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Reversed vascularized second metatarsal flap for reconstruction of Manske type ⅢB and Ⅳ thumb hypoplasia with reduced donor site morbidity 被引量:6
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作者 De-Di Tong Le-Hao Wu +7 位作者 Peng-Cheng Li Yan-Bo Rong Bo Liu WPAndrew Lee Qi-Pei Wei Lu Liu He-Jia Miao Shan-Lin Chen 《Chinese Medical Journal》 SCIE CAS CSCD 2019年第21期2565-2571,共7页
Background:The predominant method for Manske type ⅢB and Ⅳ thumb hypoplasia is pollicization.However,for those who are not willing to sacrifice the index finger,a method that could reconstruct a functionally capable... Background:The predominant method for Manske type ⅢB and Ⅳ thumb hypoplasia is pollicization.However,for those who are not willing to sacrifice the index finger,a method that could reconstruct a functionally capable and aesthetically acceptable thumb remains desirable.This study aimed to investigate and assess the functional and radiographic outcomes of utilizing a reversed vascularized second metatarsal composite flap for thumb reconstruction as a new alternative.Methods:From May 2014 to January 2017,15 patients with Manske type ⅢB or Ⅳ thumb hypoplasia who were admitted to the Department of Hand Surgery,Beijing Jishuitan Hospital were included in this study.An osteocutaneous flap containing a section of second metatarsal and its distal head was transferred in reversed position to reconstruct carpometacarpal joint.The donor site was reconstructed by a split half of the third metatarsal.Various functional reconstructions were commenced at second stage.The reconstructed thumbs were evaluated using the Kapandji score,pinch force,and the capacities of performing daily activities through a detailed questionnaire.Results:Among these 15 patients(seven type ⅢB and eight type Ⅳ),there were ten boys and five girls with median age of 4.2 years(range:2.0–7.0 years).There were seven right,three left,and five bilateral thumbs for whom only the right thumb received surgery.There were 14 metatarsal flaps survived(14/15).With an average follow-up of 19.2 months,the reconstructed thumbs had acceptable functional and aesthetic outcomes and the donor foot presented in decent appearance without signs of impaired function.All 15 children have improved the Kapandji score(from 0 to an average of 6.7),pinch force(from 0 to an average of 1.5 kg),with ability of grip and pen holding.X-ray indicated continuous bone growth.Patients and parents had good acceptance of the new thumb.Conclusions:Reconstruction of an unstable hypoplastic thumb(Manske type ⅢB and Ⅳ)with use of a vascularized metatarsal is an effective strategy.I 展开更多
关键词 thumb hypoplasia SECOND METATARSAL FLAP Donor site morbidity MICROSURGERY
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Classification of congenital thumb hypoplasia and deformity 被引量:1
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作者 Wei Wang Chuanchang Dai Lu Zhang 《Chinese Journal of Plastic and Reconstructive Surgery》 2021年第4期181-188,共8页
Background:Congenital thumb deformities account for one-third or more of all cases of congenital hand deformity.However,the current classification schemes of congenital thumb hypoplasia are no longer adequate due to t... Background:Congenital thumb deformities account for one-third or more of all cases of congenital hand deformity.However,the current classification schemes of congenital thumb hypoplasia are no longer adequate due to their lack of adaptability to increasing knowledge in the field.Hence,a modified system with the potential to adapt to ongoing advances in knowledge and understanding is desperately needed.Methods:Based on the photographs collected from thousands of cases of congenital deformities of the hand and upper limb over multiple decades in our department,we subdivided thumb hypoplasia according to the variables of morphological characteristics,anatomical structures,functional status,the relationship between thumb deformity and hand deformity,the relationship between congenital hand deformity syndrome and thumb hypoplasia,and the selection of treatment methods.Results:A total of 10 types were presented,which were elucidated with nomenclatures as well as pathological feature and symptoms.Conclusion:This modified system may shed additional light on the classification of congenital thumb anomalies,which will assist in a more effective selection of treatment modalities and offers significant benefits to both patients and practice. 展开更多
关键词 CLASSIFICATION Congenital thumb hypoplasia DEFORMITY
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桡侧腕长伸肌腱重建先天性第一腕掌关节发育不良
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作者 刘宇洲 徐秀玥 +3 位作者 王乐 劳杰 庄永青 方有生 《中华手外科杂志》 CSCD 北大核心 2023年第4期301-304,共4页
目的介绍一种修复ⅢB型拇指发育不良腕掌关节不稳的方法,采用桡侧腕长伸肌腱的一半重建第一腕掌关节,评价该手术修复ⅢB型拇指发育不良的疗效。方法对4例患儿的单侧拇指发育不良进行回顾性临床研究。均为ⅢB型拇指发育不良,且X线片示第... 目的介绍一种修复ⅢB型拇指发育不良腕掌关节不稳的方法,采用桡侧腕长伸肌腱的一半重建第一腕掌关节,评价该手术修复ⅢB型拇指发育不良的疗效。方法对4例患儿的单侧拇指发育不良进行回顾性临床研究。均为ⅢB型拇指发育不良,且X线片示第一掌骨长度接近正常。手术采用桡侧腕长伸肌腱的一半重建第一腕掌关节韧带。后期行拇对掌和伸拇功能重建。术后通过测量拇指桡侧外展、掌侧外展、伸拇和改良Kapandji量表评估临床疗效。结果术后随访1.5~3.0年,平均2.1年。术后拇指桡侧外展和掌侧外展的平均角度分别为78°和41°,患儿拇指主动桡侧外展和掌侧外展功能获得改善。术后平均拇指伸直度为-5°,接近正常拇指。4例患儿术后的第一腕掌关节均稳定。Kapandji评分显示术后所有儿童的拇对掌功能均有所改善。结论对于第一掌骨长度接近正常的ⅢB型拇指发育不良患儿,使用桡侧腕长伸肌腱的一半重建第一腕掌关节韧带结合肌腱移位的分期手术可能是一种有效的治疗策略。 展开更多
关键词 手畸形 先天性 腕掌关节 拇指发育不良 桡侧腕长伸肌腱 肌腱移位
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两个三指节拇指轴前多指家系的ZRS突变分析 被引量:4
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作者 赵熙萌 杨威 +1 位作者 孙淼 张学 《中华医学遗传学杂志》 CAS CSCD 北大核心 2016年第3期281-285,共5页
目的明确两个中国汉族具有三指节拇指特征的轴前多指家系的致病突变。方法知情同意下采集家系1的9名家系成员(患者2例)、家系2的14名家系成员(患者7例)的外周血,提取基因组DNA;应用实时定量PCR与PCR-Sanger测序,对SHH基因的调控... 目的明确两个中国汉族具有三指节拇指特征的轴前多指家系的致病突变。方法知情同意下采集家系1的9名家系成员(患者2例)、家系2的14名家系成员(患者7例)的外周血,提取基因组DNA;应用实时定量PCR与PCR-Sanger测序,对SHH基因的调控元件“极化活性区调控序列”(zone of polarizing activity regulatory sequence,ZRS)分别进行拷贝数与序列突变检测;应用变性聚丙烯酰胺凝胶电泳,检测家系1ZRS附近短串联重复序列的基因型,结合Sanger测序发现的点突变,进行单倍型分析。结果定量PCR显示两家系患者在ZRS区域均不存在拷贝数改变。Sanger测序结果显示,家系1的2例患者均存在ZRS406A〉G杂合突变、家系2的7例患者均存在ZRS105C〉G杂合突变,且突变在各自家系中均与多指表型共分离,在200名正常对照中均未检测到上述突变。已有报道ZRS的105C〉G杂合突变可引起典型的三指节拇指轴前多指;而ZRS的406A〉G杂合突变仅见于1个胫骨发育不良伴多指(趾)家系中。单倍型分析及测序结果提示,家系1中第1例出现肢端畸形的患者为ZRS406A〉G杂合突变的体细胞及生殖细胞嵌合体。结论SHH基因调控元件ZRs的406A〉G与105C〉G杂合突变分别为两个中国汉族三指节拇指轴前多指家系的致病突变。 展开更多
关键词 三指节拇指 轴前多指 极化活性区调控序列 点突变 胫骨发育不良伴多指(趾)
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"4"或"5"?重度先天性拇指发育不良的分型与治疗进展 被引量:2
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作者 薛云皓 陈山林 《中华整形外科杂志》 CSCD 2021年第9期953-961,共9页
先天性拇指发育不良临床并不少见,重度拇指发育不良对手和上肢功能都有明显影响。自从Buck-Gramcko发表了示指拇化术重建重度发育不良拇指的经典文献以来,该术式就成为治疗重度拇指发育不良的标杆,也被公认为是手外科历史上里程碑样的... 先天性拇指发育不良临床并不少见,重度拇指发育不良对手和上肢功能都有明显影响。自从Buck-Gramcko发表了示指拇化术重建重度发育不良拇指的经典文献以来,该术式就成为治疗重度拇指发育不良的标杆,也被公认为是手外科历史上里程碑样的术式之一。Blauth分型及其各种改良分型都是希望在"保留发育不良拇指的重建手术"和"示指拇化手术"之间寻找一个分界点,反复强调的还是"能做示指拇化则做示指拇化"。但现实中,尽管人们有肤色、种族、文化方面的差异,但更多的患儿家长或监护人都期待医生能尽量保留拇指,即使功能逊色一些。对他们而言,5个手指的整体外观是4个手指永远无法比拟的。过去10余年,北京积水潭医院共治疗近300例第一腕掌关节缺如的拇指发育不良患者,即使术前沟通再详细,并演示示指拇化后的"漂亮"照片,但看了保留拇指病例的术后照片后,仍有90%的家长"执拗"地选择了保留拇指。"4"或"5"不仅是数学问题,更是一个哲学命题,很多临床问题都是如此。当医生的偏好与患者及家人的期待并不一致的时候,要更多倾听一些患方的心声。文章作者通过阅读拇指发育不良领域的主要文献,并总结北京积水潭医院近10余年治疗拇指发育不良的经验,提出了新的改良分型及重建策略,旨在对相关专业的医生有所裨益。 展开更多
关键词 手畸形 修复外科手术 先天性拇指发育不良
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重度拇指发育不良的示指拇化手术效果初步分析
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作者 栗鹏程 白帆 +5 位作者 沈杰 刘波 刘路 刘畅 王志新 陈山林 《中华整形外科杂志》 CAS CSCD 北大核心 2020年第7期721-728,共8页
目的探讨示指拇化手术治疗重度拇指发育不良的功能与外观效果。方法2010年6月至2018年11月间对在北京积水潭医院手外科就诊的26例Manske改良BlauthⅢB~Ⅴ型拇指发育不良患儿进行示指拇化手术治疗。患儿手术时平均月龄为37个月(15~89个... 目的探讨示指拇化手术治疗重度拇指发育不良的功能与外观效果。方法2010年6月至2018年11月间对在北京积水潭医院手外科就诊的26例Manske改良BlauthⅢB~Ⅴ型拇指发育不良患儿进行示指拇化手术治疗。患儿手术时平均月龄为37个月(15~89个月),男19例,女7例,左手8例,右手15例,双手3例,ⅢB型4只手,Ⅳ型16只,Ⅴ型9只。术后随访外观及功能,测量拇指外展角度、Kapandji评分、捏力、指间关节和掌指关节的活动度。检查腕掌关节稳定性。使用Goldfarb功能评分和Likert量表评分评价拇指的总体功能。观察X线片上新拇指掌骨近端骨骺是否闭合,有无手术并发症。对患儿监护人和随访医生进行主观拇指外形及功能满意度调查。分析监护人对外形及功能满意度与客观指标之间的相关性、监护人与医生满意度之间的差异、3岁前与3岁后手术满意度之间的差异。结果26例患儿平均随访42个月,平均拇指桡侧外展46.2°,掌侧外展34.1°,平均Kapandji评分7.1分。平均指间关节伸直3.4°,屈曲40.7°,掌指关节伸直4.1°,屈曲38.6°。捏力(侧捏、对捏、三指捏)平均值分别为0.5、0.8、1.2 kg。所有腕掌关节稳定。Goldfarb评分平均为4分。Likert量表平均为22分。所有骨骺没有闭合。6例虎口皮肤浅表坏死,1例虎口轻度挛缩。患儿监护人对拇指外形及功能的满意度与各个客观指标之间没有相关性。患儿监护人对拇指外形及功能满意度显著低于医生满意度。监护人和医生满意度在3岁之前和3岁之后手术之间差异无统计学意义。结论对Manske改良BlauthⅢB~Ⅴ型拇指发育不良患儿行示指拇化手术,术后功能满意,但存在拇指对掌和屈指力弱的问题。医生的主观满意度较高,监护人的主观满意度较低。 展开更多
关键词 先天性拇指发育不良 示指拇化 手术技术 结果
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