In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion ...In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion mediated transamination reaction as the key step. This work also implicated a novel strategy to assemble other [a]-fused carbazoles.展开更多
A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the pre...A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the previously reported reactions of PLP derivatives, the N-terminus transamination could be accomplished efficiently with the new compound.展开更多
以ω-溴-α-酮酸为原料,发展了一种合成手性α,ω-二氨基酸的高效方法,通过手性吡哆胺催化ω-溴-α-酮酸的不对称转氨化和NH 3 对ω-溴的取代反应,在温和条件下一锅法合成了6个带有不同长度直链手性α,ω-二氨基酸,收率49~93%, ee 值最...以ω-溴-α-酮酸为原料,发展了一种合成手性α,ω-二氨基酸的高效方法,通过手性吡哆胺催化ω-溴-α-酮酸的不对称转氨化和NH 3 对ω-溴的取代反应,在温和条件下一锅法合成了6个带有不同长度直链手性α,ω-二氨基酸,收率49~93%, ee 值最高可以达91%,其结构经 1 H NMR和 13 C NMR表征。展开更多
基金supported by NSFC (No.21102026)Qiankehe [2011] 3002West Light Foundation of the Chinese Academy of Sciences
文摘In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion mediated transamination reaction as the key step. This work also implicated a novel strategy to assemble other [a]-fused carbazoles.
基金Project supported by the National Natural Science Foundation of China （Nos. 20932006 and 21002056）.
文摘A new pyridoxal-5-phosphate （PLP） derivative FHMDP was developed for the transamination of different pep- tides with three most hindered amino acid residues （Leu, Ile, Val） as their N-terminus. Compared to the previously reported reactions of PLP derivatives, the N-terminus transamination could be accomplished efficiently with the new compound.
文摘以ω-溴-α-酮酸为原料,发展了一种合成手性α,ω-二氨基酸的高效方法,通过手性吡哆胺催化ω-溴-α-酮酸的不对称转氨化和NH 3 对ω-溴的取代反应,在温和条件下一锅法合成了6个带有不同长度直链手性α,ω-二氨基酸,收率49~93%, ee 值最高可以达91%,其结构经 1 H NMR和 13 C NMR表征。
