Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of l...Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of life, and its safety. Method： A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients＇ inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapdde citrate dummy 5 mg three times a day, and in the control group, patients were given mosapdde citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Results： Among 120 included patients, 112 were screened for full analysis set （FAS）, and 105 were screened per-protocol set （PPS）. The results were as follows： （1） the improvement of total scores of symptom in the experiment group （0-4 week） were 15.93 ± 7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43± 10.16 scores and 10.79± 10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10- 8.90 scores and 1.92-8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group （P〈0.05）. （2） The improvement of scores of major symptom in the experiment group （0-4 week） were 10.68±5.35 by FAS and 10.89±5.29 by PPS and 7.40±7.41 and 7.60±7.46 in the control group, respectively. The 95% CI of net scores improvement in the two groups were 0.85-5.71 and 0.71-5.69 in FAS and PPS separately, and the improvement in the experiment group was significantly better than that in the control group （P〈0.05）. （3） The total effective rates were 86.0% and 61.8% in the experiment and the control group separately, and the Ridit analysis result展开更多
Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE model.Metho...Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE model.Methods:Chemical composition of HXTJD was analyzed by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry(MS).The change rates of mean contraction tension forces,mean amplitudes,and mean frequencies for the lower esophageal sphincter(LES)were recorded using the isolated tissue bath system,mechanical tension transducer,and PowerLab physiological recorder.After weighing the stomach,the phenol red labeling method was used to measure the gastric emptying rate.The LES ultrastructure was observed through transmission electron microscopy.Immunofluorescence and western blotting were used to detect the number of interstitial cells of Cajal(ICC)and the expression levels of c-kit protein,connexin43(Cx43),and stem cell factor(SCF).Flow cytometric analysis and enzyme-linked immunosorbent assay were conducted to detect the percentages of T helper 17(Th17)cells and regulatory T(Treg)cells and the serum concentrations of interleukin 6(IL-6),interleukin 17(IL-17),and interleukin 10(IL-10)in the rats.Results:We identified 28 chemical constituents in HXTJD.Regarding esophageal motility,we revealed that HXTJD increased the mean contraction tension forces,mean amplitudes,and mean frequency change rate of LES and the gastric emptying rate;decreased stomach weight;and improved the LES ultrastructure.Additionally,HXTJD increased the number of ICC-positive cells,and c-kit,Cx43,and SCF expression levels.Regarding esophageal inflammation,HXTJD significantly decreased the percentage of Th17 cells,and IL-6 and IL-17 concentrations,and increased the percentage of Treg cells and IL-10 concentration.Conclusion:HXTJD was found to be efficacious in the rat RE model.It may promote esophageal motility and alleviate the inflammatory response by activating the SCF/c-kit/ICC pathway and regulating the Th17/Treg cell balanc展开更多
Through field investigation and relevant literature materials, the status and problems of Tremella industrial development in Tongjiang were analyzed by SWOT model. The countermeasures such as strengthening scientific ...Through field investigation and relevant literature materials, the status and problems of Tremella industrial development in Tongjiang were analyzed by SWOT model. The countermeasures such as strengthening scientific and technological innovation, expanding money input, strengthening the brand construction, focusing on the introduction and cultivation of leading enterpdses were put forward, in order to provide theoretical basis and intellectual support for the industrial policy-making of government, and provide references for the sustainable development of tremella industry in Tongjiang.展开更多
基金Supported by Fund of Capital Medical Development and Research （No. 03III10）.
文摘Objective： To assess the effectiveness of Tongjiang Granule （TJG, 通降颗粒） on the patients with nonerosive reflux disease （NERD） of Gan （肝）-Wei （胃） incoordination syndrome, its impact on their quality of life, and its safety. Method： A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients＇ inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapdde citrate dummy 5 mg three times a day, and in the control group, patients were given mosapdde citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Results： Among 120 included patients, 112 were screened for full analysis set （FAS）, and 105 were screened per-protocol set （PPS）. The results were as follows： （1） the improvement of total scores of symptom in the experiment group （0-4 week） were 15.93 ± 7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43± 10.16 scores and 10.79± 10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10- 8.90 scores and 1.92-8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group （P〈0.05）. （2） The improvement of scores of major symptom in the experiment group （0-4 week） were 10.68±5.35 by FAS and 10.89±5.29 by PPS and 7.40±7.41 and 7.60±7.46 in the control group, respectively. The 95% CI of net scores improvement in the two groups were 0.85-5.71 and 0.71-5.69 in FAS and PPS separately, and the improvement in the experiment group was significantly better than that in the control group （P〈0.05）. （3） The total effective rates were 86.0% and 61.8% in the experiment and the control group separately, and the Ridit analysis result
基金supported by the National Natural Science Foundation of China(No.81573737 and 82074213)the science foundation of Tianjin Municipal Health Bureau(No.2023169 and 2021045)the Tianjin Municipal Health Commission Science and Technology Project(No.TJWJ2022QN057).
文摘Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE model.Methods:Chemical composition of HXTJD was analyzed by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry(MS).The change rates of mean contraction tension forces,mean amplitudes,and mean frequencies for the lower esophageal sphincter(LES)were recorded using the isolated tissue bath system,mechanical tension transducer,and PowerLab physiological recorder.After weighing the stomach,the phenol red labeling method was used to measure the gastric emptying rate.The LES ultrastructure was observed through transmission electron microscopy.Immunofluorescence and western blotting were used to detect the number of interstitial cells of Cajal(ICC)and the expression levels of c-kit protein,connexin43(Cx43),and stem cell factor(SCF).Flow cytometric analysis and enzyme-linked immunosorbent assay were conducted to detect the percentages of T helper 17(Th17)cells and regulatory T(Treg)cells and the serum concentrations of interleukin 6(IL-6),interleukin 17(IL-17),and interleukin 10(IL-10)in the rats.Results:We identified 28 chemical constituents in HXTJD.Regarding esophageal motility,we revealed that HXTJD increased the mean contraction tension forces,mean amplitudes,and mean frequency change rate of LES and the gastric emptying rate;decreased stomach weight;and improved the LES ultrastructure.Additionally,HXTJD increased the number of ICC-positive cells,and c-kit,Cx43,and SCF expression levels.Regarding esophageal inflammation,HXTJD significantly decreased the percentage of Th17 cells,and IL-6 and IL-17 concentrations,and increased the percentage of Treg cells and IL-10 concentration.Conclusion:HXTJD was found to be efficacious in the rat RE model.It may promote esophageal motility and alleviate the inflammatory response by activating the SCF/c-kit/ICC pathway and regulating the Th17/Treg cell balanc
基金Supported by Key Strategic Research and Information Service of Sichuan Crop and Livestock Breeding(2011NZ0098-19)Modern Agriculture Industry Technology System((2014)No.91)
文摘Through field investigation and relevant literature materials, the status and problems of Tremella industrial development in Tongjiang were analyzed by SWOT model. The countermeasures such as strengthening scientific and technological innovation, expanding money input, strengthening the brand construction, focusing on the introduction and cultivation of leading enterpdses were put forward, in order to provide theoretical basis and intellectual support for the industrial policy-making of government, and provide references for the sustainable development of tremella industry in Tongjiang.
