The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth...The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth model fine-tuned by various connections of the cells (junctions and adherent connections), intended to direct material and energy transports between them. This secondary control of cell metabolism decreases primary metabolic transport through the free surfaces of the cells. The cellular network is formed by triggering the endogenous electric fields, which are dominantly governed by cell membrane potential. Proliferation exhibits a different electric pattern due to the low cell-membrane potential and resulting negativity relative to its environment. This potential change characterizes cells in normal proliferation and a cluster of cells (a tumor) in the case of cancerous development. This latter has certain similarities to the leakage transport of liquid in porous media, substituting the pressure with endogenous tumor potential. The average survival of a tumor depends on the kind of available metabolic transport and the fractal dimensions of the newly built angiogenic network.展开更多
目的系统评价碳酸酐酶9(CA9)表达与肾肿瘤患者预后之间的关系。方法本研究已在PROSPERO(CRD42020160181)注册。在PubMed、Cochrane图书馆和Web of Science数据库进行文献检索,检索的文献发表时间截至2020年12月。使用Stata11.0软件对数...目的系统评价碳酸酐酶9(CA9)表达与肾肿瘤患者预后之间的关系。方法本研究已在PROSPERO(CRD42020160181)注册。在PubMed、Cochrane图书馆和Web of Science数据库进行文献检索,检索的文献发表时间截至2020年12月。使用Stata11.0软件对数据进行分析。结果共纳入27项研究,分析了CA9与疾病特异性生存率(DSS)(HR=1.18,95% CI:0.82~1.70)、总生存率(OS)(HR=1.13,95%CI:0.82~1.56)、无进展生存率(PFS)(HR=1.73,95% CI:0.97~3.09)、无复发生存率(RFS)(HR=0.99,95% CI:0.95~1.02)间的关系,再分别进行亚组分析以验证前述结果CA9与DSS(HR=1.40,95%CI:0.89~2.18);CA9与OS(HR=0.90,95%CI:0.75~1.07);CA9与PFS(HR=1.04,95%CI:0.79~1.36);CA9与RFS(HR=1.01,95%CI:0.91~1.03)。并在TCGA数据库的基础上进行生信分析,围绕CA9低、高表达之间的3种生存曲线(DSS、OS、DFS)的相应P值分别为DSS:P=0.204,OS:P=0.073,DFS:P=0.3。结论CA9在RCC患者中的表达与肾肿瘤患者预后无显著相关。展开更多
文摘The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth model fine-tuned by various connections of the cells (junctions and adherent connections), intended to direct material and energy transports between them. This secondary control of cell metabolism decreases primary metabolic transport through the free surfaces of the cells. The cellular network is formed by triggering the endogenous electric fields, which are dominantly governed by cell membrane potential. Proliferation exhibits a different electric pattern due to the low cell-membrane potential and resulting negativity relative to its environment. This potential change characterizes cells in normal proliferation and a cluster of cells (a tumor) in the case of cancerous development. This latter has certain similarities to the leakage transport of liquid in porous media, substituting the pressure with endogenous tumor potential. The average survival of a tumor depends on the kind of available metabolic transport and the fractal dimensions of the newly built angiogenic network.
