice-exceptional,”“Giftedness,”“Disability,”and“intervention.”The four most relevant,freely available studies in English were selected for critique.Despite identifying potential threats to validity among the studies,methodological similarities among them were strong enough to confidently conclude that not only do effective interventions exist for the population of gifted with ADHD,but the outcomes of these interventions may also carry over into other domains resulting in indirect effects.展开更多
BACKGROUND: At present, fluconazole and intrathecal injection of amphotericin B has been widely used to treat cryptococcal meningitis. However, the application of amphotericin B can shorten course and has good effects...BACKGROUND: At present, fluconazole and intrathecal injection of amphotericin B has been widely used to treat cryptococcal meningitis. However, the application of amphotericin B can shorten course and has good effects on the treatment of cryptococcal meningitis. OBJECTIVE: To observe the effects and poor response of the intrathecal injection of amphotericin B on the treatment of cryptococcal meningitis. DESIGN: Retrospective-case analysis. SETTING: Department of Neurology, Beijing Hospital of Ministry of Public Health. PARTICIPANTS: Eight patients with cryptococcal meningitis were selected from Department of Neurology, Beijing Hospital of Ministry of Public Health from January 1995 to January 2006. Among them, there were 3 males and 5 females aged from 17 to 41 years and the course ranged from 21 days to 3 months. Patients who had symptoms of febrile and headache, positive meninges excitation, positive latex agglutination of cryptococcus of cerebrospinal fluid and positive ink smear were selected in this study. All patients provided informed consent. METHODS: Eight patients were treated with the fluconazole and intrathecal injection of amphotericin B. ① Intracranial hypertension of patients was controlled with flowing cerebrospinal fluid by repeatedly piercing waist; meanwhile, patients were taken the intrathecal injection of amphotericin B combining with flucytosine or fluconazole treatment. The dosage of amphotericin B was 1-5 mg/d at the beginning of administration, and then, the samples were added with 2 mg dexasine and 500 mL 5% glucose solution. The dosage was increased 5.0 mg per day till 50 mg per day, and the total dosage was 3.0-4.0 g. In addition, 2 mg dexasine was mixed with 4.0-5.0 mL cerebrospinal fluid, and then the solution was gradually injected into sheath for once a week. Fluconazole was dripped into vein with the volume of 400 mg per day, and then, 14 days later, fluconazole was orally taken by patients. ② Other therapies, such as decreasing intracranial hypertension, were used at the same展开更多
2009090 Clinical observation of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma XU Li(徐立),et al.State Oncol Lab, Dept Hepatobili Surg, Cancer Center, Sun Yat-sen Univ, Guangzhou ...2009090 Clinical observation of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma XU Li(徐立),et al.State Oncol Lab, Dept Hepatobili Surg, Cancer Center, Sun Yat-sen Univ, Guangzhou 510060, Chin J Oncol 2009;31(1):58-61. Objective To observe the efficacy and safety of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma (HCC). Methods Thirty-eight patients with advanced HCC of Child-Pugh status A or B were included in this study. Patients received orally administered sorafenib at a dose of 400 mg twice a day on a continuous schedule.展开更多
基金supported by the National Natural Science Foundation of China,No.31200809
文摘Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and bloodbrain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of bloodletting at Jing points（20 μL, twice a day, for 2 days） and mild induced hypothermia（6 hours） are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury.
基金supported by funds from the National Natural Science Foundation of China[31670701&81771520]the Science Technology Department of Zhejiang Province[2014C33130&2016C34002]+1 种基金the Natural Science Foundation of Zhejiang Province[Y15H050018&LY17C070004]the Health Bureau of Zhejiang Province[2015DTA001&2016KYB005]
文摘Chronic heart failure （CHF）, a clinical syndrome resulting from the consequences of various cardiovascular diseases （CVDs）, is increasingly becoming a global cause of morbidity and mortality. We had earlier demonstrated that a 4-day forest bathing trip can provide an adjunctive therapeutic influence on patients with CHF. To further investigate the duration of the impact and the optimal frequency of forest bathing trips in patients with CHF, we recruited those subjects who had experienced the first forest bathing trip again after 4 weeks and randomly categorized them into two groups, namely, the urban control group （city） and the forest bathing group （forest）. After a second 4-day forest bathing trip, we observed a steady decline in the brain natriuretic peptide levels, a biomarker of heart failure, and an attenuated inflammatory response as well as oxidative stress. Thus, this exploratory study demonstrated the additive benefits of twice forest bathing trips in elderly patients with CHF, which could further pave the way for analyzing the effects of such interventions in CVDs.
基金supported by the Project of National Key Laboratory (51453050105ZS33)
文摘A method of measuring the velocity of fast moving object by charge coupled device （CCD） shadow photograph system is developed. This system consists of high resolution orthogonal CCD cameras, time detecting device and the pulsed laser which can generate two short laser pulses with adjustable interval more than 100 μs. Experiments are conducted to measure the velocity of the flying steel ball. The results show that the proposed velocity measurement is effective in modem ballistic measurement.
文摘To avoid the long time required for conventional sexual crossing, transgenic tobacco (Nicotiana tabacum L.) plants harboring phbA gene (encoding 3_ketothiolase) were used as the target plant for the second transformation mediated by Agrobacterium tumefaciens (Smith et Townsend) Conn LBA4404 containing pZCB which was constructed by linking phbB (encoding acetoacetyl_CoA reductase), phbC (encoding PHB synthase) and ctp sequence to pBIB_HYG under the control of CaMV 35S promoter. The hygromycin resistant transformants were morphologically normal and stable integration of phbB and phbC was confirmed by PCR and PCR_Southern. Moreover, RT_PCR_DNA hybridization analysis showed that 6.67% of the transformed tobacco plants could express both phbB and phbC at transcriptional level.
基金Item Sponsored by Natural SciencesEngineering Research Council of Canada
文摘To promote effectively dynamic recrystallization and obtain a homogeneous distribution of ultrafine grain size in strip finish rolling process,the behavior of static and dynamic recrystallization must be appropriately designed to provide an ultrafine austenite microstructure without mixed grain size.The design of rolling schedule was analyzed based on the control of the recrystallization behavior to achieve ultrafine grain size in the strip rolling process of niobium microalloyed steel.The experimental simulations were presented to validate the twice dynamic recrystallization design to achieve ultrafine grain size control.
基金supported by the National Natural Science Foundation of China (U22A20142)the Fundamental Research Funds for the Central Universities (2023JC007)。
文摘CsPbI_(2)Br perovskite solar cell has been extensively studied due to its exceptional thermal stability and relatively stable perovskite phase structure.However,the presence of bromine leads to a rapid crystallization rate of CsPbI_(2)Br films,resulting in small grain size and high defect density.Additionally,CsPbI_(2)Br demonstrates poor light absorption due to its wide bandgap.Therefore,it is crucial to control the crystallization rate and increase the film thickness to reduce defect density,enhance light absorption,and improve photovoltaic performance.In this study,we utilized a PbAc_(2)-incorporated twice spincoating(PTS) process to address these issues.Initially,PbAc_(2) was added to the CsPbI_(2)Br precursor solution to form a CsPbI_(2)Br film,which was then coated with the CsPbI_(2)Br precursor solution to produce the PTS film,Ac^(-)can delay the perovskite crystallization,leading to the formation of thicker and denser CsPbI_(2)Br films.Moreover,lone-pair electrons of the oxygen atom provided by Ac^(-)formed coordination bonds with under-coordinated Pb~(2+) ions to fill halogen ion vacancies,thereby reducing the defect density.Ultimately,the PTS CsPbI_(2)Br device achieved a peak power conversion efficiency(PCE) of 16.19% and maintained 96.7% of its initial PCE over 1500 h at room temperature under 25% relative humidity without any encapsulation.
基金supported by the National Natural Science Foun-dations of China(Grant Nos.11402230,11332009 and 11272284)
文摘Droplet migration in plane Poiseuille flow is numerically investigated with a dissipative particle dynamics method.The single droplet deformation in the channel flow is first studied to verify the current method and the physical model.The effect of the viscosity ratio between the droplet and the solvent and the effect of the confinement are systematically investigated.The droplet is in an off-centerline equilibrium position with a specific selection of the parameters.A large viscosity ratio makes the droplet locate in a near-wall equilibrium position,and a large capillary number makes the droplet migrate to the near-centerline region of the channel.For the droplet migration at the same Capillary number,there is a critical width of the channel,which is less than twice of the droplet diameter,and the droplet will only migrate to the channel centerline if the width is less than this critical value.
文摘In this article, the risk process perturbed by diffusion under interest force is considered, the continuity and twice continuous differentiability for Фδ（u,w） are discussed,the Feller expression and the integro-differential equation satisfied by Фδ （u ,w） are derived. Finally, the decomposition of Фδ（u,w） is discussed, and some properties of each decomposed part of Фδ（u,w） are obtained. The results can be reduced to some ones in Gerber and Landry＇s,Tsai and Willmot＇s, and Wang＇s works by letting parameter δ and （or） a be zero.
文摘Until now, harvesting of flap elevations from the ipsilateral thigh twice in the same patient in two operations has not been reported. We harvested thigh flaps twice from the ipsilateral thigh of a single patient in separate operations. A 44-year-old man had skin defects of the right thumb and the left middle finger. In the first operation, his right thumb was reconstructed by the hemi-pulp flap. The anterolateral thigh flap harvested from the left thigh transferred to the donor site defect of the hemi-pulp flap. Sixteen days after the first operation, another anterolateral thigh flap harvested from the left thigh transferred to the defect of the left middle finger. This operative procedure is very useful for cases requiring multi-flap transfer.
文摘A new type of double function optical circulator for double fibers is proposed in this paper. Two fiber tips and lens twice are employed in this kind of device as the coupling system for what is believed to be the first time. Because two fiber tips and lens twice are used, the function of optical circulator is duplicated in comparison with conventional optical circulator with single fiber tip. Thus the optical circulator has a low cost and a small volume comparatively. Excess loss of the coupling system and the misalignment of the lens twice in angular error and the position error to the developed circulator are analyzed and discussed by using Gauss wave and double integral in theory. The analysis results show that the excess loss is zero when each distance is equal to f between every adjacent： fraction and without misalignment error in the coupling system. In addition, the excess loss is increasing with increment of the distance error and the angular error. The errors of the angular of the optical axis to lens and the distance between the SL to lens are the main source of the excess loss. The higher the errors are, the higher the excess loss is. It＇s very important for reducing the misalignment errors in the coupling system with high ratio of coupling to achieve low excess loss. Details of design and excess loss in the coupling system of this circulator are presented.
文摘A study in cytotoxicity of gentamyein to tissue-cultured bovine corneal endothelial cells and rabbit corneal epithelial cells is reported. When the cultured cells reached confluence, they were exposed to tissue culture media containing gentamycin for 6 hours. We founl that 0.5% gentamycin caused significant damage to corneal epithelial cells---diffuse plasmolysis, with scattered cell necrosis and 5% loss.While corneal endothelial cells were exposed to 1.6 mg/ml gentamycin, extensive cell loss (approximate- ly 15%) was observed. The damaged cells recovered their normal morphology after 24 hours. When the concentration of gentamycin increased twice, serious damage to cells occured. The area of cell loss reached 40%, and the recovery of cellular morphology Was much slower. This study demonstrates that gentamycin potential cytotoxicity to corneal epithelium and endothelium, suggesting that gentamycin should be rationally used in the treatment of ocular diseases.
基金the support of the Gansu Educational Science and Technology Innovation Project(Grant No.2021CYZC-25)the Gansu Science and Technology Planning Project(Grant No.21CX6NA081)+1 种基金the National Natural Science Foundation of China(Grant No.52165028)the Key Scientific and Technological Program of Gansu Province(Grant No.22ZD6NA046).
文摘Due to the arid climate,flat terrain,certain irrigation sources and high popularization of mechanical harvest in Hexi Irrigation Area of Gansu Province,the widely adopted half film-flat-mulching for corn cultivation faces serious adverse situations,such as high soil compactness,strong film-soil adhesion,significant straw stubble and thick covering accumulation on film.Therefore,a new kind of segmented combination upper-side-discharge straw-returning and bundle self-unloading integrated corn residual film recycling machine was proposed.The scheme was characterized by small volume,low resistance,low complexity and film-impurities twice separation.It is constructed based on the concept of module subsection combination.It was composed of film surface straw cleaning device and the followed residual film recycling machine,in terms of function,any usage requirements of separate and joint operations can be satisfied.The film surface straw cleaning device is responsible for the removal of vertical corn straw and ground covering beyond the film.Although its stubble cutter roller obtuse-angle Lshaped blades paired single-helix arrangement is simple,it runs smoothly and the straw crushing effect is good enough.The layout that upper-side-discharge straw-returning cross-range screw conveyor auger is back and beyond the stubble cutter roller,eliminates the common connecting transportation mechanism between crushing and straw-returning section,so that,the system structure can be optimized and the efficiency has been significantly improved.The integrated residual film recycling machine is composed of triangular pyramid arc two-stage wing(TPATSW)type film lifting shovel,rod-tooth-belt type film-impurities separation device and semi-enclosed shaftless bundle film collector.Among them,TPATSW type film lifting shovel has good corn root whisker cutting effect,low soil contact resistance and small soil congestion area,but its ability to lift film is strong,more importantly,the special segmented configuration of shovel handle and the bo
文摘The demand for effective interventions to improve domain-specific academic outcomes for individuals with special needs at either end of the spectrum has existed for some time.Since the earlier contributions to the literature documenting gifted individuals who were simultaneously exhibiting disabilities,there has been some progress in our understanding.We now know that in individuals with both gifts and disabilities,potentially,either or both of the exceptionalities can obscure the effects of the other,which significantly delays the average time to receive a diagnosis.Such delays in diagnosis detrimentally impact the the form of effective interventions without a diagnosis.The purpose of this paper is t quality of life across various domains because there can be no opportunity to receive help in o determine whether effective interventions exist to improve domain-specific(i.e.,social,emotional,or academic)outcomes for people with both gifts and disabilities.A query was performed using evidence databases TRIP and PDQ for“twice-exceptional,”“Giftedness,”“Disability,”and“intervention.”The four most relevant,freely available studies in English were selected for critique.Despite identifying potential threats to validity among the studies,methodological similarities among them were strong enough to confidently conclude that not only do effective interventions exist for the population of gifted with ADHD,but the outcomes of these interventions may also carry over into other domains resulting in indirect effects.
文摘BACKGROUND: At present, fluconazole and intrathecal injection of amphotericin B has been widely used to treat cryptococcal meningitis. However, the application of amphotericin B can shorten course and has good effects on the treatment of cryptococcal meningitis. OBJECTIVE: To observe the effects and poor response of the intrathecal injection of amphotericin B on the treatment of cryptococcal meningitis. DESIGN: Retrospective-case analysis. SETTING: Department of Neurology, Beijing Hospital of Ministry of Public Health. PARTICIPANTS: Eight patients with cryptococcal meningitis were selected from Department of Neurology, Beijing Hospital of Ministry of Public Health from January 1995 to January 2006. Among them, there were 3 males and 5 females aged from 17 to 41 years and the course ranged from 21 days to 3 months. Patients who had symptoms of febrile and headache, positive meninges excitation, positive latex agglutination of cryptococcus of cerebrospinal fluid and positive ink smear were selected in this study. All patients provided informed consent. METHODS: Eight patients were treated with the fluconazole and intrathecal injection of amphotericin B. ① Intracranial hypertension of patients was controlled with flowing cerebrospinal fluid by repeatedly piercing waist; meanwhile, patients were taken the intrathecal injection of amphotericin B combining with flucytosine or fluconazole treatment. The dosage of amphotericin B was 1-5 mg/d at the beginning of administration, and then, the samples were added with 2 mg dexasine and 500 mL 5% glucose solution. The dosage was increased 5.0 mg per day till 50 mg per day, and the total dosage was 3.0-4.0 g. In addition, 2 mg dexasine was mixed with 4.0-5.0 mL cerebrospinal fluid, and then the solution was gradually injected into sheath for once a week. Fluconazole was dripped into vein with the volume of 400 mg per day, and then, 14 days later, fluconazole was orally taken by patients. ② Other therapies, such as decreasing intracranial hypertension, were used at the same
文摘2009090 Clinical observation of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma XU Li(徐立),et al.State Oncol Lab, Dept Hepatobili Surg, Cancer Center, Sun Yat-sen Univ, Guangzhou 510060, Chin J Oncol 2009;31(1):58-61. Objective To observe the efficacy and safety of sorafenib monotherapy in Chinese patients with advanced hepatocellular carcinoma (HCC). Methods Thirty-eight patients with advanced HCC of Child-Pugh status A or B were included in this study. Patients received orally administered sorafenib at a dose of 400 mg twice a day on a continuous schedule.
