The present paper reports the results obtained for translational and rotational velocity profiles of spherical particles for the mixed flow in a conical silo.The discrete element method(DEM)based on Hertz-Mindlin(no s...The present paper reports the results obtained for translational and rotational velocity profiles of spherical particles for the mixed flow in a conical silo.The discrete element method(DEM)based on Hertz-Mindlin(no slip)with RVD rolling friction contact model is used for simulations.Opposite correlations are found between translational and rotational velocities in different flow areas of the silo.In particular,the abrasion caused by rotation is dominant in the funnel flow area.In addition,increase of the mass flow rate of silo can effectively reduce the abrasion induced by rotation.This highlights that understanding of dynamic characteristics of particles is helpful for optimization of silos and reduction of granular material abrasion.展开更多
Currently many facets of genetic information are illdefined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model...Currently many facets of genetic information are illdefined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of m RNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by m RNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.展开更多
基金supported by the National Natural Science Foundation of China (grant Nos.12002213,11972212,and 12072200)Shanghai Municipal Natural Science Foundation (grant No.20ZR1438800)Science and Technology Commission of Shanghai Municipality (grant No.19142201500).
文摘The present paper reports the results obtained for translational and rotational velocity profiles of spherical particles for the mixed flow in a conical silo.The discrete element method(DEM)based on Hertz-Mindlin(no slip)with RVD rolling friction contact model is used for simulations.Opposite correlations are found between translational and rotational velocities in different flow areas of the silo.In particular,the abrasion caused by rotation is dominant in the funnel flow area.In addition,increase of the mass flow rate of silo can effectively reduce the abrasion induced by rotation.This highlights that understanding of dynamic characteristics of particles is helpful for optimization of silos and reduction of granular material abrasion.
基金supported by the start-up grant from“Top 100 Talents Program”of Sun Yat-sen University to JRY(50000-31131114)General Program of National Natural Science Foundation of China to JRY(31671320)
文摘Currently many facets of genetic information are illdefined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of m RNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by m RNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.
