Based on near-term climate simulations for IPCC-AR5 （The Fifth Assessment Report）, probabilistic multimodel ensemble prediction （PMME） of decadal variability of surface air temperature in East Asia （20°-50&#...Based on near-term climate simulations for IPCC-AR5 （The Fifth Assessment Report）, probabilistic multimodel ensemble prediction （PMME） of decadal variability of surface air temperature in East Asia （20°-50°N, 100°- 145°E） was conducted using the multivariate Gaussian ensemble kernel dressing （GED） methodology. The ensemble system exhibited high performance in hindcasting the deeadal （1981-2010） mean and trend of temperature anomalies with respect to 1961-90, with a RPS of 0.94 and 0.88 respectively. The interpretation of PMME for future decades （2006-35） over East Asia was made on the basis of the bivariate probability density of the mean and trend. The results showed that, under the RCP4.5 （Representative Concentration Pathway 4.5 W m-2） scenario, the annual mean temperature increases on average by about 1.1-1.2 K and the temperature trend reaches 0.6-0.7 K （30 yr）-1. The pattern for both quantities was found to be that the temperature increase will be less intense in the south. While the temperature increase in terms of the 30-yr mean was found to be virtually certain, the results for the 30-yr trend showed an almost 25% chance of a negative value. This indicated that, using a multimodel ensemble system, even if a longer-term warming exists for 2006-35 over East Asia, the trend for temperature may produce a negative value. Temperature was found to be more affected by seasonal variability, with the increase in temperature over East Asia more intense in autumn （mainly）, faster in summer to the west of 115°E, and faster still in autumn to the east of 115°E.展开更多
胃黏膜非典型增生（G ED ）不仅是胃癌的癌前病变，而且提示了胃黏膜发生腺癌的风险增加［1］。CyclinD1由Motokura等［2］于1991年从甲状旁腺瘤中克隆并提取出来，是细胞周期进程中的重要调控分子［3］。目前对于细胞周期蛋白的研究无...胃黏膜非典型增生（G ED ）不仅是胃癌的癌前病变，而且提示了胃黏膜发生腺癌的风险增加［1］。CyclinD1由Motokura等［2］于1991年从甲状旁腺瘤中克隆并提取出来，是细胞周期进程中的重要调控分子［3］。目前对于细胞周期蛋白的研究无论在形态结构、作用机制还是作为治疗靶点方面均取得了一定进展，细胞周期调控异常是近年来的研究热点之一［4］。本研究拟检测CyclinD1在GED癌变过程中基因和蛋白的表达情况，探讨其分子机制，为G ED早期癌变的发病过程提供临床诊断依据。展开更多
基金supported by the National Key Basic Research and Development (973) Program of China (Grant No. 2012CB955204)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)the Research open-fund of Jiangsu Meteorology Bureau (Grant Nos. Q201205, KM201107, and K201009)
文摘Based on near-term climate simulations for IPCC-AR5 （The Fifth Assessment Report）, probabilistic multimodel ensemble prediction （PMME） of decadal variability of surface air temperature in East Asia （20°-50°N, 100°- 145°E） was conducted using the multivariate Gaussian ensemble kernel dressing （GED） methodology. The ensemble system exhibited high performance in hindcasting the deeadal （1981-2010） mean and trend of temperature anomalies with respect to 1961-90, with a RPS of 0.94 and 0.88 respectively. The interpretation of PMME for future decades （2006-35） over East Asia was made on the basis of the bivariate probability density of the mean and trend. The results showed that, under the RCP4.5 （Representative Concentration Pathway 4.5 W m-2） scenario, the annual mean temperature increases on average by about 1.1-1.2 K and the temperature trend reaches 0.6-0.7 K （30 yr）-1. The pattern for both quantities was found to be that the temperature increase will be less intense in the south. While the temperature increase in terms of the 30-yr mean was found to be virtually certain, the results for the 30-yr trend showed an almost 25% chance of a negative value. This indicated that, using a multimodel ensemble system, even if a longer-term warming exists for 2006-35 over East Asia, the trend for temperature may produce a negative value. Temperature was found to be more affected by seasonal variability, with the increase in temperature over East Asia more intense in autumn （mainly）, faster in summer to the west of 115°E, and faster still in autumn to the east of 115°E.
文摘胃黏膜非典型增生（G ED ）不仅是胃癌的癌前病变，而且提示了胃黏膜发生腺癌的风险增加［1］。CyclinD1由Motokura等［2］于1991年从甲状旁腺瘤中克隆并提取出来，是细胞周期进程中的重要调控分子［3］。目前对于细胞周期蛋白的研究无论在形态结构、作用机制还是作为治疗靶点方面均取得了一定进展，细胞周期调控异常是近年来的研究热点之一［4］。本研究拟检测CyclinD1在GED癌变过程中基因和蛋白的表达情况，探讨其分子机制，为G ED早期癌变的发病过程提供临床诊断依据。
