A series of triptycene-derived Tr6ger＇s bases with molecular clip shaped structures have been conveniently and efficiently synthesized by one-pot condensation of corresponding amino-substituted triptycenes with paraf...A series of triptycene-derived Tr6ger＇s bases with molecular clip shaped structures have been conveniently and efficiently synthesized by one-pot condensation of corresponding amino-substituted triptycenes with paraformaldehyde in the presence of trifluoroacetic acid, and their structures have been characterized by NMR, MALDI-TOF MS spectra, elemental analyses and single-crystal X-ray diffraction. ~ 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.展开更多
以邻氨基二苯甲酮为原料,经两分子环化缩合反应制得6,12-二芳基二苯并[b,f][1,5]二氮杂环辛四烯(2a^2d);2a^2d经Li Al H4还原制得6,12-二芳基-5,6,11,12-四氢二苯并[b,f][1,5]二氮杂环辛(3a^3d);3a^3d与醛(或酮)反应,合成了一系列新型...以邻氨基二苯甲酮为原料,经两分子环化缩合反应制得6,12-二芳基二苯并[b,f][1,5]二氮杂环辛四烯(2a^2d);2a^2d经Li Al H4还原制得6,12-二芳基-5,6,11,12-四氢二苯并[b,f][1,5]二氮杂环辛(3a^3d);3a^3d与醛(或酮)反应,合成了一系列新型的多取代Trger’s base衍生物(4a^4d和5a^7a),其结构经1H NMR,13C NMR,HR-MS(ESI)和X-射线单晶衍射表征。通过分析架桥前后3a(CCDC:1498564)和6a(CCDC:1498555)的晶体结构,解释了该类化合物1H NMR中NCH质子及桥上取代基质子裂分的原因,并进一步证实了4~7为非C2轴对称结构。展开更多
基金the National Natural Science Foundation of China (Nos. 21332008, 51373180)the National Basic Research Program (No. 2011CB932501) for financial support
文摘A series of triptycene-derived Tr6ger＇s bases with molecular clip shaped structures have been conveniently and efficiently synthesized by one-pot condensation of corresponding amino-substituted triptycenes with paraformaldehyde in the presence of trifluoroacetic acid, and their structures have been characterized by NMR, MALDI-TOF MS spectra, elemental analyses and single-crystal X-ray diffraction. ~ 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
