Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 ...Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including int展开更多
研究以海藻膳食纤维为主,传统降脂中药山楂、绞股蓝、泽泻为辅的功能食品的降血脂作用。参考卫生部保健食品辅助降血脂功能评价方法,以高脂饲料建立高脂血症小鼠模型,灌胃给予含不同成分的复合物(海藻膳食纤维高、中、低剂量组,复合物...研究以海藻膳食纤维为主,传统降脂中药山楂、绞股蓝、泽泻为辅的功能食品的降血脂作用。参考卫生部保健食品辅助降血脂功能评价方法,以高脂饲料建立高脂血症小鼠模型,灌胃给予含不同成分的复合物(海藻膳食纤维高、中、低剂量组,复合物Ⅰ、Ⅱ、Ⅲ组,辛伐他汀组,正常对照组和模型组灌胃生理盐水)。4周后,测定血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)以及低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)水平,计算肝脏系数,苏木精-伊红染色观察肝脏脂肪变性程度。结果表明:海藻膳食纤维能显著降低高脂血症小鼠血清TC、TG及LDL-C水平,升高HDL-C水平;且加入少量药食同源的中药(绞股蓝提取物和泽泻提取物)后的复合型海藻膳食纤维能使高脂小鼠血脂水平更接近正常值。说明复合型海藻膳食纤维功能食品有较好的降血脂作用。展开更多
文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including int
文摘研究以海藻膳食纤维为主,传统降脂中药山楂、绞股蓝、泽泻为辅的功能食品的降血脂作用。参考卫生部保健食品辅助降血脂功能评价方法,以高脂饲料建立高脂血症小鼠模型,灌胃给予含不同成分的复合物(海藻膳食纤维高、中、低剂量组,复合物Ⅰ、Ⅱ、Ⅲ组,辛伐他汀组,正常对照组和模型组灌胃生理盐水)。4周后,测定血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)以及低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)水平,计算肝脏系数,苏木精-伊红染色观察肝脏脂肪变性程度。结果表明:海藻膳食纤维能显著降低高脂血症小鼠血清TC、TG及LDL-C水平,升高HDL-C水平;且加入少量药食同源的中药(绞股蓝提取物和泽泻提取物)后的复合型海藻膳食纤维能使高脂小鼠血脂水平更接近正常值。说明复合型海藻膳食纤维功能食品有较好的降血脂作用。
