目的 探讨使用加速度肌松监测仪（acceleromyography,AMG）定标和4个成串刺激（train of four ratio,TOF）基线值对麻醉后恢复室（post-anesthesia care unit,PACU）患者肌松残余效应监测准确性的影响,为PACU患者残余肌松的处理提供指...目的 探讨使用加速度肌松监测仪（acceleromyography,AMG）定标和4个成串刺激（train of four ratio,TOF）基线值对麻醉后恢复室（post-anesthesia care unit,PACU）患者肌松残余效应监测准确性的影响,为PACU患者残余肌松的处理提供指导。方法 选择择期全麻手术患者151例,静脉注射依托咪酯、芬太尼诱导后,使用TOF-Watch SX加速度肌松监测仪进行定标和连续测量TOF值5 min确定基线值。然后给予非去极化肌松药插管或置入喉罩。手术完成后,拔除气管导管或喉罩后转运至PACU继续肌松监测,记录TOF基线值（TOFb）和进入PACU时的实测TOF值（TOFa）。结果 共145例患者完成观察,TOFb 0.93-1.29,平均1.07±0.06,其中132例TOFb〉1.0。TOFa〈0.9者41例,肌松残余发生率为28.3%;修正后的TOF值（TOFr）〈0.9者61例,肌松残余发生率为42.1%,两种方法计算的肌松残余发生率的差异有统计学意义（掊2=6.049,P=0.019）。结论 使用AMG时,确定TOF基线值可以提高肌松残余效应监测的准确性,有利于发现潜在的肌松残余患者。展开更多
目的探讨全麻联合硬膜外麻醉下,腹腔镜手术4个成串刺激(train of four,TOF)监测T1低于20%肌松程度的可行性。方法选择行腹腔镜肠道肿瘤手术患者20例,麻醉方法采用全麻联合硬膜外麻醉,全麻前将麻醉平面控制于T6以下水平。全身麻醉采用丙...目的探讨全麻联合硬膜外麻醉下,腹腔镜手术4个成串刺激(train of four,TOF)监测T1低于20%肌松程度的可行性。方法选择行腹腔镜肠道肿瘤手术患者20例,麻醉方法采用全麻联合硬膜外麻醉,全麻前将麻醉平面控制于T6以下水平。全身麻醉采用丙泊酚、瑞芬太尼靶控输注。肌松监测采用TOFW ATCH SX肌松监测仪监测TOF,肌松药物采用非去极化肌松剂罗库溴铵,诱导剂量0.6mg/kg,追加时机为T1恢复至20%,追加剂量0.15mg/kg。记录首次给予肌松剂至T1恢复至20%的时间,每次追加药物时间至T1恢复20%时间,最后一次追加至4个成串刺激比值(train of four ratio,TOFR)恢复至0.9的时间,术中肌松剂使用剂量。记录术中肌松效果评价,包括术者抱怨肌紧张和患者体动反应。记录拔管后残余肌松并随访24h术后呼吸系统并发症。结果本组中男13例,女7例;平均年龄65岁;体质指数(23.2±3.9)kg/m2;手术时间(202.6±73.0)min,罗库溴铵用量(116.7±27.1)mg。所有患者无体动反应,术者抱怨腹肌紧张患者4例。术毕拔管时间(10.8±6.7)min,拔管后TOF中位数为107%,无残余肌松,随访24h无呼吸系统并发症。结论全麻复合硬膜外麻醉下,颤搐高度T1控制目标在20%以下可以满足大部分腹腔镜手术肌松要求。展开更多
Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparosc...Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparoscopic cholecystectomy. Methods： Ninety-six ASA Grade Ⅰ-Ⅱ patients scheduled for laparoscopic cholecystectomy were randomized into Neiguan （P6） electroacupoint stimulation group （treated group） and a placebo control group （placement of electrodes without electroacupoint stimulation）. The anesthetic regimen was standardized by needling at Neiguan on the left side and connecting the TOF peripheral nerve stimulator. The incidence of nausea, vomiting, severity, antiemetic dosage and the degree of pain were assessed at 0, 60, 120 min, and 24 h after surgery. Results： The incidence of nausea and vomiting, the dose of antiemetics and the occurrence of severe nausea were all significantly lower in the treated group compared with the control group and the score for pain was obviously reduced in patients of the treated group at 24 h post-operation （P〈0.05 or P〈0.01）. Conclusion： Transcutaneous electroacupoint stimulation at P6 with the TOF mode could reduce the incidence and severity of nausea and vomiting with analgesic effects.展开更多
With the introduction of the rocuronium and vecuronium binding agent sugammadex into clinical practice in the United States, its use for reversal of neuromuscular blockade will likely start in some institutions as a ...With the introduction of the rocuronium and vecuronium binding agent sugammadex into clinical practice in the United States, its use for reversal of neuromuscular blockade will likely start in some institutions as a “rescue” after failed reversal with neostigmine. However, sugammadex after neostigmine has not been extensively studied. Therefore, there is a question as to its effectiveness when used in this way especially in the airway compromised patients that the anesthesia provider will commonly face in this situation. Furthermore, there is a possibility of hemodynamic compromise. These two case reports demonstrate the safe and effective use of sugammadex after failed reversal with neostigmine.展开更多
文摘目的 探讨使用加速度肌松监测仪（acceleromyography,AMG）定标和4个成串刺激（train of four ratio,TOF）基线值对麻醉后恢复室（post-anesthesia care unit,PACU）患者肌松残余效应监测准确性的影响,为PACU患者残余肌松的处理提供指导。方法 选择择期全麻手术患者151例,静脉注射依托咪酯、芬太尼诱导后,使用TOF-Watch SX加速度肌松监测仪进行定标和连续测量TOF值5 min确定基线值。然后给予非去极化肌松药插管或置入喉罩。手术完成后,拔除气管导管或喉罩后转运至PACU继续肌松监测,记录TOF基线值（TOFb）和进入PACU时的实测TOF值（TOFa）。结果 共145例患者完成观察,TOFb 0.93-1.29,平均1.07±0.06,其中132例TOFb〉1.0。TOFa〈0.9者41例,肌松残余发生率为28.3%;修正后的TOF值（TOFr）〈0.9者61例,肌松残余发生率为42.1%,两种方法计算的肌松残余发生率的差异有统计学意义（掊2=6.049,P=0.019）。结论 使用AMG时,确定TOF基线值可以提高肌松残余效应监测的准确性,有利于发现潜在的肌松残余患者。
文摘目的探讨全麻联合硬膜外麻醉下,腹腔镜手术4个成串刺激(train of four,TOF)监测T1低于20%肌松程度的可行性。方法选择行腹腔镜肠道肿瘤手术患者20例,麻醉方法采用全麻联合硬膜外麻醉,全麻前将麻醉平面控制于T6以下水平。全身麻醉采用丙泊酚、瑞芬太尼靶控输注。肌松监测采用TOFW ATCH SX肌松监测仪监测TOF,肌松药物采用非去极化肌松剂罗库溴铵,诱导剂量0.6mg/kg,追加时机为T1恢复至20%,追加剂量0.15mg/kg。记录首次给予肌松剂至T1恢复至20%的时间,每次追加药物时间至T1恢复20%时间,最后一次追加至4个成串刺激比值(train of four ratio,TOFR)恢复至0.9的时间,术中肌松剂使用剂量。记录术中肌松效果评价,包括术者抱怨肌紧张和患者体动反应。记录拔管后残余肌松并随访24h术后呼吸系统并发症。结果本组中男13例,女7例;平均年龄65岁;体质指数(23.2±3.9)kg/m2;手术时间(202.6±73.0)min,罗库溴铵用量(116.7±27.1)mg。所有患者无体动反应,术者抱怨腹肌紧张患者4例。术毕拔管时间(10.8±6.7)min,拔管后TOF中位数为107%,无残余肌松,随访24h无呼吸系统并发症。结论全麻复合硬膜外麻醉下,颤搐高度T1控制目标在20%以下可以满足大部分腹腔镜手术肌松要求。
文摘Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparoscopic cholecystectomy. Methods： Ninety-six ASA Grade Ⅰ-Ⅱ patients scheduled for laparoscopic cholecystectomy were randomized into Neiguan （P6） electroacupoint stimulation group （treated group） and a placebo control group （placement of electrodes without electroacupoint stimulation）. The anesthetic regimen was standardized by needling at Neiguan on the left side and connecting the TOF peripheral nerve stimulator. The incidence of nausea, vomiting, severity, antiemetic dosage and the degree of pain were assessed at 0, 60, 120 min, and 24 h after surgery. Results： The incidence of nausea and vomiting, the dose of antiemetics and the occurrence of severe nausea were all significantly lower in the treated group compared with the control group and the score for pain was obviously reduced in patients of the treated group at 24 h post-operation （P〈0.05 or P〈0.01）. Conclusion： Transcutaneous electroacupoint stimulation at P6 with the TOF mode could reduce the incidence and severity of nausea and vomiting with analgesic effects.
文摘With the introduction of the rocuronium and vecuronium binding agent sugammadex into clinical practice in the United States, its use for reversal of neuromuscular blockade will likely start in some institutions as a “rescue” after failed reversal with neostigmine. However, sugammadex after neostigmine has not been extensively studied. Therefore, there is a question as to its effectiveness when used in this way especially in the airway compromised patients that the anesthesia provider will commonly face in this situation. Furthermore, there is a possibility of hemodynamic compromise. These two case reports demonstrate the safe and effective use of sugammadex after failed reversal with neostigmine.
