目的:探讨连续性血液净化(CBP)透析治疗急性肾衰竭的价值及对血气指标、肾功能指标和毒素清除率等指标的影响。方法:选择2019年1月-2021年1月淄博市市立医院接诊的58例急性肾衰竭患者,按信封随机法分为两组,各29例。参照组予以间歇性血...目的:探讨连续性血液净化(CBP)透析治疗急性肾衰竭的价值及对血气指标、肾功能指标和毒素清除率等指标的影响。方法:选择2019年1月-2021年1月淄博市市立医院接诊的58例急性肾衰竭患者,按信封随机法分为两组,各29例。参照组予以间歇性血液透析(IHD)治疗,研究组予以CBP透析治疗,比较两组肾功能、血气指标、毒素清除率和安全性等。结果:治疗前,两组各项肾功能、血气相关指标对比差异无统计学意义(P>0.05);治疗4周后,两组血肌酐(Scr)、β_(2)-微球蛋白(β_(2)-MG)、尿素氮(BUN)、舒张压(DBP)、收缩压(SBP)和心率指标均降低,血氧饱和度(SpO_(2))上升,且研究组Scr、β_(2)-MG和BUN指标低于参照组(P<0.05),但组间DBP、SBP、SpO_(2)对比差异无统计学意义(P>0.05)。研究组Scr、β_(2)-MG、BUN和毒素清除率高于参照组,导管栓塞、心律失常和插管部位感染等并发症发生率低于参照组(6.90% vs 27.59%),差异有统计学意义(P<0.05)。结论:在急性肾衰竭治疗中,CBP的疗效显著,可显著改善患者肾功能指标,提高毒素清除率,同时有利于降低并发症发生率,值得推广。展开更多
Objective:To explore the effect of hemodialysis (HD) in combined with hemoperfusion (HP) on the toxin clearance rate and carotid intima in patients with uremia.Methods: A total of 40 patients with uremia who were admi...Objective:To explore the effect of hemodialysis (HD) in combined with hemoperfusion (HP) on the toxin clearance rate and carotid intima in patients with uremia.Methods: A total of 40 patients with uremia who were admitted in our hospital from May, 2015 to February, 2017 were included in the study and randomized into the control group (n=20) and the study group (n=20). The patients in the two groups were given routine HD treatment. On the above basis, the patients in the study group were given HP treatment, continuously for 3 months. The toxin content, clearance rate, and serum inflammatory cytokines before and after treatment in the two groups were detected and compared. The ultrasound diagnostic apparatus was used to detect the carotid IMT before and after treatment in the two groups. Results: Scr and BUN after treatment in the two groups, and PTH andβ2-MG contents in the study group were significantly reduced when compared with before treatment. PTH andβ2-MG contents after treatment in the study group were significantly lower than those in the control group, while PTH andβ2-MG clearance rate was significantly higher than that in the control group. The serum MDA, hs-CRP, IL-6, and TNF-α levels after treatment in the two groups were significantly reduced when compared with before treatment. The serum hs-CRP, IL-6, and TNF-α levels after treatment in the study group were significantly lower than those in the control group. IMT and plaque area after treatment in the control group were significantly increased when compared with before treatment, while IMT and plaque area in the study group were not significantly changed. The plaque area after treatment in the study group was significantly less than that in the control group.Conclusions: HD in combined with HP can significantly enhance the toxin clearance rate of large molecules in patients with uremia, alleviate the inflammatory reaction, and meanwhile effectively delay the occurrence of atherosclerosis and other cardiovascular complications.展开更多
文摘目的:探讨连续性血液净化(CBP)透析治疗急性肾衰竭的价值及对血气指标、肾功能指标和毒素清除率等指标的影响。方法:选择2019年1月-2021年1月淄博市市立医院接诊的58例急性肾衰竭患者,按信封随机法分为两组,各29例。参照组予以间歇性血液透析(IHD)治疗,研究组予以CBP透析治疗,比较两组肾功能、血气指标、毒素清除率和安全性等。结果:治疗前,两组各项肾功能、血气相关指标对比差异无统计学意义(P>0.05);治疗4周后,两组血肌酐(Scr)、β_(2)-微球蛋白(β_(2)-MG)、尿素氮(BUN)、舒张压(DBP)、收缩压(SBP)和心率指标均降低,血氧饱和度(SpO_(2))上升,且研究组Scr、β_(2)-MG和BUN指标低于参照组(P<0.05),但组间DBP、SBP、SpO_(2)对比差异无统计学意义(P>0.05)。研究组Scr、β_(2)-MG、BUN和毒素清除率高于参照组,导管栓塞、心律失常和插管部位感染等并发症发生率低于参照组(6.90% vs 27.59%),差异有统计学意义(P<0.05)。结论:在急性肾衰竭治疗中,CBP的疗效显著,可显著改善患者肾功能指标,提高毒素清除率,同时有利于降低并发症发生率,值得推广。
文摘Objective:To explore the effect of hemodialysis (HD) in combined with hemoperfusion (HP) on the toxin clearance rate and carotid intima in patients with uremia.Methods: A total of 40 patients with uremia who were admitted in our hospital from May, 2015 to February, 2017 were included in the study and randomized into the control group (n=20) and the study group (n=20). The patients in the two groups were given routine HD treatment. On the above basis, the patients in the study group were given HP treatment, continuously for 3 months. The toxin content, clearance rate, and serum inflammatory cytokines before and after treatment in the two groups were detected and compared. The ultrasound diagnostic apparatus was used to detect the carotid IMT before and after treatment in the two groups. Results: Scr and BUN after treatment in the two groups, and PTH andβ2-MG contents in the study group were significantly reduced when compared with before treatment. PTH andβ2-MG contents after treatment in the study group were significantly lower than those in the control group, while PTH andβ2-MG clearance rate was significantly higher than that in the control group. The serum MDA, hs-CRP, IL-6, and TNF-α levels after treatment in the two groups were significantly reduced when compared with before treatment. The serum hs-CRP, IL-6, and TNF-α levels after treatment in the study group were significantly lower than those in the control group. IMT and plaque area after treatment in the control group were significantly increased when compared with before treatment, while IMT and plaque area in the study group were not significantly changed. The plaque area after treatment in the study group was significantly less than that in the control group.Conclusions: HD in combined with HP can significantly enhance the toxin clearance rate of large molecules in patients with uremia, alleviate the inflammatory reaction, and meanwhile effectively delay the occurrence of atherosclerosis and other cardiovascular complications.
