An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be ob...An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be obtained from alkylation of 4-bromomethylquinoline-2-ones with salicylonitrile and subsequent Thorpe-Ziegier isomerization,with aromatic aldehydes under p-TsOH as catalyst in good yields.展开更多
由于湍流混合直接观测技术难度大、成本高,很大程度限制湍流混合的研究,所以基于温、盐、流资料估算海洋湍流混合的方法应运而生。本文应用在吕宋海峡观测到的23个自由下降微结构湍流剖面仪观测数据和水文观测数据,首次对目前常用的Greg...由于湍流混合直接观测技术难度大、成本高,很大程度限制湍流混合的研究,所以基于温、盐、流资料估算海洋湍流混合的方法应运而生。本文应用在吕宋海峡观测到的23个自由下降微结构湍流剖面仪观测数据和水文观测数据,首次对目前常用的Gregg-Henyey-Polzin(GHP)细尺度参数化、Mackinnon and Gregg(MG)参数化和Thorpe尺度方法进行比较研究,评估它们的适用性。发现GHP参数化方法能够很好地估算吕宋海峡的湍流混合。虽然GHP参数化方法估算的耗散率总体上要偏弱于观测的结果,但估算和观测的差异在2倍以内的结果占71%,与微结构湍流剖面仪观测到的耗散率在水平分布和垂向分布上呈现出相同的分布特征。基于MG参数化方法发现估算的吕宋海峡西侧1200m以浅的耗散率比观测值大,但总体上呈现出相同的分布特征。另外,MG参数化估算与观测差异在2倍以内的结果占58%。表明相比于GHP参数化方法,MG参数化方法的估算值更偏离观测值。Thorpe尺度方法在估算吕宋海峡的耗散率时,估算和观测的差异在2倍以内的结果仅有30%,70%的估算结果与观测结果相差高出1个量级,空间分布上与观测结果差异较大。对比吕宋海峡湍流混合参数化方法的结果表明GHP参数化方法最优,MG参数化方法其次,Thorpe尺度方法相对GHP和MG参数化方法较差。展开更多
An efficient method for the synthesis of novel pyrido[3＇＇,2＇＇：4＇,5＇]thieno[3＇,2＇：2,3]pyrido [4,5：d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives（5） has been developed using a Pictet–Spengler reaction ...An efficient method for the synthesis of novel pyrido[3＇＇,2＇＇：4＇,5＇]thieno[3＇,2＇：2,3]pyrido [4,5：d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives（5） has been developed using a Pictet–Spengler reaction between 2-（3-aminothieno[2,3-b]pyridin-2-yl）thiazolo[3,2-a] pyrimidin-5-one（3）, which could be obtained from the condensation of 7-（chloromethyl）-5H-thiazolo[3,2-a]pyrimidin-5-one（1） with3-cyanopyridine-2-thione（2） via Thorpe–Ziegler isomerization, and aromatic aldehydes under NH2SO3 H as catalysis in good yields.展开更多
Upper turbulent mixing in the interior and surrounding areas of an anticyclonic eddy in the northern South China Sea(SCS)was estimated from underwater glider data(May 2015)in the present study,using the Gregg-HenyeyPo...Upper turbulent mixing in the interior and surrounding areas of an anticyclonic eddy in the northern South China Sea(SCS)was estimated from underwater glider data(May 2015)in the present study,using the Gregg-HenyeyPolzin parameterization and the Thorpe-scale method.The observations revealed a clear asymmetrical spatial pattern of turbulent mixing in the anticyclonic eddy area.Enhanced diffusivity(in the order of 10–3 m2/s)was found at the posterior edge of the anticyclonic mesoscale eddy;on the anterior side,diffusivity was one order of magnitude lower on average.This asymmetrical pattern was highly correlated with the eddy kinetic energy.Higher shear variance on the posterior side,which is conducive to the triggering of shear instability,may be the main mechanism for the elevated diffusivity.In addition,the generation and growth of sub-mesoscale motions that are fed by mesoscale eddies on their posterior side may also promote the occurrence of strong mixing in the studied region.The results of this study help improve our knowledge regarding turbulent mixing in the northern SCS.展开更多
An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thi...An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields.展开更多
An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-...An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.展开更多
基金financial support from the Science and Technology Department of Liaoning Province(No.2011220022)
文摘An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be obtained from alkylation of 4-bromomethylquinoline-2-ones with salicylonitrile and subsequent Thorpe-Ziegier isomerization,with aromatic aldehydes under p-TsOH as catalyst in good yields.
文摘由于湍流混合直接观测技术难度大、成本高,很大程度限制湍流混合的研究,所以基于温、盐、流资料估算海洋湍流混合的方法应运而生。本文应用在吕宋海峡观测到的23个自由下降微结构湍流剖面仪观测数据和水文观测数据,首次对目前常用的Gregg-Henyey-Polzin(GHP)细尺度参数化、Mackinnon and Gregg(MG)参数化和Thorpe尺度方法进行比较研究,评估它们的适用性。发现GHP参数化方法能够很好地估算吕宋海峡的湍流混合。虽然GHP参数化方法估算的耗散率总体上要偏弱于观测的结果,但估算和观测的差异在2倍以内的结果占71%,与微结构湍流剖面仪观测到的耗散率在水平分布和垂向分布上呈现出相同的分布特征。基于MG参数化方法发现估算的吕宋海峡西侧1200m以浅的耗散率比观测值大,但总体上呈现出相同的分布特征。另外,MG参数化估算与观测差异在2倍以内的结果占58%。表明相比于GHP参数化方法,MG参数化方法的估算值更偏离观测值。Thorpe尺度方法在估算吕宋海峡的耗散率时,估算和观测的差异在2倍以内的结果仅有30%,70%的估算结果与观测结果相差高出1个量级,空间分布上与观测结果差异较大。对比吕宋海峡湍流混合参数化方法的结果表明GHP参数化方法最优,MG参数化方法其次,Thorpe尺度方法相对GHP和MG参数化方法较差。
文摘An efficient method for the synthesis of novel pyrido[3＇＇,2＇＇：4＇,5＇]thieno[3＇,2＇：2,3]pyrido [4,5：d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives（5） has been developed using a Pictet–Spengler reaction between 2-（3-aminothieno[2,3-b]pyridin-2-yl）thiazolo[3,2-a] pyrimidin-5-one（3）, which could be obtained from the condensation of 7-（chloromethyl）-5H-thiazolo[3,2-a]pyrimidin-5-one（1） with3-cyanopyridine-2-thione（2） via Thorpe–Ziegler isomerization, and aromatic aldehydes under NH2SO3 H as catalysis in good yields.
基金The National Key R&D Plan of China under contract Nos 2017YFC0305904,2017YFC0305804 and 2016YFC1401404the National Natural Science Foundation of China under contract Nos 41876023,41630970,41806037,41706137 and 41806033+4 种基金the Guangdong Science and Technology Project under contract Nos 2019A1515111044,2018A0303130047 and 2017A030310332the Guangzhou Science and Technology Project under contract No.201707020037the Natural Science Foundation of Shenzhen University under contract No.2019078the Dedicated Fund for Promoting High-quality Economic Development in Guangdong Province(Marine Economic Development Project)under contract No.GDOE2019A03the Independent Research Project Program of State Key Laboratory of Tropical Oceanography under contract Nos LTOZZ1902 and LTO1909。
文摘Upper turbulent mixing in the interior and surrounding areas of an anticyclonic eddy in the northern South China Sea(SCS)was estimated from underwater glider data(May 2015)in the present study,using the Gregg-HenyeyPolzin parameterization and the Thorpe-scale method.The observations revealed a clear asymmetrical spatial pattern of turbulent mixing in the anticyclonic eddy area.Enhanced diffusivity(in the order of 10–3 m2/s)was found at the posterior edge of the anticyclonic mesoscale eddy;on the anterior side,diffusivity was one order of magnitude lower on average.This asymmetrical pattern was highly correlated with the eddy kinetic energy.Higher shear variance on the posterior side,which is conducive to the triggering of shear instability,may be the main mechanism for the elevated diffusivity.In addition,the generation and growth of sub-mesoscale motions that are fed by mesoscale eddies on their posterior side may also promote the occurrence of strong mixing in the studied region.The results of this study help improve our knowledge regarding turbulent mixing in the northern SCS.
文摘An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′：5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-（3-aminopyrimido[4,5-d]thieno-2-yl）quinoline-2-ones, which could be obtained from Thorpe-Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine,with aromatic aldehydes in the presence of BF3·OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields.
文摘An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.
