Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechan...Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechanisms of action are required. The botanic compound berberine(BBR) has been used as an over-the-counter antibacterial for diarrhea in China for many decades. Recent clinical studies have shown that BBR may be therapeutic in various types of chronic diseases. This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation. One of the advantages of BBR is its multiple-target effects in each of these diseases. The therapeutic efficacy of BBR may reflect a synergistic regulation of these targets, resulting in a comprehensive effect against these various chronic disorders. The safety of BBR may be due to its harmonious distribution into those targets. Although the single-target concept is still the principle for drug discovery and research, this review emphasizes the concept of a multiple target strategy, which may be an important approach toward the successful treatment of multifactorial chronic diseases.展开更多
Objective：This overview seeked to bring together the microRNA （miRNA） researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma.Data Sources：Using the keyword ...Objective：This overview seeked to bring together the microRNA （miRNA） researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma.Data Sources：Using the keyword terms ＂glioma＂ and ＂miRNA,＂ we performed the literature search in PubMed,Ovid,and web.metstr.com databases from their inception to October 2014.Study Selection：In screening out the quality of the articles,factors such as clinical setting of the study,the size of clinical samples were taken into consideration.Animal studied for verification and reviews article were also included in our data collection.Results：Despite many advance in miRNA for malignant glioma,further studies were still required to focus on the following aspects：（i） Improving the understanding about biogenesis of miRNA and up-down regulation;（ii） utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma;（iii） Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma.Conclusions：We discussed the most promising miRNA,correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy.展开更多
The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individua...The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.展开更多
基金supported by the National Mega-Project for Drug Research&Development,China(to Jiang Jian Dong)
文摘Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechanisms of action are required. The botanic compound berberine(BBR) has been used as an over-the-counter antibacterial for diarrhea in China for many decades. Recent clinical studies have shown that BBR may be therapeutic in various types of chronic diseases. This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation. One of the advantages of BBR is its multiple-target effects in each of these diseases. The therapeutic efficacy of BBR may reflect a synergistic regulation of these targets, resulting in a comprehensive effect against these various chronic disorders. The safety of BBR may be due to its harmonious distribution into those targets. Although the single-target concept is still the principle for drug discovery and research, this review emphasizes the concept of a multiple target strategy, which may be an important approach toward the successful treatment of multifactorial chronic diseases.
基金grants from the National Key Basic Research Program，the National Natural Science Foundation of China，the Program of Shanghai Subject Chief Scientist，Foundation of Shanghai Jiaotong University,School of Medicine，the Program of Shanghai Health and Family Planning Committee，Shanghai Municipal Natural Science Foundation （No.14ZR1427100）.Conflict of Interest：None declared
文摘Objective：This overview seeked to bring together the microRNA （miRNA） researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma.Data Sources：Using the keyword terms ＂glioma＂ and ＂miRNA,＂ we performed the literature search in PubMed,Ovid,and web.metstr.com databases from their inception to October 2014.Study Selection：In screening out the quality of the articles,factors such as clinical setting of the study,the size of clinical samples were taken into consideration.Animal studied for verification and reviews article were also included in our data collection.Results：Despite many advance in miRNA for malignant glioma,further studies were still required to focus on the following aspects：（i） Improving the understanding about biogenesis of miRNA and up-down regulation;（ii） utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma;（iii） Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma.Conclusions：We discussed the most promising miRNA,correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy.
文摘The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.
