In the Member States of the European Union (EU), a harmonized legislation on medicinal products has been enforced, which specifically defines herbal medicinal products and traditional herbal medicinal products. The sc...In the Member States of the European Union (EU), a harmonized legislation on medicinal products has been enforced, which specifically defines herbal medicinal products and traditional herbal medicinal products. The scope was to create a regulatory environment that takes into account the particular characteristics of herbal medicinal products. The harmonization of standards is intended to harmonize assessment and facilitate access to the market in different Member States. The standards defined by the EU herbal monographs of the Committee on Herbal Medicinal Products (HMPC) and the quality requirements laid down in the European Pharmacopoeia represent an excellent model of multinational harmonization of the regulatory environment for herbal and traditional medicines. It has also been demonstrated that this framework is at least partially applicable for herbal and traditional medicines from traditional Chinese medicine (TCM) to gain access to the EU market. Moreover, the HMPC provides specific guidance documents and pilot projects on monographs on the safety and efficacy of Chinese herbal drugs. In the European Pharmacopoeia, the number of quality monographs of herbal drugs with an origin in TCM is continuously growing. These developments indicate that globalization of traditional medicines is an ongoing process. Communication and cooperation between regulators, the scientific community, and interested stakeholders will set the stage for the convergence of diverse regulatory environments. This will contribute to worldwide availability of traditional medicines based on appropriate standards.展开更多
In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities consti...In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities constitute an important part of traditional medicines. In our study, we firstly clarified the concept of ethnomedicines and the connotations of ethnopharmacology. The particularity of ethnomedicine research were then summed up, and the development profiles of the ethnomedicines of Chinese ethnic minorities were discussed by investigating the current status and existing problems. On this basis, we abstracted the innovative development path of ethnomedicines for the first time, which was found to follows：resource study -, standardized development research -~ industrialization of the achievements and efforts for internationalization. We found that platform establishment and team training are keys to achieving innovative development. Hence, this study provided a basis for ethnomedicine development.展开更多
Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of med...Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.展开更多
The use of traditional medicines including natural drugs, especially traditional Chinese medicine (TCM), plays an important role in the prevention and treatment of human diseases;however, so far, the mechanism of its ...The use of traditional medicines including natural drugs, especially traditional Chinese medicine (TCM), plays an important role in the prevention and treatment of human diseases;however, so far, the mechanism of its prevention, health care and treatment of diseases is unclear. Here, I propose that the core mechanism of traditional medicines is to correct the relative deficiency of potassium ions in body and at the same time improve the utilization efficiency of potassium ions, so as to improve or restore cell functions in organs and tissues, and let the body return to a normal state. In order to achieve such a core goal, the therapeutic effect of natural drugs has an important relationship with the rational matching of prescriptions and the quality of drugs, with particular emphasis on the concentrations and quantum energy levels of potassium ions or their compounds in the formula. The understanding of the core effect of potassium in natural drugs has a specific and important guiding role for the artificial cultivation and rational use of natural drugs. Moreover, these ideas may also provide an important theoretical basis for the development of modern agriculture and medicine, and the rational and comprehensive utilization of potassium resources.展开更多
Herbal medicines have been gaining popularity worldwide. They are an integral component of alternative medical care and provide a rich source for innovative drug discovery. However, the rapid increase in the demand fo...Herbal medicines have been gaining popularity worldwide. They are an integral component of alternative medical care and provide a rich source for innovative drug discovery. However, the rapid increase in the demand for herbal medicines and products has led to the rapid depletion of herbal plants. In addition, rapid population growth, industrialization, and global climate change have endangered these medicinal plants. Given the imminent threat associated with the loss of medicinal plant diversity, this review highlights the need to protect these threatened plant species and avoid the loss of their therapeutic value. The aim of the study was to conserve resources and link them with current research activities and projects to develop novel and more effective drugs in the future.展开更多
Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts o...Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts of Ayurveda, do mention hazards of drugs, which are not properly manufactured or administered. Art of drug administration is unique in this ancient medical science that cautions towards concentrating on dose,indications, contra-indications, suitable vehicle, specific diet, certain restrictions etc., while administering medicines in suitable individuals. Though a huge amount of information is available and evidences are being generated on the usefulness of traditional practices in global healthcare; there is a need of generating awareness on Promoting rational use of traditional medicines in particular to Ayurvedic drugs. Conventional researchers wish to work on traditional formulations have to understand traditional principles and involve traditional physicians in their researches in the benefit of mankind.展开更多
Ischemic stroke has the characteristics of high morbidity and high mortality,which seriously endanger human health.According to the statistics,ischemic stroke in China accounts for about 80% of stroke cases,and its mo...Ischemic stroke has the characteristics of high morbidity and high mortality,which seriously endanger human health.According to the statistics,ischemic stroke in China accounts for about 80% of stroke cases,and its mortality rate is as high as 50%,but most of the ischemic stroke patients who survive have sequelae,such as hemiplegia,aphasia and so on.In recent years,people have continuously studied the pathological cascade of ischemic stroke,and also achieved some good results in animal model experiments,however,the clinical results are not satisfactory.Nowadays,the better clinically effective therapeutic drug is tissue plasminogen activator,but due to the limited time window,only a small number of patients can apply this drug in time to achieve the effect.Therefore,it is essential to study drugs that are definitive and can benefit a large number of patients with ischemic stroke.The development of traditional medicines is not as fast as the development of new drugs.For ischemic stroke,we can also turn from the study of the pathogenesis of ischemic stroke to the study of traditional drugs for the endogenous neuroprotection of ischemic stroke,and look for effective targets for neuroprotection based on traditional medicine.The multi-targets and multi-effects for the acute and convalescent phases of ischemic stroke is a direction explored by researchers,which also provides some evidence for more effective drugs for the treatment of ischemic stroke.展开更多
文摘In the Member States of the European Union (EU), a harmonized legislation on medicinal products has been enforced, which specifically defines herbal medicinal products and traditional herbal medicinal products. The scope was to create a regulatory environment that takes into account the particular characteristics of herbal medicinal products. The harmonization of standards is intended to harmonize assessment and facilitate access to the market in different Member States. The standards defined by the EU herbal monographs of the Committee on Herbal Medicinal Products (HMPC) and the quality requirements laid down in the European Pharmacopoeia represent an excellent model of multinational harmonization of the regulatory environment for herbal and traditional medicines. It has also been demonstrated that this framework is at least partially applicable for herbal and traditional medicines from traditional Chinese medicine (TCM) to gain access to the EU market. Moreover, the HMPC provides specific guidance documents and pilot projects on monographs on the safety and efficacy of Chinese herbal drugs. In the European Pharmacopoeia, the number of quality monographs of herbal drugs with an origin in TCM is continuously growing. These developments indicate that globalization of traditional medicines is an ongoing process. Communication and cooperation between regulators, the scientific community, and interested stakeholders will set the stage for the convergence of diverse regulatory environments. This will contribute to worldwide availability of traditional medicines based on appropriate standards.
文摘In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities constitute an important part of traditional medicines. In our study, we firstly clarified the concept of ethnomedicines and the connotations of ethnopharmacology. The particularity of ethnomedicine research were then summed up, and the development profiles of the ethnomedicines of Chinese ethnic minorities were discussed by investigating the current status and existing problems. On this basis, we abstracted the innovative development path of ethnomedicines for the first time, which was found to follows：resource study -, standardized development research -~ industrialization of the achievements and efforts for internationalization. We found that platform establishment and team training are keys to achieving innovative development. Hence, this study provided a basis for ethnomedicine development.
基金the All India Council of Technical Education (AICTE), New Delhi for providing financial support through MODROB (F.No-8024/RID/ BOR/MOD-74/2008-09)RPS project grants (F.No-8023/BOR/RID/RPS-204/2008-09)
文摘Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.
文摘The use of traditional medicines including natural drugs, especially traditional Chinese medicine (TCM), plays an important role in the prevention and treatment of human diseases;however, so far, the mechanism of its prevention, health care and treatment of diseases is unclear. Here, I propose that the core mechanism of traditional medicines is to correct the relative deficiency of potassium ions in body and at the same time improve the utilization efficiency of potassium ions, so as to improve or restore cell functions in organs and tissues, and let the body return to a normal state. In order to achieve such a core goal, the therapeutic effect of natural drugs has an important relationship with the rational matching of prescriptions and the quality of drugs, with particular emphasis on the concentrations and quantum energy levels of potassium ions or their compounds in the formula. The understanding of the core effect of potassium in natural drugs has a specific and important guiding role for the artificial cultivation and rational use of natural drugs. Moreover, these ideas may also provide an important theoretical basis for the development of modern agriculture and medicine, and the rational and comprehensive utilization of potassium resources.
文摘Herbal medicines have been gaining popularity worldwide. They are an integral component of alternative medical care and provide a rich source for innovative drug discovery. However, the rapid increase in the demand for herbal medicines and products has led to the rapid depletion of herbal plants. In addition, rapid population growth, industrialization, and global climate change have endangered these medicinal plants. Given the imminent threat associated with the loss of medicinal plant diversity, this review highlights the need to protect these threatened plant species and avoid the loss of their therapeutic value. The aim of the study was to conserve resources and link them with current research activities and projects to develop novel and more effective drugs in the future.
文摘Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts of Ayurveda, do mention hazards of drugs, which are not properly manufactured or administered. Art of drug administration is unique in this ancient medical science that cautions towards concentrating on dose,indications, contra-indications, suitable vehicle, specific diet, certain restrictions etc., while administering medicines in suitable individuals. Though a huge amount of information is available and evidences are being generated on the usefulness of traditional practices in global healthcare; there is a need of generating awareness on Promoting rational use of traditional medicines in particular to Ayurvedic drugs. Conventional researchers wish to work on traditional formulations have to understand traditional principles and involve traditional physicians in their researches in the benefit of mankind.
文摘Ischemic stroke has the characteristics of high morbidity and high mortality,which seriously endanger human health.According to the statistics,ischemic stroke in China accounts for about 80% of stroke cases,and its mortality rate is as high as 50%,but most of the ischemic stroke patients who survive have sequelae,such as hemiplegia,aphasia and so on.In recent years,people have continuously studied the pathological cascade of ischemic stroke,and also achieved some good results in animal model experiments,however,the clinical results are not satisfactory.Nowadays,the better clinically effective therapeutic drug is tissue plasminogen activator,but due to the limited time window,only a small number of patients can apply this drug in time to achieve the effect.Therefore,it is essential to study drugs that are definitive and can benefit a large number of patients with ischemic stroke.The development of traditional medicines is not as fast as the development of new drugs.For ischemic stroke,we can also turn from the study of the pathogenesis of ischemic stroke to the study of traditional drugs for the endogenous neuroprotection of ischemic stroke,and look for effective targets for neuroprotection based on traditional medicine.The multi-targets and multi-effects for the acute and convalescent phases of ischemic stroke is a direction explored by researchers,which also provides some evidence for more effective drugs for the treatment of ischemic stroke.
