目的分析采用经颈内静脉肝内门腔静脉分流术(Transjugular intrahepatic portosystemic stent shunt,Tipss)在治疗门静脉高压伴食管胃底静脉曲张致破裂出血的临床疗效,为临床在治疗该类患者时术式选择提供参考依据。方法以我院2015年8月...目的分析采用经颈内静脉肝内门腔静脉分流术(Transjugular intrahepatic portosystemic stent shunt,Tipss)在治疗门静脉高压伴食管胃底静脉曲张致破裂出血的临床疗效,为临床在治疗该类患者时术式选择提供参考依据。方法以我院2015年8月至2017年8月收治的门静脉高压伴食管胃底静脉曲张破裂出血患者91例作为研究对象,分为Tipss组(43例)与内镜下套扎止血治疗组(48例)。比较两种术式对患者的临床疗效;比较患者肝脏功能生化指标,统计分析患者术后并发症种类及发生率。结果行Tipss术患者显效率显著高于对照组,差异有统计学意义( P <0.05)。两组患者治疗后凝血指标血小板含量均显著增高,且Tipss组治疗后血小板显著高于对照组,凝血酶原时间低于对照组,差异有统计学意义( P <0.05)。Tipss组谷丙转氨酶水平较治疗前差异无统计学意义( P >0.05),而对照组含量较治疗前显著降低,差异有统计学意义( P <0.05);Tipss组术后血氨值(NH 3 )明显增高,且显著高于对照组术后,差异有统计学意义( P <0.05)。两种术式术后局部黏膜坏死等轻度并发症发病率差异无统计学意义( P >0.05),但Tipss组术后消化道出血、肝性脑病发病率显著高于对照组,差异有统计学意义( P <0.05)。结论与一线疗法内镜下套扎术相比,Tipss术能更有效抑制食管胃底静脉曲张破裂出血,改善患者静脉曲张情况。但较易出现严重术后并发症,建议临床医生在应用时充分评估风险,做好预防和处理工作。展开更多
BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it...BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings.展开更多
文摘目的分析采用经颈内静脉肝内门腔静脉分流术(Transjugular intrahepatic portosystemic stent shunt,Tipss)在治疗门静脉高压伴食管胃底静脉曲张致破裂出血的临床疗效,为临床在治疗该类患者时术式选择提供参考依据。方法以我院2015年8月至2017年8月收治的门静脉高压伴食管胃底静脉曲张破裂出血患者91例作为研究对象,分为Tipss组(43例)与内镜下套扎止血治疗组(48例)。比较两种术式对患者的临床疗效;比较患者肝脏功能生化指标,统计分析患者术后并发症种类及发生率。结果行Tipss术患者显效率显著高于对照组,差异有统计学意义( P <0.05)。两组患者治疗后凝血指标血小板含量均显著增高,且Tipss组治疗后血小板显著高于对照组,凝血酶原时间低于对照组,差异有统计学意义( P <0.05)。Tipss组谷丙转氨酶水平较治疗前差异无统计学意义( P >0.05),而对照组含量较治疗前显著降低,差异有统计学意义( P <0.05);Tipss组术后血氨值(NH 3 )明显增高,且显著高于对照组术后,差异有统计学意义( P <0.05)。两种术式术后局部黏膜坏死等轻度并发症发病率差异无统计学意义( P >0.05),但Tipss组术后消化道出血、肝性脑病发病率显著高于对照组,差异有统计学意义( P <0.05)。结论与一线疗法内镜下套扎术相比,Tipss术能更有效抑制食管胃底静脉曲张破裂出血,改善患者静脉曲张情况。但较易出现严重术后并发症,建议临床医生在应用时充分评估风险,做好预防和处理工作。
文摘BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings.
