Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which wa...Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which was earlier thought to be irreversible.However,it is now known that cirrhosis can in fact be reversed by treatment with oral anti-nucleotide drugs.Thus,early and accurate diagnosis of cirrhosis is important to allow an appropriate treatment strategy to be chosen and to predict the prognosis of patients with CHB.Liver biopsy is the reference standard for assessment of liver fibrosis.However,the method is invasive,and is associated with pain and complications that can be fatal.In addition,intra-and inter-observer variability compromises the accuracy of liver biopsy data.Only small tissue samples are obtained and fibrosis is heterogeneous in such samples.This confounds the two types of observer variability mentioned above.Such limitations have encouraged development of non-invasive methods for assessment of fibrosis.These include measurements of serum biomarkers of fibrosis;and assessment of liver stiffness via transient elastography,acoustic radiation force impulse imaging,real-time elastography,or magnetic resonance elastography.Although significant advances have been made,most work to date has addressed the diagnostic utility of these techniques in the context of cirrhosis caused by chronic hepatitis C infection.In the present review,we examine the advantages afforded by use of non-invasive methods to diagnose cirrhosis in patients with CHB infections and the utility of such methods in clinical practice.展开更多
The full-space transient electromagnetic response of water-filled goaves in coal mines were numerically modeled. Traditional numerical modeling methods cannot be used to simulate the underground full-space transient e...The full-space transient electromagnetic response of water-filled goaves in coal mines were numerically modeled. Traditional numerical modeling methods cannot be used to simulate the underground full-space transient electromagnetic field. We used multiple transmitting loops instead of the traditional single transmitting loop to load the transmitting loop into Cartesian grids. We improved the method for calculating the z-component of the magnetic field based on the characteristics of full space. Then, we established the full- space 3D geoelectrical model using geological data for coalmines. In addition, the transient electromagnetic responses of water-filled goaves of variable shape at different locations were simulated by using the finite-difference time-domain （FDTD） method. Moreover, we evaluated the apparent resistivity results. The numerical modeling results suggested that the resistivity differences between the coal seam and its roof and floor greatly affect the distribution of apparent resistivity, resulting in nearly circular contours with the roadway head at the center. The actual distribution of apparent resistivity for different geoelectrical models of water in goaves was consistent with the models. However, when the goal water was located in one side, a false low-resistivity anomaly would appear on the other side owing to the full-space effect but the response was much weaker. Finally, the modeling results were subsequently confirmed by drilling, suggesting that the proposed method was effective.展开更多
Accuracy of time-depth conversion in data processing of transient electromagnetic prospecting always affects the accu- rate positioning of water bodies in coal mines. In order to improve the accuracy of time-depth con...Accuracy of time-depth conversion in data processing of transient electromagnetic prospecting always affects the accu- rate positioning of water bodies in coal mines. In order to improve the accuracy of time-depth conversion, we established a mathe- matical model of time-depth conversion for a transient electromagnetic method based on the theory of "double smoke ring effect" of full space transient electromagnetic field transmission. Using a 3-layer as well as a 4-layer geo-electric model for roadway floors, we performed the time-depth conversion of theoretical curves of apparent resistance varying over time. In these curves, the depth corresponding to extreme value points is nearly the same as the depth of a geo-electric model. The position of water body deter- mined by our time-depth conversion method agrees well with the result of borehole drilling, indicating that the established time-depth conversion model can clearly improve the accuracy of spatial positioning of water bodies in coal mines.展开更多
静止无功补偿器(static var compensator,SVC)不仅可以为电力系统提供无功支撑、稳定电压,其附加控制还可以有效提高系统暂态稳定性,但SVC模型参数的不确定性以及广域测量信号时延等外部干扰给附加控制器的设计带来很大的难度.提出了一...静止无功补偿器(static var compensator,SVC)不仅可以为电力系统提供无功支撑、稳定电压,其附加控制还可以有效提高系统暂态稳定性,但SVC模型参数的不确定性以及广域测量信号时延等外部干扰给附加控制器的设计带来很大的难度.提出了一种基于自适应滑模变结构理论的SVC鲁棒控制器设计方法,所设计控制器能有效提高系统暂态稳定性,并且其对于模型不确定性以及时延有较好的鲁棒性.首先根据区域惯量中心的运动方程建立了包含SVC的电力系统模型;然后将滑模变结构理论应用于电力系统模型中,求得SVC附加控制律,并通过自适应律优化控制器参数;最后通过四机两区域系统以及IEEE9节点系统对SVC控制器效果进行了仿真验证.结果表明,SVC自适应滑模控制器可以有效提升系统暂态稳定性,并且其性能优于传统的线性控制方法.展开更多
This paper is devoted to solving the transient electric field and transient charge density on the dielectric interface under the electroquasistatic(EQS)field conditions with high accuracy.The proposed method is suitab...This paper is devoted to solving the transient electric field and transient charge density on the dielectric interface under the electroquasistatic(EQS)field conditions with high accuracy.The proposed method is suitable for both 2-D and 3-D applications.Firstly,the governing equations represented by scalar electric potential are discretized by the nodal finite element method(FEM)in space and the finite difference method in time.Secondly,the transient constrained electric field equation on the boundary(TCEFEB)is derived to calculate the normal component of the transient electric field intensities on the Dirichlet boundary and dielectric interface as well as the transient charge density on the dielectric interface.Finally,a 2-D numerical example is employed to demonstrate the validity of the proposed method.Furthermore,the comparisons of the numerical accuracy of the proposed method in this paper with the existing FEMs for electric field intensity and charge density on the dielectric interface are conducted.The results show that the numerical accuracy of the proposed method for calculating the normal component of transient electric field intensities on the Dirichlet boundary and dielectric interface as well as the transient charge density on the dielectric interface is close to that of nodal electric potential and an order of magnitude higher than those of existing FEMs.展开更多
基金Supported by A grant of the South Korea Healthcare technology R and D projectMinistry of Health and Welfare+1 种基金South KoreaNo.HI10C2020
文摘Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which was earlier thought to be irreversible.However,it is now known that cirrhosis can in fact be reversed by treatment with oral anti-nucleotide drugs.Thus,early and accurate diagnosis of cirrhosis is important to allow an appropriate treatment strategy to be chosen and to predict the prognosis of patients with CHB.Liver biopsy is the reference standard for assessment of liver fibrosis.However,the method is invasive,and is associated with pain and complications that can be fatal.In addition,intra-and inter-observer variability compromises the accuracy of liver biopsy data.Only small tissue samples are obtained and fibrosis is heterogeneous in such samples.This confounds the two types of observer variability mentioned above.Such limitations have encouraged development of non-invasive methods for assessment of fibrosis.These include measurements of serum biomarkers of fibrosis;and assessment of liver stiffness via transient elastography,acoustic radiation force impulse imaging,real-time elastography,or magnetic resonance elastography.Although significant advances have been made,most work to date has addressed the diagnostic utility of these techniques in the context of cirrhosis caused by chronic hepatitis C infection.In the present review,we examine the advantages afforded by use of non-invasive methods to diagnose cirrhosis in patients with CHB infections and the utility of such methods in clinical practice.
基金supported by the National Key Scientific Instrument and Equipment Development Project(No.2011YQ03013307)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education InstitutionsKey Laboratory of Coal Resources Exploration and Comprehensive Utilization,Ministry of Land and Resources
文摘The full-space transient electromagnetic response of water-filled goaves in coal mines were numerically modeled. Traditional numerical modeling methods cannot be used to simulate the underground full-space transient electromagnetic field. We used multiple transmitting loops instead of the traditional single transmitting loop to load the transmitting loop into Cartesian grids. We improved the method for calculating the z-component of the magnetic field based on the characteristics of full space. Then, we established the full- space 3D geoelectrical model using geological data for coalmines. In addition, the transient electromagnetic responses of water-filled goaves of variable shape at different locations were simulated by using the finite-difference time-domain （FDTD） method. Moreover, we evaluated the apparent resistivity results. The numerical modeling results suggested that the resistivity differences between the coal seam and its roof and floor greatly affect the distribution of apparent resistivity, resulting in nearly circular contours with the roadway head at the center. The actual distribution of apparent resistivity for different geoelectrical models of water in goaves was consistent with the models. However, when the goal water was located in one side, a false low-resistivity anomaly would appear on the other side owing to the full-space effect but the response was much weaker. Finally, the modeling results were subsequently confirmed by drilling, suggesting that the proposed method was effective.
文摘目的：探讨短暂性脑缺血发作（transient ischaemic attack, TIA）患者发作次数和持续时间与早期缺血性卒中风险的相关性。方法回顾性纳入2013年1月至2017年7月在六安市人民医院神经内科住院的TIA患者，根据首次发生TIA后72 h内头颅CT或MRI复查结果分为无卒中组和卒中组，比较两组患者人口统计学和临床资料。结果共纳入171例TIA患者，其中卒中组54例，无卒中组117例。两组性别、心房颤动、发病前使用抗凝药、基线血压（收缩压和舒张压）、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖、TIA病因学（心源性栓塞）、TIA发作频率（≥2次）、TIA症状持续时间、ABCD2评分（6分和7分）以及发病后使用抗高血压药存在显著性差异。多变量logistic回归分析显示，高舒张压[优势比（odds ratio, OR）1.121，95%可信区间（confidence interval, CI）1.016～1.238；P＝0.023]、高空腹血糖（OR 10.866，95% CI 3.658～30.945；P＝0.001）、ABCD2评分为6分（OR 4.221，95% CI 1.906～9.352；P〈0.001）和7分（OR 4.207，95% CI 2.040～9.961；P〈0.001）、TIA症状持续时间≥60 min（OR 3.682，95% CI 1.961～9.989；P〈0.001）和TIA发作≥2次（OR 4.220，95% CI 1.953～9.118；P〈0.001）为早期发生缺血性卒中的独立危险因素，而发病前使用抗凝药为独立保护因素（OR 0.300，95% CI 0.097～0.923；P＝0.036）。
结论症状发作次数≥2次和症状持续时间≥60 min的TIA患者早期更易发生缺血性卒中。
基金Project 2007CB209400 supported by the National Basic Research Program of China
文摘Accuracy of time-depth conversion in data processing of transient electromagnetic prospecting always affects the accu- rate positioning of water bodies in coal mines. In order to improve the accuracy of time-depth conversion, we established a mathe- matical model of time-depth conversion for a transient electromagnetic method based on the theory of "double smoke ring effect" of full space transient electromagnetic field transmission. Using a 3-layer as well as a 4-layer geo-electric model for roadway floors, we performed the time-depth conversion of theoretical curves of apparent resistance varying over time. In these curves, the depth corresponding to extreme value points is nearly the same as the depth of a geo-electric model. The position of water body deter- mined by our time-depth conversion method agrees well with the result of borehole drilling, indicating that the established time-depth conversion model can clearly improve the accuracy of spatial positioning of water bodies in coal mines.
文摘静止无功补偿器(static var compensator,SVC)不仅可以为电力系统提供无功支撑、稳定电压,其附加控制还可以有效提高系统暂态稳定性,但SVC模型参数的不确定性以及广域测量信号时延等外部干扰给附加控制器的设计带来很大的难度.提出了一种基于自适应滑模变结构理论的SVC鲁棒控制器设计方法,所设计控制器能有效提高系统暂态稳定性,并且其对于模型不确定性以及时延有较好的鲁棒性.首先根据区域惯量中心的运动方程建立了包含SVC的电力系统模型;然后将滑模变结构理论应用于电力系统模型中,求得SVC附加控制律,并通过自适应律优化控制器参数;最后通过四机两区域系统以及IEEE9节点系统对SVC控制器效果进行了仿真验证.结果表明,SVC自适应滑模控制器可以有效提升系统暂态稳定性,并且其性能优于传统的线性控制方法.
基金This work was supported by the National Natural Science Foundation of China-State Grid Corporation Joint Fund for Smart Grid(No.U1766219).
文摘This paper is devoted to solving the transient electric field and transient charge density on the dielectric interface under the electroquasistatic(EQS)field conditions with high accuracy.The proposed method is suitable for both 2-D and 3-D applications.Firstly,the governing equations represented by scalar electric potential are discretized by the nodal finite element method(FEM)in space and the finite difference method in time.Secondly,the transient constrained electric field equation on the boundary(TCEFEB)is derived to calculate the normal component of the transient electric field intensities on the Dirichlet boundary and dielectric interface as well as the transient charge density on the dielectric interface.Finally,a 2-D numerical example is employed to demonstrate the validity of the proposed method.Furthermore,the comparisons of the numerical accuracy of the proposed method in this paper with the existing FEMs for electric field intensity and charge density on the dielectric interface are conducted.The results show that the numerical accuracy of the proposed method for calculating the normal component of transient electric field intensities on the Dirichlet boundary and dielectric interface as well as the transient charge density on the dielectric interface is close to that of nodal electric potential and an order of magnitude higher than those of existing FEMs.
